Topoisomérase
Les topoisomérases sont des enzymes qui régulent la topologie de l'ADN lors de processus tels que la réplication, la transcription et la ségrégation des chromosomes en introduisant des cassures transitoires dans les brins d'ADN pour soulager le stress torsionnel. Les inhibiteurs de topoisomérase interfèrent avec ce processus, entraînant l'accumulation de cassures dans l'ADN et l'induction de la mort cellulaire, en particulier dans les cellules à division rapide. Ces inhibiteurs sont largement utilisés comme agents chimiothérapeutiques dans le traitement du cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de topoisomérase de haute qualité pour soutenir vos recherches sur la réplication de l'ADN, la thérapie contre le cancer et la régulation du cycle cellulaire.
140 produits trouvés pour "Topoisomérase"
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Garenoxacin
CAS :<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Formule :C23H20F2N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.41Banoxantrone-d12 dihydrochloride
CAS :<p>Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.</p>Formule :C22H30Cl2N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.48Chimmitecan
CAS :<p>Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.</p>Formule :C23H20N2O5Degré de pureté :98.35%Couleur et forme :SoildMasse moléculaire :404.42Topoisomerase II inhibitor 13
CAS :WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.Formule :C22H23N9Degré de pureté :99.84%Couleur et forme :SoildMasse moléculaire :413.48Voreloxin
CAS :Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.Formule :C18H19N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.44Topoisomerase IIα-IN-9
CAS :Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C14H14O4SCouleur et forme :SolidMasse moléculaire :278.32Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formule :C25H26ClN3O5Degré de pureté :97.04%Couleur et forme :SoildMasse moléculaire :483.94Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Formule :C21H21N3O2Couleur et forme :SolidMasse moléculaire :347.41Topoisomerases/ribosomes-IN-1
Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).Formule :C53H83FN6O15Couleur et forme :SolidMasse moléculaire :1063.26TAK1 inhibitor
CAS :<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Formule :C22H19ClN6O2SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :466.94(4-NH2)-Exatecan
CAS :(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).Formule :C23H21N3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :403.43Daun02
CAS :Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.Formule :C41H44N2O20Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :884.79Genz-644282
CAS :Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Formule :C22H21N3O5Degré de pureté :97.49%Couleur et forme :SolidMasse moléculaire :407.421,4-Naphthoquinone
CAS :1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.Formule :C10H6O2Degré de pureté :99.24% - 99.56%Couleur et forme :SolidMasse moléculaire :158.15Berberine
CAS :1.Formule :C20H18NO4Degré de pureté :95.71% - 99.67%Couleur et forme :SolidMasse moléculaire :336.36Voreloxin hydrochloride
CAS :Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Formule :C18H20ClN5O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :437.9Aurintricarboxylic acid
CAS :Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Formule :C22H14O9Degré de pureté :97.1%Couleur et forme :Deep Red Coarse Crystalline PowderMasse moléculaire :422.34Idarubicin hydrochloride
CAS :Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Formule :C26H27NO9·HClDegré de pureté :98.91% - 99.96%Couleur et forme :SolidMasse moléculaire :533.95SN-38
CAS :SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formule :C22H20N2O5Degré de pureté :98% - 99.97%Couleur et forme :Light-Yellow SolidMasse moléculaire :392.4Suramin Sodium Salt
CAS :Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formule :C51H34N6Na6O23S6Degré de pureté :97.47% - 99.97%Couleur et forme :WhiteMasse moléculaire :1429.15
