Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
460 produits trouvés pour "Méthyltransférase de l’ADN"
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PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Formule :C55H60FN11O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1054.2TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Couleur et forme :Odour SolidA-893
CAS :A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Formule :C29H38Cl2N4O4Couleur et forme :SolidMasse moléculaire :577.54UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.Formule :C47H70N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :847.09PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Formule :C50H58FN11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :960.13PRMT4-IN-3
PRMT4-IN-3 (compound 56) serves as a potent class I protein arginine methyltransferase (PRMT) inhibitor, specifically targeting PRMT4 with an IC50 value of 37Formule :C23H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.52MC3343
CAS :MC3343, a DNMT1/3A inhibitor, affects tumor proliferation by blocking osteosarcoma cells in the G1 or G2/M phase and induces osteogenic differentiation.Formule :C27H23N7ODegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :461.52PRMT5-IN-34
PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative protein arginine methyltransferase 5 (PRMT5/MAT).Formule :C23H19F2N5O2Masse moléculaire :435.15068PRMT5-IN-12
CAS :PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formule :C32H40N4O4Couleur et forme :SolidMasse moléculaire :544.696EPZ-719
CAS :EPZ-719 is a selective and orally available SETD2 inhibitor (IC50 = 0.005 μM), with anti-cancer activity, and can be used for hematological malignancies.Formule :C22H31FN4O3SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :450.57UNC7096
UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1Formule :C61H87N7O18SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1238.44SETD7-IN-1
SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitoryDegré de pureté :98%Couleur et forme :Odour SolidBML-278
CAS :BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, andFormule :C24H25NO4Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :391.46ND-L11B free base
ND-L11B is an effective degrader of the nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with DC50 values of 1.48 μM and 0.8 μM, respectively, and a Dmax close to 80%.Formule :C37H51F3N10O2Couleur et forme :SolidMasse moléculaire :724.862EZH2-IN-22
CAS :EZH2-IN-22 (example 92) is a potent EZH2 inhibitor, exhibiting IC50 values of <0.00051 µM for EZH2(Y641N) and EZH2(Y641F), and 0.00052 µM for EZH2 (wt). Additionally, EZH2-IN-22 demonstrates antiproliferative activity.Formule :C36H50N4O8Couleur et forme :SolidMasse moléculaire :666.8MAK-683 hydrochloride
CAS :MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Formule :C20H18ClFN6ODegré de pureté :97.02% - >99.99%Couleur et forme :SolidMasse moléculaire :412.85FTX-6058 hydrochloride
CAS :FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Formule :C22H19ClFN5O2Couleur et forme :SolidMasse moléculaire :439.87Dot1L-IN-1 TFA
Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).Formule :C34H37ClF3N9O4SCouleur et forme :SolidMasse moléculaire :760.23PRMT5-IN-36
CAS :PRMT5-IN-36 (compound 4), an orally active PRMT5 inhibitor, is utilized in cancer research studies.Formule :C20H15F3N6O2Masse moléculaire :428.37PRMT5-MTA-IN-2
PRMT5-MTA-IN-2 (compound 1) is a synergistic inhibitor of PRMT5 with an IC50 of less than 1.5 nM.Formule :C30H25F2N7O2Couleur et forme :SolidMasse moléculaire :553.56CARM1 degrader-2
PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associatedFormule :C72H100N12O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1277.71OTS186935 FA
OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells.Formule :C26H28ClN5O4Degré de pureté :99.52%Couleur et forme :SoildMasse moléculaire :509.98Ref: TM-T12344L1
1mg92,00€5mg222,00€1mL*10mM (DMSO)255,00€10mg371,00€25mg673,00€50mg1.044,00€100mg1.459,00€500mg2.907,00€GSK3735967
CAS :GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62Anticancer agent 126
Anticancer agent 126 (compound 12), a WDR5 inhibitor, exhibits anticancer properties by disrupting the WDR5-MYC interaction in cells, subsequently reducing MYCFormule :C25H11BBr2F2N2O3S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :724.23CS-VIP 8
CS-VIP 8 is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces conformational changes in the MLL1 complex, causing the dissociation of MLL1 from the complex and inhibiting MLL1 histone methyltransferase activity, thereby regulating HOX gene expression. CS-VIP 8 shows potential for research in hematological diseases such as leukemia.Formule :C43H52F4N12O7Couleur et forme :SolidMasse moléculaire :924.4018PRMT4-IN-2
PRMT4-IN-2 (compound 55) acts as a pan-inhibitor across various protein arginine methyltransferase (PRMT) isoforms, exhibiting inhibitory potencies with IC50Couleur et forme :Odour SolidSAH-EZH2
CAS :EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.Formule :C155H256N48O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3432.05EPZ-025654
CAS :EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.Formule :C29H33ClN8O3Couleur et forme :SolidMasse moléculaire :577.08SARS-CoV-2-IN-87
SARS-CoV-2-IN-87 (compound 138968421) is an effective inhibitor of the SARS-CoV-2 methyltransferases (nsp14 and nsp16).Formule :C26H40O6Masse moléculaire :448.28249MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Couleur et forme :Odour SolidEEDi-5285
CAS :EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.Formule :C24H22FN5O3SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :479.53DNMT2-IN-2
DNMT2-IN-2 is a selective inhibitor of DNA methyltransferase 2 (DNMT2) with a KD value of 3.04 μM. It targets a concealed allosteric binding site of DNMT2 and reduces m5C levels in tRNA of MOLM-13 cells. This compound works synergistically with Doxorubicin to impair cell viability and is applicable in cancer research, including studies of cervical cancer and leukemia.Couleur et forme :Odour SolidNSC 370284
CAS :NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formule :C21H25NO6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :387.43PRMT1-IN-1
CAS :PRMT1-IN-1 is a PRMT1 inhibitor.
Formule :C20H7Br6NO5Couleur et forme :SolidMasse moléculaire :820.702CM112
CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.Formule :C39H61N5O7Couleur et forme :SolidMasse moléculaire :711.4571AS-254s
AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.Formule :C36H41ClN6O3S2Couleur et forme :SolidMasse moléculaire :705.332Chaetocin
CAS :Chaetocin: a natural histone methyltransferase inhibitor; IC50 of 0.8, 2.5, and 3 μM for dSU(VAR)3-9, G9a, DIM5.
Formule :C30H28N6O6S4Degré de pureté :98.36% - 98.82%Couleur et forme :SolidMasse moléculaire :696.84BAY-6035
CAS :BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.Formule :C22H28N4O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :396.48MS115
MS115 is a selective PRMT5/MEP50 PROTAC degrader with DC50 values of 17.4 nM for PRMT5 and 11.3 nM for PRMT5 in MDAMB468 cells after 24 hours. MS115 also inhibits the proliferation of breast cancer cells.Couleur et forme :Odour SolidTet1 peptide
CAS :Tet1peptide is a neuron-specific ligand for GT1B ganglioside. It can serve as a ligand for the targeted delivery of functionalized polymers.Formule :C73H114N20O17Couleur et forme :SolidMasse moléculaire :1543.81WDR5-MYC-IN-1
WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.Couleur et forme :Odour SolidCMP-5 2HCl
