Kinésine
Les inhibiteurs de kinésine ciblent les protéines motrices kinésines, responsables du transport des cargaisons cellulaires le long des microtubules et jouant un rôle clé dans la division cellulaire, en particulier pendant la mitose. Les kinésines sont impliquées dans le mouvement des chromosomes et d'autres organites pendant la division cellulaire. Inhiber les kinésines peut perturber ces processus, entraînant un arrêt du cycle cellulaire et une mort cellulaire potentielle, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme diversifiée d'inhibiteurs de kinésine de haute qualité pour soutenir vos recherches en biologie cellulaire, mitose et thérapie contre le cancer.
89 produits trouvés pour "Kinésine".
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Mps1-IN-3
CAS :Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).Formule :C26H31N7O4SDegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :537.634BOS-172722
CAS :BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).Formule :C24H30N8ODegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :446.548Paprotrain
CAS :Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.Formule :C16H11N3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :245.28KSP ligand 1
CAS :KSP ligand 1 is a protein ligand that targets KSP (Kinesin) and can be used in the synthesis of PROTAC KSP-IN-1 for cancer research.Formule :C25H23NO3SCouleur et forme :SolidMasse moléculaire :417.52Anticancer agent 190
Anticancer agent 190 (compound 3e) is an inhibitor targeting KSP (Kinesin) and PI3Kδ, demonstrating efficacy against breast cancer.Formule :C21H13ClF2N2OSCouleur et forme :SolidMasse moléculaire :414.04052KIF18A-IN-2
CAS :KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.Formule :C25H34N4O5S2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :534.691CENP-E-IN-2
CENP-E-IN-2 (compound 3) is a photocontrollable CENP-E inhibitor exhibiting a pIC50 of 6.82 in the absence of light and a pIC50 of 5.85 under 365 nm light exposure. This compound also demonstrates antitumor activity.Couleur et forme :Odour SolidMitotic kinesin-IN-3 hydrochloride
Mitotic kinesin-IN-3 (Page 135, fourteenth) hydrochloride is an inhibitor of the mitotic motor protein (Mitotickinesin). It interferes with cell proliferation by inhibiting mitosis. This compound can be utilized in research relating to cancer, cardiac hypertrophy, immune and inflammatory diseases, as well as fungal infections.Couleur et forme :Odour SolidTTK/PLK1-IN-1
CAS :TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.Formule :C30H33N7O2Degré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :523.63KIF18A-IN-6
CAS :KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM.Formule :C28H37N3O5S2Degré de pureté :97.59%Couleur et forme :Yellow SolidMasse moléculaire :559.74Eg5-IN-3
Eg5-IN-3 (5) is an Eg5 inhibitor targeting a novel allosteric site (α4/α6/L11). It disrupts tubulin assembly, leading to abnormal and irregular formations, which subsequently causes typical mitotic arrest, akin to the effects of Monastrol.Formule :C23H23N7O2Couleur et forme :SolidMasse moléculaire :429.19132Filanesib TFA
CAS :Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.Formule :C22H23F5N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.5Mps1-IN-6
Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].Formule :C35H39N9O3Couleur et forme :SolidMasse moléculaire :633.7411H-Benzo[a]carbazole
CAS :11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.Formule :C16H11NDegré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :217.2652KIF2C-IN-1
KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.Formule :C36H39ClN4O9SCouleur et forme :SolidMasse moléculaire :738.21263Mps1-IN-4
CAS :Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.Formule :C26H31F3N6O2Couleur et forme :SolidMasse moléculaire :516.56KIF18A-IN-11
KIF18A-IN-11 (Compound 13) is an effective inhibitor of KIF18A, exhibiting IC50 values below 100 nM in OVCAR3 and MDA-MB-157 cells. It is applicable for cancer research.Formule :C28H38F2N6O4SCouleur et forme :SolidMasse moléculaire :592.26433KIF18A-IN-12
CAS :KIF18A-IN-12 (compound 9), a potent KIF18A inhibitor, exhibits an IC 50 of 45.54 nM and is utilized in cancer research.Formule :C30H39F2N5O4SCouleur et forme :SolidMasse moléculaire :603.72(S)-Monastrol
CAS :Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formule :C14H16N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.35Eg5-IN-1
Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.Formule :C23H16ClFN4ODegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :418.85
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