Altération de l'ADN/réparation de l'ADN
Les inhibiteurs de la réparation des dommages à l'ADN sont des composés qui interfèrent avec les processus impliqués dans la détection et la réparation des dommages à l'ADN. Ces inhibiteurs sont essentiels pour étudier les mécanismes de la stabilité génomique, de la mutagenèse et de la réponse aux dommages à l'ADN. Ils sont également importants dans la recherche sur le cancer, car de nombreuses tumeurs dépendent de voies spécifiques de réparation de l'ADN pour survivre. En inhibant ces voies, les inhibiteurs de la réparation des dommages à l'ADN peuvent améliorer l'efficacité de la chimiothérapie et de la radiothérapie. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité de la réparation des dommages à l'ADN pour soutenir vos recherches en biologie moléculaire, oncologie et pharmacologie.
Sous-catégories appartenant à la catégorie "Altération de l'ADN/réparation de l'ADN"
- ATM/ATR(71 produits)
- Alkylation de l'ADN(11 produits)
- Méthyltransférase de l’ADN(421 produits)
- Gyrase de l’ADN(11 produits)
- ADN-PK(51 produits)
- MTH1(1 produits)
- Antimétabolite nucléosidique/analogue(1.388 produits)
- Transcriptase inverse(43 produits)
- Sirtuine(88 produits)
- Télomérase(33 produits)
- Topoisomérase(136 produits)
Affichez 3 plus de sous-catégories
958 produits trouvés pour "Altération de l'ADN/réparation de l'ADN"
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NC190 sodium
CAS :<p>NC190 inhibits topoisomerase II, halts FM3A cell growth (IC50: 0.019 μg/ml in 48h), and suppresses DNA synthesis by 90% at 0.1 μg/ml.</p>Formule :C23H22N4NaO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.442BMS-711939
CAS :<p>BMS-711939: Potent PPARα agonist, EC50=4 nM, shown effective and safe in preclinical trials.</p>Formule :C22H20ClFN2O6Couleur et forme :SolidMasse moléculaire :462.86NHC-triphosphate
CAS :<p>NHC-triphosphate is a weak alternative substrate for the viral polymerase and changes the mobility of the product in polyacrylamide electrophoresis gels.</p>Formule :C9H16N3O15P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.16Topoisomerase IIα-IN-2
CAS :<p>Topoisomerase IIα-IN-2 (compound 5) is a DNA-binding ligands and a potent inhibitor of the topoisomerase TopoIIα.</p>Formule :C22H20N4O5Couleur et forme :SolidMasse moléculaire :420.42Naveglitazar
CAS :<p>Naveglitazar (LY 519818, LY 9818), a PPAR modulator in phase II trials for type 2 diabetes.</p>Formule :C25H26O6Couleur et forme :SolidMasse moléculaire :422.47LY-510929
CAS :<p>LY-510929: PPAR agonist for hyperlipidemia, metabolic issues, type 2 diabetes.</p>Formule :C26H25NO5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :463.55HWL-088
CAS :<p>HWL-088 is a potent free fatty acid receptor 1 (FFA1/GPR40) agonist. HWL-088 significantly improves glucose tolerance in normal and diabetic models.</p>Formule :C22H19FO4Couleur et forme :SolidMasse moléculaire :366.38CCT128930
CAS :<p>'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'</p>Formule :C18H20ClN5Degré de pureté :99.07% - 99.18%Couleur et forme :SolidMasse moléculaire :341.84PluriSIn #2
CAS :<p>PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.</p>Formule :C11H8FN3O3Degré de pureté :98% - 99.79%Couleur et forme :SolidMasse moléculaire :249.2HDAC-IN-5
CAS :<p>HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.</p>Formule :C26H24F3N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.56Ertiprotafib
CAS :<p>Ertiprotafib (PTP 112), a PTP1B and IKK-β inhibitor, is a novel insulin sensitizer for the study of type 2 diabetes and breast cancer.</p>Formule :C31H27BrO3SDegré de pureté :98.70%Couleur et forme :SolidMasse moléculaire :559.51Sirt2-IN-1
CAS :<p>Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).</p>Formule :C28H27N7O2S2Degré de pureté :99.57% - 99.84%Couleur et forme :SolidMasse moléculaire :557.69CAY10767
CAS :<p>CAY10767 is a PPARα agonist with an EC50 of 37 nM; over 2700x selective against PPARγ/δ.</p>Formule :C22H20FNO3Couleur et forme :SolidMasse moléculaire :365.4Guadecitabine sodium
CAS :<p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>Formule :C18H24N9NaO10PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.407Topoisomerase I inhibitor 7