CAS :CMP-5 2HCl is a anthelmintic agent. CMP-5 2HCl shows EC100 of 5μM against H. contortus in vitro.Formule :C21H23Cl2N3Degré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :388.33Ref: TM-T10850L
1mg73,00€5mg149,00€1mL*10mM (DMSO)160,00€10mg213,00€25mg319,00€50mg447,00€100mg610,00€ORIC-944 TFA
ORIC-944 TFA is an orally bioavailable selective polycomb repressive complex 2 (PRC2) inhibitor with antitumor activity.Formule :C28H26F4N6O3Couleur et forme :SoildMasse moléculaire :570.54LLY-284
CAS :LLY-284, a less active PRMT5 inhibitor diastereomer of LLY-283, serves as its negative control.Formule :C17H18N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.35PARP/EZH2-IN-1
CAS :PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.Formule :C43H41FN8O5Couleur et forme :SolidMasse moléculaire :768.85METTL16-IN-1
METTL16-IN-1 is a potent inhibitor of METTL16, with an IC50 value of 1.7 μM and a Kd value of 1.35 μM. It effectively suppresses the binding of U6 snRNA deletion to the METTL16 MTD, with an IC50 value of 2.5 μM. METTL16-IN-1 also exhibits antitumor activity.Formule :C19H12BrN3O6S2Masse moléculaire :520.93509DDO-2093
CAS :DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.Formule :C29H37ClFN9O3Couleur et forme :SolidMasse moléculaire :614.12GSK 591 dihydrochloride
CAS :Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.Formule :C22H30Cl2N4O2Couleur et forme :SolidMasse moléculaire :453.41UNC-4219 TFA
CAS :UNC4219 is a control for UNC3866, blocking Kme reader function in CBX & CDY chromodomains.Formule :C46H69F3N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :923.085CPI-1328
CAS :CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.Formule :C28H36ClN3O4SCouleur et forme :SolidMasse moléculaire :546.12Gintemetostat
CAS :Gintemetostat (KTX-1001) is a potent NSD2 inhibitor (IC50=0.001-0.01μM) for treating NSD2-dysregulated cancers.Formule :C25H26F4N8O2Couleur et forme :SolidMasse moléculaire :546.522'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS :2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.Formule :C9H13ClFN3O4Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :281.67AMI-1 free acid
CAS :AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.
Formule :C21H16N2O9S2Degré de pureté :97.8%Couleur et forme :SolidMasse moléculaire :504.49PROTAC EZH2 Degrader-1
CAS :PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.Formule :C54H67N7O8Couleur et forme :SolidMasse moléculaire :942.15MS8511 hydrochloride
CAS :MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.Formule :C28H42ClN5O3Degré de pureté :99.24% - 99.24%Couleur et forme :SolidMasse moléculaire :532.12O6BTG-octylglucoside
CAS :O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Formule :C24H34BrN5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :616.53(R)-GSK-3685032
CAS :(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.Formule :C22H24N6OSCouleur et forme :SolidMasse moléculaire :420.54O6-Benzylguanine
CAS :Formule :C12H11N5ODegré de pureté :>98.0%(T)(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :241.25DA-3003-1
CAS :DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.Formule :C15H16ClN3O3Degré de pureté :99.27% - 99.79%Couleur et forme :SolidMasse moléculaire :321.765'-Azido-5'-deoxyadenosine
CAS :5'-Azido-5'-deoxyadenosine is a purine nucleoside analogue, inhibit Trichomonas vaginalis and PRMT5 , click chemistry alkyne, DBCO, or BCN groups.Formule :C10H12N8O3Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :292.25EHMT2-IN-1
CAS :EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.Formule :C18H23N7OCouleur et forme :SolidMasse moléculaire :353.42(R)-HH2853
CAS :(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.Formule :C31H36F3N7O3Degré de pureté :97.53% - 98.85%Couleur et forme :SolidMasse moléculaire :611.66EZM0414 TFA
