Topoisomérase
Les topoisomérases sont des enzymes qui régulent la topologie de l'ADN lors de processus tels que la réplication, la transcription et la ségrégation des chromosomes en introduisant des cassures transitoires dans les brins d'ADN pour soulager le stress torsionnel. Les inhibiteurs de topoisomérase interfèrent avec ce processus, entraînant l'accumulation de cassures dans l'ADN et l'induction de la mort cellulaire, en particulier dans les cellules à division rapide. Ces inhibiteurs sont largement utilisés comme agents chimiothérapeutiques dans le traitement du cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de topoisomérase de haute qualité pour soutenir vos recherches sur la réplication de l'ADN, la thérapie contre le cancer et la régulation du cycle cellulaire.
126 produits trouvés pour "Topoisomérase".
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Banoxantrone-D12 dihydrochloride
CAS :Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.Formule :C22H30Cl2N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.48Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Formule :C21H21N3O2Couleur et forme :SolidMasse moléculaire :347.41Chimmitecan
CAS :Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.Formule :C23H20N2O5Degré de pureté :98.35%Couleur et forme :Yellow SolidMasse moléculaire :404.42Topoisomerase II inhibitor 19
Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and a topoisomerase II inhibitor with an IC50 of 0.34 μM. It induces damage in ctDNA.Formule :C27H16ClN3OSMasse moléculaire :465.07026Topoisomerase IIα-IN-9
CAS :Topoisomerase IIα-IN-9 ,with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Topoisomerase IIα-IN-9 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C14H14O4SCouleur et forme :SolidMasse moléculaire :278.32Merbarone
CAS :Merbarone is a Type II DNA topoisomerase inhibitor that suppresses the catalytic activity of human topoisomerase IIα by blocking DNA cleavage, subsequently inducing activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix, Merbarone triggers apoptosis in CEM cells through activation of ICE/CED-3-like proteases, making it a mechanistically informative compound for studying DNA damage responses and apoptosis pathways.Formule :C11H9N3O3SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :263.27Genz-644282
CAS :Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Formule :C22H21N3O5Degré de pureté :97.49%Couleur et forme :SolidMasse moléculaire :407.42Pixantrone dimaleate
CAS :Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.Formule :C25H27N5O10Degré de pureté :98.70% - 99.11%Couleur et forme :Blue SolidMasse moléculaire :557.21EIDD-1931
CAS :EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.Formule :C9H13N3O6Degré de pureté :99.14% - 99.73%Couleur et forme :SolidMasse moléculaire :259.22Aurintricarboxylic acid
CAS :Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Formule :C22H14O9Degré de pureté :85% - 97.1%Couleur et forme :Deep Red Coarse Crystalline PowderMasse moléculaire :422.34Voreloxin hydrochloride
CAS :Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Formule :C18H20ClN5O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :437.9Betulinic acid
CAS :Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Formule :C30H48O3Degré de pureté :98.22% - 99.7%Couleur et forme :White SolidMasse moléculaire :456.70Berberine
CAS :1.Formule :C20H18NO4Degré de pureté :95.71% - 99.67%Couleur et forme :SolidMasse moléculaire :336.36Idarubicin hydrochloride
CAS :Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Formule :C26H27NO9·HClDegré de pureté :98.91% - 99.96%Couleur et forme :SolidMasse moléculaire :533.95Topotecan
CAS :Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.Formule :C23H23N3O5Degré de pureté :96.14% - 98.23%Couleur et forme :Yellow SolidMasse moléculaire :421.45Phenoxodiol
CAS :Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Formule :C15H12O3Degré de pureté :98.07% - 99.18%Couleur et forme :White SolidMasse moléculaire :240.25Ref: TM-T16522
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg353,00€50mg537,00€100mg767,00€SN-38
CAS :SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formule :C22H20N2O5Degré de pureté :98% - 99.97%Couleur et forme :Yellow SolidMasse moléculaire :392.40Bisantrene
CAS :Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.Formule :C22H22N8Degré de pureté :96.22% - 97.13%Couleur et forme :Orange SolidMasse moléculaire :398.469-Hydroxycamptothecin
CAS :9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.Formule :C20H16N2O5Degré de pureté :98.28%Couleur et forme :Yellow SolidMasse moléculaire :364.35Razoxane
CAS :Razoxane is used as an antimitotic agent with immunosuppressive properties.Formule :C11H16N4O4Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :268.27
