Intégrine
Les inhibiteurs d'intégrines ciblent les intégrines, une famille de récepteurs de surface cellulaire qui jouent un rôle crucial dans l'adhésion cellulaire, la migration et la transduction du signal. Les intégrines sont impliquées dans la régulation du cycle cellulaire, en particulier dans des processus tels que la division et la différenciation cellulaires. Inhiber les intégrines peut perturber ces processus, entraînant un arrêt du cycle cellulaire et l'apoptose, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer et l'étude des métastases. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs d'intégrines de haute qualité pour soutenir vos recherches sur la régulation du cycle cellulaire, la biologie du cancer et le développement thérapeutique.
279 produits trouvés pour "Intégrine"
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Obrindatamab
CAS :Obrindatamab: a humanized bispecific antibody targeting B7-H3/CD3, enhances CTL-mediated cancer cell killing.Couleur et forme :LiquidAcapatamab
CAS :Acapatamab (AMG-160) is a Half-Life Extended (HLE) Bispecific T-cell Engager (BiTE) with domains that bind to PSMA and CD3. It exhibits Kd values of 14.8 nM for hPSMA and 22.4 nM for hCD3. This compound is utilized in cancer research.Couleur et forme :LiquidOS-2966
OS-2966 is a humanised de-immunised monoclonal antibody that target Integrin b1/ITGB1/CD29, malignant gliomas, glioblastomas, and astrocytomas.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :~150 kDaAnti-Mouse CD32/CD16 Antibody (2.4G2)
Anti-Mouse CD32/CD16 Antibody is a rat-derived IgG2b inhibitor targeting the mouse CD32/CD16 antigens.Couleur et forme :LiquidMasse moléculaire :150 kDaAnti-Mouse TCR γ/δ Antibody (UC7-13D5)
Anti-Mouse TCR gamma/delta Antibody is a host Armenian Hamster-derived IgG class inhibitor targeting the mouse TCR gamma/delta receptor.Couleur et forme :Odour LiquidSB273005
CAS :SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.Formule :C22H24F3N3O4Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :451.44Tirofiban
CAS :Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.Formule :C22H36N2O5SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :440.6GR 144053 trihydrochloride
CAS :platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonistFormule :C18H30Cl3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.82GSK-3008348
CAS :GSK-3008348 is an antagonist of integrin alpha(v)beta6.Formule :C29H37N5O2Degré de pureté :99.547%Couleur et forme :SolidMasse moléculaire :487.64L 703014
CAS :L 703014 is an antagonist of the fibrinogen receptor.Formule :C24H34N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.55RUC-1
CAS :RUC-1 is an αIIbβ3-selective ADP-induced platelet aggregation inhibitor.Formule :C11H15N5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :265.33MK-0668 Mesylate
CAS :MK-0668 Mesylate is the mesylate form of MK-0668 that is a very potent and orally active very late antigen-4 antagonist.Formule :C32H34Cl2N6O9S2Couleur et forme :SolidMasse moléculaire :781.68Nexinhib20
CAS :Nexinhib20 is an inhibitor of exosome synthesis and transport with anti-inflammatory activity, inhibits RAB27A and neutral sphingomyelinase 2 (nSMase2) nsMase2.Formule :C15H16N4O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :300.31UR-2922
CAS :UR-2922: Oral GPIIb/IIIa blocker with <1 nM affinity, slow 90 min k(off), no LIBS or prothrombotic effects.Formule :C25H25N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.51IS-741 calcium
CAS :IS-741 calcium is a phospholipase A2 inhibitor.Formule :C30H38CaF6N6O6S2Couleur et forme :SolidMasse moléculaire :796.86IS-741 potassium
CAS :IS-741 potassium is a phospholipase A2 inhibitor.Formule :C15H19F3KN3O3SCouleur et forme :SolidMasse moléculaire :417.49UR-3216
CAS :UR-3216 is a prodrug, selectively antagonizing GPIIb/IIIa receptors orally, with its active form, UR-2992, binding tightly to platelets.Formule :C27H29N7O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :563.56Valategrast hydrochloride
CAS :Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.Formule :C30H33Cl4N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :641.41Valategrast
