Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
451 produits trouvés pour "Méthyltransférase de l’ADN".
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PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Formule :C50H58FN11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :960.13NSC 370284
CAS :NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formule :C21H25NO6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :387.43PRMT1-IN-1
CAS :PRMT1-IN-1 is a PRMT1 inhibitor.Formule :C20H7Br6NO5Couleur et forme :SolidMasse moléculaire :820.702SAH-EZH2
CAS :EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.Formule :C155H256N48O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3432.05Bleximenib
CAS :Bleximenib (JNJ-75276617) oxalate is an orally active and highly selective menin–KMT2A interaction inhibitor, with IC50 values of 0.1 nM in humans, 0.045 nM in mice, and ≤0.066 nM in dogs, Bleximenib effectively suppresses tumor cell proliferation while inducing apoptosis and cellular differentiation. Bleximenib serves as a powerful investigational agent for leukemia and other KMT2A-driven malignancies in preclinical cancer research.Formule :C32H50FN7O3Couleur et forme :Yellow OilMasse moléculaire :599.8MS2133
MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.Formule :C58H66ClF3N14O11S2Couleur et forme :SolidMasse moléculaire :1290.41175(S)-Kaempferide
(S)-Kaempferide (ZINC167686681) is a DNA methyltransferase (DNMT) inhibitor used in tumor research.Formule :C16H12O6Couleur et forme :SolidMasse moléculaire :300.06339PRMT5-IN-40
CAS :PRMT5-IN-40 (compound 104) is an effective inhibitor of PRMT5.Formule :C20H16F5N5O2SMasse moléculaire :485.43UNC2399
CAS :UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its ICFormule :C67H104N10O17SCouleur et forme :SolidMasse moléculaire :1353.68EPZ-719
CAS :EPZ-719 is a selective and orally available SETD2 inhibitor (IC50 = 0.005 μM), with anti-cancer activity, and can be used for hematological malignancies.Formule :C22H31FN4O3SDegré de pureté :99.95%Couleur et forme :White SolidMasse moléculaire :450.57ALKBH1-IN-1
ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor with IC50 values of 0.026 μM in fluorescence polarization assays and 1.39 μM in enzyme activity assays. It can regulate the levels of DNA 6mA modifications and is useful for studying the functions of ALKBH1 and DNA 6mA.Formule :C16H11F3N4O4Masse moléculaire :380.07324UNC10013
UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.Couleur et forme :Odour SolidMRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Couleur et forme :Odour SolidCM112
CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.Formule :C39H61N5O7Couleur et forme :SolidMasse moléculaire :711.4571MS33
CAS :MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Formule :C64H84F3N11O7SCouleur et forme :SolidMasse moléculaire :1208.5E67-2
CAS :E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Formule :C21H36N6O2Couleur et forme :SolidMasse moléculaire :404.559EEDi-5285
CAS :EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.Formule :C24H22FN5O3SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :479.53AS-99 TFA
CAS :AS-99 TFA is an ASH1L inhibitor (IC50=0.79 μM) with anti-leukemic activity. It induces apoptosis, downregulates MLL target genes, and reduces leukemia burden in vivo.Formule :C29H31F6N5O5S2Couleur et forme :Yellow SolidMasse moléculaire :707.71UNC4976 TFA
UNC4976 TFA boosts CBX7 chromodomain interaction with nucleic acids and blocks gene-specific H3K27me3 binding, while enhancing DNA/RNA attachment.Formule :C49H71F3N6O10Couleur et forme :SolidMasse moléculaire :961.12CS-VIP 8
CS-VIP 8 is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces conformational changes in the MLL1 complex, causing the dissociation of MLL1 from the complex and inhibiting MLL1 histone methyltransferase activity, thereby regulating HOX gene expression. CS-VIP 8 shows potential for research in hematological diseases such as leukemia.Formule :C43H52F4N12O7Couleur et forme :SolidMasse moléculaire :924.4018
