Altération de l'ADN/réparation de l'ADN
Les inhibiteurs de la réparation des dommages à l'ADN sont des composés qui interfèrent avec les processus impliqués dans la détection et la réparation des dommages à l'ADN. Ces inhibiteurs sont essentiels pour étudier les mécanismes de la stabilité génomique, de la mutagenèse et de la réponse aux dommages à l'ADN. Ils sont également importants dans la recherche sur le cancer, car de nombreuses tumeurs dépendent de voies spécifiques de réparation de l'ADN pour survivre. En inhibant ces voies, les inhibiteurs de la réparation des dommages à l'ADN peuvent améliorer l'efficacité de la chimiothérapie et de la radiothérapie. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité de la réparation des dommages à l'ADN pour soutenir vos recherches en biologie moléculaire, oncologie et pharmacologie.
Sous-catégories appartenant à la catégorie "Altération de l'ADN/réparation de l'ADN"
- ATM/ATR(71 produits)
- Alkylation de l'ADN(11 produits)
- Méthyltransférase de l’ADN(421 produits)
- Gyrase de l’ADN(11 produits)
- ADN-PK(51 produits)
- MTH1(1 produits)
- Antimétabolite nucléosidique/analogue(1.388 produits)
- Transcriptase inverse(43 produits)
- Sirtuine(88 produits)
- Télomérase(33 produits)
- Topoisomérase(136 produits)
Affichez 3 plus de sous-catégories
957 produits trouvés pour "Altération de l'ADN/réparation de l'ADN"
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ATR-IN-18
CAS :<p>ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.</p>Formule :C19H22F3N7O5SCouleur et forme :SolidMasse moléculaire :517.48LMP744 hydrochloride
CAS :<p>LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. </p>Formule :C24H25ClN2O7Degré de pureté :99.59% - 99.85%Couleur et forme :SolidMasse moléculaire :488.92ATR-IN-6
CAS :<p>ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.</p>Formule :C28H28FN7O2Couleur et forme :SolidMasse moléculaire :513.57PARP7-IN-15
CAS :<p>PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].</p>Formule :C23H24F6N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :562.46BMS-250749
CAS :<p>BMS-250749 is a fluoroglycosylated fluoroindolocarbazole, it has antitumor activity.</p>Formule :C26H18F3N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.43MPI_5a
CAS :<p>MPI_5a selectively inhibits HDAC6 (IC50=36 nM), slightly affects other HDACs, and blocks acyl-tubulin build-up (IC50=210 nM).</p>Formule :C16H17N3O3Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :299.32Nesuparib
CAS :<p>Nesuparib, a potent PARP/TNKS1 inhibitor, has antitumor properties and potential for treating various diseases.</p>Formule :C23H24N6ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :400.48ATR-IN-8
CAS :<p>ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.</p>Formule :C20H22N6O2SCouleur et forme :SolidMasse moléculaire :410.497-Deaza-2′-deoxyguanosine 5′-triphosphate
CAS :<p>7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, functions as a telomerase inhibitor with an IC50 value of 11 μM [1].</p>Formule :C11H17N4O13P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.19HDAC6-IN-21
CAS :<p>HDAC6-IN-21 (compound 13) is an irreversible inhibitor of histone deacetylase 6 (HDAC6) [1].</p>Formule :C14H13F2N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.28SIRT-IN-1
CAS :<p>SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).</p>Formule :C19H27N5O2SDegré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :389.52KPZ560
CAS :<p>KPZ560, a potent HDAC 1 and HDAC 2 inhibitor, exhibits IC50 values of 12 nM and 68 nM, respectively.</p>Formule :C26H21N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.61SIRT6-IN-3
CAS :<p>SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts</p>Formule :C21H30Br3ClN6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.73ATR-IN-21
CAS :<p>ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].</p>Formule :C23H27N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.51PR-104A
CAS :<p>PR-104A is a hypoxia-targeted anticancer agent.</p>Formule :C14H19BrN4O9SCouleur et forme :SolidMasse moléculaire :499.29Pparδ agonist 1
