PKC
Les inhibiteurs de la protéine kinase C (PKC) ciblent la famille des kinases PKC, qui sont impliquées dans un large éventail de processus cellulaires, notamment la régulation du cycle cellulaire, l'apoptose et la différenciation. La PKC joue un rôle clé dans les voies de transduction du signal qui influencent la prolifération et la survie des cellules. L'inhibition de la PKC peut entraîner des changements dans la progression du cycle cellulaire, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer, la neurobiologie et les maladies cardiovasculaires. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de PKC de haute qualité pour soutenir vos recherches en transduction du signal, régulation du cycle cellulaire et développement thérapeutique.
102 produits trouvés pour "PKC"
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N-Desmethyltamoxifen hydrochloride
CAS :<p>N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.</p>Formule :C25H28ClNODegré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :393.95CMPD101
CAS :<p>CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).</p>Formule :C24H21F3N6ODegré de pureté :99.01% - 99.04%Couleur et forme :SolidMasse moléculaire :466.46Bisindolylmaleimide VIII acetate
CAS :<p>Bisindolylmaleimide VIII acetate is a selective PKC inhibitor with an IC50 of 158 nM in rat brain and varying IC50s for different PKC isoforms.</p>Formule :C26H26N4O4Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :458.51Mitoxantrone dihydrochloride
CAS :<p>Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.</p>Formule :C22H30Cl2N4O6Degré de pureté :97.05% - >99.99%Couleur et forme :Blue-Black Solid From Water Ethanol SolidMasse moléculaire :517.4A-3 hydrochloride
CAS :<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Formule :C12H14Cl2N2O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :321.22Delcasertib
CAS :<p>Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).</p>Formule :C120H199N45O34S2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :2880.28PKC β pseudosubstrate acetate
<p>PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.</p>Degré de pureté :95.42%Couleur et forme :SoildProtein kinase C α peptide TFA
CAS :<p>Protein Kinase C (alpha) Peptide (TFA) is a PKC-α-associated peptide functioning as a lipid-dependent serine/threonine protein kinase.</p>Formule :C68H115F3N24O26SCouleur et forme :SolidMasse moléculaire :1773.85Protein Kinase C (19-31)
CAS :<p>Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.</p>Formule :C67H118N26O16Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :1543.82Pep2m, myristoylated
CAS :<p>Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.</p>Formule :C63H118N18O14SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1383.8[Ala107]MBP(104-118)
CAS :<p>Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).</p>Formule :C67H104N20O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1493.68Delcasertib acetate
<p>Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.</p>Formule :C122H203N45O36S2Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :2940.33[Ala113]MBP(104-118)
CAS :<p>Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).</p>Formule :C67H104N20O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1493.68Myelin Basic Protein
CAS :<p>Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.</p>Formule :C60H103N21O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1390.59Psychosine
CAS :<p>Psychosine (Galactosylsphingosine) is a PKC inhibitor, and is highly cytotoxic, inducing cell death in a variety of cells.</p>Formule :C24H47NO7Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :461.63Aurothiomalate tetramer sodium
<p>Aurothiomalate tetramer sodium, a tetrameric form of Aurothiomalate sodium, functions as an anti-arthritis gold agent. It also acts as a potent and selective inhibitor of the oncogenic PKCι signaling pathway.</p>Couleur et forme :Odour SolidZIP
CAS :<p>Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.</p>Formule :C90H154N30O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1928.4Sangivamycin
CAS :<p>Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.</p>Formule :C12H15N5O5Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :309.28K-252b
CAS :<p>K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor.</p>Formule :C26H19N3O5Degré de pureté :98%Couleur et forme :Ready-To-Use SolutionMasse moléculaire :453.45Protein Kinase C (19-31) (TFA)(121545-65-1,free)
<p>Protein Kinase C (19-31) TFA is a serine-modified PKCa-derived inhibitor for testing PKC activity.</p>Formule :C69H119F3N26O18Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1657.84Fasudil
CAS :<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formule :C14H17N3O2SDegré de pureté :99.79% - 99.84%Couleur et forme :SolidMasse moléculaire :291.37NPC-15437 dihydrochloride
CAS :<p>NPC-15437 dihydrochloride is a PKC inhibitor blocking enzyme activity and phorbol ester binding, selective over other kinases, in cellular signaling research.</p>Formule :C25H52Cl2N4O2Couleur et forme :SolidMasse moléculaire :511.62Protein kinase inhibitor H-7
CAS :<p>H-7: potent PKC inhibitor with 6 μM Ki, also blocks cyclic nucleotide-dependent kinases.</p>Formule :C14H17N3O2SDegré de pureté :99.91%Couleur et forme :SoildMasse moléculaire :291.37Neuropeptide DF2
CAS :<p>Neuropeptide DF2 is an FMRFamide-related neuropeptide from crayfish.</p>Formule :C44H67N15O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :966.1Bisindolylmaleimide III