CAS :EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.Formule :C24H30F4N4O4Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :514.51PR5-LL-CM01
CAS :PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers.Formule :C23H27N7Couleur et forme :SolidMasse moléculaire :401.51AZ505 ditrifluoroacetate
CAS :AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).Formule :C33H40Cl2F6N4O8Couleur et forme :SolidMasse moléculaire :805.59EPZ020411
CAS :EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).Formule :C25H38N4O3Couleur et forme :SolidMasse moléculaire :442.6AS-85
CAS :AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.Formule :C26H28F3N5O3S2Degré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :579.66Tazemetostat
CAS :Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.Formule :C34H44N4O4Degré de pureté :98.24% - ≥95%Couleur et forme :SolidMasse moléculaire :572.74Ref: TM-T1788
2mg34,00€5mg50,00€1mL*10mM (DMSO)63,00€10mg70,00€25mg87,00€50mg96,00€100mg144,00€500mg363,00€MRTX9768
CAS :MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.Formule :C24H17FN6ODegré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :424.43Pinometostat
CAS :Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.Formule :C30H42N8O3Degré de pureté :99.19% - 99.86%Couleur et forme :SolidMasse moléculaire :562.71SGC2085 HCl
CAS :SGC2085: potent, selective CARM1 inhibitor; IC50=50 nM; >100x selectivity vs other PRMTs; impacts cancer growth.Formule :C19H24N2O2·HClDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :348.87Ref: TM-T4013
1mg88,00€2mg142,00€5mg180,00€1mL*10mM (DMSO)230,00€10mg324,00€25mg537,00€50mg782,00€100mg1.071,00€LLY-507
CAS :LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.Formule :C36H42N6ODegré de pureté :99.58% - 99.93%Couleur et forme :SolidMasse moléculaire :574.76Ref: TM-T6879
1mg42,00€2mg52,00€5mg80,00€1mL*10mM (DMSO)104,00€10mg131,00€25mg289,00€50mg522,00€100mg747,00€OICR-9429
CAS :OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.Formule :C29H32F3N5O3Degré de pureté :97.07% - 99.93%Couleur et forme :SolidMasse moléculaire :555.59Ref: TM-T6916
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)92,00€10mg105,00€25mg177,00€50mg295,00€100mg475,00€TP-064
CAS :TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.Formule :C28H34N4O2Degré de pureté :97.85%Couleur et forme :SolidMasse moléculaire :458.6Ref: TM-T28996
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)75,00€10mg113,00€25mg231,00€50mg462,00€100mg673,00€AMI-1
CAS :AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).Formule :C21H14N2Na2O9S2Degré de pureté :98% - 99.98%Couleur et forme :DrypowderMasse moléculaire :548.45SETDB1-TTD-IN-1
CAS :SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.Formule :C28H31N5O2Degré de pureté :98.26% - 99.96%Couleur et forme :SolidMasse moléculaire :469.58HLCL-61 hydrochloride
CAS :HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.Formule :C23H24N2O·ClHDegré de pureté :99.88% - 99.95%Couleur et forme :SolidMasse moléculaire :380.91MS049
CAS :MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.Formule :C15H24N2ODegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :248.36Ref: TM-T4378
2mg34,00€5mg49,00€1mL*10mM (DMSO)52,00€10mg80,00€25mg149,00€50mg222,00€100mg334,00€200mg494,00€SGC707
CAS :SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.Formule :C16H18N4O2Degré de pureté :99.75% - 99.89%Couleur et forme :SolidMasse moléculaire :298.34BRD9539
CAS :BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μMFormule :C24H21N3O3Degré de pureté :98% - 99.57%Couleur et forme :SolidMasse moléculaire :399.44MS023
CAS :MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,Formule :C17H25N3ODegré de pureté :98.31% - 99.87%Couleur et forme :SolidMasse moléculaire :287.4Ref: TM-T6900
1mg37,00€2mg49,00€1mL*10mM (DMSO)79,00€5mg84,00€10mg113,00€25mg230,00€50mg358,00€100mg532,00€500mg1.153,00€Zebularine
