Chk
Les inhibiteurs des kinases de point de contrôle (Chk) ciblent les kinases Chk1 et Chk2, qui sont des régulateurs clés de la réponse aux dommages de l'ADN et des points de contrôle du cycle cellulaire. Ces kinases arrêtent la progression du cycle cellulaire en réponse aux dommages de l'ADN, permettant ainsi le temps nécessaire à la réparation. Inhiber les kinases Chk peut empêcher l'arrêt du cycle cellulaire, forçant les cellules endommagées à poursuivre le cycle et à subir finalement l'apoptose. Les inhibiteurs de Chk sont particulièrement précieux dans la recherche sur le cancer, où ils peuvent sensibiliser les cellules tumorales aux agents endommageant l'ADN. Chez CymitQuimica, nous offrons une variété d'inhibiteurs de Chk de haute qualité pour soutenir vos recherches sur la réponse aux dommages de l'ADN, la régulation du cycle cellulaire et l'oncologie.
42 produits trouvés pour "Chk"
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CHK1-IN-4 hydrochloride
<p>CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1).</p>Formule :C18H19BrClN7O2Degré de pureté :99.29%Couleur et forme :SoildMasse moléculaire :480.75Monalizumab
CAS :<p>Monalizumab, a humanized antibody, enhances NK cell function by inhibiting NKG2A; used in HNSCC studies.</p>Degré de pureté :95% - > 95%Couleur et forme :LiquidMasse moléculaire :147 kDa (average)WAY-230563
CAS :<p>WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cells</p>Formule :C17H12N2O2SDegré de pureté :98.40%Couleur et forme :SolidMasse moléculaire :308.35CBP501 Affinity Peptide
CAS :<p>CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].</p>Formule :C68H119N21O25SCouleur et forme :SolidMasse moléculaire :1662.86Zimistobart
CAS :<p>Zimistobart (BMS-986315) is a fully human IgG1 antibody that targets and binds to NKG2A. It is applicable in research for non-small cell lung cancer (NSCLC). For an isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Couleur et forme :LiquidCCT241533 dihydrochloride
CAS :<p>Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.</p>Formule :C23H29Cl2FN4O4Couleur et forme :SolidMasse moléculaire :515.41Chk1-IN-6
CAS :<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Formule :C16H18F3N7Couleur et forme :SolidMasse moléculaire :365.364CHK1-IN-12
<p>CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.</p>Formule :C19H19N7O2Couleur et forme :SolidMasse moléculaire :377.16002CHK1-IN-9
<p>CHK1-IN-9 (compound 11) is an orally active CHK1 inhibitor with an IC50 of 0.55 nM. It enhances the effects of DNA-damaging agents on tumor cells and exhibits synergistic anticancer activity with Gemcitabine.</p>CCT244747
CAS :<p>CCT244747 is a potent and selective CHK1 inhibitor oral, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis .</p>Formule :C20H24N8O2Degré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :408.46GDC-0425
CAS :<p>GDC-0425 (RG-7602), an oral selective ChK1 inhibitor, targets multiple cancers.</p>Formule :C18H19N5OCouleur et forme :SolidMasse moléculaire :321.38GDC-0575 dihydrochloride
CAS :<p>GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective, orally active CHK1 inhibitor (IC50: 1.2 nM) that exhibits antitumour effects.</p>Formule :C16H22BrCl2N5OCouleur et forme :SolidMasse moléculaire :451.19LY2880070
CAS :<p>LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.</p>Formule :C19H23N7O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :381.43GDC-0575
CAS :<p>GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).</p>Formule :C16H20BrN5ODegré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :378.27SCH900776
CAS :<p>SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.</p>Formule :C15H18BrN7Degré de pureté :96.69% - 99.6%Couleur et forme :SolidMasse moléculaire :376.25GDC0575 monohydrochloride
CAS :<p>GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.</p>Formule :C16H21BrClN5ODegré de pureté :97.85%Couleur et forme :SolidMasse moléculaire :414.73SAR-020106
CAS :<p>SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.</p>Formule :C19H19ClN6ODegré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :382.85Rabusertib
CAS :<p>Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.</p>Formule :C18H22BrN5O3Degré de pureté :98.86% - 99.87%Couleur et forme :SolidMasse moléculaire :436.3CCT245737
CAS :<p>CCT245737 is an orally active, selective Chk1 inhibitor, and is >1,000-fold selective over CHK2 and CDK1.Cost-effective and quality-assured.</p>Formule :C16H16F3N7ODegré de pureté :98.06% - 99.69%Couleur et forme :SolidMasse moléculaire :379.34AZD-7762
CAS :<p>AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.</p>Formule :C17H19FN4O2SDegré de pureté :98.96% - 99.19%Couleur et forme :SolidMasse moléculaire :362.42AZD7762 HCl
CAS :<p>AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.</p>Formule :C17H20ClFN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.88PV-1115
CAS :<p>PV-1115 is an effective and highly selective inhibitor of the Chk2.</p>Formule :C20H19N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.41NSC 109555 ditosylate
CAS :<p>Chk2 inhibitor,ATP-competitive</p>Formule :C26H32N10O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.66PV-1019
CAS :<p>PV-1019 (NSC 744039), a potent Chk2 inhibitor, has an IC50 of 24 nM and blocks Chk2 autophosphorylation and IR-induced apoptosis.</p>Formule :C18H17N7O3Couleur et forme :SolidMasse moléculaire :379.37VRX-0466617
CAS :<p>VRX-0466617 is a novel selective Chk2 inhibitor.</p>Formule :C19H20BrN5O2SCouleur et forme :SolidMasse moléculaire :462.36TCS 2312
CAS :<p>checkpoint kinase 1 (chk1) inhibitor</p>Formule :C25H24N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :412.48SC-203885
CAS :<p>SC-203885 is a checkpoint kinase 2 inhibitor.</p>Formule :C15H13N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.3M443
CAS :<p>M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.</p>Formule :C31H30F3N7O2Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :589.61NR2F6 modulator-1
CAS :<p>NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.</p>Formule :C23H17NO5SDegré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :419.45CHK1-IN-3
CAS :<p>CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).</p>Formule :C20H23N9ODegré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :405.46CCT241533 hydrochloride
CAS :<p>CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>Formule :C23H28ClFN4O4Degré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :478.95MU-380
CAS :<p>MU-380 is an effective and selective inhibitor of CHK1.</p>Formule :C15H15BrF3N7Couleur et forme :SolidMasse moléculaire :430.23CCT241533
CAS :<p>CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>Formule :C23H27FN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.48VER-00158411
CAS :<p>VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).</p>Formule :C31H34N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.64CHK1-IN-2
CAS :<p>CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).</p>Formule :C20H22N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.48CHK1-IN-4
CAS :<p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>Formule :C18H18BrN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.29CHK-IN-1
CAS :<p>CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.</p>Formule :C18H19ClFN5OSDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :407.89BBI-355
CAS :<p>BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.</p>Formule :C19H19N7O2Couleur et forme :SolidMasse moléculaire :377.40CHK1-IN-11
CAS :<p>CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.</p>Formule :C20H22N8O2Couleur et forme :SolidMasse moléculaire :406.44CHK1 inhibitor
CAS :<p>CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.</p>Formule :C17H21BrN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.28Chk1-IN-5
CAS :<p>Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.</p>Formule :C18H18FN7O2Couleur et forme :SolidMasse moléculaire :383.38PHI-101
CAS :<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Formule :C19H19FN4O2SDegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :386.44Ref: TM-T81490
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