Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2235 produits trouvés pour "Chromatine/Épigénétique"
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KR-39038
CAS :<p>KR-39038 is an oral GRK5 inhibitor for heart failure research; blocks HDAC5 pathway, IC50: 0.02 μM, fights cardiac hypertrophy.</p>Formule :C24H32ClFN6OCouleur et forme :SolidMasse moléculaire :475.00BChE/HDAC6-IN-2
CAS :<p>BChE/HDAC6-IN-2 is an inhibitor of BChE and HDAC6 with neuroprotective and ROS scavenging activity and a metal ion co-agonist and inhibits tau phosphorylation.</p>Formule :C27H30N4O4Degré de pureté :98.47%Couleur et forme :SoildMasse moléculaire :474.55BG48
CAS :<p>BG48, a COMET probe, enables precise optical epigenetic control and photochromically blocks human histone deacetylases with visible light.</p>Formule :C25H23N5OSCouleur et forme :SolidMasse moléculaire :441.55(3S,4S)-Tofacitinib
CAS :<p>(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.</p>Formule :C16H20N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.37Asteltoxin
CAS :<p>Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.</p>Formule :C23H30O7Couleur et forme :SolidMasse moléculaire :418.486HDAC2-IN-2
CAS :<p>HDAC2-IN-2 (compound 124) acts as an HDAC2 inhibitor, exhibiting a Kd value ranging from 0.1-1 μM.</p>Formule :C18H15N3O3SCouleur et forme :SolidMasse moléculaire :353.40E3330
CAS :<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Formule :C21H30O6Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :378.46TMPA
CAS :<p>TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.</p>Formule :C21H32O6Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :380.48GSK-1268997
CAS :<p>GSK-1268997 is a bio-active chemical.</p>Formule :C21H23N7O3SDegré de pureté :99.33% - 99.81%Couleur et forme :SolidMasse moléculaire :453.52UNC0224
CAS :<p>UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.</p>Formule :C26H43N7O2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :485.67MY-1B
CAS :<p>MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.</p>Formule :C22H18BrN3O2Degré de pureté :99.81% - >99.99%Couleur et forme :SoildMasse moléculaire :436.3JAK-IN-30
CAS :<p>JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50</p>Formule :C19H26N8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.53ZYJ-34c
CAS :<p>ZYJ-34c is a potent oral antitumor activities histone deacetylase inhibitor (HDACi).</p>Formule :C31H42N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :582.69SIRT1-IN-3
CAS :<p>SIRT1-IN-3 (compound 3j) is a potent and selective inhibitor of silent information regulator 1 (SIRT1) with an IC 50 of 4.2 μM [1].</p>Formule :C13H15BrN2OCouleur et forme :SolidMasse moléculaire :295.17Eleven-Nineteen-Leukemia Protein IN-1
CAS :<p>ENL-IN-1: Potent ENL YEATS domain inhibitor with 14.5 nM IC50, enhances thermal stability in vitro.</p>Formule :C27H33N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :487.6Angiogenesis agent 1
CAS :<p>Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.</p>Formule :C20H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.4LSD1-IN-5
CAS :<p>LSD1-IN-5, a reversible LSD1 inhibitor, boosts H3K4me2 without affecting LSD1 expression; IC50: 121 nM.</p>Formule :C15H13BrN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.18EZH2-IN-7
CAS :<p>EZH2-IN-7 inhibits EZH2, reducing H3K27me3 and tumor growth (e.g., breast, prostate cancer, leukemia). Potential in cancer research.</p>Formule :C31H37D2N5O3SCouleur et forme :SolidMasse moléculaire :563.75CM-579
CAS :<p>CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.</p>Formule :C29H40N4O3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :492.655-Aza-4'-thio-2'-deoxycytidine
CAS :<p>5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].</p>Formule :C8H12N4O3SCouleur et forme :SolidMasse moléculaire :244.27Tripolin A
CAS :<p>Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)</p>Formule :C15H11NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :253.25DC_C66
CAS :<p>DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.</p>Formule :C28H22NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.48Aurora kinase inhibitor-9
CAS :<p>Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.</p>Formule :C19H17Cl2N3O4SCouleur et forme :SolidMasse moléculaire :454.33G9a-IN-2
CAS :<p>G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).</p>Formule :C30H42N4O4Couleur et forme :SolidMasse moléculaire :522.68HDAC1/MAO-B-IN-1