CAS :<p>Pparδ agonist 1 is an agonist of PPAR-δ(EC50 of 5.06 nM).</p>Formule :C26H27NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.5Topoisomerase inhibitor 2
CAS :<p>Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].</p>Formule :C23H23N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.46GSK-3484862
CAS :<p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>Formule :C19H19N5OSDegré de pureté :99.87% - 99.963%Couleur et forme :SolidMasse moléculaire :365.459-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS :<p>9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential</p>Formule :C22H18ClFN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.84ARN-21934
CAS :<p>ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.</p>Formule :C21H24N6Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :360.46ATR-IN-20
<p>ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.</p>Formule :C29H31N5O4SCouleur et forme :SolidMasse moléculaire :545.65LCB-2853
CAS :<p>LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.</p>Formule :C21H24ClNO4SDegré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :421.94BM152054
CAS :<p>BM152054 is a potent PPARγ ligand that induces glucose utilization in peripheral tissues by enhancing insulin action.</p>Formule :C22H18N2O4S3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :470.58GNE-8505
CAS :<p>GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).</p>Formule :C21H24F3N5OCouleur et forme :SolidMasse moléculaire :419.44L-783483
CAS :<p>L-783483 is an agonist of PPAR.</p>Formule :C22H21ClF3NO4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :487.92WAY-354574
CAS :<p>WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].</p>Formule :C20H23ClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.93Prostaglandin B3
CAS :<p>Prostaglandin B3 (PGB3) is a secondary alcohol belonging to the prostaglandin B class, characterized by its relatively low affinity for human PPARγ, exhibiting a K_i value greater than 1 mM, in contrast to PGB1 and PGB2, which have K_i values of 26.28 ± 8.7 μM and 77 ± 37.7 μM, respectively [1].</p>Formule :C20H28O4Couleur et forme :SolidMasse moléculaire :332.43Makaluvamine A
CAS :<p>Makaluvamine A comes from the fruiting bodies of Didymium bahiense that act as active anti-cancer agents and DNA topo II inhibitors.</p>Formule :C11H11N3OCouleur et forme :SolidMasse moléculaire :201.22SDOX
CAS :<p>SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.</p>Formule :C69H97NO20S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1324.63Oxamflatin
CAS :<p>Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor with an alkyne group capable of azide-alkyne cycloaddition reactions (CuAAc).</p>Formule :C17H14N2O4SDegré de pureté :98.25%Couleur et forme :SolidMasse moléculaire :342.37SU-11752
CAS :<p>SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.</p>Formule :C26H27N3O5SCouleur et forme :SolidMasse moléculaire :493.57AZ 5704
CAS :<p>ATM kinase inhibitor with 0.6 nM IC50, >600-fold selective, enhances irinotecan effects, oral use.</p>Formule :C23H23FN6O2Couleur et forme :SolidMasse moléculaire :434.47K-756
CAS :<p>K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).</p>Formule :C24H27N5O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :433.5Ambamustine
CAS :<p>Ambamustine (PTT 119): a tripeptide nitrogen mustard, DNA inhibitor/alkylator with antitumor properties, researched for various disorders.</p>Formule :C29H39Cl2FN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :629.61DNMT-IN-3
CAS :<p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>Formule :C37H39N7OCouleur et forme :SolidMasse moléculaire :597.75AZD4619
CAS :<p>AZD4619 is a potent, selective and reversible orally bioavailable agonist of PPARα receptor.</p>Formule :C25H26O8S2Couleur et forme :SolidMasse moléculaire :518.6ATM-IN-1
CAS :<p>ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.</p>Formule :C30H36N6O3Couleur et forme :SolidMasse moléculaire :528.65Zabofloxacin