CAS :Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.Formule :C9H12N2O5Degré de pureté :99.04% - >99.99%Couleur et forme :SolidMasse moléculaire :228.2UNC0642
CAS :UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).Formule :C29H44F2N6O2Degré de pureté :98.75% - 99.5%Couleur et forme :SolidMasse moléculaire :546.7Ref: TM-T4166
1mg38,00€2mg50,00€5mg82,00€1mL*10mM (DMSO)89,00€10mg124,00€25mg219,00€50mg358,00€100mg537,00€200mg782,00€EED226
CAS :EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.Formule :C17H15N5O3SDegré de pureté :98.14% - 99.33%Couleur et forme :SolidMasse moléculaire :369.4Succinic acid sodium
CAS :Succinic acid sodium is an orally active anxiolytic.Formule :C4H6O4·xNaCouleur et forme :Solidγ-Oryzanol
CAS :γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in theFormule :C40H58O4Degré de pureté :mixture - mixtureCouleur et forme :White Or White Crystalline Powder OdourlessMasse moléculaire :602.9GSK591
CAS :GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).Formule :C22H28N4O2Degré de pureté :99.35% - 99.45%Couleur et forme :SolidMasse moléculaire :380.48Ref: TM-T6853
1mg46,00€2mg58,00€5mg95,00€1mL*10mM (DMSO)101,00€10mg137,00€25mg268,00€50mg404,00€100mg567,00€OTS186935 hydrochloride
OTS186935 HCl inhibits SUV39H2 (IC50 6.49 nM), curbs tumor growth in mice, and modulates γ-H2AX in cancer cells.Formule :C25H27Cl2N5O2Couleur et forme :SolidMasse moléculaire :522.31SGC0946
CAS :SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.Formule :C28H40BrN7O4Degré de pureté :98% - 99.82%Couleur et forme :SolidMasse moléculaire :618.57Gambogenic acid
CAS :Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.Formule :C38H46O8Degré de pureté :97.47% - 99.6%Couleur et forme :SolidMasse moléculaire :630.77Ref: TM-T8201
1mg47,00€5mg92,00€1mL*10mM (DMSO)128,00€10mg152,00€25mg268,00€50mg429,00€100mg685,00€200mg888,00€UNC0646
CAS :UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Formule :C36H59N7O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :621.9AZ505
CAS :AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).Formule :C29H38Cl2N4O4Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :577.54Ref: TM-TQ0100
1mg60,00€5mg130,00€1mL*10mM (DMSO)165,00€10mg178,00€25mg295,00€50mg462,00€100mg623,00€Tazemetostat hydrobromide
CAS :Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).Formule :C34H45BrN4O4Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :653.65Ref: TM-T17002
2mg40,00€5mg57,00€10mg77,00€1mL*10mM (DMSO)79,00€50mg90,00€100mg150,00€200mg219,00€500mg358,00€BIX-01294
CAS :BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).Formule :C28H38N6O2Degré de pureté :98.58% - 99.64%Couleur et forme :SolidMasse moléculaire :490.64Ref: TM-T7697
1mg38,00€5mg80,00€10mg111,00€1mL*10mM (DMSO)124,00€25mg197,00€50mg295,00€100mg447,00€200mg607,00€Piribedil
CAS :Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.Formule :C16H18N4O2Degré de pureté :99.79% - 99.82%Couleur et forme :SolidMasse moléculaire :298.34C-7280948
CAS :C-7280948 is a PRMT1 inhibitor.Formule :C14H16N2O2SDegré de pureté :99.55% - ≥95%Couleur et forme :SolidMasse moléculaire :276.35Ref: TM-T2097
5mg46,00€1mL*10mM (DMSO)49,00€10mg66,00€25mg109,00€50mg178,00€100mg268,00€200mg414,00€500mg667,00€CM-579 trihydrochloride
CM-579 trihydrochloride: reversible G9a/DNMT inhibitor with IC50s 16 nM (G9a) & 32 nM (DNMT); potent against various cancer cells.Formule :C29H43Cl3N4O3Couleur et forme :SolidMasse moléculaire :602.04EPZ005687
CAS :EPZ005687 is a potent and selective inhibitor of EZH2.Formule :C32H37N5O3Degré de pureté :97.06% - 99.64%Couleur et forme :SolidMasse moléculaire :539.67WDR5-0103
CAS :WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).Formule :C21H25N3O4Degré de pureté :98% - 99.61%Couleur et forme :SolidMasse moléculaire :383.44
