PERK
Les inhibiteurs de PERK (Protéine kinase R (PKR)-like Endoplasmic Reticulum Kinase) ciblent la voie PERK, impliquée dans la réponse cellulaire au stress du réticulum endoplasmique (ER) et la régulation de l'apoptose. PERK joue un rôle crucial dans la réponse aux protéines mal repliées (UPR) en arrêtant la traduction des protéines et en favorisant la survie cellulaire sous conditions de stress. Cependant, une activation prolongée de PERK peut conduire à l'apoptose. Inhiber PERK peut moduler ces réponses au stress, ce qui rend ces inhibiteurs précieux dans la recherche sur les maladies neurodégénératives, le cancer et les troubles métaboliques. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de PERK de haute qualité pour soutenir vos recherches sur l'apoptose, le stress du RE et l'homéostasie cellulaire.
31 produits trouvés pour "PERK".
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RAPT-37-Me
CAS :RAPT-37-Me is a GCN2 inhibitor, exhibiting IC50 values for GCN2, PERK, HRl, and PKR of 0.002 μM, >10 μM, 4.40 μM, and 1.31 μM, respectively.Formule :C22H21BrFN7OMasse moléculaire :498.36HC-5404-Fu
CAS :HC-5404-Fu is an inhibitor of PERK with anti-tumor activity. This compound inhibits the signaling pathway of the endoplasmic reticulum stress response. Additionally, HC-5404-Fu increases the sensitivity of renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). It holds potential for research into renal cell carcinoma, stomach cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors.Formule :C28H28F2N4O7Couleur et forme :SolidMasse moléculaire :570.54eIF4E-IN-4
CAS :eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.Formule :C20H19ClN5O5PCouleur et forme :SolidMasse moléculaire :475.822HR-19011
CAS :HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP,antiproliferative.Formule :C25H19F6N3O3Degré de pureté :99.89%Couleur et forme :Yellow SolidMasse moléculaire :523.43Ref: TM-T63665
2mg79,00€5mg120,00€1mL*10mM (DMSO)138,00€10mg192,00€25mg385,00€50mg625,00€100mg982,00€200mg1.333,00€eIF4A-IN-1
CAS :eIF4A-IN-1 is an eIF4A inhibitor used in tumor research.Formule :C31H33N3O5Couleur et forme :SolidMasse moléculaire :527.61HC-7366
CAS :HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.Formule :C20H15ClF2N6O4SDegré de pureté :99.84%Couleur et forme :White SolidMasse moléculaire :508.89KRAS-IN-56
CAS :KRAS-IN-56 (Compound 18) is a KRAS inhibitor with an EC50 of 33 μM. It disrupts the interaction between GTP-KRAS and SOS1, and reduces p-ERK levels. KRAS-IN-56 is applicable for research related to lung cancer.Formule :C19H19N3O2Masse moléculaire :321.37NCATS-SM0225
CAS :NCATS-SM0225 is an ER-associated degradation (ERAD) inhibitor and a direct binder of VDAC1, VDAC2, and VDAC3. It has an IC50 of 1.02 μM for ERAD inhibition and a Kd of 3.13 μM for binding to human VDAC1. NCATS-SM0225 disrupts cellular calcium homeostasis, enhances VDAC1-IP3R coupling, and activates PERK. The compound selectively kills cancer cells and has shown tumor growth inhibition in melanoma xenograft models. It is useful for research into various cancers, including melanoma, as well as studies on ERAD and calcium homeostasis regulatory mechanisms.Formule :C23H28N2O4S2Masse moléculaire :460.61ISR activator 3
CAS :ISR activator 3 (Compound cc81) is the active metabolite of A8. It activates the integrated stress response (ISR) by binding to RIG-I (KD≈ 0.55 μM) without inducing lipid droplet clearance. Additionally, ISR activator 3 enhances the interferon response under viral mimic signaling. This compound is applicable in studies of neurodegenerative diseases and immune stress.Formule :C23H21N3O3S2Masse moléculaire :451.56APL-4098
CAS :APL-4098 is an orally active, selective, ATP-competitive GCN2 inhibitor with a Ki of 4.39 nM and a Kd of 2.9 nM. It reduces the phosphorylation levels of eIF2α and the expression of ATF4. APL-4098 impairs mitochondrial function and exhibits cytotoxicity against primary acute myeloid leukemia cells. It is applicable in studies related to acute myeloid leukemia.Formule :C17H12ClFN6O3SMasse moléculaire :434.83HC-5404
CAS :HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Formule :C24H24F2N4O3Degré de pureté :99.33%Couleur et forme :White SolidMasse moléculaire :454.47
