Altération de l'ADN/réparation de l'ADN
Les inhibiteurs de la réparation des dommages à l'ADN sont des composés qui interfèrent avec les processus impliqués dans la détection et la réparation des dommages à l'ADN. Ces inhibiteurs sont essentiels pour étudier les mécanismes de la stabilité génomique, de la mutagenèse et de la réponse aux dommages à l'ADN. Ils sont également importants dans la recherche sur le cancer, car de nombreuses tumeurs dépendent de voies spécifiques de réparation de l'ADN pour survivre. En inhibant ces voies, les inhibiteurs de la réparation des dommages à l'ADN peuvent améliorer l'efficacité de la chimiothérapie et de la radiothérapie. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité de la réparation des dommages à l'ADN pour soutenir vos recherches en biologie moléculaire, oncologie et pharmacologie.
Sous-catégories appartenant à la catégorie "Altération de l'ADN/réparation de l'ADN"
- ATM/ATR(71 produits)
- Alkylation de l'ADN(11 produits)
- Méthyltransférase de l’ADN(421 produits)
- Gyrase de l’ADN(11 produits)
- ADN-PK(51 produits)
- MTH1(1 produits)
- Antimétabolite nucléosidique/analogue(1.388 produits)
- Transcriptase inverse(43 produits)
- Sirtuine(88 produits)
- Télomérase(33 produits)
- Topoisomérase(136 produits)
Affichez 3 plus de sous-catégories
958 produits trouvés pour "Altération de l'ADN/réparation de l'ADN"
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PPARα agonist 1
<p>PPARα agonist 1 is a complete and potent PPARα agonist.</p>Formule :C27H34O4Couleur et forme :SolidMasse moléculaire :422.56L2H2-6OTD
CAS :<p>L2H2-6OTD is a telomerase inhibitor with G-quadruplex loops; IC50: 15 nM.</p>Formule :C30H30N10O8Couleur et forme :SolidMasse moléculaire :658.62DNA crosslinker 4 dihydrochloride
CAS :<p>DNA Crosslinker 4 binds DNA's minor groove, inhibits NCI-H460, A2780, MCF-7 cancer cells, and is used in cancer research.</p>Formule :C16H24Cl2N8OCouleur et forme :SolidMasse moléculaire :415.3215-keto-Prostaglandin E2
CAS :<p>15-keto-Prostaglandin E2, an endogenous metabolite, inhibits STAT3 activation through binding to Cys259 and regulates breast cancer cell growth and progression.</p>Formule :C20H30O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.452-Ethylhexyl diphenyl phosphate
CAS :<p>2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and acts as a PPARG agonist (EC20: 2.04 µM). Additionally, it inhibits the transcriptional activity of ERRγ (IC50: 1.3 µM) and enhances the expression of 3β-HSD1, human chorionic gonadotropin (hCG), and progesterone secretion. This compound is applicable in studies related to female reproduction and fetal development.</p>Formule :C20H27O4PCouleur et forme :SolidMasse moléculaire :362.40SARS-CoV-2 nsp14-IN-1
<p>SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.</p>Formule :C20H20N6O5SCouleur et forme :SolidMasse moléculaire :456.48PPARγ phosphorylation inhibitor 1
<p>PPARγ phosphorylation inhibitor 1 (Compound 10) is a potent PPARγ binding agent (IC50: 24 nM) with antidiabetic effects.</p>Formule :C22H14Cl2N2O4Couleur et forme :SolidMasse moléculaire :441.26Intoplicine
CAS :<p>Intoplicine is an inhibitor of DNA topoisomerase I and II.</p>Formule :C21H24N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.44Gimatecan
CAS :<p>Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Formule :C25H25N3O5Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :447.48Topoisomerase I/II inhibitor 2
<p>Compound 1a inhibits Topoisomerase I/II, shrinks mouse liver tumors, IC50: 6.83/9.82 μM for LM9/Huh7 cells.</p>Formule :C19H16N2O4Couleur et forme :SolidMasse moléculaire :336.34GSK1820795A
CAS :<p>GSK1820795A: Telmisartan analog, selective hGPR132a antagonist, blocks yeast activation by N-acylamides, angiotensin II antagonist, partial PPARγ agonist.</p>Formule :C35H34N8Couleur et forme :SolidMasse moléculaire :566.7Topotecan acetate
CAS :<p>Topotecan acetate is an inhibitor of topoisomerase.</p>Formule :C25H27N3O7Couleur et forme :SolidMasse moléculaire :481.498DNA-PK-IN-8
CAS :<p>DNA-PK-IN-8: Potent, selective oral DNA-PK inhibitor, IC50 = 0.8 nM, boosts anti-cancer effects with Doxorubicin.</p>Formule :C19H22N8O2Couleur et forme :SolidMasse moléculaire :394.43Namitecan
CAS :<p>Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.</p>Formule :C23H22N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.44Topoisomerase II inhibitor 5
<p>Topoisomerase II inhibitor 5 (Compound E24) is a DNAtopoisomerase II inhibitor with anticancer effects.</p>Formule :C26H27N5O4Couleur et forme :SolidMasse moléculaire :473.52HDAC8-IN-12