CAS :Valategrast: potent, oral dual α4β1/α4β7 integrin antagonist, may treat COPD and asthma.Formule :C30H32Cl3N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :604.95Integrin-IN-2
CAS :Integrin-IN-2, an oral αv integrin blocker, enhances αvβ6/3/5/8 affinities with pIC50s: 7.8/8.4/8.4/7.4.Formule :C27H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.55Zaurategrast ethyl ester sulfate
CAS :Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.Formule :C56H60Br2N8O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1197.01Zaurategrast ethyl ester
CAS :Zaurategrast ethyl ester, an α4β1/α4β7 integrin antagonist prodrug of CT7758, treats inflammatory/autoimmune conditions.Formule :C28H29BrN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :549.46IMB-10
CAS :IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.Formule :C19H15NOS2Couleur et forme :SolidMasse moléculaire :337.46Ro 43-5054
CAS :Ro 43-5054 is a small molecular, noncyclic peptidomimetic inhibitor.Formule :C24H27N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :497.5CLT-28643
CAS :CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Formule :C19H17N3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :351.36Sibrafiban
CAS :Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.Formule :C20H28N4O6Couleur et forme :SolidMasse moléculaire :420.46Integrin modulator 1
CAS :Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.Formule :C13H14N2O4Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :262.26Chrysotobibenzyl
CAS :Chrysotobibenzyl from Dendrobium pulchellum stems may trigger cell death in detached cells and hinder lung cancer growth.Formule :C19H24O5Couleur et forme :SolidMasse moléculaire :332.39TCS 2314
CAS :TCS 2314, Selective VLA-4 antagonist (IC50=4.4 nM), high clearance/low oral bioavailability, for asthma research.Formule :C28H34N4O6Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :522.59BMS-587101
CAS :BMS-587101 is a small molecule antagonist of LFA-1, which can reduce inflammation and joint destruction in the mouse model of arthritis.Formule :C26H20Cl2N4O4SCouleur et forme :SolidMasse moléculaire :555.43BOP sodium
CAS :BOP sodium salt is an inhibitor of alpha9beta1 and alpha4beta1 integrin.Formule :C25H29N3NaO7SCouleur et forme :SolidMasse moléculaire :538.57Zalunfiban
CAS :RUC-4 is an aIIb 3 antagonist. It is also used for prehospital therapy of myocardial infarction.Formule :C16H18N8O2SCouleur et forme :SolidMasse moléculaire :386.43MK-0668
CAS :MK-0668 is a very potent and orally active very late antigen-4 antagonist.Formule :C31H30Cl2N6O6SCouleur et forme :SolidMasse moléculaire :685.58XVA143
CAS :XVA143 is an integrin α/β I-like allosteric antagonist, inhibits LFA-1 (αLβ2 integrin)-dependent firm adhesion, induces extended conformations of integrins.Formule :C25H21Cl2N3O8Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :562.36BMS-688521
CAS :BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory activity.Formule :C26H19Cl2N5O4Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :536.37Ref: TM-T14676
1mg108,00€5mg264,00€1mL*10mM (DMSO)311,00€10mg371,00€25mg665,00€50mg874,00€100mg1.063,00€200mg1.423,00€αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).Formule :C28H35F3N6O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :672.67Balamapimod
CAS :Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.Formule :C30H32ClN7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.14NSC47924
CAS :NSC47924 is a laminin receptor (LR) inhibitor.Formule :C18H17NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :279.33Firategrast
CAS :Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervousFormule :C27H27F2NO6Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :499.5Ref: TM-TQ0291
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg133,00€25mg268,00€50mg439,00€100mg708,00€200mg964,00€Elarofiban
CAS :Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.Formule :C22H32N4O4Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :416.51Tirofiban HCl
CAS :Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.