CAS :<p>Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I.</p>Formule :C22H19N3O5Couleur et forme :SolidMasse moléculaire :405.4LG100754
CAS :<p>LG100754 (UVI 2112) is an insulin sensitizer and RXR modulator, antagonizing RXR homodimers while agonizing RXR:PPARα/γ heterodimers.</p>Formule :C26H36O3Couleur et forme :SolidMasse moléculaire :396.569-Hydroxyellipticine hydrochloride
CAS :<p>9-Hydroxyellipticine hydrochloride is an inhibitor of Topo II and RyR, exhibits antitumor and antileukemic activity, and inhibits carrageenan gum-induced edema.</p>Formule :C17H15ClN2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :298.77Topoisomerase II inhibitor 16
CAS :<p>Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the</p>Formule :C19H12F4N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.33Topoisomerase IV inhibitor 1
CAS :<p>Compound 7d: Inhibits TOPO IV (IC50: 0.23 μM), DNA gyrase (IC50: 0.43 μM), antibacterial against S. aureus (MIC: 0.972 μM), E. coli (MIC: 0.608 μM).</p>Formule :C34H32FN7O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :685.72PB131
CAS :<p>PB131, a selective and brain-permeable HDAC6 inhibitor, exhibits high binding affinity (IC50: 1.8 nM) and potent anti-inflammatory activity, making it suitable</p>Formule :C16H16FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :301.32GW 9578
CAS :<p>GW 9578 is a PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.</p>Formule :C26H34F2N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :492.62Chiglitazar
CAS :<p>Chiglitazar is a PPAR α/γ/δ agonist and insulin sensitizer used in the treatment of type 2 diabetes mellitus , anti-inflammatory and anti-fibrotic.</p>Formule :C36H29FN2O4Couleur et forme :SolidMasse moléculaire :572.63HDAC-IN-58
CAS :<p>HDAC-IN-58, a selective HDAC6 inhibitor, exhibits potent inhibitory activity with an IC50 of 2.06 nM, rendering it suitable for research into chronic</p>Formule :C16H13ClF2N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.81Topoisomerase IV inhibitor 2
CAS :<p>Compound 5d, a potent TOPO IV inhibitor (IC50: 0.35 μM), also inhibits DNA gyrase (IC50: 0.55 μM) and has antibacterial activity.</p>Formule :C33H30FN7O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :671.7HDAC ligand-1
CAS :<p>HDAC ligand-1 is a synthetic precursor utilized in the production of PROTAC-based HDAC degraders [1].</p>Formule :C7H8N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :136.15ATR-IN-23
CAS :<p>ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces</p>Formule :C20H22N6O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.56BRD 9757
CAS :<p>BRD 9757 (N-Hydroxy-1-cyclopentene-1-carboxamide) is a selective inhibitor of HDAC6 (IC50 = 30 nM).</p>Formule :C6H9NO2Degré de pureté :98.39% - 99.87%Couleur et forme :SolidMasse moléculaire :127.14NSC16168
CAS :<p>NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.</p>Formule :C17H15NO9S3Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :473.5Dehydroepiandrosterone sulfate
CAS :<p>Dehydroepiandrosterone sulfate (PB-005) influences the migration of neurons, arborization of dendrites, and formation of new synapses.</p>Formule :C19H28O5SDegré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :368.49ISX-1
CAS :<p>ISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia.</p>Formule :C14H14N4O2SDegré de pureté :98.7%Couleur et forme :SolidMasse moléculaire :302.35Linotroban
CAS :<p>Linotroban（CL-871502） is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity.</p>Formule :C14H15NO5S2Degré de pureté :97.95% - >99.99%Couleur et forme :SolidMasse moléculaire :341.4Dazmegrel
CAS :<p>Dazmegrel (UK 38,485) is a thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy.</p>Formule :C16H17N3O2Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :283.33Vutiglabridin
CAS :<p>Vutiglabridin (HSG4112), a PON2 modulator, is more stable and aids weight loss than Glabridin. In phase 2 trials for obesity, shows promise for PD therapy.</p>Formule :C22H26O4Degré de pureté :98.47% - 99.07%Couleur et forme :SolidMasse moléculaire :354.44Chloroquinoxaline sulfonamide
