Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2612 produits trouvés pour "Chromatine/Épigénétique"
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DR2313
CAS :DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.Formule :C8H10N2OSDegré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :182.24JQKD82
CAS :JQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma.Formule :C27H40N4O5Degré de pureté :100.00%Couleur et forme :SolidMasse moléculaire :500.63Pacritinib
CAS :Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Formule :C28H32N4O3Degré de pureté :99.25% - 99.49%Couleur et forme :SolidMasse moléculaire :472.58CPI203
CAS :CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).Formule :C19H18ClN5OSDegré de pureté :99.13% - 99.77%Couleur et forme :SolidMasse moléculaire :399.9YKL-06-061
CAS :YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.Formule :C30H37N7O2Degré de pureté :99.52% - 99.79%Couleur et forme :SolidMasse moléculaire :527.66ZM-447439
CAS :ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.Formule :C29H31N5O4Degré de pureté :99.11% - 99.59%Couleur et forme :Pale Yellow SolidMasse moléculaire :513.59Isoxazole
CAS :Isoxazole (1,2-oxazole) is the inhibitor of acetylcholinesterase (AChE). The ligands of Isoxazole bind to and inhibit the Sxc- antiporter.Formule :C3H3NODegré de pureté :98% - 99.34%Couleur et forme :Colorless LiquidMasse moléculaire :69.06Bisindolylmaleimide IV
CAS :Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)
Formule :C20H13N3O2Degré de pureté :98.83%Couleur et forme :Dark Red SolidMasse moléculaire :327.34AZ6102
CAS :AZ6102: Potent TNKS1/2 inhibitor, 100x selective over PARPs, IC50 = 5 nM in DLD-1 Wnt pathway.Formule :C25H28N6ODegré de pureté :97.98% - 99.91%Couleur et forme :SolidMasse moléculaire :428.53Birabresib
CAS :Birabresib (MK-8628) is a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4Formule :C25H22ClN5O2SDegré de pureté :98.3% - 99.36%Couleur et forme :SolidMasse moléculaire :491.99Ref: TM-T6032
2mg46,00€5mg70,00€10mg90,00€25mg142,00€50mg222,00€100mg375,00€200mg560,00€500mg893,00€1mL*10mM (DMSO)74,00€OAC1
CAS :OAC1 (BAS 00287861) activates Oct4, boosts iPSC efficiency, and speeds up reprogramming.Formule :C14H11N3ODegré de pureté :99.49% - 99.65%Couleur et forme :SolidMasse moléculaire :237.26Ref: TM-T2040
1mg34,00€2mg47,00€5mg66,00€10mg92,00€25mg164,00€50mg299,00€100mg540,00€1mL*10mM (DMSO)66,00€JNJ-7706621
CAS :JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.Formule :C15H12F2N6O3SDegré de pureté :99.1% - 99.85%Couleur et forme :SolidMasse moléculaire :394.36Ref: TM-T6126
1mg48,00€5mg100,00€10mg155,00€25mg268,00€50mg432,00€100mg595,00€200mg833,00€1mL*10mM (DMSO)94,00€Fraxinellone
CAS :1.Formule :C14H16O3Degré de pureté :99.35% - 99.92%Couleur et forme :SolidMasse moléculaire :232.27Ref: TM-T6S0071
2mg34,00€5mg50,00€10mg84,00€25mg152,00€50mg222,00€100mg334,00€200mg494,00€1mL*10mM (DMSO)81,00€A1874
CAS :A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
Formule :C58H62Cl3F2N9O7SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :1173.59Apabetalone
CAS :Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary arteryFormule :C20H22N2O5Degré de pureté :98.08% - ≥98%Couleur et forme :SolidMasse moléculaire :370.4I-BRD9
CAS :I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.Formule :C22H22F3N3O3S2Degré de pureté :98.16% - 99.51%Couleur et forme :SolidMasse moléculaire :497.55Ref: TM-T6859
1mg38,00€2mg49,00€5mg71,00€10mg107,00€25mg205,00€50mg389,00€100mg577,00€1mL*10mM (DMSO)79,00€M1001
CAS :M1001 is a HIF-2α agonist.Formule :C17H17N3O2SDegré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :327.4Cerdulatinib
