ATM/ATR
Les inhibiteurs de l'ATM (Ataxia Telangiectasia Mutated) et de l'ATR (ATM and Rad3-related) ciblent des kinases clés impliquées dans la réponse aux dommages de l'ADN (DDR), activées en réponse aux cassures double brin de l'ADN et au stress de réplication. Ces inhibiteurs perturbent la capacité des kinases à détecter et réparer les dommages de l'ADN, ce qui peut entraîner une instabilité génomique accrue et la mort cellulaire, en particulier dans les cellules cancéreuses qui dépendent de mécanismes de réparation de l'ADN robustes pour survivre. Les inhibiteurs de l'ATM/ATR sont des outils cruciaux dans la recherche et la thérapie contre le cancer, notamment en combinaison avec des agents endommageant l'ADN. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de l'ATM/ATR de haute qualité pour soutenir vos recherches sur la réponse aux dommages de l'ADN, la biologie du cancer et le développement thérapeutique.
72 produits trouvés pour "ATM/ATR".
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Elimusertib hydrochloride(1876467-74-1 free base)
Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumorFormule :C20H22ClN7ODegré de pureté :98.8% - 99.03%Couleur et forme :SolidMasse moléculaire :411.89Ref: TM-T10468
1mg34,00€5mg84,00€1mL*10mM (DMSO)92,00€10mg114,00€25mg224,00€50mg331,00€100mg470,00€200mg647,00€Garcinone C
CAS :Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Formule :C23H26O7Degré de pureté :99.13% - 99.92%Couleur et forme :SolidMasse moléculaire :414.45FEN1-IN-1
CAS :FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.Formule :C15H12N2O5SDegré de pureté :99.72% - 99.93%Couleur et forme :White SolidMasse moléculaire :332.33Berzosertib
CAS :Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.Formule :C24H25N5O3SDegré de pureté :97.34% - >99.99%Couleur et forme :SolidMasse moléculaire :463.55Ref: TM-T2669
1mg34,00€5mg71,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg146,00€50mg213,00€100mg340,00€200mg497,00€500mg790,00€GJ071 oxalate
CAS :GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.Formule :C20H29N3O7SDegré de pureté :99.93%Couleur et forme :White SolidMasse moléculaire :455.53Ref: TM-T31932
1mg73,00€5mg149,00€1mL*10mM (DMSO)166,00€10mg213,00€25mg319,00€50mg450,00€100mg605,00€200mg802,00€Antitumor agent-28
CAS :Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.Formule :C25H32N6O4SCouleur et forme :SolidMasse moléculaire :512.63ATM Inhibitor-9
ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].Formule :C25H32N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.56CA-M11
CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.Formule :C34H46N2O6SCouleur et forme :SolidMasse moléculaire :610.80Hexapeptide-11
CAS :Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.Formule :C36H48N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :676.8ATM Inhibitor-8
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value ofFormule :C26H34N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.59Abd110
CAS :Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].Formule :C41H42N8O7SCouleur et forme :SolidMasse moléculaire :790.89ATR-IN-9
CAS :ATR-IN-9 from patent WO2020087170A1 is a potent ATR kinase inhibitor with an IC50 of 10 nM.Formule :C22H27N7O2Couleur et forme :SolidMasse moléculaire :421.505ICT10336
ICT10336 is a hypoxia-reactive prodrug of the ATR inhibitor AZD6738. It specifically activates under hypoxic conditions in vitro, selectively releasing AZD6738. This action inhibits ATR activation at the T1989 and S428 phosphorylation sites, consequently disrupting HIF1a-mediated adaptation of hypoxic cancer cells and inducing cell death in both 2D and 3D cancer models. ICT10336 is also a metabolic substrate of CYPOR activity.Formule :C32H40N10O7SCouleur et forme :SolidMasse moléculaire :708.28021PIK-93
CAS :PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Formule :C14H16ClN3O4S2Degré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :389.88Ref: TM-T2616
1mg42,00€5mg85,00€1mL*10mM (DMSO)94,00€10mg105,00€25mg200,00€50mg305,00€100mg427,00€200mg613,00€AZD0156
CAS :AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.Formule :C26H31N5O3Degré de pureté :99.13% - 99.87%Couleur et forme :SolidMasse moléculaire :461.56GJ103 sodium salt
CAS :GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.Formule :C16H13N4NaO3SDegré de pureté :99.70% - 99.91%Couleur et forme :Orange SolidMasse moléculaire :364.36Ceralasertib
CAS :Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.Formule :C20H24N6O2SDegré de pureté :98% - 99.99%Couleur et forme :White SolidMasse moléculaire :412.51Adefovir dipivoxil
CAS :Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity againstFormule :C20H32N5O8PDegré de pureté :98% - 99.80%Couleur et forme :SolidMasse moléculaire :501.47KU-55933
CAS :KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.Formule :C21H17NO3S2Degré de pureté :97.21% - >99.99%Couleur et forme :Yellow SolidMasse moléculaire :395.49AZD-7648
CAS :AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Formule :C18H20N8O2Degré de pureté :99.03% - 99.85%Couleur et forme :SolidMasse moléculaire :380.4Ref: TM-T7122
1mg38,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg177,00€50mg295,00€100mg447,00€200mg650,00€