CAS :<p>Chloroquinoxaline sulfonamide (Chloroquinoxaline) is an organic micropollutant with antimicrobial activity.</p>Formule :C14H11ClN4O2SDegré de pureté :99.79% - 99.89%Couleur et forme :SolidMasse moléculaire :334.78DN-1289
<p>DN-1289: oral, BBB-penetrating, selectively inhibits DLK (IC50=17nM) & LZK (IC50=40nM), blocks p-c-Jun in mouse optic nerve crush.</p>Formule :C18H19F4N7O2Degré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :441.38SIRT5 inhibitor 1
CAS :<p>SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.</p>Formule :C31H39FN6O6S2Degré de pureté :97.8%Couleur et forme :SolidMasse moléculaire :674.81Cedazuridine
CAS :<p>Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.</p>Formule :C9H14F2N2O5Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :268.21AGI-24512
CAS :<p>AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in</p>Formule :C24H24N4O2Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :400.47Procainamide
CAS :<p>Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.</p>Formule :C13H21N3ODegré de pureté :99.92% - 99.92%Couleur et forme :SolidMasse moléculaire :235.33L82
CAS :<p>L82: A selective, non-competitive DNA Lig1 inhibitor with anti-proliferative effects on breast cancer cells. IC50=12 μM.</p>Formule :C11H8ClN5O4Degré de pureté :97.45% - 98.91%Couleur et forme :SolidMasse moléculaire :309.67BTB09089
CAS :<p>BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production</p>Formule :C14H12Cl2N4OS2Degré de pureté :99.78%Couleur et forme :SoildMasse moléculaire :387.31SIRT6-IN-5
CAS :<p>SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.</p>Formule :C19H14N2O6Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :366.32HDAC8-IN-20a
CAS :<p>HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM.</p>Formule :C15H15NO4Degré de pureté :98.24% - 99.22%Couleur et forme :SolidMasse moléculaire :273.28Suksdorfin
CAS :<p>Suksdorfin has hypoglycemic effects and activates PPARγ, which promotes insulin-dependent glucose uptake by adipocytes and can be used to study obesity .</p>Formule :C21H24O7Degré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :388.41Bobcat339 hydrochloride
CAS :<p>Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.</p>Formule :C16H13Cl2N3ODegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :334.2Alalevonadifloxacin
CAS :<p>Alalevonadifloxacin is a DNA gyrase and DNA topoisomerase inhibitor and a novel antibacterial compound of the quinolone class targeting MRSa.</p>Formule :C23H30FN3O8SDegré de pureté :99.75% - 99.82%Couleur et forme :SoildMasse moléculaire :527.56Pegamotecan
CAS :<p>Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell</p>Formule :C52H48N6O14Degré de pureté :96.40% - 97.83%Couleur et forme :SolidMasse moléculaire :980.984Miriplatin hydrate
CAS :Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).Formule :C34H70N2O5PtDegré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :782.01BRD6688
CAS :<p>BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes</p>Formule :C16H18N4ODegré de pureté :97.53%Couleur et forme :SolidMasse moléculaire :282.34PARP10-IN-2
CAS :<p>PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and</p>Formule :C14H10N2O2Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :238.24Tenifatecan
CAS :<p>Tenifatecan (SN2310) is a highly lipophilic preparation of 7-ethyl-10-hydroxycamptothecin (SN) with potential antitumor activity.</p>Formule :C55H72N2O9Degré de pureté :99.58% - 99.82%Couleur et forme :SolidMasse moléculaire :905.17SS-208
CAS :<p>SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.</p>Formule :C13H11Cl2N3O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :344.15(R)-(-)-Rolipram
CAS :<p>(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.</p>Formule :C16H21NO3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :275.34Givinostat hydrochloride
CAS :<p>Givinostat HCl (ITF2357 HCl) inhibits HDAC1/3 (IC50: 198/157 nM) with anti-inflammatory, anti-angiogenic, and antineoplastic properties.</p>Formule :C24H28ClN3O4Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :457.95EB-47
