Altération de l'ADN/réparation de l'ADN
Les inhibiteurs de la réparation des dommages à l'ADN sont des composés qui interfèrent avec les processus impliqués dans la détection et la réparation des dommages à l'ADN. Ces inhibiteurs sont essentiels pour étudier les mécanismes de la stabilité génomique, de la mutagenèse et de la réponse aux dommages à l'ADN. Ils sont également importants dans la recherche sur le cancer, car de nombreuses tumeurs dépendent de voies spécifiques de réparation de l'ADN pour survivre. En inhibant ces voies, les inhibiteurs de la réparation des dommages à l'ADN peuvent améliorer l'efficacité de la chimiothérapie et de la radiothérapie. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité de la réparation des dommages à l'ADN pour soutenir vos recherches en biologie moléculaire, oncologie et pharmacologie.
Sous-catégories appartenant à la catégorie "Altération de l'ADN/réparation de l'ADN"
- ATM/ATR(71 produits)
- Alkylation de l'ADN(11 produits)
- Méthyltransférase de l’ADN(422 produits)
- Gyrase de l’ADN(11 produits)
- ADN-PK(50 produits)
- MTH1(1 produits)
- Antimétabolite nucléosidique/analogue(1.388 produits)
- Transcriptase inverse(43 produits)
- Sirtuine(88 produits)
- Télomérase(33 produits)
- Topoisomérase(136 produits)
Affichez 3 plus de sous-catégories
963 produits trouvés pour "Altération de l'ADN/réparation de l'ADN"
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Antibacterial agent 236
CAS :<p>Anti bacterial agent 236 (Compound 4l), an orally effective inhibitor of DNA gyrase and topoisomerase IV (with IC50 values of 3.2 and 300 nM in Staphylococcus aureus, respectively), exhibits broad-spectrum antibacterial activity. It also demonstrates favorable pharmacokinetic properties in mice.</p>Formule :C26H27N5O2SCouleur et forme :SolidMasse moléculaire :473.59ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54SARS-CoV-2 nsp14-IN-1
<p>SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.</p>Formule :C20H20N6O5SCouleur et forme :SolidMasse moléculaire :456.48ATR kinase-IN-3
CAS :<p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>Formule :C24H27F2N9O2Couleur et forme :SolidMasse moléculaire :511.53TMU 35435
CAS :<p>TMU 35435 is an inhibitor of histone deacetylases (HDAC). It enhances radiosensitivity by inducing the accumulation of misfolded proteins and autophagy (autophagy) in TNBC, and inhibits the NHEJ pathway through ubiquitination of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).</p>Formule :C22H25N3O3Couleur et forme :SolidMasse moléculaire :379.45Camptothecin-20(S)-O-propionate
CAS :<p>CZ-48 is a DNA topoisomerase inhibitor.</p>Formule :C23H20N2O5Couleur et forme :SolidMasse moléculaire :404.42G-631
CAS :<p>G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.</p>Formule :C19H22F2N6O3Couleur et forme :SolidMasse moléculaire :420.41DNA crosslinker 1 dihydrochloride
CAS :<p>DNA Crosslinker 1 binds DNA minor groove with 1.1°C affinity increase; used in cancer research.</p>Formule :C15H22Cl2N8OCouleur et forme :SolidMasse moléculaire :401.29Atiratecan
CAS :<p>Atiratecan (TP300), a CH0793076-based camptothecin prodrug, combats BCRP+/- tumors; doesn't affect AChE.</p>Formule :C31H34N6O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.64PPARγ agonist 1
<p>PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects.</p>Formule :C34H39NO3Couleur et forme :SolidMasse moléculaire :509.68Pparδ agonist 5
<p>Pparδ agonist 5 is a selective, orally active PPARδ agonist with an EC50 of 0.335 μM and better selectivity than GW0742.</p>Formule :C23H21F3N2O2SCouleur et forme :SolidMasse moléculaire :446.49Sirtuin-IN-2
<p>Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.</p>Formule :C28H46N8O6SCouleur et forme :SolidMasse moléculaire :622.78MC3138
CAS :<p>MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.</p>Formule :C25H25NO6Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :435.47DNA-PK-IN-6
CAS :<p>DNA-PK-IN-6 inhibits DNA-PKcs, disrupting tumor DNA repair and triggering apoptosis; enhances radiotherapy and targets various tumors (WO2021197159A1).</p>Formule :C19H21N7OCouleur et forme :SolidMasse moléculaire :363.42DNA crosslinker 2 dihydrochloride
CAS :<p>Potent DNA crosslinker 2 binds minor groove, increases Tm by 1.2°C, and inhibits NCI-H460, A2780, MCF-7 cancer cells.</p>Formule :C15H22Cl2N8OCouleur et forme :SolidMasse moléculaire :401.29ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Formule :C25H29FN6O3Couleur et forme :SolidMasse moléculaire :480.53LP-284