CAS :Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Formule :C20H27N7O3SDegré de pureté :98.74% - 99.49%Couleur et forme :SolidMasse moléculaire :445.54Ref: TM-T2487
1mg42,00€2mg52,00€5mg74,00€10mg101,00€25mg175,00€50mg268,00€100mg409,00€200mg573,00€500mg888,00€1mL*10mM (DMSO)81,00€MRTX-1719
CAS :MRTX-1719 is a potent and selective inhibitor of the PRMT5/MTA complex with an IC50 value of <10 nM against PRMT5/MTAMTAPDELSDMA cell lines.Cost-effective and quality-assured.Formule :C23H18ClFN6O2Degré de pureté :98.27% - 99.18%Couleur et forme :SolidMasse moléculaire :464.88Pim1/AKK1-IN-1
CAS :Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.Formule :C20H13N5ODegré de pureté :97.03% - 98.69%Couleur et forme :SolidMasse moléculaire :339.35Ref: TM-T5093
1mg85,00€2mg124,00€5mg173,00€10mg263,00€25mg464,00€50mg672,00€100mg945,00€1mL*10mM (DMSO)192,00€SGC-SMARCA-BRDVIII
CAS :SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM,Formule :C19H25N5O3Degré de pureté :99.54% - 99.92%Couleur et forme :SolidMasse moléculaire :371.43Ref: TM-T9568
1mg44,00€5mg66,00€10mg101,00€25mg222,00€50mg356,00€100mg530,00€500mg1.153,00€1mL*10mM (DMSO)54,00€Hispidulin
CAS :Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).Formule :C16H12O6Degré de pureté :98.53% - 99.87%Couleur et forme :SolidMasse moléculaire :300.26RK-287107
CAS :RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).Formule :C22H26F2N4O2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :416.46C-7280948
CAS :C-7280948 is a PRMT1 inhibitor.Formule :C14H16N2O2SDegré de pureté :99.55% - ≥95%Couleur et forme :SolidMasse moléculaire :276.35Ref: TM-T2097
5mg46,00€10mg66,00€25mg109,00€50mg178,00€100mg268,00€200mg414,00€500mg667,00€1mL*10mM (DMSO)49,00€Cucurbitacin I
CAS :Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.Formule :C30H42O7Degré de pureté :96.69% - 99.8%Couleur et forme :SolidMasse moléculaire :514.65γ-Oryzanol
CAS :γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in theFormule :C40H58O4Degré de pureté :mixture - mixtureCouleur et forme :White Or White Crystalline Powder OdourlessMasse moléculaire :602.9EED226
CAS :EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.Formule :C17H15N5O3SDegré de pureté :98.14% - 99.33%Couleur et forme :SolidMasse moléculaire :369.4Fucosterol
CAS :Fucosterol, from E. stolonifera, has anti-diabetic, anti-adipogenic, anti-cancer properties; it affects PPARα and C/EBPα to control fat cell formation.Formule :C29H48ODegré de pureté :98% - 99.68%Couleur et forme :White PowderMasse moléculaire :412.69Iniparib
CAS :Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).Formule :C7H5IN2O3Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :292.03Ref: TM-T6224
5mg52,00€10mg73,00€25mg119,00€50mg216,00€100mg340,00€200mg540,00€500mg863,00€1mL*10mM (DMSO)52,00€Anacardic Acid
CAS :Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases.Formule :C22H36O3Degré de pureté :97.47% - 99.87%Couleur et forme :SolidMasse moléculaire :348.52EDO-S101
CAS :EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.Formule :C19H28Cl2N4O2Degré de pureté :98.02% - 99.44%Couleur et forme :SolidMasse moléculaire :415.36Buformin hydrochloride
CAS :Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.Formule :C6H16ClN5Degré de pureté :97.83%Couleur et forme :SolidMasse moléculaire :193.68MLN8054
CAS :MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.Formule :C25H15ClF2N4O2Degré de pureté :98.07% - 98.26%Couleur et forme :SolidMasse moléculaire :476.86Ref: TM-T6315
1mg50,00€2mg67,00€5mg84,00€10mg120,00€25mg220,00€50mg356,00€100mg537,00€1mL*10mM (DMSO)88,00€Nudifloramide
CAS :Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD).Formule :C7H8N2O2Degré de pureté :99.7% - ≥95%Couleur et forme :SolidMasse moléculaire :152.15AZD1208
CAS :AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.
