Topoisomérase
Les topoisomérases sont des enzymes qui régulent la topologie de l'ADN lors de processus tels que la réplication, la transcription et la ségrégation des chromosomes en introduisant des cassures transitoires dans les brins d'ADN pour soulager le stress torsionnel. Les inhibiteurs de topoisomérase interfèrent avec ce processus, entraînant l'accumulation de cassures dans l'ADN et l'induction de la mort cellulaire, en particulier dans les cellules à division rapide. Ces inhibiteurs sont largement utilisés comme agents chimiothérapeutiques dans le traitement du cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de topoisomérase de haute qualité pour soutenir vos recherches sur la réplication de l'ADN, la thérapie contre le cancer et la régulation du cycle cellulaire.
141 produits trouvés pour "Topoisomérase"
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CBX-12
CBX-12 is a peptide drug conjugate (PDC) that targets tumors in an antigen-independent manner and exhibits antitumor activity. Comprising a pH-sensitive peptide (pHLIP), an auto-cleavable linker, and the topoisomerase 1 (TOP1) inhibitor Exatecan, it effectively targets cancerous cells.Formule :C169H240FN35O49S2Masse moléculaire :3629.05Daun02
CAS :Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.Formule :C41H44N2O20Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :884.79(4-NH2)-Exatecan
CAS :(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).Formule :C23H21N3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :403.43Marbofloxacin
CAS :Marbofloxacin (Zeniquin) is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.Formule :C17H19FN4O4Degré de pureté :99.76% - 99.84%Couleur et forme :SolidMasse moléculaire :362.36Phenoxodiol
CAS :Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Formule :C15H12O3Degré de pureté :98.07% - 99.18%Couleur et forme :SolidMasse moléculaire :240.25Ref: TM-T16522
1mg66,00€5mg144,00€10mg227,00€25mg373,00€50mg567,00€100mg810,00€1mL*10mM (DMSO)159,00€Betulinic acid
CAS :Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Formule :C30H48O3Degré de pureté :98.22% - 99.7%Couleur et forme :White Crystalline PowderMasse moléculaire :456.70Idarubicin hydrochloride
CAS :Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Formule :C26H27NO9·HClDegré de pureté :98.91% - 99.96%Couleur et forme :SolidMasse moléculaire :533.95Voreloxin hydrochloride
CAS :Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Formule :C18H20ClN5O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :437.9SN-38
CAS :SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formule :C22H20N2O5Degré de pureté :98% - 99.97%Couleur et forme :Light-Yellow SolidMasse moléculaire :392.4Topotecan
CAS :Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.Formule :C23H23N3O5Degré de pureté :96.14% - 98.23%Couleur et forme :Light Yellow Needle Crystal Or Crystalline PowderMasse moléculaire :421.45Pixantrone dimaleate
CAS :Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.Formule :C25H27N5O10Degré de pureté :98.70% - 99.11%Couleur et forme :SolidMasse moléculaire :557.21Indotecan
CAS :Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).Formule :C26H26N2O7Degré de pureté :97% - 98%Couleur et forme :SolidMasse moléculaire :478.49Suramin Sodium Salt
CAS :Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formule :C51H34N6Na6O23S6Degré de pureté :97.47% - 99.97%Couleur et forme :WhiteMasse moléculaire :1429.15Ref: TM-T2160
1mg39,00€5mg87,00€10mg115,00€25mg190,00€50mg285,00€100mg408,00€200mg620,00€1mL*10mM (DMSO)101,00€(S)-10-Hydroxycamptothecin
CAS :(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Formule :C20H16N2O5Degré de pureté :99.09% - 99.81%Couleur et forme :SolidMasse moléculaire :364.35Artemisitene
CAS :Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.Formule :C15H20O5Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :280.32Ref: TM-T21065
1mg95,00€5mg187,00€10mg329,00€25mg560,00€50mg800,00€100mg1.103,00€1mL*10mM (DMSO)281,00€Bisantrene
CAS :Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.Formule :C22H22N8Degré de pureté :96.07% - 98.57%Couleur et forme :SolidMasse moléculaire :398.46Razoxane
CAS :Razoxane is used as an antimitotic agent with immunosuppressive properties.Formule :C11H16N4O4Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :268.27Amonafide
CAS :Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.Formule :C16H17N3O2Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :283.33Ref: TM-T6336
1mg39,00€2mg51,00€5mg80,00€10mg87,00€25mg163,00€50mg281,00€100mg467,00€1mL*10mM (DMSO)92,00€β-Lapachone
CAS :β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.Formule :C15H14O3Degré de pureté :99.76% - 99.88%Couleur et forme :SolidMasse moléculaire :242.27Ellipticine hydrochloride
CAS :Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.Formule :C17H15ClN2Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :282.76Bimolane
CAS :Bimolane is a topoisomerase II inhibitor.Formule :C20H32N6O6Degré de pureté :99.13% - 99.29%Couleur et forme :SolidMasse moléculaire :452.5Gatifloxacin hydrochloride
CAS :Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.Formule :C19H23ClFN3O4Degré de pureté :99.85% - 99.89%Couleur et forme :SolidMasse moléculaire :411.86Aurintricarboxylic acid
