Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2548 produits trouvés pour "Chromatine/Épigénétique"
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PARP-1/HDAC-IN-1
CAS :PARP-1/HDAC-IN-1 is a PARP-1 and HDAC6 inhibitor with anticancer, antimigratory, and antiangiogenic activities and is used in tumor research.Formule :C22H18N4O4Degré de pureté :95.94%Couleur et forme :SolidMasse moléculaire :402.4STR-V-53
CAS :STR-V-53, an HDAC inhibitor (IC50 in nM), increases histone acetylation in tumor cells by inhibiting these enzymes, thereby regulating gene expression. STR-V-53 inhibits tumor growth and induces apoptosis [1].Formule :C21H30N4O8Couleur et forme :SolidMasse moléculaire :466.48DS44470011
CAS :DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.Formule :C21H19N3O4Couleur et forme :SolidMasse moléculaire :377.39PRMT5-IN-37
CAS :PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.Formule :C21H15F4N5O2Couleur et forme :SolidMasse moléculaire :445.37HYDAMTIQ
CAS :HYDAMTIQ, a PARP-1/2 inhibitor (IC 50 : 29-38 nM), exhibits a range of pharmacological effects including anticancer, anti-inflammatory, and ischemic protective properties. It effectively reduces pulmonary PARP activity and alleviates symptoms such as allergen-induced cough and dyspnea while also diminishing bronchial hyperresponsiveness to methacholine. Moreover, HYDAMTIQ shows potent tumor suppressor activity in various cancers such as ovarian, breast, prostate, pancreatic, and glioblastoma multiforme. Demonstrating in vivo efficacy, HYDAMTIQ has been tested in animal models for conditions like cerebral ischemia, asthma, and cancer [1].Formule :C14H14N2O2SCouleur et forme :SolidMasse moléculaire :274.34Basroparib
CAS :Basroparib is an inhibitor of ribose polymerase (PARP) and has shown antitumour effects.Formule :C18H21F2N7O3Couleur et forme :SolidMasse moléculaire :421.4MDH1/2-IN-1
CAS :MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.Formule :C25H33NO4Couleur et forme :SolidMasse moléculaire :411.534SRI-43265
CAS :SRI-43265 (compound 40) inhibits the dimerization of human antigen R protein (HuR), which is involved in cancer and inflammation pathogenesis [1].Formule :C19H20N6OCouleur et forme :SolidMasse moléculaire :348.4PRMT5-IN-18
CAS :PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.Formule :C32H42N4O4Couleur et forme :SolidMasse moléculaire :546.70NVS-BPTF-1
CAS :NVS-BPTF-1 is a specific inhibitor of bromodomain and PHD finger containing transcription factor (BPTF), exhibiting a dissociation constant (K_D) of 71 nM [1].Formule :C26H28FN7O3SCouleur et forme :SolidMasse moléculaire :537.6115:0 PG sodium
CAS :15:0 PG sodium serves as an activator for the Protein Kinase C family and is an anionic phospholipid located in the membranes of mitochondria and microsomes. It plays a crucial role in the composition of pulmonary surfactants, especially within the membrane of the pulmonary lamellar bodies.Formule :C36H70NaO10PCouleur et forme :SolidMasse moléculaire :716.90NSD2-PWWP1-IN-2
CAS :NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.Formule :C29H30N4Couleur et forme :SolidMasse moléculaire :434.575PRMT5-IN-49
CAS :PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39BRD4 Inhibitor-33
CAS :BRD4 Inhibitor-33 (example 13), a potent inhibitor of BRD4, is applicable in research related to both acute and chronic kidney diseases [1].Formule :C24H20N4O2Couleur et forme :SolidMasse moléculaire :396.44EED ligand 1
EED ligand 1: potent PRC2 inhibitor targeting EED subunit.Formule :C19H19FN8OCouleur et forme :SolidMasse moléculaire :394.41(1-Nitroethene-1,2-diyl)dibenzene
CAS :(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.Formule :C14H11NO2Couleur et forme :SolidMasse moléculaire :225.24PRMT5-IN-50
CAS :PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.Formule :C26H23F3N6OCouleur et forme :SolidMasse moléculaire :492.496CM-414
CAS :CM-414: HDAC/PDE5 inhibitor, targeting Alzheimer’s, IC50s: PDE5 (60 nM), HDAC1/2/3/6. Reduces Aβ, pTau in mice, boosts cognition.Formule :C23H29N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.51BRD4-IN-7
CAS :BRD4-IN-7, also known as compound 120, acts as a BRD4 inhibitor.Formule :C29H24F2N4O3Couleur et forme :SolidMasse moléculaire :514.52RL5a
CAS :RL5a (compound C23) is a novel inhibitor of SETD8.Formule :C17H19N3OCouleur et forme :SolidMasse moléculaire :281.35