CAS :<p>EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).</p>Formule :C24H27N9O6Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :537.53CEP-9722
CAS :<p>CEP-9722 is a PARP-1 and PARP-2 inhibitor with anticancer activity and is used in the study of ovarian cancer.</p>Formule :C24H26N4O3Degré de pureté :98.38% - 98.56%Couleur et forme :SolidMasse moléculaire :418.49ACY-957
CAS :<p>ACY-957: Oral HDAC1/2 inhibitor (IC50: HDAC1=7nM, HDAC2=18nM, HDAC3=1300nM); inactive on HDAC4/5/6/7/8/9.</p>Formule :C24H23N5OSDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :429.54OUL232
CAS :<p>OUL232 is a potent single ARTs PARP7, PARP10, PARP11, PARP12, PARP14 and PARP15 inhibitor for cancer and tumour research.</p>Formule :C10H10N4O2SDegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :250.28ACY-1083
CAS :<p>ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.</p>Formule :C17H18F2N4O2Degré de pureté :99.19% - 99.43%Couleur et forme :SolidMasse moléculaire :348.35BRD4097
CAS :<p>BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve</p>Formule :C16H17N3O2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :283.33BRD2492
CAS :<p>BRD2492 is an HDAC1 and HDAC2 inhibitor with antiproliferative activity, inhibits HDAC1/2 and induces apoptosis.</p>Formule :C20H18N4O2Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :346.38KRP-101
CAS :<p>KRP-101, a PPARɑ agonist, is used potentially for the treatment of diabetes and hyperlipidaemia.</p>Formule :C26H26FNO5Couleur et forme :SolidMasse moléculaire :451.49PPARγ agonist 7
CAS :<p>PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ).</p>Formule :C20H30O6Couleur et forme :SolidMasse moléculaire :366.45K-756
CAS :<p>K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).</p>Formule :C24H27N5O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :433.5L-783483
CAS :<p>L-783483 is an agonist of PPAR.</p>Formule :C22H21ClF3NO4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :487.92ATR-IN-21
CAS :<p>ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].</p>Formule :C23H27N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.51HDAC8-IN-4
CAS :<p>HDAC8-IN-4 is a selective HDAC8 inhibitor, exhibiting inhibitory activity with IC50 values of 0.15 μM for HDAC8 and 12 μM for HDAC3 [1].</p>Formule :C17H14N2O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.44Duocarmycin analog-2
CAS :<p>Duocarmycin analog-2 is a potent DNA alkylating agent that exhibits antitumor effects and can be used in the synthesis of immunocouplers.</p>Formule :C29H23ClN4O3Couleur et forme :SolidMasse moléculaire :510.97GNE-8505
CAS :<p>GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).</p>Formule :C21H24F3N5OCouleur et forme :SolidMasse moléculaire :419.44CM-579 trihydrochloride (1846570-40-8 free base)
<p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>Formule :C29H43Cl3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.04LCB-2853
CAS :<p>LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.</p>Formule :C21H24ClNO4SDegré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :421.94ARN-21934
CAS :<p>ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.</p>Formule :C21H24N6Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :360.46XY-4
CAS :<p>XY-4, a derivative of 1-palmitoyl lysophosphatidic acid (1-palmitoyl LPA094) and an agonist of peroxisome proliferator-activated receptor γ (PPARγ), effectively</p>Formule :C19H37F2O6PCouleur et forme :SolidMasse moléculaire :430.46Bocodepsin hydrochloride
CAS :<p>Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration.</p>Formule :C26H40ClN5O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :618.21TP0480066
CAS :<p>TP0480066 inhibits topoisomerase II, DNA gyrase (IC50=1.1nM), topo IV (IC50=62.89nM), effective against drug-resistant bacteria and N. gonorrhoeae.</p>Formule :C18H14FN3O5Couleur et forme :SolidMasse moléculaire :371.32Topoisomerase IIα-IN-8
CAS :<p>Topoisomerase IIα-IN-8 (compound 15) serves as a modest inhibitor of human DNA topoisomerase IIα (htIIα), exhibiting an inhibitory concentration (IC50) of 462 ± 38.0 μM [1].</p>Formule :C15H15FN6OCouleur et forme :SolidMasse moléculaire :314.324ATR-IN-13