CAS :<p>Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6</p>Formule :C23H20N4O2Degré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :384.43PKCiota-IN-2
CAS :<p>PKCiota-IN-2 selectively inhibits PKC-ι (IC50=2.8nM) and also blocks PKC-α, ε (IC50s=71nM, 350nM).</p>Formule :C24H21N5ODegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :395.46LY 379196
<p>LY 379196, a potent PKC-β inhibitor (IC 50: 50 nM for PKC βI and 30 nM for PKC βII), effectively suppresses the proliferation of bovine retinal microvascular endothelial cells (BREC) induced by VEGF, IGF-1, and bFGF. This compound serves as an antiproliferative agent for proliferative retinopathy.</p>Formule :C30H34N4O5SCouleur et forme :SolidMasse moléculaire :562.68(8R)-8-Hydroxyepoxyboetirane A
<p>(8R)-8-Hydroxyepoxyboetirane A is a neuroactivating compound that interacts with PKCδ-C1B. This compound binds into the PKC enzyme pocket through hydrogen bonds with glycine-253, leucine-251, and threonine-242. It induces the release of NRG1 and promotes the differentiation of neural stem cells into neurons. (8R)-8-Hydroxyepoxyboetirane A holds potential for research into nervous system disorders.</p>Couleur et forme :Odour SolidPKCδ Peptide Substrate
CAS :<p>PKCδ Peptide Substrate is a highly specific substrate for the δ-type of Protein kinase C, composed of a sequence that mirrors murine eEF-1α (422-443) and</p>Formule :C109H191N35O29SCouleur et forme :SolidMasse moléculaire :2487.97Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS :<p>Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.</p>Formule :C56H110N22O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1315.61Ac-MBP (1-11)
CAS :<p>Ac-MBP 1-11, a primary encephalitogenic epitope in myelin basic protein (MBP), is a dominant short peptide sequence[1].</p>Formule :C2H3K2OPS3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.411-Oleoyl-2-acetyl-sn-glycerol
CAS :<p>1-Oleoyl-2-acetyl-sn-glycerol (1-oleoyl-2-acetyl-glycerol) is a PKC activator that induces superoxide production.</p>Formule :C23H42O5Couleur et forme :SolidMasse moléculaire :398.58Protein Kinase C (19-36)
CAS :<p>Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.</p>Formule :C93H159N35O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2151.48PKC β pseudosubstrate
CAS :<p>Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).</p>Formule :C177H294N62O38S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3994.84SAMβA TFA
<p>SAMβA TFA, a selective antagonist of Mfn1-βIIPKC association conjugated to the cell permeable peptide TAT47-57, is a rationally designed inhibitor that improves</p>Formule :C50H73N17O16·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1168.22 (free acid)(±)-1,2-Diolein
CAS :<p>(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.</p>Formule :C39H72O5Couleur et forme :SolidMasse moléculaire :620.99PKC-θ inhibitor
CAS :<p>PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.</p>Formule :C20H25F3N6O3Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :454.45Protein kinase inhibitor H-7 dihydrochloride
CAS :<p>Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor.</p>Formule :C14H19Cl2N3O2SDegré de pureté :99.54%Couleur et forme :White Crystalline SolidMasse moléculaire :364.29Taurochenodeoxycholic Acid
CAS :<p>Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.</p>Formule :C26H45NO6SDegré de pureté :99.53% - 99.86%Couleur et forme :SolidMasse moléculaire :499.7HA-100
CAS :<p>HA-100 is an inhibitor of protein kinase</p>Formule :C13H15N3O2SDegré de pureté :99.44%Couleur et forme :Pale Yellow Crystalline SolidMasse moléculaire :277.34Midostaurin
CAS :<p>PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.</p>Formule :C35H30N4O4Degré de pureté :97.61% - >99.99%Couleur et forme :SolidMasse moléculaire :570.64R59949
CAS :<p>R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.</p>Formule :C28H25F2N3OSDegré de pureté :97.04%Couleur et forme :SolidMasse moléculaire :489.58TAS-301
CAS :<p>TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.</p>Formule :C23H19NO3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :357.4Fasudil hydrochloride
CAS :<p>Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.</p>Formule :C14H18ClN3O2SDegré de pureté :99.54% - ≥95%Couleur et forme :White SolidMasse moléculaire :327.83Darovasertib
CAS :<p>Darovasertib (LXS196) is a potent PKC inhibitor, orally active, with IC50 of 1.9 nM (PKCα), 0.4 nM (PKCθ), 3.1 μM (GSK3β).</p>Formule :C22H23F3N8ODegré de pureté :98.72% - ≥95%Couleur et forme :SolidMasse moléculaire :472.47Chelerythrine chloride
CAS :<p>Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to</p>Formule :C21H18ClNO4Degré de pureté :95% - 99.19%Couleur et forme :Yellow To Orange SolidMasse moléculaire :383.83Ζ-Stat
CAS :<p>ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in</p>Formule :C10H8O10S3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :384.36Taurolithocholic acid sodium salt
CAS :<p>Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but</p>Formule :C26H44NNaO5SDegré de pureté :99.79% - 99.93%Couleur et forme :SolidMasse moléculaire :505.69Desmethylglycitein
CAS :<p>Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has</p>Formule :C15H10O5Degré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :270.24Go 6983
CAS :<p>Go 6983 is a PKC inhibitor with IC50 values of 7, 7, 6, 10, and 60 nM for PKCα, PKCβ, PKCγ, PKCδ, and PKCζ, respectively. High-Quality, Low-Cost!</p>Formule :C26H26N4O3Degré de pureté :98.41% - 99.85%Couleur et forme :SolidMasse moléculaire :442.51
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