CAS :<p>Zabofloxacin inhibits bacterial topoisomerases II/IV, effectively targeting gram-positive pathogens like S. aureus and S. pneumoniae.</p>Formule :C19H20FN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.39ATR-IN-13
CAS :<p>ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).</p>Formule :C24H24FN9OCouleur et forme :SolidMasse moléculaire :473.51SRT3657
CAS :<p>SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.</p>Formule :C40H54N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :774.97Lexitropsin 1
CAS :<p>Lexitropsin 1 is a new anticancer drug.</p>Formule :C15H19N7O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.42Epigenetic factor-IN-1
CAS :<p>Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.</p>Formule :C32H34FN5O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :667.77NH2-methylpropanamide-Exatecan TFA
CAS :<p>Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.</p>Formule :C30H30F4N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :634.58AZ31
CAS :<p>AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,</p>Formule :C24H28N4O3Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :420.5Ragaglitazar
CAS :<p>Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.</p>Formule :C25H25NO5Degré de pureté :97.46% - 98.56%Couleur et forme :SolidMasse moléculaire :419.47Lartesertib
CAS :<p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>Formule :C23H21FN6O3Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :448.45E7016
CAS :<p>E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.</p>Formule :C20H19N3O3Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :349.38PARP-1-IN-4
CAS :<p>PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.</p>Formule :C22H15Cl2N3O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :424.28Camonsertib
CAS :<p>Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.</p>Formule :C21H26N6O3Degré de pureté :99.6% - 99.93%Couleur et forme :SolidMasse moléculaire :410.47IACS-52825
CAS :<p>IACS-52825 is a DLK inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model and can be used to study neurological disorders.</p>Formule :C16H13F7N4O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :426.29CGS 15435
CAS :<p>CGS 15435: potent TxA2 synthase inhibitor, IC50=1 nM; less selective for PGI2 synthase, COX, and liposynthase.</p>Formule :C20H21ClN2O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :356.85GSK1820795A
CAS :<p>GSK1820795A: Telmisartan analog, selective hGPR132a antagonist, blocks yeast activation by N-acylamides, angiotensin II antagonist, partial PPARγ agonist.</p>Formule :C35H34N8Couleur et forme :SolidMasse moléculaire :566.7PPARα agonist 1
<p>PPARα agonist 1 is a complete and potent PPARα agonist.</p>Formule :C27H34O4Couleur et forme :SolidMasse moléculaire :422.56LP-284
CAS :<p>LP-284 is a DNA alkylating agent effective against solid tumors and hematologic cancers like MCL.</p>Formule :C16H20N2O4Couleur et forme :SolidMasse moléculaire :304.34Topoisomerase inhibitor 5
CAS :<p>Topoisomerase inhibitor 5 (compound 158) is an inhibitor of bacterial topoisomerase, with a minimum inhibitory concentration of 0.125 μg/mL, and exhibits anti-tuberculosis activity.</p>Formule :C24H25FN4O6Couleur et forme :SolidMasse moléculaire :484.477DNA-PK-IN-8
CAS :<p>DNA-PK-IN-8: Potent, selective oral DNA-PK inhibitor, IC50 = 0.8 nM, boosts anti-cancer effects with Doxorubicin.</p>Formule :C19H22N8O2Couleur et forme :SolidMasse moléculaire :394.43Topoisomerase II inhibitor 5
<p>Topoisomerase II inhibitor 5 (Compound E24) is a DNAtopoisomerase II inhibitor with anticancer effects.</p>Formule :C26H27N5O4Couleur et forme :SolidMasse moléculaire :473.52HDAC8-IN-12
CAS :<p>HDAC8-IN-12 (compound 5k), a non-hydroxamic acid derivative, serves as a selective HDAC8 inhibitor with an IC 50 of 0.12 nM and demonstrates potent efficacy against breast cancer. This compound enhances anti-tumor immunity by activating T cells, elevating M1 macrophage levels, and reducing M2 macrophage proportions. In an orthotopic mouse model of breast cancer, HDAC8-IN-12, administered at 50 mg/kg, effectively suppresses tumor growth.</p>Formule :C16H17N3O5Couleur et forme :SolidMasse moléculaire :331.32DNA-PK-IN-6