CAS :<p>LP-284 is a DNA alkylating agent effective against solid tumors and hematologic cancers like MCL.</p>Formule :C16H20N2O4Couleur et forme :SolidMasse moléculaire :304.34(Rac)-RG108
CAS :<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Formule :C19H14N2O4Couleur et forme :SolidMasse moléculaire :334.326ATR kinase-IN-2
CAS :<p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>Formule :C24H29F2N9O2Couleur et forme :SolidMasse moléculaire :513.54PPARα/γ agonist 1
<p>PPARα/γ agonist 1 is a potent and dual PPARα/γ partial agonist which is a promising prototype for the research of dyslipidemia and diabetes.</p>Formule :C18H19NO2Couleur et forme :SolidMasse moléculaire :281.35DNA-PK-IN-15
CAS :DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.Formule :C23H23N9OCouleur et forme :SolidMasse moléculaire :441.49Topoisomerase inhibitor 5
CAS :<p>Topoisomerase inhibitor 5 (compound 158) is an inhibitor of bacterial topoisomerase, with a minimum inhibitory concentration of 0.125 μg/mL, and exhibits anti-tuberculosis activity.</p>Formule :C24H25FN4O6Couleur et forme :SolidMasse moléculaire :484.477KU 59403
CAS :KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).Formule :C29H32N4O4S2Degré de pureté :99.10%Couleur et forme :SolidMasse moléculaire :564.72HDAC6-IN-51
CAS :HDAC6-IN-51 (Compound 7e) is a selective inhibitor of HDAC6, exhibiting an IC50 value of 42.9 nM. This compound demonstrates effective anti-pulmonary fibrosis activity.Formule :C24H24ClN5O3Couleur et forme :SolidMasse moléculaire :465.93Cas9-IN-1
<p>Cas9-IN-1 is a potent inhibitor of Cas9 with an IC50 value of 7.02 μM. Cas9-IN-1 acts by binding apo-Cas9 and blocking the formation of the Cas9:gRNA complex.</p>Formule :C17H11Cl2F3N2O3SCouleur et forme :SolidMasse moléculaire :451.25SP-C01
CAS :<p>SP-C01 is an orally active soluble epoxide hydrolase (sEH) inhibitor and a partial agonist of PPARγ. It can inhibit the phosphorylation of Ser273.</p>Formule :C22H22F4N2O5Couleur et forme :SolidMasse moléculaire :470.41TDI-015051
CAS :<p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>Formule :C22H22FN5O4SCouleur et forme :SolidMasse moléculaire :471.505Carbacyclin
CAS :<p>Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.</p>Formule :C21H34O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.49DLK-IN-1
CAS :DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.Formule :C20H24F3N5O2Couleur et forme :SolidMasse moléculaire :423.43WSD0628
CAS :WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].Formule :C23H23F2N5O2Couleur et forme :SolidMasse moléculaire :439.462-Ethylhexyl diphenyl phosphate
CAS :<p>2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and acts as a PPARG agonist (EC20: 2.04 µM). Additionally, it inhibits the transcriptional activity of ERRγ (IC50: 1.3 µM) and enhances the expression of 3β-HSD1, human chorionic gonadotropin (hCG), and progesterone secretion. This compound is applicable in studies related to female reproduction and fetal development.</p>Formule :C20H27O4PCouleur et forme :SolidMasse moléculaire :362.40Topoisomerase II inhibitor 18
CAS :<p>Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].</p>Formule :C20H21N3OSCouleur et forme :SolidMasse moléculaire :351.47PPARγ agonist 17
CAS :<p>PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.</p>Formule :C48H63NO7Couleur et forme :SolidMasse moléculaire :766.016Anti-NASH agent 2
CAS :<p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>Formule :C32H51N3O2Couleur et forme :SolidMasse moléculaire :509.766Intoplicine
CAS :Intoplicine is an inhibitor of DNA topoisomerase I and II.Formule :C21H24N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.44Gimatecan
CAS :Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formule :C25H25N3O5Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :447.48E-3030 free acid
CAS :<p>E-3030 free acid, a PPAR agonist, lowers blood glucose, triglycerides, and insulin; boosts adiponectin; reduces apo C-III; and raises lipoprotein lipase.</p>Formule :C22H23ClFNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.87Levofloxacin mesylate
CAS :<p>Levofloxacin mesylate is an orally active antibiotic effective against both Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase and topoisomerase IV enzymes. Levofloxacin mesylate is employed in research related to chronic periodontitis, airway inflammation, and BK viremia. Additionally, it possesses anti-Orthopoxvirus activity.</p>Formule :C19H24FN3O7SCouleur et forme :SolidMasse moléculaire :457.473Namitecan
CAS :Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.Formule :C23H22N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.44PARP1/2-IN-4
