Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2235 produits trouvés pour "Chromatine/Épigénétique"
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BRD4-BD1-IN-1
CAS :<p>BRD4-BD1-IN-1 (Compound 9a) is a BRD4-BD1 inhibitor(IC50= 38.20 μM).</p>Formule :C16H15BrN4O4Couleur et forme :SolidMasse moléculaire :407.22A2AAR/HDAC-IN-1
CAS :<p>A2AAR/HDAC-IN-1 (compound 14c) is an orally active, balanced A2AAR/HDAC dual inhibitor of A2AAR (Ki: 163.5 nM), HDAC1 (IC50: 145.3 nM). effect.</p>Formule :C24H21N7O2Couleur et forme :SolidMasse moléculaire :439.47ARTD10/PARP10-IN-2
CAS :<p>ARTD10/PARP10-IN-2: A potent, non-selective PARP inhibitor, IC50: ARTD10/PARP10 (2.0μM), ARTD1/PARP1 (9.7μM).</p>Formule :C12H13N3O3Couleur et forme :SolidMasse moléculaire :247.25BNS
CAS :<p>BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.</p>Formule :C18H16N2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46MARK-IN-4
CAS :<p>MARK-IN-4 inhibits microtubule kinase (MARK) effectively (IC50: 1 nM), a target for Alzheimer's therapy.</p>Formule :C21H23N7OSCouleur et forme :SolidMasse moléculaire :421.52DCE_42
CAS :<p>DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.</p>Formule :C22H19N9O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.51JAK-IN-11
CAS :<p>JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.</p>Formule :C23H22FN5O4SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :483.52PARP1-IN-9
CAS :<p>PARP1-IN-9, potent PARP1 inhibitor with 30.51 nM IC50, outperforms Olaparib in anticancer efficacy.</p>Formule :C18H21N3O5Couleur et forme :SolidMasse moléculaire :359.38BRD4 Inhibitor-25
<p>BRD4 Inhibitor-25 blocks BRD4 (BD1: IC50 0.82 μM, BD2: 1.94 μM), induces cell death in ovarian cancer, used in cancer research.</p>Formule :C29H27N5O6SCouleur et forme :SolidMasse moléculaire :573.62CAY10685
CAS :<p>CAY10685, a CPTH2 analog with an alkyne for click reactions, inhibits NAT10 to study cancer-related chromatin changes.</p>Formule :C17H16ClN3SCouleur et forme :SolidMasse moléculaire :329.85DNMT3A-IN-1
CAS :<p>DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).</p>Formule :C30H38N6O4Couleur et forme :SolidMasse moléculaire :546.66NCDM-32B
CAS :<p>NCDM-32B, a novel potent and selective KDM4 inhibitor, impairs viability and transforms phenotypes of basal breast cancer.</p>Formule :C15H30N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.41AChE/HDAC-IN-1
CAS :<p>COX-2-IN-23 (A10) inhibits AChE & HDAC (IC50s: 0.12 & 0.23 nM), has antioxidant/metal-binding traits, and is used in Alzheimer's research.</p>Formule :C26H27ClN4O3Couleur et forme :SolidMasse moléculaire :478.97TYK2-IN-11
CAS :<p>TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.</p>Formule :C18H17N5O3SCouleur et forme :SolidMasse moléculaire :383.42SGC6870
CAS :<p>SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases.</p>Formule :C23H21BrN2O2SCouleur et forme :SolidMasse moléculaire :469.39BRD4 Inhibitor-26
<p>BRD4 Inhibitor-26: blocks BRD4 (BD1 and BD2) with IC50 of 0.82 μM & 1.94 μM; used in ovarian cancer research.</p>Formule :C29H27N5O6SCouleur et forme :SolidMasse moléculaire :573.62103D5R
CAS :<p>103D5R selectively inhibits hif-1α, reducing its levels in hypoxia or with cobalt ions, dose- and time-dependently.</p>Formule :C20H21N3O2Couleur et forme :SolidMasse moléculaire :335.4MAT2A-IN-6
CAS :<p>MAT2A-IN-6 inhibits MAT2A, may slow MTAP-deficient cancer cell growth, has research value in cancer.</p>Formule :C18H13ClF3N3O3Couleur et forme :SolidMasse moléculaire :411.76CP-690550A
CAS :<p>Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.</p>Formule :C15H21N5O2Couleur et forme :SolidMasse moléculaire :303.36MZ-242
CAS :<p>MZ-242 is an effective and selective inhibitor of Sirt2.</p>Formule :C24H27N7O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.65Antiproliferative agent-17
CAS :<p>Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1].</p>Formule :C26H28N2OSCouleur et forme :SolidMasse moléculaire :416.58KDOAM-25
CAS :<p>KDOAM-25, a potent KDM5 inhibitor, enhances H3K4 methylation, hampers MM1S cell growth; IC50: 71 nM (5A), 19 nM (5B), 69 nM (5C/D).</p>Formule :C15H25N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :307.39HDAC6/8/BRPF1-IN-1
CAS :<p>HDAC6/8/BRPF1-IN-1 is a cancer-research inhibitor for HDAC6, HDAC8, BRPF1 with IC50: 344-908 nM and Kd: 175.2 nM.</p>Formule :C18H17N3O5SCouleur et forme :SolidMasse moléculaire :387.41UNC2327
CAS :<p>UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM).</p>Formule :C14H17N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.38AA-CW236
CAS :<p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>Formule :C17H16ClF3N4O2Couleur et forme :SolidMasse moléculaire :400.78NN-390
