Altération de l'ADN/réparation de l'ADN
Les inhibiteurs de la réparation des dommages à l'ADN sont des composés qui interfèrent avec les processus impliqués dans la détection et la réparation des dommages à l'ADN. Ces inhibiteurs sont essentiels pour étudier les mécanismes de la stabilité génomique, de la mutagenèse et de la réponse aux dommages à l'ADN. Ils sont également importants dans la recherche sur le cancer, car de nombreuses tumeurs dépendent de voies spécifiques de réparation de l'ADN pour survivre. En inhibant ces voies, les inhibiteurs de la réparation des dommages à l'ADN peuvent améliorer l'efficacité de la chimiothérapie et de la radiothérapie. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité de la réparation des dommages à l'ADN pour soutenir vos recherches en biologie moléculaire, oncologie et pharmacologie.
Sous-catégories appartenant à la catégorie "Altération de l'ADN/réparation de l'ADN"
- ATM/ATR(71 produits)
- Alkylation de l'ADN(11 produits)
- Méthyltransférase de l’ADN(421 produits)
- Gyrase de l’ADN(11 produits)
- ADN-PK(51 produits)
- MTH1(1 produits)
- Antimétabolite nucléosidique/analogue(1.388 produits)
- Transcriptase inverse(43 produits)
- Sirtuine(88 produits)
- Télomérase(33 produits)
- Topoisomérase(136 produits)
Affichez 3 plus de sous-catégories
958 produits trouvés pour "Altération de l'ADN/réparation de l'ADN"
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Epigenetic factor-IN-1
CAS :<p>Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.</p>Formule :C32H34FN5O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :667.77PR-104A
CAS :<p>PR-104A is a hypoxia-targeted anticancer agent.</p>Formule :C14H19BrN4O9SCouleur et forme :SolidMasse moléculaire :499.29ATM-IN-1
CAS :<p>ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.</p>Formule :C30H36N6O3Couleur et forme :SolidMasse moléculaire :528.65Pradofloxacin
CAS :<p>Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.</p>Formule :C21H21FN4O3Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :396.41DNMT-IN-3
CAS :<p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>Formule :C37H39N7OCouleur et forme :SolidMasse moléculaire :597.75MPI_5a
CAS :<p>MPI_5a selectively inhibits HDAC6 (IC50=36 nM), slightly affects other HDACs, and blocks acyl-tubulin build-up (IC50=210 nM).</p>Formule :C16H17N3O3Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :299.32DNA-PK-IN-10
CAS :<p>DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].</p>Formule :C25H28N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.539-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS :<p>9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential</p>Formule :C22H18ClFN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.84SRT3657
CAS :<p>SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.</p>Formule :C40H54N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :774.97NH2-methylpropanamide-Exatecan TFA
CAS :<p>Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.</p>Formule :C30H30F4N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :634.58DY-46-2
CAS :<p>DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.</p>Formule :C19H22N6O5SDegré de pureté :99.12% - 99.12%Couleur et forme :SolidMasse moléculaire :446.48HDAC/BET-IN-1
CAS :<p>HDAC/BET-IN-1 inhibits HDAC1 (IC50: 0.163 μM), HDAC6 (IC50: 0.067 μM), BRD4 (Ki: 0.076 μM), and fights leukemia.</p>Formule :C29H40N4O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :604.71Trovafloxacin mesylate
CAS :<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Formule :C21H19F3N4O6SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :512.46NT160
CAS :<p>NT160 is a fluorinated radioactive compound, a potent class IIa histone deacetylase (HDAC) inhibitor, used in the study of neurological diseases.</p>Formule :C21H21F3N4O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :418.41Antipsychotic agent 54
CAS :<p>Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM).</p>Formule :C21H23FN2O4Degré de pureté :98.10%Couleur et forme :SolidMasse moléculaire :386.42HDAC6-IN-8
