Endocrinologie/Hormones
Les inhibiteurs en endocrinologie/hormonaux sont des composés qui bloquent l'action des hormones ou interfèrent avec les voies de signalisation hormonales. Ces inhibiteurs sont essentiels pour étudier la régulation des systèmes endocriniens et pour développer des traitements pour les maladies liées aux hormones, telles que le diabète, les troubles de la thyroïde et les cancers hormonodépendants. En modulant l'activité hormonale, ces inhibiteurs peuvent aider à élucider les interactions complexes au sein du système endocrinien. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité en endocrinologie/hormonaux pour soutenir vos recherches en endocrinologie, pharmacologie et sciences médicales.
Sous-catégories appartenant à la catégorie "Endocrinologie/Hormones"
- Récepteur des androgènes(230 produits)
- Annexine A(16 produits)
- Aromatase(23 produits)
- Récepteur d'œstrogène/progestatif(66 produits)
- GPR(1 produits)
- Récepteur des glucocorticoïdes(165 produits)
- LHRH(2 produits)
- Récepteur opioïde(327 produits)
- Récepteur de prostaglandine(126 produits)
- RAAS(89 produits)
- Réductase(51 produits)
- Somatostatine(57 produits)
- Récepteur des hormones thyroïdiennes (THR)(34 produits)
- Récepteur de la vasopressine(48 produits)
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3427 produits trouvés pour "Endocrinologie/Hormones"
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THR-β agonist 6
CAS :THR-β Agonist 6, a selective and orally active compound targeting the thyroid hormone receptor β (THR-β), demonstrates specificity with EC50 values of 0.03 μMFormule :C20H14Cl2N6O3Couleur et forme :SolidMasse moléculaire :457.27β-Endorphin, equine
CAS :Endorphin Beta is A substance produced in the brain, especially in the pituitary gland, Endorphin Beta blocks the sensation of pain.Formule :C154H248N42O44SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3423.94DPP-4/GPR119 modulator 1
CAS :Orally active DPP-4 inhibitor/GPR119 agonist, Compound 22 lowers glucose, moderate hERG inhibition, IC50 4.9 µM, for diabetes research.Formule :C30H39ClN10O3Couleur et forme :SolidMasse moléculaire :623.15Bexirestrant
CAS :Bexirestrant is an orally active ER-α degrader commonly employed in the research of antiestrogen and antineoplastic therapies.Formule :C29H26F3NO2Couleur et forme :SolidMasse moléculaire :477.527Ganoderic acid Df
CAS :Ganoderic acid Df, a lanostane triterpenoid from Ganoderma lucidum, inhibits aldose reductase with IC50 of 22.8 μM.Formule :C30H44O7Couleur et forme :SolidMasse moléculaire :516.67Inocoterone acetate
CAS :Inocoterone acetate is a nonsteroidal antiandrogen that binds to the androgen receptor and possesses antiandrogenic activity in animal models.Formule :C18H26O3Couleur et forme :SolidMasse moléculaire :290.40AM-5262
CAS :AM-5262 is a potent GPR40 Full Agonist with improved rat PK profile and general selectivity profile.Formule :C33H35FO4Couleur et forme :SolidMasse moléculaire :514.63ER degrader 4
CAS :ER degrader 4, a selective and orally active compound, effectively degrades estrogen receptors and exhibits anti-tumor activity [1].Formule :C26H19FO4SCouleur et forme :SolidMasse moléculaire :446.49Antidiabetic agent 15
Antidiabetic agent 15 (compound 1B15) acts as a dual inhibitor of AT1R and NEP, reducing oxidative stress and restoring mitochondrial membrane potential.Formule :C26H23NO5Couleur et forme :SolidMasse moléculaire :429.15762Nurr1 agonist 12
