Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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Momelotinib
CAS :Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Formule :C23H22N6O2Degré de pureté :97.07% - 99.56%Couleur et forme :SolidMasse moléculaire :414.46Ref: TM-T1849
1mg35,00€2mg50,00€5mg77,00€10mg89,00€25mg158,00€50mg245,00€100mg385,00€200mg592,00€1mL*10mM (DMSO)84,00€MS436
CAS :MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.Formule :C18H17N5O3SDegré de pureté :97.95% - 98.92%Couleur et forme :SolidMasse moléculaire :383.42Ref: TM-T1854
2mg42,00€5mg62,00€10mg95,00€25mg172,00€50mg268,00€100mg429,00€200mg615,00€1mL*10mM (DMSO)69,00€SNS-314 Mesylate
CAS :SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Formule :C18H15ClN6OS2·CH4O3SDegré de pureté :99.44% - 99.92%Couleur et forme :SolidMasse moléculaire :527.04BAY-598
CAS :BAY 598 is a potent and selective competitive inhibitor of SMYD2, exhibiting >100-fold selectivity over SMYD3, SUV420H1, and SUV420H2. Cost-effective and quality-assured.Formule :C22H20Cl2F2N6O3Degré de pureté :99.18% - 99.78%Couleur et forme :SolidMasse moléculaire :525.342',3',5'-triacetyl-5-Azacytidine
CAS :2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.Formule :C14H18N4O8Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :370.31Ref: TM-T7840
2mg38,00€5mg50,00€10mg75,00€25mg122,00€50mg177,00€100mg266,00€200mg385,00€1mL*10mM (DMSO)60,00€GSK046
CAS :GSK046 (iBET-BD2), potent oral BET BD2 inhibitor; IC50: BRD2 (264 nM), BRD3 (98 nM), BRD4 (49 nM), BRDT (214 nM); immunomodulatory.Formule :C23H27FN2O4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :414.47Ref: TM-T8932
1mg57,00€5mg120,00€10mg200,00€25mg447,00€50mg715,00€100mg1.108,00€200mg1.485,00€1mL*10mM (DMSO)133,00€RO495
CAS :RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assaysFormule :C17H14Cl2N6ODegré de pureté :97.94%Couleur et forme :SolidMasse moléculaire :389.24Ref: TM-T22416
1mg46,00€5mg86,00€10mg126,00€25mg235,00€50mg344,00€100mg465,00€200mg625,00€1mL*10mM (DMSO)94,00€GSK6853
CAS :GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.Formule :C22H27N5O3Degré de pureté :98.71% - 99.21%Couleur et forme :SolidMasse moléculaire :409.48(Z)-LFM-A13
CAS :(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.Formule :C11H8Br2N2O2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :360Niraparib
CAS :Niraparib (MK-4827) inhibits PARP1/PARP2 (IC50: 3.8/2.1 nM), effective on BRCA mutant cancers, 330x less effective on PARP3, V-PARP, Tank1.Formule :C19H20N4ODegré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :320.39Ref: TM-T3231
5mg57,00€10mg84,00€25mg105,00€50mg137,00€100mg205,00€200mg304,00€500mg515,00€1mL*10mM (DMSO)63,00€AKBA
CAS :AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.Formule :C32H48O5Degré de pureté :97.85% - 99.77%Couleur et forme :SolidMasse moléculaire :512.72MN-64
CAS :MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.Formule :C18H16O2Degré de pureté :99.5% - 99.93%Couleur et forme :SolidMasse moléculaire :264.32SGC0946
CAS :SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.Formule :C28H40BrN7O4Degré de pureté :98% - 99.82%Couleur et forme :SolidMasse moléculaire :618.57SMI-16a
CAS :SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Formule :C13H13NO3SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :263.31Ref: TM-T3989
1mg34,00€2mg46,00€5mg66,00€10mg93,00€25mg152,00€50mg222,00€100mg334,00€1mL*10mM (DMSO)87,00€OF-1
CAS :OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.Formule :C17H18BrN3O4SDegré de pureté :98.55% - ≥95%Couleur et forme :SolidMasse moléculaire :440.31Ref: TM-T2127
1mg35,00€5mg74,00€10mg123,00€25mg240,00€50mg385,00€100mg595,00€200mg833,00€1mL*10mM (DMSO)74,00€AT9283
CAS :AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).
