Topoisomérase
Les topoisomérases sont des enzymes qui régulent la topologie de l'ADN lors de processus tels que la réplication, la transcription et la ségrégation des chromosomes en introduisant des cassures transitoires dans les brins d'ADN pour soulager le stress torsionnel. Les inhibiteurs de topoisomérase interfèrent avec ce processus, entraînant l'accumulation de cassures dans l'ADN et l'induction de la mort cellulaire, en particulier dans les cellules à division rapide. Ces inhibiteurs sont largement utilisés comme agents chimiothérapeutiques dans le traitement du cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de topoisomérase de haute qualité pour soutenir vos recherches sur la réplication de l'ADN, la thérapie contre le cancer et la régulation du cycle cellulaire.
126 produits trouvés pour "Topoisomérase".
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Amsacrine
CAS :Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.Formule :C21H19N3O3SDegré de pureté :99.2% - 99.34%Couleur et forme :Yellow SolidMasse moléculaire :393.46PluriSIn #2
CAS :PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.Formule :C11H8FN3O3Degré de pureté :98% - 99.79%Couleur et forme :White SolidMasse moléculaire :249.2T638
CAS :T638 is an inhibitor of topoisomerase II (TOP2). It specifically inhibits the activity of TOP2A with an IC50 of 0.7 uM and effectively suppresses the growth of cancer cells.Formule :C18H16N4OSCouleur et forme :SolidMasse moléculaire :336.41Daniquidone
CAS :Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity for neoplasmsFormule :C15H11N3ODegré de pureté :98.42% - 99.16%Couleur et forme :Yellow SolidMasse moléculaire :249.27Pyrazoloacridine
CAS :Pyrazoloacridine (PD 115934) binds DNA, inhibits topo I/II, has 1.25 μM IC50 in K562 cells, and exhibits anti-cancer effects.Formule :C19H21N5O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :367.4Pegamotecan
CAS :Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cellFormule :C52H48N6O14Degré de pureté :96.40% - 97.83%Couleur et forme :SolidMasse moléculaire :980.984Anticancer agent 216
CAS :Anticanceragent 216 (34A) is a camptothecin compound with IC50 values of 9.6 nM for MCF-7 cells and 11.6 nM for MDA-MB-231 cells.Formule :C23H21N3O6Couleur et forme :SolidMasse moléculaire :435.43SDOX
CAS :SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.Formule :C69H97NO20S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1324.63LMP744 hydrochloride
CAS :LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.Formule :C24H25ClN2O7Degré de pureté :99.59% - 99.85%Couleur et forme :SolidMasse moléculaire :488.92DBCO-PEG4-GGFG-Dxd
CAS :DBCO-PEG4-GGFG-Dxd is an ADC intermediate with Dxd payload and DBCO handle used to study the construction of targeted anti-tumor drugs via click chemistry.Formule :C72H79FN10O17Degré de pureté :96.58% - 98.02%Couleur et forme :White SolidMasse moléculaire :1375.45Topoisomerase I inhibitor 9
CAS :Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 valueFormule :C23H15Br2FN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.19ARN-21934
CAS :ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.Formule :C21H24N6Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :360.46Ref: TM-T36968
1mg58,00€2mg85,00€5mg128,00€1mL*10mM (DMSO)141,00€10mg200,00€25mg353,00€50mg482,00€100mg665,00€200mg893,00€Trovafloxacin mesylate
CAS :Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formule :C21H19F3N4O6SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :512.469-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS :9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potentialFormule :C22H18ClFN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.84Topoisomerase inhibitor 2
CAS :Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].Formule :C23H23N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :433.46Gimatecan
CAS :Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formule :C25H25N3O5Degré de pureté :98.47%Couleur et forme :Yellow SolidMasse moléculaire :447.48Topoisomerase II inhibitor 18
CAS :Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].Formule :C20H21N3OSCouleur et forme :SolidMasse moléculaire :351.47Topobexin
CAS :Topobexin (Topobexin 9) is a highly selective TOP2B inhibitor. It selectively inhibits TOP2B in vitro and stabilizes TOP2B on DNA. Topobexin offers significant protection to cardiomyocytes against DAU-induced damage. In rabbit models, Topobexin prevents anthracycline-induced cardiotoxicity and the decrease in left ventricular contractile function caused by DAU.Formule :C29H35N3O4Masse moléculaire :489.61Topotecan acetate
CAS :Topotecan acetate is an inhibitor of topoisomerase.Formule :C25H27N3O7Couleur et forme :SolidMasse moléculaire :481.498Intoplicine
CAS :Intoplicine is an inhibitor of DNA topoisomerase I and II.Formule :C21H24N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.44Saintopin
CAS :Saintopin is an antitumor antibiotic and an inhibitor of DNA topoisomerases I and II, which induces DNA cleavage [1] [2].Formule :C18H10O7Couleur et forme :SolidMasse moléculaire :338.27Anticancer agent 215
CAS :Anticanceragent 215 (1) is a camptothecin derivative with IC50 values of 5.2 nM and 8.2 nM against MCF-7 and MDA-MB-231 cells, respectively.Formule :C23H22FN3O4Couleur et forme :SolidMasse moléculaire :423.44LMP517
CAS :LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].Formule :C22H19FN2O5Couleur et forme :SolidMasse moléculaire :410.4Edotecarin
CAS :Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).Formule :C29H28N4O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :608.55Topoisomerase I/II inhibitor 7
CAS :Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.Formule :C18H13ClN2O3Couleur et forme :SolidMasse moléculaire :340.76Karenitecin
CAS :Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.Formule :C25H28N2O4SiDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.59