CAS :<p>HDAC8-IN-12 (compound 5k), a non-hydroxamic acid derivative, serves as a selective HDAC8 inhibitor with an IC 50 of 0.12 nM and demonstrates potent efficacy against breast cancer. This compound enhances anti-tumor immunity by activating T cells, elevating M1 macrophage levels, and reducing M2 macrophage proportions. In an orthotopic mouse model of breast cancer, HDAC8-IN-12, administered at 50 mg/kg, effectively suppresses tumor growth.</p>Formule :C16H17N3O5Couleur et forme :SolidMasse moléculaire :331.32Levofloxacin mesylate
CAS :<p>Levofloxacin mesylate is an orally active antibiotic effective against both Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase and topoisomerase IV enzymes. Levofloxacin mesylate is employed in research related to chronic periodontitis, airway inflammation, and BK viremia. Additionally, it possesses anti-Orthopoxvirus activity.</p>Formule :C19H24FN3O7SCouleur et forme :SolidMasse moléculaire :457.473PPARα/γ agonist 1
<p>PPARα/γ agonist 1 is a potent and dual PPARα/γ partial agonist which is a promising prototype for the research of dyslipidemia and diabetes.</p>Formule :C18H19NO2Couleur et forme :SolidMasse moléculaire :281.35NU5455
CAS :<p>NU5455 is a potent DNA-PKcs inhibitor, oral, boosts doxorubicin in liver tumors, amplifies topoisomerase inhibitors, no adverse effects.</p>Formule :C34H33N3O5SCouleur et forme :SolidMasse moléculaire :595.71Lys(CO-C3-p-I-Ph)-O-tBu
CAS :<p>Lys(CO-C3-p-I-Ph)-O-tBu, a pharmacokinetic modifier (PK modifier), enhances the pharmacokinetic properties of PSMA ligand molecules by increasing their residence time in plasma through improved binding to albumin and reducing absorption by the salivary glands, potentially extending the active compound's half-life. Moreover, Ac-PSMA-trillium is an effective PSMA-targeting compound for various biological applications when modified with different radioactive isotopes. When labeled with 111 In, it serves as a DOTA chelating agent and imaging agent. Alternatively, when labeled with 225 Ac, it acts as a Macropa chelator for targeted radionuclide therapy (TRT) in researching metastatic castration-resistant prostate cancer (mCRPC) [1] [2].</p>Formule :C20H31IN2O3Couleur et forme :SolidMasse moléculaire :474.38Edotecarin
CAS :<p>Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).</p>Formule :C29H28N4O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.55Karenitecin
CAS :<p>Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.</p>Formule :C25H28N2O4SiDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.59ATR-IN-17
CAS :<p>ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).</p>Formule :C22H28N6O2SCouleur et forme :SolidMasse moléculaire :440.56OSUAB-0284
CAS :<p>OSUAB-0284 is an inhibitor of bacterial topoisomerase. It exhibits significant activity against staphylococci, particularly methicillin-resistant Staphylococcus aureus (MRSA). The compound exerts its antibacterial effect by inhibiting bacterial topoisomerase and may be used in research on infections caused by drug-resistant bacteria, including MRSA.</p>Formule :C22H23FN6O6Couleur et forme :SolidMasse moléculaire :486.45ATM Inhibitor-4
<p>ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.</p>Formule :C26H29FN6O3Couleur et forme :SolidMasse moléculaire :492.55PARP-1/HDAC-IN-1
CAS :<p>PARP-1/HDAC-IN-1 is a PARP-1 and HDAC6 inhibitor with anticancer, antimigratory, and antiangiogenic activities and is used in tumor research.</p>Formule :C22H18N4O4Degré de pureté :95.94%Couleur et forme :SolidMasse moléculaire :402.4KU 59403
CAS :<p>KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).</p>Formule :C29H32N4O4S2Degré de pureté :99.10%Couleur et forme :SolidMasse moléculaire :564.72PPARγ agonist 2
<p>PPARγ agonist 2 is a highly effective compound that acts as a partial agonist for PPARγ.</p>Formule :C24H20O5Couleur et forme :SolidMasse moléculaire :388.41SPR719
CAS :<p>SPR719 is an inhibitor of gyrase B, has bactericidal activity.</p>Formule :C21H25FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.46ATR-IN-14
CAS :<p>ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.</p>Formule :C20H20FN7OCouleur et forme :SolidMasse moléculaire :393.42WSD0628
CAS :<p>WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].</p>Formule :C23H23F2N5O2Couleur et forme :SolidMasse moléculaire :439.46DNA-PK-IN-9
<p>DNA-PK-IN-9 (YK6) is a potent DNA-PK inhibitor with an IC50 of 10.47 nM, important in cancer research.</p>Formule :C21H21N5O2Couleur et forme :SolidMasse moléculaire :375.42Topoisomerase II inhibitor 18
CAS :<p>Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].</p>Formule :C20H21N3OSCouleur et forme :SolidMasse moléculaire :351.47PPARγ agonist 17
CAS :<p>PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.</p>Formule :C48H63NO7Couleur et forme :SolidMasse moléculaire :766.016Anti-NASH agent 2
CAS :<p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>Formule :C32H51N3O2Couleur et forme :SolidMasse moléculaire :509.766SP-C01
