FAK
Les inhibiteurs de la kinase d'adhésion focale (FAK) ciblent la FAK, une kinase impliquée dans l'adhésion cellulaire, la migration et l'angiogenèse. La FAK est fréquemment surexprimée dans les tumeurs et contribue à la formation de nouveaux vaisseaux sanguins qui alimentent la tumeur en nutriments. L'inhibition de la FAK peut perturber ces processus, faisant des inhibiteurs de la FAK des outils précieux en thérapie anticancéreuse et en recherche sur l'angiogenèse. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la FAK de haute qualité pour soutenir vos recherches en biologie cellulaire, cancer et angiogenèse.
74 produits trouvés pour "FAK".
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Roslin 2 bromide
CAS :Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.Formule :C13H19BrN4Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :311.221FC 11
CAS :FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.Formule :C41H42F3N13O9SCouleur et forme :SolidMasse moléculaire :949.91Ifebemtinib
CAS :Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.Formule :C28H28F4N6O4Degré de pureté :98.47% - 99.93%Couleur et forme :White SolidMasse moléculaire :588.5533FAK-IN-3
FAK-IN-3 inhibits FAK, reduces PA-1 cell migration/invasion, and tumor growth, with no major side effects.Formule :C28H28N6O4Couleur et forme :SolidMasse moléculaire :512.56FAK-IN-23
CAS :FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).Formule :C32H38F3N5O8Couleur et forme :SolidMasse moléculaire :677.668FAK-IN-26
CAS :FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.Formule :C20H19BrFN5O2Couleur et forme :SolidMasse moléculaire :460.30OXA-11
CAS :OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.Formule :C37H49F3N7O5PDegré de pureté :98.70% - 99.20%Couleur et forme :White SolidMasse moléculaire :759.8FAK-IN-21
CAS :FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.Formule :C22H22F2N8O3SCouleur et forme :SolidMasse moléculaire :516.52FAK inhibitor 6
CAS :Compound 26F: potent enzyme inhibitor (IC50=28.2nM), low cytotoxicity (IC50=3.32μM), induces dose-dependent apoptosis in MDA-MB-231, blocks G0/G1 phase.Formule :C25H24FN5O2SCouleur et forme :SolidMasse moléculaire :477.55FAK activator-1
CAS :FAKactivator-1 (5aHCl) is a compound that functions as a FAK activator and mucosal healing inducer. It enhances the phosphorylation of FAK at the Tyr-397 site, thereby facilitating FAK activation. This agent promotes mucosal healing and is applicable in research related to gastrointestinal mucosal injury associated with non-steroidal anti-inflammatory drugs.Formule :C21H27ClF3N5O2Masse moléculaire :473.92JP-153
CAS :JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.Formule :C21H19NO5Couleur et forme :SolidMasse moléculaire :365.379Pyk2-IN-2
CAS :Pyk2-IN-2 (compound 13j) acts as a Pyk2 inhibitor, exhibiting an IC 50 value of 0.608 μM for FAK kinase [1].Formule :C27H27N7OCouleur et forme :SolidMasse moléculaire :465.55FAK-IN-6
FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.Formule :C25H31ClN5O6PSCouleur et forme :SolidMasse moléculaire :596.04Ifebemtinib tosylate
CAS :Ifebemtinib (tosylate) (BI-853520 (tosylate); IN-10018 (tosylate)) is a highly selective PTK2 kinase inhibitor with anti-tumor properties. It inhibits FAK autophosphorylation in prostate cancer cells and suppresses spheroid formation and in situ tumor growth in vivo. Ifebemtinib (tosylate) is applicable in cancer research, including studies on solid tumors, breast cancer, and malignant pleural mesothelioma.Formule :C35H36F4N6O7SCouleur et forme :SolidMasse moléculaire :760.76
