Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2553 produits trouvés pour "Chromatine/Épigénétique"
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MS8815
CAS :MS8815 is a selective EZH2 PROTAC degrader with IC50 of 8.6 nM, used in triple-negative breast cancer research.Formule :C65H87N9O8SCouleur et forme :SolidMasse moléculaire :1154.51HLCL-61
CAS :HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).Formule :C23H24N2OCouleur et forme :SolidMasse moléculaire :344.45JAK1-IN-9
CAS :JAK1-IN-9 (compound 23a) is a potent, selective inhibitor of JAK1, demonstrating an IC50 of 72 nM.Formule :C16H13IN6Couleur et forme :SolidMasse moléculaire :416.22Milpecitinib
CAS :Milpecitinib (Compound 21a) is a potent and selective Janus tyrosine kinase (JAK) inhibitor with anti-inflammatory properties. It shows promise for research in cancer and inflammatory diseases.
Formule :C20H20N4O2SCouleur et forme :SolidMasse moléculaire :380.463HDAC-IN-27
HDAC-IN-27 is a potent and orally active inhibitor of HDAC Class I (0.43 nM - 3.01 nM for HDAC1-3).Formule :C20H22N4O2Couleur et forme :SolidMasse moléculaire :350.41BRD4/NAMPT-IN-1
CAS :BRD4/NAMPT-IN-1 (Compound A2) exhibits strong inhibitory effects on NAMPT and BRD4, with IC50 values of 35 nM (NAMPT) and 58 nM (BRD4). This compound significantly suppresses the growth and migration of liver cancer cells while promoting apoptosis. Additionally, BRD4/NAMPT-IN-1 demonstrates potent anticancer activity in HCCLM3 xenograft mouse models without noticeable toxicity.Formule :C30H30ClN7O2SMasse moléculaire :588.12PRMT5-MTA-IN-3
CAS :PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.Formule :C19H17F3N6O3Couleur et forme :SolidMasse moléculaire :434.372ATR kinase-IN-2
CAS :ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.Formule :C24H29F2N9O2Couleur et forme :SolidMasse moléculaire :513.54HDAC6-IN-13
HDAC6-IN-13: potent, selective HDAC6 inhibitor; oral; IC50=0.019μM; targets HDAC1/2/3; crosses blood-brain barrier; anti-inflammatory.Formule :C23H22N4OCouleur et forme :SolidMasse moléculaire :370.45BBC0403
CAS :BBC0403 is a BRD2 inhibitor, inhibiting BRD2 and BRD2, and suppresses NF-κB and MAPK signaling pathways.Formule :C21H22N2O5Degré de pureté :98.15%Couleur et forme :SolidMasse moléculaire :382.41Ref: TM-T88118
1mg59,00€5mg124,00€10mg193,00€25mg358,00€50mg512,00€100mg707,00€1mL*10mM (DMSO)131,00€PFI-6-COOH
CAS :PFI-6-COOH (Compound 18) is a ligand for the eleven-nineteen leukemia (ENL) protein, and is utilized in the synthesis of the ENL PROTAC degrader MS41.Formule :C23H21N3O6Couleur et forme :SolidMasse moléculaire :435.43SGC-BRDVIII-NC
CAS :SGC-BRDVIII-NC (Compound 35) serves as a negative control for the SMARCA2/4 and PB1 bromodomain (BRD) inhibitors. The binding ability of the protein-ligand is completely eliminated in SGC-BRDVIII-NC through the methylation of the phenolic hydroxyl group. This compound is applicable for research in adipogenesis.Formule :C20H27N5O3Couleur et forme :SolidMasse moléculaire :385.46rel-A-395 hydrochloride
CAS :rel-A-395 hydrochloride is the relative configuration of A-395 hydrochloride. A-395 is an antagonist of protein-protein interactions within the polycomb repressive complex 2 (PRC2). It inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 value of 18 nM.Formule :C26H36ClFN4O2SCouleur et forme :SolidMasse moléculaire :523.11KDOAM-25 citrate
CAS :KDOAM-25 citrate inhibits KDM5A/B/C/D (IC50: 71, 19, 69, 69 nM); boosts H3K4 methylation, hinders MM1S cell growth. [1]Formule :C21H33N5O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.51HDAC11-IN-2
CAS :HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11). It demonstrates IC50 values of 51.1 ×10^-3 μM for HDAC11 and 5 μM for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.Formule :C25H35N3O3Couleur et forme :SolidMasse moléculaire :425.564XY153
XY153 (8l) is a BD2 selective BET inhibitor targeting BRD4, 3 & 2 with IC50s: 0.79, 5.31 & 5.09 nM, useful in acute myeloid leukemia & cancer research.Formule :C33H34FN3O4Couleur et forme :SolidMasse moléculaire :555.64JAK2-IN-11
CAS :JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ≤10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.Formule :C31H31F3N8O4Couleur et forme :SolidMasse moléculaire :639.64PRMT5-IN-48
CAS :PRMT5-IN-48 (compound D3) is an orally active PRMT5 inhibitor with an IC50 of 20.7 nM, displaying antitumor activity. It effectively suppresses the growth of various cancer cells, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is applicable for research in non-Hodgkin's lymphoma (NHL).Formule :C30H37N5O3Couleur et forme :SolidMasse moléculaire :515.646ER272
CAS :ER272 is a natural PKC activator, inducing hippocampal neurogenesis.Formule :C24H34O6Couleur et forme :SolidMasse moléculaire :418.52HIF-1/2α-IN-1
HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.Formule :C17H16N6O4Couleur et forme :SolidMasse moléculaire :368.35