Nurr1 agonist 12 (Compound 37) acts as an agonist of the nuclear receptor-related protein 1 (Nurr1), enhancing its transcriptional activity with an EC50 of 0.06 μM. It stimulates human response elements NBRE, NurRE, and DR5 with EC50 values of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Additionally, Nurr1 agonist 12 induces the expression of neurotrophic genes regulated by Nurr1, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin). The compound also demonstrates neuroprotective effects against neurotoxicity caused by Paraquat.Formule :C18H12ClN3OCouleur et forme :SolidMasse moléculaire :321.76Myrciacetin
CAS :Myrciacetin from Rhododendron inhibits rat aldose reductase with IC50 of 13 μM.Formule :C17H16O6Couleur et forme :SolidMasse moléculaire :316.309Epi-Cryptoacetalide
Epi-Cryptoacetalide is a useful organic compound for research related to life sciences and the catalog number is T126054.Formule :C18H22O3Couleur et forme :SolidMasse moléculaire :286.371ODM-204
CAS :ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme(IC50s of 80 nM and 22 nM, respectively).Formule :C20H21F3N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :374.40MT-7716 hydrochloride
CAS :MT-7716 hydrochloride is a selective agonist of non-peptide nociceptin receptor (NOP)Formule :C27H29ClN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :477(S,S)-J-113397
CAS :(S,S)-J-113397 is an isomer of J-113397 . J-113397 is an Opioid Receptor antagonist [1] .Formule :C24H37N3O2Couleur et forme :SolidMasse moléculaire :399.57GPR88 agonist 2
GPR88 agonist 2 (compound 53) serves as a potent, brain-penetrant agonist of GPR88, exhibiting an EC50 of 14 µM in the GPR88 cAMP functional assay [1].Couleur et forme :Odour SolidGalloylalbiflorin
CAS :Galloylalbiflorin, an AR antagonist with IC50 53.3μM, is sourced from Paeonia lactiflora roots, exhibiting anti-androgenic properties.Formule :C30H32O15Couleur et forme :SolidMasse moléculaire :632.57TD-802
CAS :TD-802, an AR-targeting PROTAC with microsomal stability, shows promise for castration-resistant prostate cancer.Formule :C52H61ClN10O6Couleur et forme :SolidMasse moléculaire :957.56GNE-502
CAS :GNE-502 is an orally active and potent estrogen receptor (ER) degrader, specifically designed for research on breast cancer.Formule :C25H30FN3O3SCouleur et forme :SolidMasse moléculaire :471.59Clocinnamox mesylate
CAS :Clocinnamox mesylate: irreversible μ-opioid blocker; Ki: 0.7 nM (mouse μ), 1.9 nM (δ), 5.7 nM (κ).Formule :C30H33ClN2O7SCouleur et forme :SolidMasse moléculaire :601.11CP 85339
CAS :CP 85339 is an aspartic acid protease inhibitor for X-ray analysis of peptide-renin complexes.Formule :C31H49ClN4O6SCouleur et forme :SolidMasse moléculaire :641.26PSDalpha
PSDalpha, a conjugate of PS, TB, and 17β-estradiol, degrades ERα with peak absorption at 465 nm, effectively inhibiting MCF-7 cell growth.Formule :C44H39N3O2SCouleur et forme :SolidMasse moléculaire :673.86Bufrolin
CAS :Bufrolin is a potent GPR35 agonist, mast cell stabilizer, and anti-inflammatory research agent.Formule :C18H16N2O6Couleur et forme :SolidMasse moléculaire :356.33[Met5]-Enkephalin, amide
CAS :[Met5]-Enkephalin, amide activates δ and ζ opioid receptors; has multiple forms and varying plasma levels.Formule :C27H36N6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.68Angiotensin II (1-4), human
CAS :Angiotensin II constricts blood vessels and boosts blood pressure by escalating norepinephrine release.Formule :C24H37N7O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :551.59Glucocorticoids receptor agonist 2