Formule :C21H21N3O2SDegré de pureté :97.24% - 99.83%Couleur et forme :SolidMasse moléculaire :379.48Ruboxistaurin mesylate
CAS :Ruboxistaurin: PKC beta inhibitor, eases oxidative stress, heart issues & nephropathy in diabetic rats, halts retinal neovascularization.Formule :C29H32N4O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.65AZ505
CAS :AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).Formule :C29H38Cl2N4O4Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :577.54Ref: TM-TQ0100
1mg60,00€5mg130,00€10mg178,00€25mg295,00€50mg462,00€100mg623,00€1mL*10mM (DMSO)165,00€MI-503
CAS :MI-503 is an efficient and selective Menin-MLL inhibitor. MI-503 has a significant inhibitory effect on human MLL leukemia cell line. Cost-effective and quality-assured.Formule :C28H27F3N8SDegré de pureté :99.87% - 99.99%Couleur et forme :SolidMasse moléculaire :564.63Ref: TM-TQ0069
1mg50,00€5mg114,00€10mg178,00€25mg334,00€50mg557,00€100mg888,00€1mL*10mM (DMSO)141,00€Niraparib hydrochloride
CAS :Niraparib hydrochloride (MK-4827) is a PARP inhibitor with potential cancer treatment effects, causing DNA damage and apoptosis.Formule :C19H21ClN4ODegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :356.85Bromosporine
CAS :Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.Formule :C17H20N6O4SDegré de pureté :99.65% - 99.79%Couleur et forme :SolidMasse moléculaire :404.44Ref: TM-T6255
1mg44,00€2mg57,00€5mg93,00€10mg133,00€25mg260,00€50mg416,00€100mg665,00€200mg888,00€1mL*10mM (DMSO)92,00€8-CHLOROQUINAZOLIN-4(1H)-ONE
CAS :8-CHLOROQUINAZOLIN-4(1H)-ONE is inhibitor of Poly [ADP-ribose] polymerase 1 (human)Formule :C8H5ClN2ODegré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :180.59(R)-(-)-JQ1 Enantiomer
CAS :(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
Formule :C23H25ClN4O2SDegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :456.99ICG001
CAS :ICG001 antagonizes Wnt signaling, binds CBP with 3 μM IC50, not p300.Formule :C33H32N4O4Degré de pureté :99.06% - 99.95%Couleur et forme :SolidMasse moléculaire :548.63Ref: TM-T2237
1mg34,00€5mg66,00€10mg101,00€25mg197,00€50mg341,00€100mg530,00€500mg1.134,00€1mL*10mM (DMSO)81,00€Rucaparib hydrochloride
CAS :Rucaparib hydrochloride (AG014699) is an oral PARP inhibitor with Ki 1.4 nM for PARP1 and hinders H6PD, studied in CRPC research.Formule :C19H19ClFN3OCouleur et forme :SolidMasse moléculaire :359.83GSK1379725A
CAS :GSK1379725A is a selective BPTF ligand (Kd = 2.8 μM).
Formule :C23H23FN6O3Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :450.47Nicotinamide riboside chloride
CAS :NR, also SRT647, is a B3 vitamin form; precursor to NAD+.Formule :C11H15ClN2O5Degré de pureté :98.92% - 99.86%Couleur et forme :SolidMasse moléculaire :290.7Rucaparib acetate
CAS :Rucaparib acetate, an oral PARP-1, -2, -3 inhibitor (Ki 1.4 nM for PARP1), also moderately inhibits H6PD; promising for CRPC research.Formule :C21H22FN3O3Couleur et forme :SolidMasse moléculaire :383.423PF-9363
CAS :PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.Formule :C20H20N4O6SDegré de pureté :99.03% - 99.7%Couleur et forme :SolidMasse moléculaire :444.46JQEZ5
CAS :JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).Formule :C30H38N8O2Degré de pureté :98.14% - ≥98%Couleur et forme :SolidMasse moléculaire :542.68EB-47 dihydrochloride
CAS :EB 47 is an effective inhibitor of PARP-1 (IC50: 45 nM).Formule :C24H29Cl2N9O6Couleur et forme :SolidMasse moléculaire :610.45