Formule :C19H23N7O2Degré de pureté :99.83% - 99.98%Couleur et forme :SolidMasse moléculaire :381.43SETDB1-TTD-IN-1
CAS :SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.Formule :C28H31N5O2Degré de pureté :98.26% - 99.96%Couleur et forme :SolidMasse moléculaire :469.58JMJD7-IN-1
CAS :JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM.Formule :C16H8Cl2N2O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :363.15PF-9366
CAS :PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor (IC50: 420 nM; Kd: 170 nM).Formule :C20H19ClN4Degré de pureté :97.28% - 99.88%Couleur et forme :SolidMasse moléculaire :350.84Ref: TM-T5191
1mg46,00€5mg96,00€10mg130,00€25mg227,00€50mg321,00€100mg442,00€200mg642,00€1mL*10mM (DMSO)92,00€AG-270
CAS :AG-270 is an allosteric and orally active inhibitor of MAT2A.Formule :C30H27N5O2Degré de pureté :98.28% - 98.87%Couleur et forme :SolidMasse moléculaire :489.57Ref: TM-T9050
1mg110,00€2mgÀ demander5mg256,00€10mg378,00€25mg628,00€50mg882,00€100mg1.225,00€200mg1.673,00€C-82
CAS :C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.Formule :C33H34N6O4Degré de pureté :98.86% - 99.66%Couleur et forme :SolidMasse moléculaire :578.66Itacitinib
CAS :Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.Formule :C26H23F4N9ODegré de pureté :96.4% - 99.5%Couleur et forme :SolidMasse moléculaire :553.51A-966492
CAS :A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.Formule :C18H17FN4ODegré de pureté :98.53% - 99.27%Couleur et forme :SolidMasse moléculaire :324.35Ref: TM-T6366
2mg34,00€5mg52,00€10mg94,00€25mg163,00€50mg261,00€100mg374,00€200mg530,00€1mL*10mM (DMSO)52,00€GSK503
CAS :GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.Formule :C31H38N6O2Degré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :526.67PFI-4
CAS :PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.Formule :C21H24N4O3Degré de pureté :99.53% - ≥95%Couleur et forme :SolidMasse moléculaire :380.44NI-57
CAS :NI-57 inhibits BRPF family proteins: BRPF1 (IC50=3.1nM), BRPF2 (IC50=46nM), BRPF3 (IC50=140nM).Formule :C19H17N3O4SDegré de pureté :99.88% - >99.99%Couleur et forme :SolidMasse moléculaire :383.42Menin-MLL inhibitor MI-2
CAS :Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.Formule :C18H25N5S2Degré de pureté :97.46%Couleur et forme :SolidMasse moléculaire :375.55Ref: TM-T2649
2mg39,00€5mg58,00€10mg84,00€25mg160,00€50mg230,00€100mg356,00€200mg522,00€1mL*10mM (DMSO)64,00€Molibresib besylate
CAS :Molibresib besylate (GSK 525762C) is a BET protein family inhibitor used in the study of refractory hematologic malignant diseases.Formule :C28H28ClN5O5SDegré de pureté :99.64% - 99.64%Couleur et forme :SolidMasse moléculaire :582.07Oroxylin A
CAS :Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Formule :C16H12O5Degré de pureté :98.72% - 99.55%Couleur et forme :SolidMasse moléculaire :284.26Ref: TM-T6S1315
1mg37,00€5mg71,00€10mg90,00€25mg147,00€50mg208,00€100mg309,00€200mg447,00€1mL*10mM (DMSO)84,00€Tofacitinib
CAS :Tofacitinib (Tasocitinib) is an orally Janus kinase inhibitor. Tofacitinib is used for the treatment of rheumatoid arthritis. Cost effective and quality assured.Formule :C16H20N6ODegré de pureté :99% - >99.99%Couleur et forme :SolidMasse moléculaire :312.37BRD9539
CAS :BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μMFormule :C24H21N3O3Degré de pureté :98% - 99.57%Couleur et forme :SolidMasse moléculaire :399.44Seclidemstat
CAS :Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.Formule :C20H23ClN4O4SDegré de pureté :98.28% - 99.76%Couleur et forme :SolidMasse moléculaire :450.94Ref: TM-T4527
5mg46,00€10mg69,00€25mg114,00€50mg177,00€100mg335,00€200mg500,00€500mg807,00€1mL*10mM (DMSO)50,00€Veliparib dihydrochloride
CAS :Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.Formule :C13H18Cl2N4ODegré de pureté :98% - 99.81%Couleur et forme :SolidMasse moléculaire :317.21Remodelin
