Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2235 produits trouvés pour "Chromatine/Épigénétique"
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Molidustat
CAS :<p>Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。</p>Formule :C13H14N8O2Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :314.3AW68
CAS :<p>AW68 is a potential small molecule BRD4 inhibitor that prevents and treats BRD4-related diseases and can be used in cancer research.</p>Formule :C22H21ClN6Degré de pureté :98.52% - 98.52%Couleur et forme :SoildMasse moléculaire :404.89Bendazol
CAS :<p>Bendazol (Dibazol) is always used as the drug for hypertension and cerebral Angiospasm.</p>Formule :C14H12N2Degré de pureté :98.7% - 99.87%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :208.26MAK683
CAS :<p>MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).</p>Formule :C20H17FN6ODegré de pureté :98.25% - 99.92%Couleur et forme :SolidMasse moléculaire :376.39Ilginatinib hydrochloride
CAS :<p>Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.</p>Formule :C21H21ClFN7Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :425.89N6-Cyclohexyladenosine
CAS :<p>N6-Cyclohexyladenosine (CHA) is a selective agonist of A1 receptor with EC50 of 8.2 Nm.</p>Formule :C16H23N5O4Degré de pureté :99.84% - 99.98%Couleur et forme :SolidMasse moléculaire :349.38BMS-986158
CAS :<p>BMS-986158: BET inhibitor, IC50 of 6.6 nM in SCLC, 5 nM in TNBC cells.</p>Formule :C30H33N5O2Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :495.62PI3Kα/HDAC6-IN-1
<p>PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.</p>Formule :C27H30F3N7O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :669.7PRMT5-IN-12
CAS :<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Formule :C32H40N4O4Couleur et forme :SolidMasse moléculaire :544.696HIV-1 protease-IN-10
<p>HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) and</p>Formule :C23H40O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :396.56AB3067
<p>AB3067 is a PROTAC degrader targeting BET protein, efficiently recruiting two distinct E3 ligases, Cereblon and VHL, with strong affinity (demonstrated by IC50 values of 559 nM for VHL and 190 nM for CRBN in vivo HEK293). It degrades BRD2, BRD3, BRD4, and CRBN with DC50 values of 2.1~2.3, 1.6, 15, and 75 nM, respectively. Additionally, AB3067 inhibits the proliferation of RKO cells, with an EC50 of 111 nM. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL and CRBN)</p>Formule :C74H91ClFN11O17S2Couleur et forme :SolidMasse moléculaire :1525.16ZL0590
CAS :<p>ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.</p>Formule :C23H27F3N4O4SDegré de pureté :99.77%Couleur et forme :SoildMasse moléculaire :512.55PROTAC BRD4 Degrader-9
CAS :<p>PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.</p>Formule :C59H71F2N9O15S4Couleur et forme :SolidMasse moléculaire :1312.5TAT-cyclo-CLLFVY
CAS :<p>Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).</p>Formule :C111H188N42O24S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2559.1UNC4976
<p>UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.</p>Formule :C47H70N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :847.09KDM1A-IN-29
CAS :<p>KDM1A-IN-29 is a histone demethylase inhibitor.</p>Formule :C16H16ClN3O4SCouleur et forme :SoildMasse moléculaire :381.83HDAC/CD13-IN-1
<p>HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μM</p>Formule :C27H41Cl2N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :570.55SMARCA2 degrader-17
CAS :<p>SMARCA2 degrader-17 is a degrader of SMARCA2, exhibiting synergistic antiproliferative effects with Adagrasib in cancer cells and capable of inhibiting tumor growth.</p>Formule :C47H58N10O6SCouleur et forme :SolidMasse moléculaire :891.09PROTAC BET degrader-2
CAS :<p>PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).</p>Formule :C41H42N10O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :770.84NP213
CAS :<p>NP213 is a rapidly acting synthetic antimicrobial peptide (AMP).</p>Formule :C42H84N28O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1093.3UNC2399
CAS :<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Formule :C67H104N10O17SCouleur et forme :SolidMasse moléculaire :1353.68Dihydrochlamydocin
CAS :<p>Dihydrochlamydocin, an inhibitor of histone deacetylases (HDAC), exhibits potent cytostatic activity against mastocytoma cells.</p>Formule :C28H40N4O6Couleur et forme :SolidMasse moléculaire :528.65ZXH-3-26
CAS :<p>ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.</p>Formule :C38H37ClN8O7SDegré de pureté :98.90% - 98.90%Couleur et forme :SolidMasse moléculaire :785.27JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
<p>JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a BRD4 ligand and a PROTAC linker, and is used in the synthesis of PROTAC BRD4 Degrader-29.</p>Formule :C43H51ClN8O3S2Couleur et forme :SolidMasse moléculaire :827.5PROTAC SMARCA2/4-degrader-29