CAS :Arylpyrazole-based glucocorticoid agonist with potent anti-inflammatory effects; doesn't affect insulin secretion.Formule :C25H25FN2OCouleur et forme :SolidMasse moléculaire :388.48PD 125967
CAS :PD 125967 is a renin inhibitor, which represents a group of pharmaceutical drugs used primarily to treat essential hypertension.Formule :C51H67N5O4Couleur et forme :SolidMasse moléculaire :814.111-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone
CAS :Methyl-2-quinolone from Evodia rutaecarpa blocks angiotensin II receptor with 48.2 μM IC50.Formule :C25H35NOCouleur et forme :SolidMasse moléculaire :365.55PD 132002
CAS :PD 132002 is a renin inhibitor.Formule :C31H50N4O9SCouleur et forme :SolidMasse moléculaire :654.82Boc-ypgflt(O-tbu)
CAS :Boc-ypgflt(O-tbu) is a delta-receptor-selective opioid antagonist.Formule :C44H64N6O11Couleur et forme :SolidMasse moléculaire :853.01Faznolutamide
CAS :Faznolutamide is an antiandrogen agent [1] [2] .Formule :C19H17FN4O2SCouleur et forme :SolidMasse moléculaire :384.43PROTAC ERα Y537S degrader-1
CAS :PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group.Formule :C46H49N5O6Couleur et forme :SolidMasse moléculaire :767.91(Rac)-SNC80
CAS :(Rac)-SNC80, a racemic δ-opioid agonist (K i 1.78 nM), shows potential for treating various headache disorders.Formule :C28H39N3O2Couleur et forme :SolidMasse moléculaire :449.63[Ala17]-MCH
CAS :Potent MCH receptor agonist with EC50 of 17 nM (MCH1) & 54 nM (MCH2); prefers MCH1 (Ki 0.16 nM) over MCH2 (Ki 34 nM).Formule :C97H155N29O26S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2271.71Raloxifene 4-Monomethyl Ether
CAS :Raloxifene 4-Monomethyl Ether (Compound 37), an estrogen receptor α inhibitor, has an IC50 of 1 μM against MCF-7 cells.Formule :C29H29NO4SCouleur et forme :SolidMasse moléculaire :487.61Saralasin
CAS :Competitive non-selective angiotensin II antagonist.Formule :C42H65N13O10Degré de pureté :98%Couleur et forme :PowderMasse moléculaire :912Triamcinolone Benetonide
CAS :Triamcinolone benetonide is a synthetic glucocorticoid corticosteroid exhibiting potent anti-inflammatory properties.Formule :C35H42FNO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :623.71Ac-RYYRWK-NH2
CAS :Selective NOP receptor partial agonist peptide; Ki=0.71 nM; >4000 nM for μ, δ, κ receptors; boosts food intake in vivo.Formule :C49H69N15O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1012.17AZ'6421
CAS :"AZ'6421: A PROTAC degrading estrogen receptor alpha; potent in anti-tumor activity, useful for cancer research."Formule :C52H65F3N6O7SCouleur et forme :SolidMasse moléculaire :975.17Naldemedine
CAS :Naldemedine (S 297995), developed by Shionogi, is a drug for opioid side effects like constipation. It's well tolerated with minor GI issues.Formule :C32H34N4O6Couleur et forme :SolidMasse moléculaire :570.64BigLEN(rat)
CAS :Potent GPR171 agonist (EC50 = 1.6 nM). ProSAAS-derived peptide. Regulates body weight in mice and promotes the outgrowth of neurites in Neuro2A cells.Formule :C76H128N24O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1746ER degrader 5
CAS :ER degrader 5: potent ER degrader, anti-cancer, for breast cancer research.Formule :C26H18F2O4SCouleur et forme :SolidMasse moléculaire :464.48C-Type Natriuretic Peptide (1-53), human
CAS :CNP, from natriuretic family, first in pigs, now in other species, processes into CNP-22/CNP-53, similar to ANP/BNP, with varying potencies.Formule :C251H417N81O71S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5801.77RLA-5331
