Altération de l'ADN/réparation de l'ADN
Les inhibiteurs de la réparation des dommages à l'ADN sont des composés qui interfèrent avec les processus impliqués dans la détection et la réparation des dommages à l'ADN. Ces inhibiteurs sont essentiels pour étudier les mécanismes de la stabilité génomique, de la mutagenèse et de la réponse aux dommages à l'ADN. Ils sont également importants dans la recherche sur le cancer, car de nombreuses tumeurs dépendent de voies spécifiques de réparation de l'ADN pour survivre. En inhibant ces voies, les inhibiteurs de la réparation des dommages à l'ADN peuvent améliorer l'efficacité de la chimiothérapie et de la radiothérapie. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité de la réparation des dommages à l'ADN pour soutenir vos recherches en biologie moléculaire, oncologie et pharmacologie.
Sous-catégories appartenant à la catégorie "Altération de l'ADN/réparation de l'ADN"
- ATM/ATR(71 produits)
- Alkylation de l'ADN(11 produits)
- Méthyltransférase de l’ADN(421 produits)
- Gyrase de l’ADN(11 produits)
- ADN-PK(51 produits)
- MTH1(1 produits)
- Antimétabolite nucléosidique/analogue(1.388 produits)
- Transcriptase inverse(43 produits)
- Sirtuine(88 produits)
- Télomérase(33 produits)
- Topoisomérase(136 produits)
Affichez 3 plus de sous-catégories
958 produits trouvés pour "Altération de l'ADN/réparation de l'ADN"
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Colibactin 742
CAS :<p>Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leads</p>Formule :C37H42N8O5S2Couleur et forme :SolidMasse moléculaire :742.91BML-278
CAS :<p>BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and</p>Formule :C24H25NO4Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :391.46SCR7
CAS :<p>SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).</p>Formule :C18H14N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :334.4(±)9-HEPE
CAS :<p>(±)9-HEPE is produced by non-enzymatic oxidation of EPA.</p>Formule :C20H30O3Couleur et forme :SolidMasse moléculaire :318.457Tibesaikosaponin V
CAS :<p>TKV, a triterpene diglycoside from Bupleurum chinense, curbs lipid build-up and fat content in adipocytes without harm and hinders fat cell differentiation.</p>Formule :C42H68O15Couleur et forme :SolidMasse moléculaire :812.98Melphalan
CAS :<p>Melphalan is an alkylating agent. It has been used in combination with the HDAC inhibitor as a drug for the treatment of multiple myeloma (MM) cell lines and as a chemotherapy agent for breast cancer cell lines.</p>Formule :C13H18Cl2N2O2Masse moléculaire :305.21Leriglitazone hydrochloride
CAS :<p>Leriglitazone hydrochloride, a pioglitazone metabolite, is a PPARγ agonist with Ki of 1.2 μM and EC50 of 680 nM.</p>Formule :C19H21ClN2O4SCouleur et forme :SolidMasse moléculaire :408.90MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Couleur et forme :Odour SolidPhosphoramide mustard
CAS :<p>Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.</p>Formule :C4H11Cl2N2O2PDegré de pureté :93.00%Couleur et forme :SolidMasse moléculaire :221.02GSK3735967
CAS :<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62BRD7586
CAS :<p>BRD7586 is a cell-permeable small molecule inhibitor of SpCas9 that enhances SpCas9 specificity.</p>Formule :C17H14ClN3O3S2Degré de pureté :97.70% - 99.03%Couleur et forme :SolidMasse moléculaire :407.89VK-1727
<p>VK-1727 inhibits EBNA1 DNA binding, reducing proliferation of EBV-positive cells while sparing EBV-negative cells, useful for multiple sclerosis research.</p>Formule :C29H25NO4Degré de pureté :98.074%Couleur et forme :SolidMasse moléculaire :451.512'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS :<p>2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.</p>Formule :C9H13ClFN3O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :281.67(4-NH2)-Exatecan