CAS :<p>PROTAC SMARCA2/4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.</p>Formule :C44H51N11O4Couleur et forme :SolidMasse moléculaire :797.95PROTAC BRD4 Degrader-5
CAS :<p>PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.</p>Formule :C50H62ClN9O8S2Couleur et forme :SolidMasse moléculaire :1016.67Pumecitinib
CAS :<p>Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.</p>Formule :C17H20N8O2SDegré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :400.46PROTAC EED degrader-1
<p>PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.</p>Formule :C55H60FN11O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1054.2PROTAC BRD4 Degrader-30
<p>PROTACBRD4 degrader-30 is an ISOX-DUAL-based PROTAC degrader, targeting BRD4 with an IC50 value of 65 nM. It is used in research studies related to c-Myc oncoproteins and the pathophysiology of cancer cells.</p>Couleur et forme :Odour SolidCBB1007 trihydrochloride (1379573-92-8 free base)
CAS :<p>CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).</p>Formule :C27H37Cl3N8O4Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :643.99EXQ-2d
<p>EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.</p>Formule :C18H17N3O3Couleur et forme :SolidMasse moléculaire :323.35WDR5 ligand 2
CAS :<p>WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.</p>Formule :C29H31F3N4O4Couleur et forme :SolidMasse moléculaire :556.576Sirtuin modulator 5
CAS :<p>Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.</p>Formule :C24H23N3O4Couleur et forme :SolidMasse moléculaire :417.46PRMT5-IN-9
CAS :<p>PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.</p>Formule :C25H23F3N6OCouleur et forme :SolidMasse moléculaire :480.495HDAC6 degrader-3
CAS :<p>HDAC6 degrader-3: potent, selective, degrades HDAC6 at 19.4 nM, weakens HDAC1 at 0.647 μM, induces α-tubulin hyperacetylation.</p>Formule :C41H41F4N7O11Couleur et forme :SolidMasse moléculaire :883.8PROTAC SMARCA2/4 degrader-36
CAS :<p>PROTACSMARCA2/4 degrader-36 (Compound 29) is a potent dual degrader targeting SMARCA2 and SMARCA4, exhibiting DC50 values of 0.22 nM and 0.85 nM, respectively. Additionally, PROTACSMARCA2/4 degrader-36 demonstrates antiproliferative activity.</p>Formule :C53H62ClN9O4SCouleur et forme :SolidMasse moléculaire :956.635LSD1/HDAC6-IN-1
<p>LSD1/HDAC6-IN-1 is an oral dual inhibitor of LSD1/HDAC6 with anti-tumor effects, useful for multiple myeloma research.</p>Couleur et forme :SolidPROTAC BRD4 Degrader-8
<p>PROTAC BRD4 Degrader-8: BRD4 inhibitor with IC50s of 1.1/1.4 nM for BD1/BD2, degrades BRD4 in PC3 cells.</p>Couleur et forme :LiquidCB1R/AMPK modulator 1
<p>Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R.</p>Formule :C25H22Cl2N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.45PROTAC SMARCA2/4-degrader-25
<p>PROTAC SMARCA2/4-degrader-25 is a PROTAC that targets SMARCA2/4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2/4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.</p>Formule :C44H50N10O9S2Couleur et forme :SolidMasse moléculaire :927.06MZP-54
CAS :<p>MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)</p>Formule :C55H66ClN7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1036.67CDD-1102 HCl
<p>CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.</p>Formule :C32H31ClN6O3Degré de pureté :98.30%Couleur et forme :SoildMasse moléculaire :583.08MNN-02-155
CAS :<p>MNN-02-155 is a bivalent molecular glue that can simultaneously interact with both p300/CBP and BCL6. It effectively induces the activation of BCL6-targeted reporter genes and promotes cell death. This compound is used in the research of diffuse large B-cell lymphoma (DLBCL).</p>Formule :C56H68ClF2N15O7Couleur et forme :SolidMasse moléculaire :1136.69Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS :<p>Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.</p>Formule :C56H110N22O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1315.61Eldocasiran
CAS :<p>Eldocasiran, a micro-RNA-193a-3p analogue, exhibits anticancer properties. It is utilized in cancer research [1].</p>Formule :C423H529N161O305P42Couleur et forme :SolidMasse moléculaire :14049.5ZMF-23
<p>ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis and</p>Formule :C22H23Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.36FTX-6058
CAS :<p>FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.</p>Formule :C22H18FN5O2Couleur et forme :SolidMasse moléculaire :403.417HDAC6-IN-56
<p>HDAC6-IN-56 (compound 18d) is an inhibitor of HDAC6, with an IC50 of 1.3 nM. This compound can inhibit the S phase and induce apoptosis in HCT-116 colon cancer cells.</p>Formule :C25H27ClN4O4SCouleur et forme :SolidMasse moléculaire :514.14415Mersalyl
CAS :<p>Mersalyl is an organic mercurial diuretic.</p>Formule :C13H16HgNNaO6Couleur et forme :SolidMasse moléculaire :505.854Nicotinamide riboside malate
CAS :<p>Orally active NAD+ booster, NR malate enhances metabolism, supports cognitive function, and is a vitamin B3 source.</p>Formule :C15H20N2O10Couleur et forme :SolidMasse moléculaire :388.33
