HSP
Les inhibiteurs des protéines de choc thermique (HSP) ciblent les HSP, une famille de chaperons moléculaires qui aident au repliement des protéines, à leur stabilité et à leur protection contre les dommages induits par le stress. Les HSP sont souvent surexprimées dans les cellules cancéreuses, les aidant à survivre dans des conditions stressantes telles que l'hypoxie et la chimiothérapie. Inhiber les HSP peut perturber ces mécanismes de protection, entraînant la mort cellulaire. Les inhibiteurs des HSP sont donc précieux dans la thérapie contre le cancer et la recherche sur les réponses au stress. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de HSP de haute qualité pour soutenir vos recherches sur l'homéostasie des protéines, les réponses au stress et l'oncologie.
185 produits trouvés pour "HSP".
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Myrtucommulone
CAS :Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.Formule :C38H52O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :668.81Flavokawain 1i
CAS :Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties.Formule :C21H18O4Couleur et forme :SolidMasse moléculaire :334.37Colletofragarone A2
CAS :Colletofragarone A2 from Colletotrichum sp. blocks mutant p53 and HSP90, aiding cancer treatment.Formule :C22H26O6Couleur et forme :SolidMasse moléculaire :386.44C086
CAS :C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.Formule :C29H28O8Couleur et forme :SolidMasse moléculaire :504.53SW02
CAS :SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).Formule :C19H23BrN2O5Couleur et forme :SolidMasse moléculaire :439.3Grp94 Inhibitor-3
Grp94 Inhibitor-3 (Compound C6) is a selective inhibitor of glucose-regulated protein 94 (Grp94), with an affinity of 5.52 μM. It shows potential for research in primary open-angle glaucoma and metastatic cancer.Formule :C24H20ClNO4Couleur et forme :SolidMasse moléculaire :421.87Macbecin I
CAS :Hsp90 inhibitorFormule :C30H42N2O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.66DCEM1
CAS :DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.Formule :C22H23N3O2SCouleur et forme :SolidMasse moléculaire :393.50Teprenone Impurity 5
CAS :Teprenone Impurity 5 (5Z-GGA) is the cis isomer of Teprenone. It exhibits inhibitory activity on the proliferation of human ovarian cancer cells, Caov-3, and can halt the invasion process of these cancer cells. Additionally, Teprenone Impurity 5 induces the expression of heat shock protein 70 (HSP70) and thioredoxin (Trx). This compound is applicable for research in ovarian cancer.Formule :C23H38OMasse moléculaire :330.56Hsp110-STAT3 interaction-IN-1
CAS :Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.Formule :C23H31N3O4SCouleur et forme :SolidMasse moléculaire :445.58HSP90-IN-32
CAS :HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.Formule :C33H40N2O4Couleur et forme :SolidMasse moléculaire :528.68ETB
CAS :ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.Formule :C24H33NO6Couleur et forme :SolidMasse moléculaire :431.52HSP90α-IN-1
CAS :HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.Formule :C19H16N4O2Couleur et forme :SolidMasse moléculaire :332.356HSP90-IN-28
CAS :HSP90-IN-28 (compound 12 h) is a potent and selective Hsp90 inhibitor, with an IC50 of 0.46 μM for Hsp90α. It demonstrates approximately 48 times more selectivity for Hsp90α compared to Hsp90β (IC50 = 22.28 μM).Formule :C23H21NO2SMasse moléculaire :375.49KUNG65
CAS :KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Formule :C23H20ClFO4Couleur et forme :SolidMasse moléculaire :414.85Hsp90-IN-37
CAS :Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.Formule :C12H15N3O2Couleur et forme :SolidMasse moléculaire :233.266DDO-6691
CAS :DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.Formule :C22H17N3O2SCouleur et forme :SolidMasse moléculaire :387.45TRAP1-IN-2
CAS :TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.Formule :C46H42F6N2O5P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :878.77TBPH-1
CAS :TBPH is a brominated flame retardant that exacerbates hepatic steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It disrupts phospholipid metabolism, reducing levels of cardiolipin (CL) and phosphatidylserine (PS). TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH induces lung injury through a mitochondrial-derived ds-DNA mediated inflammatory response. It is also used to investigate the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.Formule :C24H34Br4O4Masse moléculaire :706.15Monorden diacetate
CAS :Monorden diacetate a Hsp90 Inhibitor. Monorden diacetate is a Promising Lead Compound for the Development of Novel Fungicides.Formule :C22H21ClO8Couleur et forme :SolidMasse moléculaire :448.85
