Thrombine
Les inhibiteurs de la thrombine sont des composés qui bloquent la thrombine, une enzyme impliquée dans le processus de coagulation sanguine, qui joue également un rôle dans la promotion de l'angiogenèse. La thrombine peut stimuler la formation de nouveaux vaisseaux sanguins dans les tumeurs, favorisant ainsi leur croissance et leurs métastases. En inhibant la thrombine, ces composés peuvent réduire l'angiogenèse et la progression tumorale. Les inhibiteurs de la thrombine sont importants à la fois dans la recherche sur le cancer et dans l'étude des maladies vasculaires. Chez CymitQuimica, nous offrons une sélection d'inhibiteurs de la thrombine de haute qualité pour soutenir vos recherches en hémostase, oncologie et angiogenèse.
62 produits trouvés pour "Thrombine".
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Enoxaparin sodium
CAS :Enoxaparin, a low-weight heparin approved by FDA for STEMI, enhances antithrombin and prevents clotting by inhibiting factors XIa, IXa, Xa, IIa.Formule :C42H59N3Na4O35S2Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :1322AEBSF hydrochloride
CAS :AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.Formule :C8H11ClFNO2SDegré de pureté :98% - 99.81%Couleur et forme :SolidMasse moléculaire :239.69H-D-Phe-Pip-Arg-pNA dihydrochloride
CAS :H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238) is a sensitive and accurate thrombin detection substrate for measuring antithrombin-heparin cofactor (AT-III).Formule :C27H38Cl2N8O5Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :625.547Bivalirudin
CAS :Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clottingFormule :C98H138N24O33Degré de pureté :98.80% - >99.99%Couleur et forme :White SolidMasse moléculaire :2180.29Argatroban
CAS :Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.Formule :C23H36N6O5SDegré de pureté :99.77% - >99.99%Couleur et forme :White SolidMasse moléculaire :508.63Ichorcumab
CAS :Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :~148 kDaIdarucizumab
CAS :Idarucizumab, a humanized monoclonal antibody fragment, serves as the first reversal agent for direct oral anticoagulants (DOACs).Couleur et forme :LiquidOM-189
CAS :OM-189 is a selective inhibitor of synthetic thrombin.Formule :C24H36N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.65YD-3
CAS :YD-3 is a PAR4 antagonist that significantly inhibits thrombin-induced platelet aggregation in rabbits (IC(50)=28.3 microM). In addition, YD-3 suppresses thrombin-induced proliferation of vascular smooth muscle cells (VSMCs) and reduces neointimal thickening after balloon injury. Through Ras- and ERK1/2-mediated signaling pathways, YD-3 impedes thrombin-driven VSMC proliferation. When analyzed with Western blot, YD-3 primarily inhibits thrombin-induced expression of vascular endothelial growth factor receptor 2 (Flk-1) without affecting extracellular signal-regulated kinase 1/2 phosphorylation. YD-3 could potentially have value in elucidating the pathophysiology of thrombin-induced angiogenesis.Formule :C23H20N2O2Couleur et forme :SolidMasse moléculaire :356.42Thrombin inhibitor 13
CAS :Thrombin inhibitor 13 (Compound 13a) acts as a covalent reversible inhibitor of thrombin (thrombin, FIIa) with an IC50 of 0.7 nM. This compound prolongs activated partial thromboplastin time (aPTT) and prothrombin time (PT), demonstrating both antithrombotic and anticoagulant properties.Formule :C16H17ClN6OSCouleur et forme :SolidMasse moléculaire :376.864Atopaxar Hydrobromide
CAS :Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.Formule :C29H39BrFN3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.539Flovagatran
CAS :Flovagatran (TGN 255) is a potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.Formule :C27H36BN3O7Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :525.4Efegatran sulfate
CAS :Efegatran sulfate (LY294468 sulfate) is a potent thrombin inhibitor used in the treatment of thrombotic disorders.Formule :C21H34N6O7SDegré de pureté :97.51% - 99.49%Couleur et forme :SolidMasse moléculaire :514.6TPO agonist 1
CAS :TPO agonist 1, Thrombopoietin (TPO) mimetic, promotes platelet/megakaryocyte production, for thrombocytopenia research.Formule :C25H22N8O2Degré de pureté :98%Couleur et forme :Red SolidMasse moléculaire :466.4946Atopaxar
CAS :Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.Formule :C29H38FN3O5Degré de pureté :97.07% - 98.07%Couleur et forme :SolidMasse moléculaire :527.6275Melagatran
CAS :Melagatran is an orally available, direct synthetic thrombin inhibitor that does not require endogenous cofactors other than thrombin.Cost-effective and quality-assured.Formule :C22H31N5O4Degré de pureté :99.79% - >99.99%Couleur et forme :White SolidMasse moléculaire :429.5126Thrombin inhibitor 1
CAS :Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).Formule :C22H20Cl2F2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :497.32SCH79797 dihydrochloride
CAS :SCH79797 dihydrochloride is a PAR1 antagonist with IC50 70 nM, Ki 35 nM, antiproliferative, and pro-apoptotic properties.Formule :C23H27Cl2N5Degré de pureté :99.5%Couleur et forme :White SolidMasse moléculaire :444.4Antiplatelet agent 3
CAS :Antiplatelet agent 3 (Compound K-10) is a compound with antiplatelet aggregation activity, exhibiting IC50 values of 2.55, 3.22, and 2.09 mg/mL for platelet aggregation induced by ADP, AA, and COL, respectively. It holds potential for research in cardiovascular diseases.Formule :C38H32N2O5Couleur et forme :SolidMasse moléculaire :596.671SAR107375
CAS :SAR107375 is a potent, orally active dual inhibitor of thrombin and factor Xa, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively [1].Formule :C24H30ClN5O5S2Couleur et forme :SolidMasse moléculaire :568.11