CAS :<p>DNA-PK-IN-6 inhibits DNA-PKcs, disrupting tumor DNA repair and triggering apoptosis; enhances radiotherapy and targets various tumors (WO2021197159A1).</p>Formule :C19H21N7OCouleur et forme :SolidMasse moléculaire :363.42MC3138
CAS :<p>MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.</p>Formule :C25H25NO6Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :435.47PPARγ agonist 1
<p>PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects.</p>Formule :C34H39NO3Couleur et forme :SolidMasse moléculaire :509.68G-631
CAS :<p>G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.</p>Formule :C19H22F2N6O3Couleur et forme :SolidMasse moléculaire :420.41TMU 35435
CAS :<p>TMU 35435 is an inhibitor of histone deacetylases (HDAC). It enhances radiosensitivity by inducing the accumulation of misfolded proteins and autophagy (autophagy) in TNBC, and inhibits the NHEJ pathway through ubiquitination of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).</p>Formule :C22H25N3O3Couleur et forme :SolidMasse moléculaire :379.45Antibacterial agent 236
CAS :<p>Anti bacterial agent 236 (Compound 4l), an orally effective inhibitor of DNA gyrase and topoisomerase IV (with IC50 values of 3.2 and 300 nM in Staphylococcus aureus, respectively), exhibits broad-spectrum antibacterial activity. It also demonstrates favorable pharmacokinetic properties in mice.</p>Formule :C26H27N5O2SCouleur et forme :SolidMasse moléculaire :473.59Lys(CO-C3-p-I-Ph)-O-tBu
CAS :<p>Lys(CO-C3-p-I-Ph)-O-tBu, a pharmacokinetic modifier (PK modifier), enhances the pharmacokinetic properties of PSMA ligand molecules by increasing their residence time in plasma through improved binding to albumin and reducing absorption by the salivary glands, potentially extending the active compound's half-life. Moreover, Ac-PSMA-trillium is an effective PSMA-targeting compound for various biological applications when modified with different radioactive isotopes. When labeled with 111 In, it serves as a DOTA chelating agent and imaging agent. Alternatively, when labeled with 225 Ac, it acts as a Macropa chelator for targeted radionuclide therapy (TRT) in researching metastatic castration-resistant prostate cancer (mCRPC) [1] [2].</p>Formule :C20H31IN2O3Couleur et forme :SolidMasse moléculaire :474.38ATR kinase-IN-3
CAS :<p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>Formule :C24H27F2N9O2Couleur et forme :SolidMasse moléculaire :511.53PARP1/2-IN-4
CAS :<p>PARP1/2-IN-4 (compound 3) is an inhibitor of PARP1/2.</p>Formule :C23H30FN5O6Couleur et forme :SolidMasse moléculaire :491.51Bizelesin
CAS :<p>Bizelesin, a synthetic antineoplastic agent, binds DNA, disrupts replication, triggers cell-cycle arrest, and induces senescence.</p>Formule :C43H36Cl2N8O5Couleur et forme :SolidMasse moléculaire :815.7Sirtuin-IN-2
<p>Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.</p>Formule :C28H46N8O6SCouleur et forme :SolidMasse moléculaire :622.78ATM Inhibitor-1
CAS :<p>ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.</p>Formule :C27H36N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :492.61Camptothecin-20(S)-O-propionate
CAS :<p>CZ-48 is a DNA topoisomerase inhibitor.</p>Formule :C23H20N2O5Couleur et forme :SolidMasse moléculaire :404.42ATR kinase-IN-2
CAS :<p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>Formule :C24H29F2N9O2Couleur et forme :SolidMasse moléculaire :513.54OSUAB-0284
CAS :<p>OSUAB-0284 is an inhibitor of bacterial topoisomerase. It exhibits significant activity against staphylococci, particularly methicillin-resistant Staphylococcus aureus (MRSA). The compound exerts its antibacterial effect by inhibiting bacterial topoisomerase and may be used in research on infections caused by drug-resistant bacteria, including MRSA.</p>Formule :C22H23FN6O6Couleur et forme :SolidMasse moléculaire :486.45ATM Inhibitor-4
<p>ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.</p>Formule :C26H29FN6O3Couleur et forme :SolidMasse moléculaire :492.55KU 59403