CAS :<p>SP-C01 is an orally active soluble epoxide hydrolase (sEH) inhibitor and a partial agonist of PPARγ. It can inhibit the phosphorylation of Ser273.</p>Formule :C22H22F4N2O5Couleur et forme :SolidMasse moléculaire :470.41Topoisomerase inhibitor 5
CAS :<p>Topoisomerase inhibitor 5 (compound 158) is an inhibitor of bacterial topoisomerase, with a minimum inhibitory concentration of 0.125 μg/mL, and exhibits anti-tuberculosis activity.</p>Formule :C24H25FN4O6Couleur et forme :SolidMasse moléculaire :484.477Topoisomerase I/II inhibitor 7
CAS :<p>Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.</p>Formule :C18H13ClN2O3Couleur et forme :SolidMasse moléculaire :340.76DNA-PK-IN-6
CAS :<p>DNA-PK-IN-6 inhibits DNA-PKcs, disrupting tumor DNA repair and triggering apoptosis; enhances radiotherapy and targets various tumors (WO2021197159A1).</p>Formule :C19H21N7OCouleur et forme :SolidMasse moléculaire :363.42MC3138
CAS :<p>MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.</p>Formule :C25H25NO6Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :435.47LP-284
CAS :<p>LP-284 is a DNA alkylating agent effective against solid tumors and hematologic cancers like MCL.</p>Formule :C16H20N2O4Couleur et forme :SolidMasse moléculaire :304.34Simmitecan hydrochloride
CAS :<p>Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.</p>Formule :C34H39ClN4O6Degré de pureté :98.20% - 98.93%Couleur et forme :SolidMasse moléculaire :635.15KU-60019
CAS :<p>KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).</p>Formule :C30H33N3O5SDegré de pureté :98.05% - 98.50%Couleur et forme :SolidMasse moléculaire :547.67BAY-8400
<p>BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in</p>Formule :C21H17F2N5ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :393.39OBI-3424
CAS :<p>OBI-3424, a highly selective prodrug, is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent.</p>Formule :C21H25N4O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.427YF438
CAS :<p>YF438 is an HDAC inhibitor that demonstrates potent anti-cancer activity both in vitro and in vivo. It inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2 from MDMX, and promoting the degradation of MDM2.</p>Formule :C23H26N4O5Couleur et forme :SolidMasse moléculaire :438.48Merbarone
CAS :<p>Merbarone is a Type II DNA topoisomerase inhibitor. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the n</p>Formule :C11H9N3O3SCouleur et forme :SolidMasse moléculaire :263.27NSC61610
CAS :<p>NSC61610 is anti-inflammatory that activates PPARγ in vitro via LANCL2 and adenylate cyclase/cAMP-dependent pathways, thereby improving experimental colitis.</p>Formule :C34H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :548.59Zabofloxacin hydrochloride
CAS :<p>Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.</p>Formule :C19H21ClFN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.86Phenanthriplatin
CAS :<p>Phenanthriplatin, also known as cis-[Pt(NH3)2-(phenanthridine)Cl]NO3, is a new drug candidate. It belongs to a family of platinum(II)-based agents which includes cisplatin, oxaliplatin and carboplatin. Phenanthriplatin Acts As a Covalent Poison of Topoiso</p>Formule :C13H11ClN4O3PtCouleur et forme :SolidMasse moléculaire :501.79SR-4370
CAS :<p>SR-4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp.</p>Formule :C17H18F2N2ODegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :304.33Mavodelpar free base
CAS :<p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>Formule :C31H30FNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.57Fotemustine
CAS :<p>Fotemustine: antineoplastic, chloroethylates DNA, blocks synthesis, causes cell arrest/apoptosis, lipophilic, crosses blood-brain barrier.</p>Formule :C9H19ClN3O5PCouleur et forme :SolidMasse moléculaire :315.69ATR-IN-24
CAS :<p>ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].</p>Formule :C23H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :418.49Lerzeparib
CAS :<p>Lerzeparib is a PARP (ADP-ribose polymerase) inhibitor that exhibits antineoplastic activity [1].</p>Formule :C21H20FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.4MDL-811
CAS :<p>MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),</p>Formule :C25H25BrCl2FN3O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :681.42Antitumor agent-104
CAS :<p>Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme</p>Formule :C31H33FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.63PARP7-IN-16 free base
CAS :<p>PARP7-IN-16 free base is the freebase form of PARP7-IN-16. As a selective oral inhibitor of PARP-1/2/7, it demonstrates IC50 values of 0.94, 0.87, and 0.21 nM, respectively. This compound is utilized in the research of breast and prostate cancer.</p>Formule :C25H27FN4O4Couleur et forme :SolidMasse moléculaire :466.50