CAS :<p>ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).</p>Formule :C24H24FN9OCouleur et forme :SolidMasse moléculaire :473.51GSK-3484862
CAS :<p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>Formule :C19H19N5OSDegré de pureté :99.87% - 99.963%Couleur et forme :SolidMasse moléculaire :365.45Peliglitazar
CAS :<p>Peliglitazar is a activator of α/γ peroxisome proliferator-activated receptor.</p>Formule :C30H30N2O7Couleur et forme :SolidMasse moléculaire :530.57SR 2595
CAS :<p>SR2595 is an inverse agonist of nuclear receptor PPARγ with an IC 50 of 30 nM [1].</p>Formule :C37H38N2O3Couleur et forme :SolidMasse moléculaire :558.71BMS-250749
CAS :<p>BMS-250749 is a fluoroglycosylated fluoroindolocarbazole, it has antitumor activity.</p>Formule :C26H18F3N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.43HDAC6-IN-21
CAS :<p>HDAC6-IN-21 (compound 13) is an irreversible inhibitor of histone deacetylase 6 (HDAC6) [1].</p>Formule :C14H13F2N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.28DS-6930
CAS :<p>DS-6930 is an potent and selective PPAR γ Agonists with EC50 of 41 nM.</p>Formule :C23H21N3O4Couleur et forme :SolidMasse moléculaire :403.43CM-675
CAS :<p>CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to</p>Formule :C31H32N6O3Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :536.62SIRT6-IN-3
CAS :<p>SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts</p>Formule :C21H30Br3ClN6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.73Makaluvamine A
CAS :<p>Makaluvamine A comes from the fruiting bodies of Didymium bahiense that act as active anti-cancer agents and DNA topo II inhibitors.</p>Formule :C11H11N3OCouleur et forme :SolidMasse moléculaire :201.22Tankyrase-IN-5
CAS :<p>Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2, with half-maximal inhibitory</p>Formule :C17H18N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.34SU-11752
CAS :<p>SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.</p>Formule :C26H27N3O5SCouleur et forme :SolidMasse moléculaire :493.57Pparδ agonist 1
CAS :<p>Pparδ agonist 1 is an agonist of PPAR-δ(EC50 of 5.06 nM).</p>Formule :C26H27NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.5U-46619
CAS :<p>U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (</p>Formule :C21H34O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.49ATR-IN-20
<p>ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.</p>Formule :C29H31N5O4SCouleur et forme :SolidMasse moléculaire :545.65CAY10410
CAS :<p>CAY10410 is a PGD2/PGJ2 analog, modified for enhanced PPARγ activity and metabolic stability, non-toxic to SH-SY5Y cells at ≤25μM.</p>Formule :C20H30O3Couleur et forme :SolidMasse moléculaire :318.45LMP744 hydrochloride
CAS :<p>LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. </p>Formule :C24H25ClN2O7Degré de pureté :99.59% - 99.85%Couleur et forme :SolidMasse moléculaire :488.92AZ 5704
CAS :<p>ATM kinase inhibitor with 0.6 nM IC50, >600-fold selective, enhances irinotecan effects, oral use.</p>Formule :C23H23FN6O2Couleur et forme :SolidMasse moléculaire :434.479A1P9
CAS :<p>9A1P9, a multi-tail ionizable cationic phospholipid, facilitates membrane destabilization and is applicable for CRISPR-Cas9 gene editing in mice [1].</p>Formule :C27H58NO4PCouleur et forme :SolidMasse moléculaire :491.73BO 2367
CAS :<p>BO 2367, a topoisomerase inhibitor, is used to suppress the growth of tumor .</p>Formule :C21H22ClF2N3O3Couleur et forme :SolidMasse moléculaire :437.87ATR-IN-22
CAS :<p>ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and</p>Formule :C25H31N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.56ATR-IN-5
CAS :<p>ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.</p>Formule :C27H32F3N9OCouleur et forme :SolidMasse moléculaire :555.6Topoisomerase I inhibitor 9
CAS :<p>Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value</p>Formule :C23H15Br2FN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.19Topoisomerase inhibitor 2
CAS :<p>Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].</p>Formule :C23H23N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.46