CAS :<p>KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).</p>Formule :C29H32N4O4S2Degré de pureté :99.10%Couleur et forme :SolidMasse moléculaire :564.72Pparδ agonist 5
<p>Pparδ agonist 5 is a selective, orally active PPARδ agonist with an EC50 of 0.335 μM and better selectivity than GW0742.</p>Formule :C23H21F3N2O2SCouleur et forme :SolidMasse moléculaire :446.49DNA crosslinker 2 dihydrochloride
CAS :<p>Potent DNA crosslinker 2 binds minor groove, increases Tm by 1.2°C, and inhibits NCI-H460, A2780, MCF-7 cancer cells.</p>Formule :C15H22Cl2N8OCouleur et forme :SolidMasse moléculaire :401.29PARP1-IN-30
CAS :<p>PARP1-IN-30 is a specific and effective PARP1 inhibitor with cytotoxic properties. It precisely inhibits PARP1 in tumor cells lacking breast cancer 1 protein (BRCA1) or BRCA2. PARP1-IN-30 holds potential for use in cancer research.</p>Formule :C14H12ClNO4SCouleur et forme :SolidMasse moléculaire :325.77Carbacyclin
CAS :<p>Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.</p>Formule :C21H34O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.49ATM Inhibitor-2
<p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).</p>Formule :C26H31N7O3Couleur et forme :SolidMasse moléculaire :489.57ATR-IN-14
CAS :<p>ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.</p>Formule :C20H20FN7OCouleur et forme :SolidMasse moléculaire :393.42Topoisomerase I/II inhibitor 7
CAS :<p>Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.</p>Formule :C18H13ClN2O3Couleur et forme :SolidMasse moléculaire :340.76DNA crosslinker 1 dihydrochloride
CAS :<p>DNA Crosslinker 1 binds DNA minor groove with 1.1°C affinity increase; used in cancer research.</p>Formule :C15H22Cl2N8OCouleur et forme :SolidMasse moléculaire :401.29SPR719
CAS :<p>SPR719 is an inhibitor of gyrase B, has bactericidal activity.</p>Formule :C21H25FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.46ATM Inhibitor-11
CAS :<p>ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.</p>Formule :C27H33FN6O2Couleur et forme :SolidMasse moléculaire :492.59PPARγ agonist 2
<p>PPARγ agonist 2 is a highly effective compound that acts as a partial agonist for PPARγ.</p>Formule :C24H20O5Couleur et forme :SolidMasse moléculaire :388.41Atiratecan
CAS :<p>Atiratecan (TP300), a CH0793076-based camptothecin prodrug, combats BCRP+/- tumors; doesn't affect AChE.</p>Formule :C31H34N6O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.64WSD0628
CAS :<p>WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].</p>Formule :C23H23F2N5O2Couleur et forme :SolidMasse moléculaire :439.46KSQ-4279 (gentisate)
CAS :<p>KSQ-4279 (gentisate) (Compound Formula I) serves as an effective inhibitor of USP1 and a selective inhibitor of PARP1. This compound shows promise for use in cancer research.</p>Formule :C34H31F3N8O5Couleur et forme :SolidMasse moléculaire :688.66Topoisomerase II inhibitor 18
CAS :<p>Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].</p>Formule :C20H21N3OSCouleur et forme :SolidMasse moléculaire :351.47PPARγ agonist 17
CAS :<p>PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.</p>Formule :C48H63NO7Couleur et forme :SolidMasse moléculaire :766.016PARP-1/HDAC-IN-1
CAS :<p>PARP-1/HDAC-IN-1 is a PARP-1 and HDAC6 inhibitor with anticancer, antimigratory, and antiangiogenic activities and is used in tumor research.</p>Formule :C22H18N4O4Degré de pureté :95.94%Couleur et forme :SolidMasse moléculaire :402.4ATR-IN-17
CAS :<p>ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).</p>Formule :C22H28N6O2SCouleur et forme :SolidMasse moléculaire :440.56Karenitecin
CAS :<p>Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.</p>Formule :C25H28N2O4SiDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.59Anti-NASH agent 2
CAS :<p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>Formule :C32H51N3O2Couleur et forme :SolidMasse moléculaire :509.766Edotecarin
CAS :<p>Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).</p>Formule :C29H28N4O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.55NU5455