CAS :Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.Formule :C15H14N4SDegré de pureté :99.39% - 99.83%Couleur et forme :SolidMasse moléculaire :282.363Ref: TM-T3499
2mg37,00€5mg52,00€10mg73,00€25mg123,00€50mg175,00€100mg236,00€200mg353,00€1mL*10mM (DMSO)56,00€PT-2385
CAS :PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).Formule :C17H12F3NO4SDegré de pureté :98.91% - 99.55%Couleur et forme :SolidMasse moléculaire :383.34Ref: TM-T7848
1mg63,00€2mg93,00€5mg144,00€10mg222,00€25mg379,00€50mg532,00€100mg740,00€200mg982,00€1mL*10mM (DMSO)119,00€Venadaparib
CAS :Venadaparib, a PARP inhibitor (IC50: 1.4/1.0 nM for PARP1/2), is orally active, selective, not affecting PARP-5, used in tumor studies.Formule :C23H23FN4O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :406.45Ref: TM-T9430
1mg46,00€2mg59,00€5mg90,00€10mg137,00€25mg268,00€50mg439,00€100mg645,00€1mL*10mM (DMSO)90,00€RN-1 dihydrochloride
CAS :RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).Formule :C23H31Cl2N3O2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :452.42Ruxolitinib
CAS :Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.Formule :C17H18N6Degré de pureté :99.4% - >99.99%Couleur et forme :SolidMasse moléculaire :306.36Ref: TM-T1829
5mg55,00€10mg71,00€25mg96,00€50mg110,00€100mg146,00€200mg231,00€500mg393,00€1mL*10mM (DMSO)62,00€GSK2801
CAS :GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.Formule :C20H21NO4SDegré de pureté :97.78% - 99.45%Couleur et forme :SolidMasse moléculaire :371.455-Methyl-2'-deoxycytidine
CAS :5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.Formule :C10H15N3O4Degré de pureté :99.18% - 99.69%Couleur et forme :SolidMasse moléculaire :241.242-methyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one
CAS :2-methyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one is ligand of CBP.Formule :C10H11NOSDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :193.275-Fluoro-2'-deoxycytidine
CAS :5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .Formule :C9H12FN3O4Degré de pureté :97.91%Couleur et forme :Fine White PowderMasse moléculaire :245.21Ref: TM-T7718
2mg34,00€5mg48,00€10mg64,00€25mg90,00€50mg138,00€100mg200,00€200mg296,00€500mg497,00€1mL*10mM (DMSO)50,00€A-366
CAS :A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.Formule :C19H27N3O2Degré de pureté :97.28% - 99.8%Couleur et forme :SolidMasse moléculaire :329.44Ref: TM-T3624
1mg35,00€2mg50,00€5mg74,00€10mg90,00€25mg208,00€50mg359,00€100mg530,00€1mL*10mM (DMSO)82,00€UNC3866 TFA(1872382-47-2 free base)
CAS :UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.Formule :C45H67F3N6O10Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :909.046-Thioguanine
CAS :6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.Formule :C5H5N5SDegré de pureté :98.75% - >99.99%Couleur et forme :Odorless Or Almost Odorless Pale Yellow Crystalline PowderMasse moléculaire :167.19IOX4
CAS :IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)Formule :C15H16N6O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :328.33NEO2734
CAS :NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).Formule :C22H24F3N3O3Degré de pureté :98.72% - 98.8%Couleur et forme :SolidMasse moléculaire :435.44Ref: TM-T8658
1mg108,00€5mg260,00€10mg430,00€25mg710,00€50mg973,00€100mg1.333,00€500mg2.673,00€1mL*10mM (DMSO)286,00€Panaxadiol
CAS :Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Formule :C30H52O3Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :460.73XL228
CAS :XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formule :C22H31N9ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :437.54Ref: TM-T17267
1mg52,00€2mg73,00€5mg94,00€10mg141,00€25mg244,00€50mg371,00€100mg552,00€1mL*10mM (DMSO)104,00€Tozasertib
CAS :Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formule :C23H28N8OSDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :464.59