Formule :C22H37ClN2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :477.06Bexotegrast HCl
CAS :Bexotegrast (PLN-74809) inhibits αVβ1/αVβ6 integrins, preventing TGF-β1 activation to treat IPF and PSC.Formule :C27H38Cl2N6O3Couleur et forme :SolidMasse moléculaire :565.54BI-1950
CAS :BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Formule :C32H26Cl2FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.5Carotegrast
CAS :Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.Formule :C27H24Cl2N4O5Couleur et forme :SolidMasse moléculaire :555.41L 738167
CAS :L 738167 is a potent antagonist of the long-acting fibrinogen receptor.Formule :C25H34N6O6SCouleur et forme :SolidMasse moléculaire :546.64Gly-Arg-Gly-Asp-Ser TFA
CAS :Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.Formule :C19H31F3N8O11Couleur et forme :SolidMasse moléculaire :604.49α7β1 integrin modulator-1
CAS :α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].Formule :C23H29N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.56Integrin Antagonists 27
CAS :Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.Formule :C24H20N4O5Couleur et forme :SolidMasse moléculaire :444.44JNJ-26076713
CAS :JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.Formule :C29H38N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.643-Hydroxyxanthone
CAS :3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFormule :C13H8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :212.2ICAM-1-IN-1
CAS :ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.Formule :C15H11BrN2O2SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :363.23Ref: TM-T13147
1mg175,00€5mg371,00€1mL*10mM (DMSO)409,00€10mg557,00€25mg887,00€50mg1.198,00€100mg1.611,00€500mg3.232,00€TAK 029
CAS :TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.Formule :C19H23N5O7Couleur et forme :SolidMasse moléculaire :433.42BIO-7662
CAS :BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.Formule :C38H48N6O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :748.89αvβ6 integrin inhibitor 2
CAS :αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.Formule :C21H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.49Synstatin (92-119)
CAS :Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 andFormule :C133H207N35O46Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3032.27ATN-161
CAS :ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.Formule :C23H35N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :597.64TC-I 15
CAS :α2β1 integrin inhibitorFormule :C23H28N4O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.62L-739758
CAS :L-739758 is a glycoprotein IIb/IIIa inhibitor.Formule :C22H26N4O5S3Couleur et forme :SolidMasse moléculaire :522.66αvβ1 integrin-IN-2
CAS :αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.Formule :C29H38N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.64Teclistamab
CAS :Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :143.64 kDaLotrafiban hydrochloride
CAS :Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.Formule :C23H33ClN4O4Couleur et forme :SolidMasse moléculaire :464.99SC-52012
CAS :SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.Formule :C25H30N4O6Degré de pureté :97.20%Couleur et forme :SolidMasse moléculaire :482.53Lotrafiban
CAS :Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.Formule :C23H32N4O4Couleur et forme :SolidMasse moléculaire :428.52Zaurategrast
CAS :Zaurategrast (CDP323) is an oral α4-integrin antagonist that blocks VCAM-1 interactions and is used to study immune cell trafficking.Formule :C26H25BrN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.41Lamifiban
CAS :Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.Formule :C24H28N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.5SB-267268
CAS :SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).Formule :C22H24F3N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :451.44αvβ1 integrin-IN-1
CAS :αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.Formule :C26H34N6O6SDegré de pureté :99.39% - 99.69%Couleur et forme :SolidMasse moléculaire :558.65Ref: TM-T13473
1mg109,00€5mg260,00€1mL*10mM (DMSO)319,00€10mg409,00€25mg660,00€50mg888,00€100mg1.224,00€200mg1.648,00€Roxifiban acetate
CAS :Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used inFormule :C23H33N5O8Degré de pureté :97.91% - 98.36%Couleur et forme :SolidMasse moléculaire :507.54Des-ethyl-carafiban
CAS :Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.Formule :C22H23N5O5Couleur et forme :SolidMasse moléculaire :437.448GSK3335103
CAS :GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Formule :C27H36FN3O4Couleur et forme :SolidMasse moléculaire :485.59GR 83895
CAS :GR 83895 is an antagonist of prototype fibrinogen receptor.Formule :C29H39N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.74SF0166
CAS :SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Formule :C23H27F2N5O4Couleur et forme :SolidMasse moléculaire :475.49Zalunfiban dihydrochloride
Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.Formule :C16H20Cl2N8O2SCouleur et forme :SolidMasse moléculaire :459.35Fradafiban
CAS :Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.Formule :C20H21N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.40L 734217
CAS :L 734217 is an antagonist of the fibrinogen receptor.Formule :C18H31N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :353.46OPN expression inhibitor 1
CAS :OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.Formule :C25H33N3O5Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :455.55Ref: TM-T62820
1mg126,00€5mg258,00€1mL*10mM (DMSO)259,00€10mg385,00€25mg695,00€50mg1.009,00€100mg1.314,00€α5β1 integrin agonist-1
CAS :α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.Formule :C24H26FN5O9Couleur et forme :SolidMasse moléculaire :547.496-B345TTQ
CAS :6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.Formule :C22H20BrNO4Couleur et forme :SolidMasse moléculaire :442.303SR121566A
CAS :SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).Formule :C20H25N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.51