CAS :<p>NU5455 is a potent DNA-PKcs inhibitor, oral, boosts doxorubicin in liver tumors, amplifies topoisomerase inhibitors, no adverse effects.</p>Formule :C34H33N3O5SCouleur et forme :SolidMasse moléculaire :595.71Topoisomerase II inhibitor 6
<p>Topoisomerase II inhibitor 6, a potent tryptanthrin derivative, blocks G2 phase in CCRF-CEM cells, induces DNA breaks, and may be used for cancer research.</p>Formule :C19H18N4O2Couleur et forme :SolidMasse moléculaire :334.37PPARα/γ agonist 1
<p>PPARα/γ agonist 1 is a potent and dual PPARα/γ partial agonist which is a promising prototype for the research of dyslipidemia and diabetes.</p>Formule :C18H19NO2Couleur et forme :SolidMasse moléculaire :281.35Levofloxacin mesylate
CAS :<p>Levofloxacin mesylate is an orally active antibiotic effective against both Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase and topoisomerase IV enzymes. Levofloxacin mesylate is employed in research related to chronic periodontitis, airway inflammation, and BK viremia. Additionally, it possesses anti-Orthopoxvirus activity.</p>Formule :C19H24FN3O7SCouleur et forme :SolidMasse moléculaire :457.473Namitecan
CAS :<p>Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.</p>Formule :C23H22N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.44ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Formule :C25H29FN6O3Couleur et forme :SolidMasse moléculaire :480.53Gimatecan
CAS :<p>Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Formule :C25H25N3O5Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :447.48DNA-PK-IN-9
<p>DNA-PK-IN-9 (YK6) is a potent DNA-PK inhibitor with an IC50 of 10.47 nM, important in cancer research.</p>Formule :C21H21N5O2Couleur et forme :SolidMasse moléculaire :375.42Intoplicine
CAS :<p>Intoplicine is an inhibitor of DNA topoisomerase I and II.</p>Formule :C21H24N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.442-Ethylhexyl diphenyl phosphate
CAS :<p>2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and acts as a PPARG agonist (EC20: 2.04 µM). Additionally, it inhibits the transcriptional activity of ERRγ (IC50: 1.3 µM) and enhances the expression of 3β-HSD1, human chorionic gonadotropin (hCG), and progesterone secretion. This compound is applicable in studies related to female reproduction and fetal development.</p>Formule :C20H27O4PCouleur et forme :SolidMasse moléculaire :362.40DLK-IN-1
CAS :<p>DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.</p>Formule :C20H24F3N5O2Couleur et forme :SolidMasse moléculaire :423.43L2H2-6OTD
CAS :<p>L2H2-6OTD is a telomerase inhibitor with G-quadruplex loops; IC50: 15 nM.</p>Formule :C30H30N10O8Couleur et forme :SolidMasse moléculaire :658.62SP-C01
CAS :<p>SP-C01 is an orally active soluble epoxide hydrolase (sEH) inhibitor and a partial agonist of PPARγ. It can inhibit the phosphorylation of Ser273.</p>Formule :C22H22F4N2O5Couleur et forme :SolidMasse moléculaire :470.41DNA crosslinker 4 dihydrochloride
CAS :<p>DNA Crosslinker 4 binds DNA's minor groove, inhibits NCI-H460, A2780, MCF-7 cancer cells, and is used in cancer research.</p>Formule :C16H24Cl2N8OCouleur et forme :SolidMasse moléculaire :415.3215-keto-Prostaglandin E2
CAS :<p>15-keto-Prostaglandin E2, an endogenous metabolite, inhibits STAT3 activation through binding to Cys259 and regulates breast cancer cell growth and progression.</p>Formule :C20H30O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.45TDI-015051
CAS :<p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>Formule :C22H22FN5O4SCouleur et forme :SolidMasse moléculaire :471.505Cas9-IN-1
<p>Cas9-IN-1 is a potent inhibitor of Cas9 with an IC50 value of 7.02 μM. Cas9-IN-1 acts by binding apo-Cas9 and blocking the formation of the Cas9:gRNA complex.</p>Formule :C17H11Cl2F3N2O3SCouleur et forme :SolidMasse moléculaire :451.25HDAC6-IN-51
CAS :<p>HDAC6-IN-51 (Compound 7e) is a selective inhibitor of HDAC6, exhibiting an IC50 value of 42.9 nM. This compound demonstrates effective anti-pulmonary fibrosis activity.</p>Formule :C24H24ClN5O3Couleur et forme :SolidMasse moléculaire :465.93DNA-PK-IN-15
CAS :<p>DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.</p>Formule :C23H23N9OCouleur et forme :SolidMasse moléculaire :441.49DNA-PK-IN-2
