PERK
Les inhibiteurs de PERK (Protéine kinase R (PKR)-like Endoplasmic Reticulum Kinase) ciblent la voie PERK, impliquée dans la réponse cellulaire au stress du réticulum endoplasmique (ER) et la régulation de l'apoptose. PERK joue un rôle crucial dans la réponse aux protéines mal repliées (UPR) en arrêtant la traduction des protéines et en favorisant la survie cellulaire sous conditions de stress. Cependant, une activation prolongée de PERK peut conduire à l'apoptose. Inhiber PERK peut moduler ces réponses au stress, ce qui rend ces inhibiteurs précieux dans la recherche sur les maladies neurodégénératives, le cancer et les troubles métaboliques. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de PERK de haute qualité pour soutenir vos recherches sur l'apoptose, le stress du RE et l'homéostasie cellulaire.
26 produits trouvés pour "PERK"
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Daraxonrasib
CAS :Daraxonrasib is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Formule :C44H58N8O5SDegré de pureté :98.24% - 99.96%Couleur et forme :SolidMasse moléculaire :811.05PERK-IN-6
CAS :PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Formule :C23H22N6ODegré de pureté :99.62% - 99.92%Couleur et forme :SolidMasse moléculaire :398.46PERK-IN-4
CAS :PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Formule :C24H19F4N5ODegré de pureté :99.44% - 99.49%Couleur et forme :SolidMasse moléculaire :469.43Claturafenib
CAS :Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Formule :C18H15Cl2F2N5O3SDegré de pureté :98.68% - 99.85%Couleur et forme :SolidMasse moléculaire :490.31EIF2α activator 2
CAS :EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.Formule :C21H20F6N2O2Degré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :446.39Ref: TM-T62637
1mg62,00€5mg130,00€10mg203,00€25mg380,00€50mg556,00€100mg799,00€200mg1.094,00€1mL*10mM (DMSO)144,00€2BAct
CAS :2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress responseFormule :C19H16ClF3N4O3Degré de pureté :97.97% - 99.04%Couleur et forme :SolidMasse moléculaire :440.8Takeda-6d
CAS :Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Formule :C27H19ClFN5O3SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :547.99Ref: TM-T22436
1mg97,00€2mg135,00€5mg188,00€10mg283,00€25mg462,00€50mg645,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)255,00€ONO-8130
CAS :ONO-8130 is an orally available antagonist of EP1 receptor.Formule :C25H28N2O5S2Degré de pureté :97.82%Couleur et forme :SolidMasse moléculaire :500.63GSK621
CAS :GSK621 is a specific and potent AMPK activator.Formule :C26H20ClN3O5Degré de pureté :97.02% - 97.05%Couleur et forme :SolidMasse moléculaire :489.91Ref: TM-T6854
1mg52,00€2mgÀ demander5mg106,00€10mg180,00€25mg311,00€50mg502,00€100mg743,00€200mg1.026,00€IACS-13909
CAS :IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Formule :C17H18Cl2N6Degré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :377.27GSK2606414
CAS :GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.Formule :C24H20F3N5ODegré de pureté :98% - >99.99%Couleur et forme :SolidMasse moléculaire :451.44Bufotalin
CAS :<p>1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.</p>Formule :C26H36O6Degré de pureté :99.45% - 99.91%Couleur et forme :White To Off-White SolidMasse moléculaire :444.56SHP099
CAS :SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cellsFormule :C16H19Cl2N5Degré de pureté :98.73% - 99.4%Couleur et forme :SolidMasse moléculaire :352.26Ref: TM-T3564
1mg34,00€2mg49,00€5mg74,00€10mg94,00€25mg165,00€50mg213,00€100mg388,00€1mL*10mM (DMSO)57,00€ISRIB (trans-isomer)
CAS :ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Formule :C22H24Cl2N2O4Degré de pureté :97.86% - 99.27%Couleur et forme :SolidMasse moléculaire :451.34GSK2656157
CAS :GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Formule :C23H21FN6ODegré de pureté :98.59% - >99.99%Couleur et forme :SolidMasse moléculaire :416.45Ref: TM-T2654
2mg35,00€5mg50,00€10mg81,00€25mg142,00€50mg259,00€100mg467,00€200mg632,00€1mL*10mM (DMSO)56,00€SHP389
CAS :SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.Formule :C23H29ClN8O2Degré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :484.98DNL343
CAS :DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.Formule :C20H19ClF3N3O4Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :457.83eIF4A3-IN-1
CAS :<p>eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.</p>Formule :C29H23BrClN5O2Degré de pureté :99.49% - 99.89%Couleur et forme :SolidMasse moléculaire :588.88PF-07284892
CAS :PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.Formule :C21H22ClN7SDegré de pureté :97.77%Couleur et forme :SolidMasse moléculaire :439.96GCN2-IN-6
CAS :GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).Formule :C19H12Cl2F2N4O3SDegré de pureté :95.04% - 98%Couleur et forme :SolidMasse moléculaire :485.29eIF4E-IN-4
CAS :<p>eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.</p>Formule :C20H19ClN5O5PCouleur et forme :SolidMasse moléculaire :475.822eIF4A-IN-1
CAS :eIF4A-IN-1 is an eIF4A inhibitor used in tumor research.Formule :C31H33N3O5Couleur et forme :SolidMasse moléculaire :527.61HC-7366
CAS :HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.Formule :C20H15ClF2N6O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :508.89HC-5404-Fu
CAS :HC-5404-Fu is an inhibitor of PERK with anti-tumor activity. This compound inhibits the signaling pathway of the endoplasmic reticulum stress response. Additionally, HC-5404-Fu increases the sensitivity of renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). It holds potential for research into renal cell carcinoma, stomach cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors.Formule :C28H28F2N4O7Couleur et forme :SolidMasse moléculaire :570.54HR-19011
CAS :HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP,antiproliferative.Formule :C25H19F6N3O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :523.43Ref: TM-T63665
2mg90,00€5mg137,00€10mg219,00€25mg440,00€50mg704,00€100mg1.103,00€200mg1.499,00€1mL*10mM (DMSO)157,00€HC-5404
CAS :HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Formule :C24H24F2N4O3Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :454.47
