Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
451 produits trouvés pour "Méthyltransférase de l’ADN".
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Dot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Couleur et forme :Odour SolidEPZ-719
CAS :EPZ-719 is a selective and orally available SETD2 inhibitor (IC50 = 0.005 μM), with anti-cancer activity, and can be used for hematological malignancies.Formule :C22H31FN4O3SDegré de pureté :99.95%Couleur et forme :White SolidMasse moléculaire :450.57EZH2-IN-5
CAS :EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Formule :C26H37BrN4O2Couleur et forme :SolidMasse moléculaire :517.512TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Couleur et forme :Odour SolidEEDi-5285
CAS :EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.Formule :C24H22FN5O3SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :479.53AS-99 TFA
CAS :AS-99 TFA is an ASH1L inhibitor (IC50=0.79 μM) with anti-leukemic activity. It induces apoptosis, downregulates MLL target genes, and reduces leukemia burden in vivo.Formule :C29H31F6N5O5S2Couleur et forme :Yellow SolidMasse moléculaire :707.71SAH-EZH2
CAS :EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.Formule :C155H256N48O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3432.05A-893
CAS :A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Formule :C29H38Cl2N4O4Couleur et forme :SolidMasse moléculaire :577.54UNC4976 TFA
UNC4976 TFA boosts CBX7 chromodomain interaction with nucleic acids and blocks gene-specific H3K27me3 binding, while enhancing DNA/RNA attachment.Formule :C49H71F3N6O10Couleur et forme :SolidMasse moléculaire :961.12PRMT5-IN-43
CAS :PRMT5-IN-43 (compound 4A) is an inhibitor of PRMT5, primarily utilized in cancer research.Formule :C22H17ClF3N5O2Couleur et forme :SolidMasse moléculaire :475.85Tet1
CAS :Tet1 is a peptide with the sequence HLNILSTLWKYRC. It specifically binds to the neuronal ganglioside receptor GT1b, which gives it the ability to target neurons. Tet1 is suitable for research related to drug delivery.Formule :C76H119N21O18SCouleur et forme :SolidMasse moléculaire :1646.95G9D-4
G9D-4 is an effective degrader of G9a with a DC50 value of 0.1 μM in PANC-1 cells, and it does not directly interfere with GLP proteins (DC50 greater than 10 μM). This compound plays a significant role in pancreatic cancer research.Couleur et forme :Odour SolidLLC0424
LLC0424 is a potent and selective degrader of the nuclear receptor-binding SET domain 2 (NSD2), with a DC50 of 20 nM. It reduces H3K36me2 levels and inhibits the growth of acute lymphoblastic leukemia (ALL) cell lines, making it useful for research in ALL.Couleur et forme :Odour SolidMS-8709
CAS :MS-8709 is a potent and selective G9a/GLP PROTAC Degrader with a DC50(G9a) of 274 nM and a DC50(GLP) of 260 nM. It induces G9a/GLP protein degradation in a concentration-dependent and time-dependent manner via the ubiquitin-proteasome system, without affecting mRNA expression levels. MS-8709 demonstrates superior cell growth inhibition compared to the parent compound UNC0642 in prostate cancer, leukemia, and lung cancer cell models, and exhibits mouse pharmacokinetic characteristics suitable for in vivo efficacy studies.Formule :C64H95F2N11O7SDegré de pureté :99.98%Masse moléculaire :1200.57MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Couleur et forme :Odour SolidC 21
CAS :PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Formule :C90H161ClN36O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2166.94Methylation Compound Library
xnum methylation-related compounds that can be used for high-throughput and high-content screening.Couleur et forme :Odour SolidRef: TM-L3510
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderPRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Couleur et forme :Odour SolidDNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Couleur et forme :Odour SolidFTX-6058 hydrochloride
CAS :FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Formule :C22H19ClFN5O2Couleur et forme :SolidMasse moléculaire :439.87