CAS :<p>DNA-PK-IN-2 is an inhibitor of the DNA-PK enzyme complex, useful in cancer research.</p>Formule :C20H23N5O3Couleur et forme :SolidMasse moléculaire :381.43DNA crosslinker 3 dihydrochloride
CAS :<p>Compound 1: a DNA minor groove binder with 1.4°C ΔTm; useful in cancer research.</p>Formule :C15H22Cl2N8OCouleur et forme :SolidMasse moléculaire :401.29TH1338
CAS :<p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>Formule :C22H21N3O4Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :391.42SARS-CoV-2 nsp14-IN-1
<p>SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.</p>Formule :C20H20N6O5SCouleur et forme :SolidMasse moléculaire :456.48TERT activator-2
CAS :<p>TERT activator-2 (Compound 1030) is an activator of telomerase reverse transcriptase (TERT), which enhances the expression levels of TERT within cells. TERT activator-2 is applicable to research related to cellular lifespan and telomere functions.</p>Formule :C21H22N2O2Couleur et forme :SolidMasse moléculaire :334.412PPARγ phosphorylation inhibitor 1
<p>PPARγ phosphorylation inhibitor 1 (Compound 10) is a potent PPARγ binding agent (IC50: 24 nM) with antidiabetic effects.</p>Formule :C22H14Cl2N2O4Couleur et forme :SolidMasse moléculaire :441.26E-3030 free acid
CAS :<p>E-3030 free acid, a PPAR agonist, lowers blood glucose, triglycerides, and insulin; boosts adiponectin; reduces apo C-III; and raises lipoprotein lipase.</p>Formule :C22H23ClFNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.87PPARγ modulator-2
CAS :<p>PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.</p>Formule :C26H21NO7S3SeCouleur et forme :SolidMasse moléculaire :634.6(1S,2R,7S)-Sitafloxacin
CAS :<p>(1S,2R,7S)-Sitafloxacin (DU-6856) is an enantiomer of Sitafloxacin and functions as a topoisomerase inhibitor. As an antibiotic, it demonstrates inhibitory activity against Escherichia coli DNA gyrase (IC50 0.18 μg/mL) and Staphylococcus aureus topoisomerase IV. (1S,2R,7S)-Sitafloxacin exhibits antibacterial properties and is utilized in the study of various bacterial infections.</p>Formule :C19H18ClF2N3O3Couleur et forme :SolidMasse moléculaire :409.81(S)-WSD0628
CAS :<p>(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.</p>Formule :C23H23F2N5O2Couleur et forme :SolidMasse moléculaire :439.458(1R,2S,7R)-Sitafloxacin
CAS :<p>(R)-Sitafloxacin (DU-6857) is an enantiomer of Sitafloxacin (DU-6859a) and functions as a topoisomerase inhibitor, demonstrating an IC50 of 0.18 μg/mL against DNA gyrase.</p>Formule :C19H18ClF2N3O3Couleur et forme :SolidMasse moléculaire :409.814Amezalpat
CAS :<p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>Formule :C34H41N3O4Couleur et forme :SolidMasse moléculaire :555.707ATR-IN-19
CAS :<p>ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].</p>Formule :C18H19N7OSCouleur et forme :SolidMasse moléculaire :381.45Topotecan acetate
CAS :<p>Topotecan acetate is an inhibitor of topoisomerase.</p>Formule :C25H27N3O7Couleur et forme :SolidMasse moléculaire :481.498RU-0415529
CAS :<p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>Formule :C21H29N3O4SCouleur et forme :SolidMasse moléculaire :419.538ATR-IN-12
<p>ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.</p>Formule :C22H27N5O3SCouleur et forme :SolidMasse moléculaire :441.55O6BTG-C8-αGlu
CAS :<p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>Formule :C24H34BrN5O7SCouleur et forme :SolidMasse moléculaire :616.525PPARγ-IN-5
CAS :<p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>Formule :C22H23ClO7Couleur et forme :SolidMasse moléculaire :434.867PPARα/δ agonist 3
CAS :<p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>Formule :C23H25F3N2O4Couleur et forme :SolidMasse moléculaire :450.451Topoisomerase I inhibitor 8
CAS :<p>Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells.</p>Formule :C24H21FN2O4Couleur et forme :SolidMasse moléculaire :420.43ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54Topoisomerase I/II inhibitor 2