RLA-5331: iron activator with anti-androgen properties; inhibits mCRPC cell proliferation.Formule :C40H43F3N6O7SCouleur et forme :SolidMasse moléculaire :808.87PD 123177
CAS :PD 123177 is an inhibitor of Nonpeptide angiotensin AII-2.Formule :C29H28N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.56AKR1Cs-IN-1
AKR1Cs-IN-1 (Compound 29) is an effective and broad-spectrum inhibitor of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). It achieves subtype inhibition by simultaneously binding to the SP2 and SP3 pockets, thereby blocking metabolic pathways related to drug resistance. In enzyme assays, AKR1Cs-IN-1 exhibits significant inhibitory activity with IC50 values of 0.09, 0.28, 0.05, and 0.51 µM for AKR1C1, AKR1C2, AKR1C3, and AKR1C4, respectively. The compound shows excellent resensitizing effects in doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, effectively enhancing the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on breast cancer resistance.Couleur et forme :Odour Solid[Orn8]-Urotensin II
CAS :[Orn8]-Urotensin II is a Urotensin receptor ligand and a partial agonist at Urotensin receptors.Formule :C63H83N13O18S2Couleur et forme :SolidMasse moléculaire :1374.5517-Epiestriol
CAS :17-Epiestriol, metabolite of estrone, forms via 16α-hydroxy intermediate and binds ERα and ERβ with affinity less than 17β-estradiol.Formule :C18H24O3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :288.38Emd 55068
CAS :Emd 55068 is a synthetic antagonist of renin.Formule :C41H65N9O6Couleur et forme :SolidMasse moléculaire :780.01(S)-CVN424
CAS :(S)-CVN424 modulates GPR6, key for neurological/psychiatric research, including Parkinson's.Formule :C24H29F2N5O3Couleur et forme :SolidMasse moléculaire :473.525Nocistatin
CAS :Nocistatin, a neuropeptide, blocks Nociceptin effects and inhibits 5-HT release, acting on an opioid-related receptor.Formule :C32H56N10O12Couleur et forme :SolidMasse moléculaire :772.85Helianorphin-19
Helianorphin-19: Potent KOR agonist (Ki=25 nM; EC50=45 nM), 200x selective over μ/δ receptors, effective in mouse pain model, non-sedative.Couleur et forme :LiquidTRV056
CAS :TRV056 is a Gq-biased AT1R agonist effective in Gq-mediated signaling and a basis for similar drug development.Formule :C52H74N14O13Couleur et forme :SolidMasse moléculaire :1103.249β-Lipotropin (60-65)
CAS :β-Lipotropin (60-65) (β-LPH (60-65)), an opioid agonist, is a significant [1] opioid peptide.Formule :C33H47N9O8SCouleur et forme :SolidMasse moléculaire :729.85DP32
CAS :DP32 is a dual-function compound incorporating an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. It is applicable in analgesia-related research.Formule :C57H77N13O7Couleur et forme :SolidMasse moléculaire :1056.30[DAla2, DArg6] Dynorphin A, (1-13) (porcine)
CAS :'[DAla2, DArg6] Dynorphin A (1-13) porcine is a potent opioid peptide resistant to enzymatic degradation.'Formule :C76H128N24O15Couleur et forme :SolidMasse moléculaire :1617.98β-Endorphin (rat)
CAS :β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities.Formule :C157H254N42O44SCouleur et forme :SolidMasse moléculaire :3466.07Dynorphin B (1-13) (TFA)
Dynorphin B (1-13) TFA acts as an agonist on opioid κ-receptor .Formule :C76H116N21F3O19Couleur et forme :SolidMasse moléculaire :1684.86Kylo-0603