CAS :<p>Compound 12C, with altered cap groups, shows wide-range enzyme inhibition; 9m and 9q target HDAC6 specifically.</p>Formule :C23H17BrFN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.32Bocodepsin
CAS :<p>Bocodepsin (OKI-179) is a selective, orally active inhibitor of histone deacetylases (HDAC) with demonstrated antitumor efficacy.</p>Formule :C26H39N5O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :581.75ATR-IN-29
CAS :<p>ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].</p>Formule :C19H22N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.43Zabofloxacin
CAS :<p>Zabofloxacin inhibits bacterial topoisomerases II/IV, effectively targeting gram-positive pathogens like S. aureus and S. pneumoniae.</p>Formule :C19H20FN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.3910-Nitrolinoleic acid
CAS :<p>10-Nitrolinoleate, a nitration product of linoleate, modulates PPARγ, enhancing glucose uptake, and aids in muscle relaxation via NO/cGMP pathway.</p>Formule :C18H31NO4Couleur et forme :SolidMasse moléculaire :325.44WAY-354574
CAS :<p>WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].</p>Formule :C20H23ClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.93PARP7-IN-16
CAS :<p>PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively.</p>Formule :C25H26FN4NaO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.49SDOX
CAS :<p>SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.</p>Formule :C69H97NO20S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1324.63Furegrelate sodium
CAS :<p>Furegrelate sodium (U-63557A) is an orally active thromboxane synthase inhibitor with an IC50 of 15 nM in platelets.</p>Formule :C15H10NNaO3Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :275.23Lexitropsin 1
CAS :<p>Lexitropsin 1 is a new anticancer drug.</p>Formule :C15H19N7O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.427-Deaza-2′-deoxyguanosine 5′-triphosphate
CAS :<p>7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, functions as a telomerase inhibitor with an IC50 value of 11 μM [1].</p>Formule :C11H17N4O13P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.19(S)-Ceralasertib
CAS :<p>(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.</p>Formule :C20H24N6O2SCouleur et forme :SolidMasse moléculaire :412.51ATR-IN-18
CAS :<p>ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.</p>Formule :C19H22F3N7O5SCouleur et forme :SolidMasse moléculaire :517.48Prostaglandin B3
CAS :<p>Prostaglandin B3 (PGB3) is a secondary alcohol belonging to the prostaglandin B class, characterized by its relatively low affinity for human PPARγ, exhibiting a K_i value greater than 1 mM, in contrast to PGB1 and PGB2, which have K_i values of 26.28 ± 8.7 μM and 77 ± 37.7 μM, respectively [1].</p>Formule :C20H28O4Couleur et forme :SolidMasse moléculaire :332.43Ambamustine
CAS :<p>Ambamustine (PTT 119): a tripeptide nitrogen mustard, DNA inhibitor/alkylator with antitumor properties, researched for various disorders.</p>Formule :C29H39Cl2FN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :629.61ATR-IN-8
CAS :<p>ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.</p>Formule :C20H22N6O2SCouleur et forme :SolidMasse moléculaire :410.49Oxamflatin
CAS :<p>Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor with an alkyne group capable of azide-alkyne cycloaddition reactions (CuAAc).</p>Formule :C17H14N2O4SDegré de pureté :98.25%Couleur et forme :SolidMasse moléculaire :342.37KD-3010
CAS :<p>KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.</p>Formule :C30H33F3N2O8S2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :670.72Nesuparib
CAS :<p>Nesuparib, a potent PARP/TNKS1 inhibitor, has antitumor properties and potential for treating various diseases.</p>Formule :C23H24N6ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :400.48KPZ560
CAS :<p>KPZ560, a potent HDAC 1 and HDAC 2 inhibitor, exhibits IC50 values of 12 nM and 68 nM, respectively.</p>Formule :C26H21N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.61AZD4619
