Topoisomérase
Les topoisomérases sont des enzymes qui régulent la topologie de l'ADN lors de processus tels que la réplication, la transcription et la ségrégation des chromosomes en introduisant des cassures transitoires dans les brins d'ADN pour soulager le stress torsionnel. Les inhibiteurs de topoisomérase interfèrent avec ce processus, entraînant l'accumulation de cassures dans l'ADN et l'induction de la mort cellulaire, en particulier dans les cellules à division rapide. Ces inhibiteurs sont largement utilisés comme agents chimiothérapeutiques dans le traitement du cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de topoisomérase de haute qualité pour soutenir vos recherches sur la réplication de l'ADN, la thérapie contre le cancer et la régulation du cycle cellulaire.
139 produits trouvés pour "Topoisomérase"
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Topoisomerase II inhibitor 13
CAS :WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.Formule :C22H23N9Degré de pureté :99.84%Couleur et forme :SoildMasse moléculaire :413.48Voreloxin
CAS :Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.Formule :C18H19N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.44Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Formule :C21H21N3O2Couleur et forme :SolidMasse moléculaire :347.41CH-0793076
CAS :<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formule :C26H26N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.51Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formule :C25H26ClN3O5Degré de pureté :97.04%Couleur et forme :SoildMasse moléculaire :483.94TAK1 inhibitor
CAS :<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Formule :C22H19ClN6O2SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :466.94Topoisomerases/ribosomes-IN-1
Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).Formule :C53H83FN6O15Couleur et forme :SolidMasse moléculaire :1063.26AuL1
AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.Formule :C29H50AuCl2N5Couleur et forme :SolidMasse moléculaire :736.61CBX-12
CBX-12 is a peptide drug conjugate (PDC) that targets tumors in an antigen-independent manner and exhibits antitumor activity. Comprising a pH-sensitive peptide (pHLIP), an auto-cleavable linker, and the topoisomerase 1 (TOP1) inhibitor Exatecan, it effectively targets cancerous cells.Formule :C169H240FN35O49S2Masse moléculaire :3629.05Dichlorogelignate
CAS :Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].Formule :C32H34O18Couleur et forme :SolidMasse moléculaire :706.6(4-NH2)-Exatecan
CAS :(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).Formule :C23H21N3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :403.43Daun02
CAS :Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.Formule :C41H44N2O20Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :884.791,4-Naphthoquinone
CAS :1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.Formule :C10H6O2Degré de pureté :99.24% - 99.56%Couleur et forme :SolidMasse moléculaire :158.15Genz-644282
CAS :Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Formule :C22H21N3O5Degré de pureté :97.49%Couleur et forme :SolidMasse moléculaire :407.42Berberine
CAS :1.Formule :C20H18NO4Degré de pureté :95.71% - 99.67%Couleur et forme :SolidMasse moléculaire :336.36Ref: TM-T4S0797
5mgÀ demander10mgÀ demander25mgÀ demander50mg93,00€100mg125,00€500mg266,00€1mL*10mM (DMSO)55,00€SN-38
CAS :SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formule :C22H20N2O5Degré de pureté :98% - 99.97%Couleur et forme :Light-Yellow SolidMasse moléculaire :392.4Aurintricarboxylic acid
CAS :Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Formule :C22H14O9Degré de pureté :97.1%Couleur et forme :Deep Red Coarse Crystalline PowderMasse moléculaire :422.34Voreloxin hydrochloride
CAS :Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Formule :C18H20ClN5O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :437.9Idarubicin hydrochloride
CAS :Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Formule :C26H27NO9·HClDegré de pureté :98.91% - 99.96%Couleur et forme :SolidMasse moléculaire :533.95Phenoxodiol
CAS :Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Formule :C15H12O3Degré de pureté :98.07% - 99.18%Couleur et forme :SolidMasse moléculaire :240.25Ref: TM-T16522
1mg66,00€5mg144,00€10mg227,00€25mg373,00€50mg567,00€100mg810,00€1mL*10mM (DMSO)159,00€