CAS :KYLO-0603 is an orally active and selective THR-β agonist with an EC50 of 31.07 nM. It effectively reduces serum cholesterol and low-density lipoprotein cholesterol levels. By activating THR-β receptors, KYLO-0603 enhances the expression of THR-regulated genes like iodothyronine deiodinase 1 (Dio1), malic enzyme 1 (Me1), and thyroid hormone-responsive (Thrsp) gene, while it inhibits the expression of inflammatory and fibrosis-related genes, including low-density lipoprotein receptor (LDL-R) gene. This compound is applicable for the study of metabolic associated steatohepatitis (MASH) and liver fibrosis.Formule :C81H134N8O28Couleur et forme :SolidMasse moléculaire :1667.97(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8)
CAS :E-2078, known chemically as (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8), is a stable analog of Dynorphin A (1–8) and functions as a kappa opioidFormule :C50H81N15O9Couleur et forme :SolidMasse moléculaire :1036.27PRL 3195
CAS :PRL 3195: Somatostatin antagonist, Ki: 6 nM (sst5), 17 nM (sst2), 66 nM (sst3), 1 μM (sst1/4).Formule :C58H69ClN12O9S2Couleur et forme :SolidMasse moléculaire :1177.83ALR2-IN-6
ALR2-IN-6 (compound 9) is a potent competitive inhibitor of ALR2, with a Ki value of 0.064 μM. It is applicable in research related to neuropathy, retinopathy, and nephropathy.Formule :C21H19BrFN3OCouleur et forme :SolidMasse moléculaire :427.06955Prepro-TRH-(160-169)
CAS :Prepro-TRH-(160-169), a pro-TRH peptide, enhances TRH-stimulated TSH secretion.Formule :C54H75N11O18SCouleur et forme :SolidMasse moléculaire :1198.3THR-β agonist 2 diacetate
THR-β agonist 2 diacetate (Compound 3) is a potent THR-β agonist with potential applications in researching metabolic disorders such as obesity, hyperlipidemia, hypercholesterolemia, and diabetes, as well as other conditions like steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis, and other related diseases and conditions.Couleur et forme :Odour SolidAc-RYYRWK-NH2 TFA
CAS :Ac-RYYRWK-NH2: potent, specific NOP receptor partial agonist with 0.071 nM affinity; no affinity for μ/κ/δ-opioid receptors.Formule :C51H70F3N15O11Couleur et forme :SolidMasse moléculaire :1126.21PROTAC ERα Degrader-7
CAS :PROTAC ERα Degrader-7 (Compound i-320) is a powerful PROTAC degrader targeting the estrogen receptor alpha (ERα), exhibiting a DC50 of 0.000006 µM. This compound consists of a cereblon-binding segment, LBM, connected to ERBM, an ERα-binding ligand that includes a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring [1].Formule :C46H49F2N5O4Couleur et forme :SolidMasse moléculaire :773.91Melanin Concentrating Hormone, salmon TFA
MCH (salmon) TFA is a 19-amino-acid neuropeptide affecting appetite, energy, sleep, and heart health via GPCR SLC-1/GPR24 and MCHR2.Formule :C91H140F3N27O26S4Couleur et forme :SolidMasse moléculaire :2213.5Aclerastide
CAS :Aclerastide, an angiotensin receptor agonist, decreases fibrosis in wounds; effect increases with use duration, blocked by AT antagonist.Formule :C42H64N12O11Couleur et forme :SolidMasse moléculaire :913.03PROTAC ERα Degrader-8
CAS :PROTAC ERα Degrader-8 (compound ii-56), a highly potent degrader of Erα, achieves a DC50 of just 0.000006 μM in MCF7 cells [1].Formule :C47H51N5O4Couleur et forme :SolidMasse moléculaire :749.94[Nphe1]Nociceptin(1-13)NH2 TFA
[Nphe1]Nociceptin(1-13)NH2 is a selective nociceptin receptor antagonist with potential analgesic properties, pKi=8.4, pA2=6.0.Formule :C63H101F3N22O17Couleur et forme :SolidMasse moléculaire :1495.61Floramanoside C
CAS :Floramanoside C exhibits 2,2-diphenyl-1-picrylhydrazyl scavenging and aldose reductase inhibitory activities [1].Formule :C21H18O15Couleur et forme :SolidMasse moléculaire :510.36[Ala17]-MCH TFA