CAS :<p>AZD4619 is a potent, selective and reversible orally bioavailable agonist of PPARα receptor.</p>Formule :C25H26O8S2Couleur et forme :SolidMasse moléculaire :518.6BM152054
CAS :<p>BM152054 is a potent PPARγ ligand that induces glucose utilization in peripheral tissues by enhancing insulin action.</p>Formule :C22H18N2O4S3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :470.58Sipoglitazar
CAS :<p>Sipoglitazar, a PPARγ agonist, is used potentially for the treatment of diabetes.</p>Formule :C25H25N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :463.55Sirtuin modulator 1
CAS :<p>Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.</p>Formule :C31H32ClN5O2S2Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :606.2SIRT-IN-1
CAS :<p>SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).</p>Formule :C19H27N5O2SDegré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :389.52Ac-Exatecan
CAS :<p>Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.</p>Formule :C26H24FN3O5Degré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :477.48ZL-2201
CAS :<p>ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.</p>Formule :C20H25N9O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :503.54PARP7-IN-15
CAS :<p>PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].</p>Formule :C23H24F6N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.46ATR-IN-6
CAS :<p>ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.</p>Formule :C28H28FN7O2Couleur et forme :SolidMasse moléculaire :513.57E7016
CAS :<p>E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.</p>Formule :C20H19N3O3Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :349.38IACS-52825
CAS :<p>IACS-52825 is a DLK inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model and can be used to study neurological disorders.</p>Formule :C16H13F7N4O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :426.29CGS 15435
CAS :<p>CGS 15435: potent TxA2 synthase inhibitor, IC50=1 nM; less selective for PGI2 synthase, COX, and liposynthase.</p>Formule :C20H21ClN2O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :356.85PARP-1-IN-4
CAS :<p>PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.</p>Formule :C22H15Cl2N3O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :424.28Lartesertib
CAS :<p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>Formule :C23H21FN6O3Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :448.45AZ31
CAS :<p>AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,</p>Formule :C24H28N4O3Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :420.5Ragaglitazar
CAS :<p>Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.</p>Formule :C25H25NO5Degré de pureté :97.46% - 98.56%Couleur et forme :SolidMasse moléculaire :419.47Camonsertib
CAS :<p>Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.</p>Formule :C21H26N6O3Degré de pureté :99.6% - 99.93%Couleur et forme :SolidMasse moléculaire :410.47E-3030 free acid
CAS :<p>E-3030 free acid, a PPAR agonist, lowers blood glucose, triglycerides, and insulin; boosts adiponectin; reduces apo C-III; and raises lipoprotein lipase.</p>Formule :C22H23ClFNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.87ATM Inhibitor-1
CAS :<p>ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.</p>Formule :C27H36N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :492.61PPARγ agonist 1
<p>PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects.</p>Formule :C34H39NO3Couleur et forme :SolidMasse moléculaire :509.68TP3011
CAS :<p>TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.</p>Formule :C26H26N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.51G-631
CAS :<p>G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.</p>Formule :C19H22F2N6O3Couleur et forme :SolidMasse moléculaire :420.41(Rac)-RG108
CAS :<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Formule :C19H14N2O4Couleur et forme :SolidMasse moléculaire :334.326TMU 35435