CAS :<p>HDAC1/MAO-B-IN-1 is a selective Alzheimer’s research inhibitor with IC50s: HDAC1 (21.4 nM) & MAO-B (99 nM); crosses the blood-brain barrier.</p>Formule :C18H17ClN2O2Couleur et forme :SolidMasse moléculaire :328.79Tankyrase-IN-4
<p>Tankyrase-IN-4 is a potent inhibitor of tankyrase 1 (TNKS1), exhibiting an IC50 of 0.8 nM, and is utilized in cancer research.</p>Formule :C25H24N6O5Couleur et forme :SolidMasse moléculaire :488.5LP99
CAS :<p>LP99 is an epigenetic probe.</p>Formule :C26H30ClN3O4SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :516.05TM6089
CAS :<p>TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.</p>Formule :C13H14N4O3SDegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :306.34FAK/aurora kinase-IN-1
CAS :<p>FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].</p>Formule :C23H24ClN7O3Couleur et forme :SolidMasse moléculaire :481.93BET bromodomain inhibitor 3
CAS :<p>BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT.</p>Formule :C18H17N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :339.35PRMT4-IN-1
CAS :<p>PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].</p>Formule :C23H28FN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.49PARP11 inhibitor ITK7
CAS :<p>ITK7 is a potent, selective PARP11 inhibitor with an IC50 of 14 nM, useful for cellular localization research.</p>Formule :C17H14N4OSCouleur et forme :SolidMasse moléculaire :322.38HDAC-IN-41
CAS :<p>HDAC-IN-41 is a selective class I HDAC inhibiting HDAC1, 2, & 3 with IC50: 0.62-1.46 µM; oral use; has NO-release.</p>Formule :C20H22N4O6SCouleur et forme :SolidMasse moléculaire :446.48BI-831266
CAS :<p>BI-831266 is a potent and selective Aurora kinase B inhibitor.</p>Formule :C27H38ClN7O2Couleur et forme :SolidMasse moléculaire :528.09KF 13218
CAS :<p>KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.</p>Formule :C20H20N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.38YUKA1
CAS :<p>YUKA1, a cell-permeable KDM5A inhibitor with a weak effect on KDM5C, increase H3K4me3 and inhibit the proliferation, prevent drug-resistant.</p>Formule :C13H16N4O2SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :292.36HDAC-IN-30
CAS :<p>HDAC-IN-30 is a potent HDAC inhibitor targeting HDAC1, 2, 3, 6, and 8 with strong antitumor efficacy.</p>Formule :C22H23N5O3Couleur et forme :SolidMasse moléculaire :405.45HDAC6-IN-14
<p>HDAC6-IN-14, an inhibitor of HDAC6 (HDAC), exhibits high selectivity with an IC50 value of 42 nM, demonstrating over 100-fold selectivity compared to HDAC1,</p>Formule :C24H30FN3O4Couleur et forme :SolidMasse moléculaire :443.51JFD00244
CAS :<p>JFD00244 is an inhibitor of sirtuin 2 (SIRT2). It has an anti-tumor effect.</p>Formule :C30H26N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :478.54Y06036
CAS :<p>Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).</p>Formule :C16H15BrN2O5SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :427.27PRMT5-IN-2
CAS :<p>PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.</p>Formule :C17H16ClFN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.78NCD38
CAS :<p>NCD38 is a potent, selective LSD1 inhibitor.</p>Formule :C37H37ClF3N3O4Degré de pureté :98.21% - 98.86%Couleur et forme :SolidMasse moléculaire :680.16(Rac)-BAY1238097
CAS :<p>(Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.</p>Formule :C25H33N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :451.56JAK-2/3-IN-2
CAS :<p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).</p>Formule :C19H19ClN2OSCouleur et forme :SolidMasse moléculaire :358.89EZM 2302
CAS :<p>EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.</p>Formule :C29H37ClN6O5Degré de pureté :97.47% - ≥98%Couleur et forme :SolidMasse moléculaire :585.09HDAC6-IN-11
CAS :<p>HDAC6-IN-11 (Compound 9) is a cancer cell growth blocker, selectively inhibiting HDAC6 (>300-fold) with an IC50 of 20.7 nM.</p>Formule :C19H16N2O4Couleur et forme :SolidMasse moléculaire :336.34HDAC8/BRPF1-IN-1
CAS :<p>Compound 23a, dual HDAC8/BRPF1 inhibitor: IC50 HDAC8 = 443 nM, Kd BRPF1 = 67 nM; weak against HDAC1/6.</p>Formule :C19H19N3O6SCouleur et forme :SolidMasse moléculaire :417.44OHM1
CAS :<p>OHM1, an analog of HIF1α CTAD, effectively inhibits the interaction between HIF1α CTAD and p300/CBP by targeting the CH1 domain with a binding affinity of 0.53</p>Formule :C24H42N6O5Couleur et forme :SolidMasse moléculaire :494.63J1038
CAS :<p>J1038 is a novel Histone Deacetylase 8 (HDAC8) Inhibitor .</p>Formule :C10H10N2O3SCouleur et forme :SolidMasse moléculaire :238.26A2B57
CAS :<p>A2B57 is a selective SIRT2 inhibitor.</p>Formule :C22H19N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.42