<p>Compound 1a inhibits Topoisomerase I/II, shrinks mouse liver tumors, IC50: 6.83/9.82 μM for LM9/Huh7 cells.</p>Formule :C19H16N2O4Couleur et forme :SolidMasse moléculaire :336.34SIRT6 activator 2
CAS :<p>SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.</p>Formule :C23H23N3O6Couleur et forme :SolidMasse moléculaire :437.45TP3011
CAS :<p>TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.</p>Formule :C26H26N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.51(Rac)-RG108
CAS :<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Formule :C19H14N2O4Couleur et forme :SolidMasse moléculaire :334.326Simmitecan hydrochloride
CAS :<p>Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.</p>Formule :C34H39ClN4O6Degré de pureté :98.20% - 98.93%Couleur et forme :SolidMasse moléculaire :635.15KU-60019
CAS :<p>KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).</p>Formule :C30H33N3O5SDegré de pureté :98.05% - 98.50%Couleur et forme :SolidMasse moléculaire :547.67BAY-8400
<p>BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in</p>Formule :C21H17F2N5ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :393.39OBI-3424
CAS :<p>OBI-3424, a highly selective prodrug, is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent.</p>Formule :C21H25N4O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.427Zabofloxacin hydrochloride
CAS :<p>Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.</p>Formule :C19H21ClFN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.86Merbarone
CAS :<p>Merbarone is a Type II DNA topoisomerase inhibitor. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the n</p>Formule :C11H9N3O3SCouleur et forme :SolidMasse moléculaire :263.27NSC61610
CAS :<p>NSC61610 is anti-inflammatory that activates PPARγ in vitro via LANCL2 and adenylate cyclase/cAMP-dependent pathways, thereby improving experimental colitis.</p>Formule :C34H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :548.59Phenanthriplatin
CAS :<p>Phenanthriplatin, also known as cis-[Pt(NH3)2-(phenanthridine)Cl]NO3, is a new drug candidate. It belongs to a family of platinum(II)-based agents which includes cisplatin, oxaliplatin and carboplatin. Phenanthriplatin Acts As a Covalent Poison of Topoiso</p>Formule :C13H11ClN4O3PtCouleur et forme :SolidMasse moléculaire :501.79YF438
CAS :<p>YF438 is an HDAC inhibitor that demonstrates potent anti-cancer activity both in vitro and in vivo. It inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2 from MDMX, and promoting the degradation of MDM2.</p>Formule :C23H26N4O5Couleur et forme :SolidMasse moléculaire :438.48SR-4370
CAS :<p>SR-4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp.</p>Formule :C17H18F2N2ODegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :304.33Mavodelpar free base
CAS :<p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>Formule :C31H30FNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.57Fotemustine
CAS :<p>Fotemustine: antineoplastic, chloroethylates DNA, blocks synthesis, causes cell arrest/apoptosis, lipophilic, crosses blood-brain barrier.</p>Formule :C9H19ClN3O5PCouleur et forme :SolidMasse moléculaire :315.69MDL-811
CAS :<p>MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),</p>Formule :C25H25BrCl2FN3O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :681.42ATR-IN-24
CAS :<p>ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].</p>Formule :C23H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :418.49Antitumor agent-104
CAS :<p>Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme</p>Formule :C31H33FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.63Lerzeparib
CAS :<p>Lerzeparib is a PARP (ADP-ribose polymerase) inhibitor that exhibits antineoplastic activity [1].</p>Formule :C21H20FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.4PARP7-IN-16 free base
CAS :<p>PARP7-IN-16 free base is the freebase form of PARP7-IN-16. As a selective oral inhibitor of PARP-1/2/7, it demonstrates IC50 values of 0.94, 0.87, and 0.21 nM, respectively. This compound is utilized in the research of breast and prostate cancer.</p>Formule :C25H27FN4O4Couleur et forme :SolidMasse moléculaire :466.50