CAS :<p>TMU 35435 is an inhibitor of histone deacetylases (HDAC). It enhances radiosensitivity by inducing the accumulation of misfolded proteins and autophagy (autophagy) in TNBC, and inhibits the NHEJ pathway through ubiquitination of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).</p>Formule :C22H25N3O3Couleur et forme :SolidMasse moléculaire :379.45Antibacterial agent 236
CAS :<p>Anti bacterial agent 236 (Compound 4l), an orally effective inhibitor of DNA gyrase and topoisomerase IV (with IC50 values of 3.2 and 300 nM in Staphylococcus aureus, respectively), exhibits broad-spectrum antibacterial activity. It also demonstrates favorable pharmacokinetic properties in mice.</p>Formule :C26H27N5O2SCouleur et forme :SolidMasse moléculaire :473.59Carbacyclin
CAS :<p>Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.</p>Formule :C21H34O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.49ATR kinase-IN-3
CAS :<p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>Formule :C24H27F2N9O2Couleur et forme :SolidMasse moléculaire :511.53PARP1/2-IN-4
CAS :<p>PARP1/2-IN-4 (compound 3) is an inhibitor of PARP1/2.</p>Formule :C23H30FN5O6Couleur et forme :SolidMasse moléculaire :491.51Sirtuin-IN-2
<p>Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.</p>Formule :C28H46N8O6SCouleur et forme :SolidMasse moléculaire :622.78SIRT6 activator 2
CAS :<p>SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.</p>Formule :C23H23N3O6Couleur et forme :SolidMasse moléculaire :437.45Bizelesin
CAS :<p>Bizelesin, a synthetic antineoplastic agent, binds DNA, disrupts replication, triggers cell-cycle arrest, and induces senescence.</p>Formule :C43H36Cl2N8O5Couleur et forme :SolidMasse moléculaire :815.7ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54Topoisomerase I inhibitor 8
CAS :<p>Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells.</p>Formule :C24H21FN2O4Couleur et forme :SolidMasse moléculaire :420.43ATR kinase-IN-2
CAS :<p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>Formule :C24H29F2N9O2Couleur et forme :SolidMasse moléculaire :513.54PPARα/δ agonist 3
CAS :<p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>Formule :C23H25F3N2O4Couleur et forme :SolidMasse moléculaire :450.451PPARγ-IN-5
CAS :<p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>Formule :C22H23ClO7Couleur et forme :SolidMasse moléculaire :434.867O6BTG-C8-αGlu
CAS :<p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>Formule :C24H34BrN5O7SCouleur et forme :SolidMasse moléculaire :616.525ATR-IN-12
<p>ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.</p>Formule :C22H27N5O3SCouleur et forme :SolidMasse moléculaire :441.55RU-0415529
CAS :<p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>Formule :C21H29N3O4SCouleur et forme :SolidMasse moléculaire :419.538ATR-IN-19
CAS :<p>ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].</p>Formule :C18H19N7OSCouleur et forme :SolidMasse moléculaire :381.45Amezalpat
CAS :<p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>Formule :C34H41N3O4Couleur et forme :SolidMasse moléculaire :555.707(1R,2S,7R)-Sitafloxacin
CAS :<p>(R)-Sitafloxacin (DU-6857) is an enantiomer of Sitafloxacin (DU-6859a) and functions as a topoisomerase inhibitor, demonstrating an IC50 of 0.18 μg/mL against DNA gyrase.</p>Formule :C19H18ClF2N3O3Couleur et forme :SolidMasse moléculaire :409.814Camptothecin-20(S)-O-propionate
CAS :<p>CZ-48 is a DNA topoisomerase inhibitor.</p>Formule :C23H20N2O5Couleur et forme :SolidMasse moléculaire :404.42Pparδ agonist 5
<p>Pparδ agonist 5 is a selective, orally active PPARδ agonist with an EC50 of 0.335 μM and better selectivity than GW0742.</p>Formule :C23H21F3N2O2SCouleur et forme :SolidMasse moléculaire :446.49(S)-WSD0628
CAS :<p>(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.</p>Formule :C23H23F2N5O2Couleur et forme :SolidMasse moléculaire :439.458(1S,2R,7S)-Sitafloxacin
CAS :<p>(1S,2R,7S)-Sitafloxacin (DU-6856) is an enantiomer of Sitafloxacin and functions as a topoisomerase inhibitor. As an antibiotic, it demonstrates inhibitory activity against Escherichia coli DNA gyrase (IC50 0.18 μg/mL) and Staphylococcus aureus topoisomerase IV. (1S,2R,7S)-Sitafloxacin exhibits antibacterial properties and is utilized in the study of various bacterial infections.</p>Formule :C19H18ClF2N3O3Couleur et forme :SolidMasse moléculaire :409.81PARP1-IN-30