CAS :<p>(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).</p>Formule :C23H21N3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :403.43O6BTG-octylglucoside
CAS :O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Formule :C24H34BrN5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :616.53Banoxantrone dihydrochloride
CAS :<p>Banoxantrone dihydrochloride (AQ4N dihydrochloride) is a novel hypoxic cytotoxin that selectively kills hypoxic cells through an iNOS-dependent mechanism.</p>Formule :C22H30Cl2N4O6Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :517.45'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
CAS :<p>5'-O-DMT-dU, a dUTPase inhibitor (Ki > 1 mM) for E. coli, is used in DNA synthesis.</p>Formule :C30H30N2O7Couleur et forme :SolidMasse moléculaire :530.57Heptaplatin
CAS :<p>Heptaplatin, an anticancer platinum compound, counters many cancers, including cisplatin-resistant types, with a 17% response rate and tolerable toxicity.</p>Formule :C11H20N2O6PtCouleur et forme :White Crystalline PowderMasse moléculaire :471.36HDAC-IN-4
CAS :<p>HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.</p>Formule :C20H21N3O2Couleur et forme :SolidMasse moléculaire :335.4SIRT5 inhibitor 3
CAS :<p>SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .</p>Formule :C22H12FN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.35Methyl methanesulfonate (Standard)
CAS :<p>Methyl methanesulfonate (Standard) is a standard material used in the analysis of methyl methanesulfonate, typically referenced in its research and analysis.</p>Formule :C2H6O3SCouleur et forme :SolidMasse moléculaire :110.13Balaglitazone
CAS :<p>Balaglitazone is a PPARγ agonist that regulates blood glucose and is used in studies of heart failure and myocardial infarction.</p>Formule :C20H17N3O4SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :395.43CP-868388 free base
CAS :<p>CP-868388 free base (CP-868388) is a PPARα agonist with hypolipidemic and anti-inflammatory activity and is used in the study of dyslipidemia.</p>Formule :C26H33NO5Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :439.54(R)-(+)-Bay-K-8644
CAS :<p>(R)-(+)-Bay-K-8644, a Ca2+ channel agonist, is a dihydropyridine agonist that induces central respiratory depression and inhibits platelet activation in cats.</p>Formule :C16H15F3N2O4Degré de pureté :96.51% - 96.51%Couleur et forme :SolidMasse moléculaire :356.3Gepotidacin
CAS :<p>Gepotidacin is a triazaacenaphthylene antibacterial inhibiting bacterial type II topoisomerase with lower resistance potential than fluoroquinolones.</p>Formule :C24H28N6O3Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :448.52AMA-37
CAS :<p>AMA-37 is a selective, reversible, and ATP-competitive DNA-PK inhibitor.</p>Formule :C17H17NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :283.32Daun02
CAS :<p>Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.</p>Formule :C41H44N2O20Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :884.79Gancaonin L
CAS :<p>Gancaonin L is a natural product that can be used as a reference standard. The CAS number of Gancaonin L is 129145-50-2.</p>Formule :C20H18O6Couleur et forme :SolidMasse moléculaire :354.3589-Hydroxyellipticin free base
CAS :<p>9-hydroxyellipticine is a potent cytotoxic and antitumor agent. 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine.</p>Formule :C17H14N2OCouleur et forme :SolidMasse moléculaire :262.31Phosphoramide mustard cyclohexanamine
CAS :<p>Phosphoramide mustard cyclohexanamine is active metabolite of cyclophosphamide, an alkylating agent that cross-links DNA strands,causes cell death, antitumor.</p>Formule :C10H24Cl2N3O2PDegré de pureté :95%Couleur et forme :SolidMasse moléculaire :320.2RPR121056
CAS :<p>RPR121056 is a Irinotecan metabolite, which is generated by CYP3A4. Irinotecan is an antineoplastic agent that inhibits topoisomerase type I.</p>Formule :C33H38N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :618.68Gatifloxacin mesylate