CAS :<p>NN-390: selective HDAC6 inhibitor, IC50 9.8 μM, blood-brain barrier penetrant, potential for metastatic group 3 neural tube cancer research.</p>Formule :C17H16F4N2O4SCouleur et forme :SolidMasse moléculaire :420.38EZH2-IN-9
CAS :<p>EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.</p>Formule :C28H32ClF2N3O5SCouleur et forme :SolidMasse moléculaire :596.09EZH2-IN-11
CAS :<p>EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.</p>Formule :C28H36ClN3O5SCouleur et forme :SolidMasse moléculaire :562.12Aurora Kinases-IN-2
CAS :<p>Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.</p>Formule :C22H18ClN5O3Couleur et forme :SolidMasse moléculaire :435.86DC-BPi-11
CAS :<p>DC-BPi-11 inhibits BPTF at IC50 698 nM and significantly reduces leukemia cell growth.</p>Formule :C20H23N5O2SCouleur et forme :SolidMasse moléculaire :397.49JS1310
CAS :<p>JS1310 is a selective PRMT7 inhibitor (IC50: 5 μM against human PRMT7). JS1310 has shown anti-cancer effects on different cancer cells.</p>Formule :C23H22FN5O3Couleur et forme :SolidMasse moléculaire :435.45CypD inhibitor C-9
CAS :<p>CypD inhibitor C-9 is a CypD inhibitor, it attenuates mitochondrial and cellular perturbation insulted by Aß and calcium stress.</p>Formule :C22H22N4O4S2Couleur et forme :SolidMasse moléculaire :470.56BET-IN-2
CAS :<p>BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1).</p>Formule :C23H29N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :363.5PIM1-IN-6
CAS :<p>PIM1-IN-6 (5h) inhibits PIM-1 (IC50: 0.60 μM) and is cytotoxic to HCT-116 (IC50: 1.51 μM) and MCF-7 cells (IC50: 15.2 μM).</p>Formule :C21H18N6O4Couleur et forme :SolidMasse moléculaire :418.41TNKS-IN-41
CAS :TNKS-IN-41 highly potent and selective inhibitor of tankyrase.Formule :C24H22N10O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :482.5K00135
CAS :<p>K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.</p>Formule :C18H18N4ODegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :306.36MC-1353
CAS :<p>MC-1353 is a potent, selective inhibitor of HDAC class I.</p>Formule :C16H16N2O3Couleur et forme :SolidMasse moléculaire :284.31PBRM1-BD2-IN-1
CAS :<p>PBRM1-BD2-IN-1: Selective PBRM1 inhibitor with Kd 0.7μM, IC50 0.2μM, useful in cancer research.</p>Formule :C17H19ClN2OCouleur et forme :SolidMasse moléculaire :302.84-iodo-SAHA
CAS :<p>4-Iodo-SAHA (1k), an oral HDAC inhibitor for cancer research, has EC50s from 0.12 to 1.3 μM across various cell lines.</p>Formule :C14H19IN2O3Couleur et forme :SolidMasse moléculaire :390.22HDAC1-IN-4
CAS :<p>HDAC1-IN-4 is a potent inhibitor of Plasmodium falciparum HDAC1 (PfHDAC1) with low cytotoxicity and antimalarial effects (IC50<5 nM).</p>Formule :C21H24BrClN6O2Couleur et forme :SolidMasse moléculaire :507.82JAK-IN-20
CAS :<p>JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.</p>Formule :C28H30FN7O2Couleur et forme :SolidMasse moléculaire :515.58PIM1-IN-7
CAS :<p>PIM1-IN-7 inhibits PIM-1 (IC50: 0.67μM), toxic to HCT-116/MCF-7 cells (IC50: 42.9/7.68μM).</p>Formule :C23H23N5OCouleur et forme :SolidMasse moléculaire :385.46HDAC/CK2-IN-1
CAS :<p>HDAC/CK2-IN-1 (compound 38) acts as an inhibitor of HDAC1 (IC 50 = 1.46 μM), HDAC6 (IC 50 = 0.66 μM), and CK2 (IC 50 = 3.67 μM). It demonstrates promising antiproliferative effects on various cell lines, including Jurkat, MCF-7, HCT-116, and HL-60.</p>Formule :C15H18Br4N4O2Couleur et forme :SolidMasse moléculaire :605.95BRD4-BD1/2-IN-1
CAS :<p>BRD4-BD1/2-IN-1 efficiently blocks BRD4 BD-1/2 under 100 nM IC50 (US20150148375A1, cmpd 5).</p>Formule :C21H14F2N4O2Couleur et forme :SolidMasse moléculaire :392.36DPQ
CAS :<p>DPQ inhibits PARP-1, aids in neuroprotection, restores ATP, and lessens neuronal injury from NMDA.</p>Formule :C18H26N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.41AMPK activator 9
CAS :<p>AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.</p>Formule :C31H28F4N4O4Couleur et forme :SolidMasse moléculaire :596.57ART-IN-1
CAS :<p>ART-IN-1 (compound 7) is a selective inhibitor of PARP with IC 50 s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively [1].</p>Formule :C14H13NO2SCouleur et forme :SolidMasse moléculaire :259.32Peficitinib hydrochloride
CAS :<p>Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).</p>Formule :C18H23ClN4O2Couleur et forme :SolidMasse moléculaire :362.86VE-465
CAS :<p>VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.</p>Formule :C22H28N8OSCouleur et forme :SolidMasse moléculaire :452.58PRMT5-IN-17
CAS :<p>PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.</p>Formule :C26H33N7O2Couleur et forme :SolidMasse moléculaire :475.59