'[Ala17]-MCH TFA is an MCH analogue, a selective MCHR1 ligand (Ki=0.16 nM) with high affinity (Kd=0.37 nM), and low MCHR2 affinity (Ki=34 nM).Formule :C99H156F3N29O28S4Couleur et forme :SolidMasse moléculaire :2385.73MCH(human, mouse, rat) TFA
MCH TFA, a peptide, selectively binds MCH1R and MCH2R with IC50 of 0.3nM, 1.5nM; EC50s are 3.9nM (MCH1R) and 0.1nM (MCH2R) in CHO cells.Formule :C107H161F3N30O28S4Couleur et forme :SolidMasse moléculaire :2500.86Abaloparatide
CAS :Abaloparatide (BA 058) is a selective PTHR1 analog that promotes bone growth and may be researched for osteoporosis.Formule :C174H300N56O49Couleur et forme :SolidMasse moléculaire :3960.59hFSH-β-(33-53) (TFA)
hFSH-β-(33-53) TFA, a thiol-containing peptide representing the second follicle-stimulating hormone receptor (FSHR) binding domain, acts as an FSHR antagonist.Formule :C115H183N31O32SxC2HF3O2Couleur et forme :SolidMasse moléculaire :2657.96Yp537
CAS :Yp537 acts as an estrogen receptor (ER) inhibitor, specifically preventing the dimerization of the human estrogen receptor [1].Formule :C64H104N13O22PSCouleur et forme :SolidMasse moléculaire :1470.62(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin
CAS :'(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin blocks oxytocin receptors, stopping oxytocin effects on CA1 neuron currents.'Formule :C45H69N9O12S2Couleur et forme :SolidMasse moléculaire :992.21Eprosartan
CAS :Eprosartan is a selective AT1 receptor blocker with IC50s of 9.2 nM (rat) and 3.9 nM (human), used for hypertension.Formule :C23H24N2O4SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :424.51TrxR1 prodrug-1
TrxR1 prodrug-1 (compound 5u) is a potent inhibitor of TrxR1, demonstrating significant antitumor activity in nude mice and NSCLC organoids.Formule :C22H30N2O6S2Couleur et forme :SolidMasse moléculaire :482.6139,10-Dihydrophenanthrene
CAS :9,10-Dihydrophenanthrene has inhibitory activity against the androgen receptor and can be used in related research in the field of life sciences.Formule :C14H12Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :180.25DDHF20
DDHF20 is an inhibitor of Staphylococcus aureus, specifically targeting and inhibiting its thioredoxin reductase (TrxR) by acting as a competitive inhibitor at the NADPH binding site. DDHF20 shows potential for research in combating infections related to Staphylococcus aureus.Formule :C34H28O4Couleur et forme :SolidMasse moléculaire :500.58Rimexolone
CAS :Rimexolone is a glucocorticoid steroid used to treat inflammation in the eye.Formule :C24H34O3Couleur et forme :SolidMasse moléculaire :370.52Tetrahydro Aldosterone
CAS :Tetrahydro Aldosterone is a steroidal compound that inhibits the adrenal angiotensin II receptor, with an IC50 of 10 μM.Formule :C21H32O5Couleur et forme :SolidMasse moléculaire :364.48PRL 2915
CAS :PRL 2915 is a potent antagonist of the human somatostatin subtype 2 receptor (hsst 2), exhibiting a binding affinity (K_i) of 12 nM [1].Formule :C59H71ClN12O8S2Couleur et forme :SolidMasse moléculaire :1175.85PRO20
PRO20 is a specific and competitive antagonist of the (pro)renin receptor (PRR). It inhibits the calcium influx induced by Proproin with an IC50 value of 81 nmol/L. By blocking the binding of Prorenin to PRR, PRO20 inhibits the activation of the renin-angiotensin system (RAS), reducing the production of angiotensin II (Ang II) and exerting antihypertensive effects. PRO20 holds promise for research in antihypertensive agents.