CAS :<p>PARP1-IN-30 is a specific and effective PARP1 inhibitor with cytotoxic properties. It precisely inhibits PARP1 in tumor cells lacking breast cancer 1 protein (BRCA1) or BRCA2. PARP1-IN-30 holds potential for use in cancer research.</p>Formule :C14H12ClNO4SCouleur et forme :SolidMasse moléculaire :325.77PPARγ modulator-2
CAS :<p>PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.</p>Formule :C26H21NO7S3SeCouleur et forme :SolidMasse moléculaire :634.6ATM Inhibitor-2
<p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).</p>Formule :C26H31N7O3Couleur et forme :SolidMasse moléculaire :489.57TERT activator-2
CAS :<p>TERT activator-2 (Compound 1030) is an activator of telomerase reverse transcriptase (TERT), which enhances the expression levels of TERT within cells. TERT activator-2 is applicable to research related to cellular lifespan and telomere functions.</p>Formule :C21H22N2O2Couleur et forme :SolidMasse moléculaire :334.412DNA crosslinker 2 dihydrochloride
CAS :<p>Potent DNA crosslinker 2 binds minor groove, increases Tm by 1.2°C, and inhibits NCI-H460, A2780, MCF-7 cancer cells.</p>Formule :C15H22Cl2N8OCouleur et forme :SolidMasse moléculaire :401.29TH1338
CAS :<p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>Formule :C22H21N3O4Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :391.42DNA crosslinker 3 dihydrochloride
CAS :<p>Compound 1: a DNA minor groove binder with 1.4°C ΔTm; useful in cancer research.</p>Formule :C15H22Cl2N8OCouleur et forme :SolidMasse moléculaire :401.29DNA crosslinker 1 dihydrochloride
CAS :<p>DNA Crosslinker 1 binds DNA minor groove with 1.1°C affinity increase; used in cancer research.</p>Formule :C15H22Cl2N8OCouleur et forme :SolidMasse moléculaire :401.29ATM Inhibitor-11
CAS :<p>ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.</p>Formule :C27H33FN6O2Couleur et forme :SolidMasse moléculaire :492.59Atiratecan
CAS :<p>Atiratecan (TP300), a CH0793076-based camptothecin prodrug, combats BCRP+/- tumors; doesn't affect AChE.</p>Formule :C31H34N6O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.64DNA-PK-IN-2
CAS :<p>DNA-PK-IN-2 is an inhibitor of the DNA-PK enzyme complex, useful in cancer research.</p>Formule :C20H23N5O3Couleur et forme :SolidMasse moléculaire :381.43KSQ-4279 (gentisate)
CAS :<p>KSQ-4279 (gentisate) (Compound Formula I) serves as an effective inhibitor of USP1 and a selective inhibitor of PARP1. This compound shows promise for use in cancer research.</p>Formule :C34H31F3N8O5Couleur et forme :SolidMasse moléculaire :688.66DNA-PK-IN-15
CAS :<p>DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.</p>Formule :C23H23N9OCouleur et forme :SolidMasse moléculaire :441.49HDAC6-IN-51
CAS :HDAC6-IN-51 (Compound 7e) is a selective inhibitor of HDAC6, exhibiting an IC50 value of 42.9 nM. This compound demonstrates effective anti-pulmonary fibrosis activity.Formule :C24H24ClN5O3Couleur et forme :SolidMasse moléculaire :465.93Cas9-IN-1
<p>Cas9-IN-1 is a potent inhibitor of Cas9 with an IC50 value of 7.02 μM. Cas9-IN-1 acts by binding apo-Cas9 and blocking the formation of the Cas9:gRNA complex.</p>Formule :C17H11Cl2F3N2O3SCouleur et forme :SolidMasse moléculaire :451.25TDI-015051
CAS :<p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>Formule :C22H22FN5O4SCouleur et forme :SolidMasse moléculaire :471.505ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Formule :C25H29FN6O3Couleur et forme :SolidMasse moléculaire :480.53Topoisomerase II inhibitor 6
<p>Topoisomerase II inhibitor 6, a potent tryptanthrin derivative, blocks G2 phase in CCRF-CEM cells, induces DNA breaks, and may be used for cancer research.</p>Formule :C19H18N4O2Couleur et forme :SolidMasse moléculaire :334.37DLK-IN-1
CAS :DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.Formule :C20H24F3N5O2Couleur et forme :SolidMasse moléculaire :423.43
