Protosappanin A

CAS : 102036-28-2

Ref. TM-TJS1779

Informations sur le produit

• Nom: Protosappanin A
• Synonymes: PTA, 3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one, 3,10,11-trihydroxy-6H-dibenzo[b,d]oxocin-7(8H)-one, 6H-Dibenz(b,d)oxocin-7(8H)-one, 3,10,11-trihydroxy-, Sappanol B
• CAS: 102036-28-2

Description

Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 272.25
• Formule: C₁₅H₁₂O₅
• Degré de pureté: 100%
• Couleur/Forme: Solid