CAS :<p>PARP1/2-IN-4 (compound 3) is an inhibitor of PARP1/2.</p>Formule :C23H30FN5O6Couleur et forme :SolidMasse moléculaire :491.51PPARα agonist 1
<p>PPARα agonist 1 is a complete and potent PPARα agonist.</p>Formule :C27H34O4Couleur et forme :SolidMasse moléculaire :422.56TP3011
CAS :<p>TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.</p>Formule :C26H26N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.51Bizelesin
CAS :<p>Bizelesin, a synthetic antineoplastic agent, binds DNA, disrupts replication, triggers cell-cycle arrest, and induces senescence.</p>Formule :C43H36Cl2N8O5Couleur et forme :SolidMasse moléculaire :815.7Edotecarin
CAS :<p>Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).</p>Formule :C29H28N4O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.55ATR-IN-14
CAS :<p>ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.</p>Formule :C20H20FN7OCouleur et forme :SolidMasse moléculaire :393.42ATM Inhibitor-2
<p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).</p>Formule :C26H31N7O3Couleur et forme :SolidMasse moléculaire :489.57Simmitecan hydrochloride
CAS :<p>Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.</p>Formule :C34H39ClN4O6Degré de pureté :98.20% - 98.93%Couleur et forme :SolidMasse moléculaire :635.15KU-60019
CAS :<p>KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).</p>Formule :C30H33N3O5SDegré de pureté :98.05% - 98.50%Couleur et forme :SolidMasse moléculaire :547.67BAY-8400
<p>BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in</p>Formule :C21H17F2N5ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :393.39OBI-3424
CAS :OBI-3424, a highly selective prodrug, is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent.Formule :C21H25N4O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.427Merbarone
CAS :<p>Merbarone is a Type II DNA topoisomerase inhibitor. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the n</p>Formule :C11H9N3O3SCouleur et forme :SolidMasse moléculaire :263.27Phenanthriplatin
CAS :<p>Phenanthriplatin, also known as cis-[Pt(NH3)2-(phenanthridine)Cl]NO3, is a new drug candidate. It belongs to a family of platinum(II)-based agents which includes cisplatin, oxaliplatin and carboplatin. Phenanthriplatin Acts As a Covalent Poison of Topoiso</p>Formule :C13H11ClN4O3PtCouleur et forme :SolidMasse moléculaire :501.79YF438
CAS :<p>YF438 is an HDAC inhibitor that demonstrates potent anti-cancer activity both in vitro and in vivo. It inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2 from MDMX, and promoting the degradation of MDM2.</p>Formule :C23H26N4O5Couleur et forme :SolidMasse moléculaire :438.48NSC61610
CAS :<p>NSC61610 is anti-inflammatory that activates PPARγ in vitro via LANCL2 and adenylate cyclase/cAMP-dependent pathways, thereby improving experimental colitis.</p>Formule :C34H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :548.59Zabofloxacin hydrochloride
CAS :<p>Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.</p>Formule :C19H21ClFN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.86SR-4370
CAS :<p>SR-4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp.</p>Formule :C17H18F2N2ODegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :304.33Ref: TM-T4389
Produit arrêtéFotemustine
CAS :<p>Fotemustine: antineoplastic, chloroethylates DNA, blocks synthesis, causes cell arrest/apoptosis, lipophilic, crosses blood-brain barrier.</p>Formule :C9H19ClN3O5PCouleur et forme :SolidMasse moléculaire :315.69Mavodelpar free base
CAS :<p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>Formule :C31H30FNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.57ATR-IN-24
CAS :<p>ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].</p>Formule :C23H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :418.49Lerzeparib
CAS :<p>Lerzeparib is a PARP (ADP-ribose polymerase) inhibitor that exhibits antineoplastic activity [1].</p>Formule :C21H20FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.4MDL-811
CAS :<p>MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),</p>Formule :C25H25BrCl2FN3O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :681.42Antitumor agent-104
CAS :<p>Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme</p>Formule :C31H33FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.63PARP7-IN-16 free base
CAS :<p>PARP7-IN-16 free base is the freebase form of PARP7-IN-16. As a selective oral inhibitor of PARP-1/2/7, it demonstrates IC50 values of 0.94, 0.87, and 0.21 nM, respectively. This compound is utilized in the research of breast and prostate cancer.</p>Formule :C25H27FN4O4Couleur et forme :SolidMasse moléculaire :466.50