CAS :Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Formule :C22H14O9Degré de pureté :97.1%Couleur et forme :Deep Red Coarse Crystalline PowderMasse moléculaire :422.34Groenlandicine
CAS :Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential as an anti-Alzheimer's agent.Formule :C19H16NO4Degré de pureté :98.59% - 99.77%Couleur et forme :SolidMasse moléculaire :322.34Topovale
CAS :Topovale (ARC111) is a potent inhibitor of topoisomerase I.Formule :C23H23N3O5Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :421.45Irinotecan
CAS :Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.Formule :C33H38N4O6Degré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :586.68Dxd
CAS :Dxd (OQM5SD32BQ) is a potent DNA topoisomerase I inhibitor (IC50= 0.31 μM). Dxd was used as a conjugate drug for HER2-targeted ADCs. High-Quality, Low-Cost!Formule :C26H24FN3O6Degré de pureté :98.21% - ≥98%Couleur et forme :SolidMasse moléculaire :493.48Berberine
CAS :1.Formule :C20H18NO4Degré de pureté :95.71% - 99.67%Couleur et forme :SolidMasse moléculaire :336.36Ref: TM-T4S0797
5mgÀ demander10mgÀ demander25mgÀ demander50mg93,00€100mg125,00€500mg266,00€1mL*10mM (DMSO)55,00€Amsacrine hydrochloride
CAS :Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.Formule :C21H20ClN3O3SDegré de pureté :99.05% - 99.92%Couleur et forme :SolidMasse moléculaire :429.92Rubitecan
CAS :Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.Formule :C20H15N3O6Degré de pureté :97.54%Couleur et forme :Yellow Amorphous PowderMasse moléculaire :393.351,4-Naphthoquinone
CAS :1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.Formule :C10H6O2Degré de pureté :99.24% - 99.56%Couleur et forme :SolidMasse moléculaire :158.15Levofloxacin
CAS :Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.Formule :C18H20FN3O4Degré de pureté :98.14% - 99.80%Couleur et forme :Off-White To Yellow CrystalsMasse moléculaire :361.37TAS-103 dihydrochloride
CAS :TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.Formule :C20H21Cl2N3O2Degré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :406.319-amino-CPT
CAS :9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.Formule :C20H17N3O4Degré de pureté :99.13% - 99.82%Couleur et forme :Orange-Yellow PowderMasse moléculaire :363.379-Hydroxycamptothecin
CAS :9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.Formule :C20H16N2O5Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :364.35Isosteviol
CAS :Isosteviol is a natural sweetener with anti-inflammatory, anti-tumor, glucose-lowering, and other health benefits.Formule :C20H30O3Degré de pureté :99.72% - 99.97%Couleur et forme :SolidMasse moléculaire :318.45SW044248
CAS :SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.Formule :C22H23N5O2SDegré de pureté :99.56% - 99.87%Couleur et forme :SolidMasse moléculaire :421.52Niranthin
CAS :Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L.Formule :C24H32O7Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :432.51Ref: TM-TN4660
1mg364,00€5mg803,00€10mg1.206,00€25mg2.118,00€50mg3.392,00€100mg5.424,00€1mL*10mM (DMSO)853,00€EIDD-1931
CAS :<p>EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.</p>Formule :C9H13N3O6Degré de pureté :99.14% - 99.73%Couleur et forme :SolidMasse moléculaire :259.22Pirarubicin
CAS :Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.Formule :C32H37NO12Degré de pureté :97.80% - 99.15%Couleur et forme :Red Crystalline PowderMasse moléculaire :627.64Coralyne chloride
CAS :Coralyne chloride is a protoberberine with strong anticancer activity.Formule :C22H22ClNO4Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :399.87Garenoxacin mesylate hydrate
CAS :Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strainsFormule :C23H20F2N2O4·CH4O3S·H2ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :540.53Exatecan Mesylate
CAS :Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).Formule :C25H26FN3O7SDegré de pureté :97.32% - 99.9%Couleur et forme :SolidMasse moléculaire :531.55Levofloxacin hydrochloride
CAS :Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.Formule :C18H21ClFN3O4Degré de pureté :99.78% - 99.98%Couleur et forme :SolidMasse moléculaire :397.8Nitidine chloride
CAS :1.Formule :C21H18ClNO4Degré de pureté :96.59% - 99.55%Couleur et forme :SolidMasse moléculaire :383.82Prulifloxacin
CAS :Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis by blocking topoisomerase II and IV.Formule :C21H20FN3O6SDegré de pureté :99.47%Couleur et forme :Yellow Or Slightly Yellow PowerMasse moléculaire :461.46Belotecan hydrochloride
CAS :Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activityFormule :C25H28ClN3O4Degré de pureté :99.63% - ≥95%Couleur et forme :SolidMasse moléculaire :469.96Ref: TM-T7551
1mg35,00€5mg70,00€10mg96,00€25mg153,00€50mg210,00€100mg296,00€200mg439,00€1mL*10mM (DMSO)72,00€Rabdosiin
CAS :Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.Formule :C36H30O16Degré de pureté :98.64% - 99.49%Couleur et forme :SolidMasse moléculaire :718.61Berberine hydrogen sulphate
CAS :Berberine hydrogen sulphate, a plant alkaloid, has broad antimicrobial effects on bacteria, fungi, and protozoa.Formule :C20H19NO8SDegré de pureté :99% - 99.82%Couleur et forme :Yellow Crystals Off-White To Yellow PowderMasse moléculaire :433.43Genz-644282
CAS :Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Formule :C22H21N3O5Degré de pureté :97.49%Couleur et forme :SolidMasse moléculaire :407.42