Couleur et forme :Odour SolidDPC-AJ1951 TFA
DPC-AJ1951 TFA is a 14 amino acid peptide, potent PTH/PPR agonist, tested in bone resorption assays.Formule :C78H128F3N23O21Couleur et forme :SolidMasse moléculaire :1781.02(Glu2)-TRH
CAS :(Glu2)-TRH: Stable TRH analog; reduces TRH's cholinergic action; no thyroliberinase metabolism; neuroprotective with antidepressant, anticonvulsant effects.Formule :C15H22N4O6Couleur et forme :SolidMasse moléculaire :354.36Osteostatin
CAS :Osteostatin, derived from parathyroid hormone-related protein (PTHrP) 107-111, has demonstrated properties conducive to bone repair in animal models presentingFormule :C27H41N9O8Couleur et forme :SolidMasse moléculaire :619.677α-(Thiomethyl)spironolactone
CAS :7α-(Thiomethyl)spironolactone is a steroid receptor antagonist and major spironolactone metabolite, steroid metabolism, nuclear receptor, and coronavirus.Formule :C23H32O3SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :388.56NPFF1-R antagonist 1
NPFF1-R antagonist 1 (compound 8b) is a piperidine analog and an effective neuropeptide FF (NPFF) receptor antagonist. It exhibits 15-fold selectivity for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.Formule :C37H44N4OMasse moléculaire :560.35151VinclozolinM2-2204
VinclozolinM2-2204 is an androgen receptor AUTOTAC degrader with a DC50 of 200 nM in LNCaP prostate cancer cells. It induces the formation of AR+LC3+ autophagic membranes and is applicable for cancer research.Formule :C43H51Cl2N3O9Masse moléculaire :823.30024DP50
DP50 is a bifunctional compound containing both an opioid receptor agonist (MOP) and a neuropeptide FF receptor (NPFFR) antagonist. It can be utilized in studies related to analgesia.Formule :C58H72N8O7Masse moléculaire :992.5524PIPE-3297
PIPE-3297 (compound 25) is a selective kappa opioid receptor (KOR) agonist that activates the G protein signaling pathway with an EC50 of 1.1 nM and exhibits low β-arrestin-2 recruitment activity (10%). Additionally, PIPE-3297 promotes myelination and has anti-inflammatory properties.Formule :C23H30N2OMasse moléculaire :350.23581Nurr1 agonist 9
Nurr1 agonist 9 (Compound 36) acts as an agonist for Nurr1, with an EC50 of 0.090 µM and a Kd of 0.17 µM. It activates Nurr1 homodimers (NurRE, EC50 = 0.094 µM) and Nurr1-RXR heterodimers (DR5, EC50 = 0.165 µM). This compound induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in Parkinson's disease organoid models and can penetrate the human brain endothelial cell barrier.
Formule :C21H19ClN4O2Masse moléculaire :394.11965Awl 60
CAS :Awl 60 is a substance P (6-11) non-competitive antagonist.Formule :C57H65N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1036.25SB 205607 dihydrobromide
CAS :non-peptide δ1 opioid receptor agonistFormule :C23H24N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :344.45Ethamoxytriphetol
CAS :Ethamoxytriphetol is a non-steroidal estrogen antagonist.Formule :C27H33NO3Couleur et forme :SolidMasse moléculaire :419.56Bradykinin potentiator-5
CAS :Bradykinin potentiator-5 is a peptide inflammatory mediator, causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall.Formule :C30H41N7O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :611.69Enalapril
CAS :Enalapril is a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.Formule :C20H28N2O5Degré de pureté :99.47% - 99.51%Couleur et forme :SolidMasse moléculaire :376.455-O-β-D-Glucopyranosylmyricanol
5-O-beta-D-Glucopyranosylmyricanol is a useful organic compound for research related to life sciences and the catalog number is T123967.Formule :C27H36O10Couleur et forme :SolidMasse moléculaire :520.575
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