CAS :<p>Gatifloxacin mesylate, a 4th-gen fluoroquinolone antibiotic, inhibits DNA gyrase and topoisomerase IV.</p>Formule :C20H26FN3O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.5Gatifloxacin sesquihydrate
CAS :<p>Gatifloxacin sesquihydrate, a bacterial DNA gyrase inhibitor, is used to treat tuberculosis and pneumonia.</p>Formule :C19H24FN3O5Couleur et forme :SolidMasse moléculaire :393.41Telomerase-IN-3
CAS :<p>Telomerase-IN-3 is an inhibitor of telomerase.</p>Formule :C19H16ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.82Epitalon
CAS :<p>Epithalon (also known as Epitalon or Epithalone) is the synthetic version of the polypeptide Epithalamin which is naturally produced in the pineal gland.</p>Formule :C14H22N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.35(R)-GSK-3685032
CAS :<p>(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.</p>Formule :C22H24N6OSCouleur et forme :SolidMasse moléculaire :420.54Ciprofloxacin hydrochloride monohydrate
CAS :<p>Ciprofloxacin hydrochloride monohydrate (Bay-09867 hydrochloride monohydrate) is a fluoroquinolone antibiotic with potent antibacterial activity.</p>Formule :C17H21ClFN3O4Degré de pureté :99.23% - 99.85%Couleur et forme :White Or Yellowish Crystalline PowderMasse moléculaire :385.82PTGR2-IN-1
CAS :<p>PTGR2-IN-1 is a potent inhibito of PTGR2r. PTGR2-IN-1 increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells.</p>Formule :C19H22N2O2Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :310.39YK-3-237
CAS :<p>YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative</p>Formule :C19H21BO7Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :372.18Pentamidine dihydrochloride
CAS :<p>Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (</p>Formule :C19H26Cl2N4O2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :413.34Pixantrone dimaleate
CAS :<p>Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.</p>Formule :C25H27N5O10Degré de pureté :98.70% - 99.11%Couleur et forme :SolidMasse moléculaire :557.21Silver sulfadiazine
CAS :<p>Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.</p>Formule :C10H9AgN4O2SDegré de pureté :99.04% - 99.58%Couleur et forme :SolidMasse moléculaire :357.14BYK204165
CAS :<p>BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)</p>Formule :C15H12N2O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :252.27AK-7
CAS :<p>AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.</p>Formule :C19H21BrN2O3SDegré de pureté :98.43% - 99.34%Couleur et forme :SolidMasse moléculaire :437.35Voxtalisib
CAS :<p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>Formule :C13H14N6ODegré de pureté :98.21% - 99.69%Couleur et forme :SolidMasse moléculaire :270.29Remetinostat
CAS :<p>Remetinostat (SHP-141), a hydroxamic acid-based inhibitor of histone deacetylase enzymes, is currently being developed for the treatment of cutaneous T-cell</p>Formule :C16H21NO6Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :323.34Pixantrone hydrochloride
CAS :<p>Pixantrone hydrochloride is a topoisomerase II inhibitor and DNA intercalator with anti-tumor properties.</p>Formule :C17H20ClN5O2Couleur et forme :SolidMasse moléculaire :361.83PJ34
CAS :<p>PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.</p>Formule :C17H17N3O2Degré de pureté :95.05% - 99.85%Couleur et forme :SolidMasse moléculaire :295.34Resminostat hydrochloride
CAS :<p>Resminostat hydrochloride (RAS2410 hydrochloride) is an effective inhibitor of HDAC1/HDAC3/HDAC6 (IC50: 42.5/50.1/71.8 nM), respectively, and shows less potent</p>Formule :C16H20ClN3O4SDegré de pureté :97.63% - 99.68%Couleur et forme :SolidMasse moléculaire :385.86L67
CAS :<p>L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).</p>Formule :C16H14Br2N4O4Degré de pureté :98.34% - 99.56%Couleur et forme :SolidMasse moléculaire :486.11
