Endocrinologie/Hormones

<p>CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM.</p>

<p>CRTh2 antagonist 1 is a CRTh2 antagonist (IC50: 89 nM).</p>

<p>LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).</p>

<p>TUG-469 is an agonist of free fatty acid 1(FFA) receptor.</p>

<p>AZ12216052 is a GRP8 antagonist with anxiolytic and anti-inflammatory activity and can be used to study obesity and metabolic disorders.</p>

<p>Endomorphin 1 acetate is a μ-opioid receptor agonist with antinociceptive and analgesic effects and can be used to study neurological diseases.</p>

<p>Dimethomorph is a fungicide and sterol biosynthesis inhibitor that inhibits fungal cell wall formation,. inhibits androgen receptor (AR) .</p>

<p>PF-4455242 HCl is a selective and orally available κ-opioid receptor antagonist that exhibiting antidepressant effects.</p>

<p>Capesaris (GTX-758) is an oral estrogen receptor α agonist, used in prostate cancer research.</p>

<p>OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.</p>

<p>MK-3984 is a selective androgen receptor modulator, used in the study of conditions caused by androgen deficiency.</p>

<p>Camizestrant (Estrogen receptor antagonist 2) is an antagonist of the estrogen receptor and can be used in studies about ER+ HER2-advanced breast cancer[1].</p>

<p>Norethisterone enanthate (NSC-9564) is a long-acting parenteral progestogen with antigonadotropic effects.</p>

<p>Glutaurine aceate containing glutamine and taurine residues is an orally active hormone of the parathyroid.</p>

<p>(Rac)-Acolbifene (EM-343) is the racemic form of Acolbifene.</p>

<p>27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.</p>

<p>Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.</p>

<p>Pipendoxifene hydrochloride is a selective modulator of estrogen receptor.</p>

<p>GSK9027, a nonsteroidal GR agonist, is a partial 2×GRE reporter gene activator, less potent than dexamethasone.</p>

<p>NXT629 is a PPAR-α antagonist with anticancer activity, inhibiting PPARδ, and can be used in ovarian cancer and melanoma research.</p>

<p>Rentiapril is an orally active inhibitor of angiotensin converting enzyme (ACE), with antihypertensive activity.</p>

<p>Omapatrilat is a metalloprotease ACE and NEP dual inhibitor (Ki: 0.64 and 0.45 nM, respectively).</p>

<p>VPC-14449 is a selective androgen receptor DNA-binding domain (AR-DBD) inhibitor, useful in prostate cancer research.</p>

DS20362725 is a selective estrogen-related receptor alpha (ERRα) agonist, commonly used in the study of metabolic disorders.

<p>Ralaniten (EPI-002), a potent AR-NTD antagonist, inhibits AR with IC50 of 7.4 μM, for CRPC study.</p>

<p>ADL-5747 (ADL-5747 (free base)) (free base) is a delta opioid receptor agonist used in the treatment of neurological disorders, skin and musculoskeletal</p>

<p>TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a</p>

<p>AZD9567: potent, selective SGRM, oral, IC50=3.8nM, effective in SCW joint inflammation.</p>

<p>Moveltipril (Moveltipril calcium) is a potent angiotensin-converting enzyme (ACE) inhibitor.Moveltipril is converted to captopril in the body for action.</p>

<p>ZD-6888 Hydrochloride, an angiotensin type 1 receptor antagonist, is used potentially for the treatment of hypertension.</p>

<p>Posatirelin, a synthetic peptide, modulates and nourishes brain systems, aiding in vascular dementia research.</p>

<p>GPR35 agonist 2 (TC-G 1001) is a potent GPR35 agonist.The EC50 values of GPR35 agonist 2 in the β-arrestin and Ca2+ release assays were 26 and 3.2 nM,</p>

<p>P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R (IC50: 3.17 μM) and GPR17 (IC50: 1.67 μM) antagonist.</p>

<p>Buloxibutid: a novel AT2 receptor agonist, Ki=0.4 nM (AT2), 10 μM (AT1).</p>

<p>AT-121 is a dual μ-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively).</p>

<p>G36 is a cell-permeable non-steroidal antagonist of GPER.</p>

<p>Lorundrostat is an aldosterone synthase inhibitor.</p>

<p>Cymit Quimica provides this product solely for uses within the scope of any statute or law providing for an immunity, exemption, or exception to patent infringement (“Exempted Uses”), including but not limited to 35 U.S.C. § 271(e)(1) in the United States, the Bolar type exemption in Europe, and any corresponding exception to patent infringement in any other country. It is the sole responsibility of the purchaser or user of this product, and the purchaser or user of this product agrees to engage only in such Exempted Uses, and to comply with all applicable intellectual property laws and/or regulations. The purchaser of this product agrees to indemnify Cymit Quimica against all claims in connection with the performance of the respective commercial agreement (e.g. supply agreement) and possible infringements of intellectual property rights.</p>

<p>Terlakiren (CP-80,794) is a renin inhibitor that inhibits the potency of human renin and can be used to study neurological disorders of the hypertensive type.</p>

<p>YL-365 is a highly potent and selective GPR34 antagonist that exhibits excellent activity in neuropathic pain models for the study of neurologic diseases.</p>

<p>LY2881835 is a potent and selective GPR40 agonist.</p>

<p>Y134, an oral estrogen receptor inhibitor, is 121x more selective for ERα (Ki=0.09 nM) over ERβ (Ki=11.31 nM), and blocks ER+ breast cancer cell growth.</p>

<p>CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia.</p>

<p>GR 89696 fumarate is a highly selective κ2 opioid receptor agonist (IC50 = 0.04nM) with anti-pruritchy, anti-injury and neuroprotective effects.</p>

<p>Fezagepras sodium (Setogepram sodium salt) is an orally active GPR40 agonist and is an antagonist or inverse agonist for GPR84, with anti-fibrotic, anti-</p>

<p>IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis.</p>

<p>Trimebutine CTB salt (GIC-1001) is an opioid receptor agonist used in the study of pain.</p>

<p>SCH-486757 is an agonist of nociceptin-1 (NOP1) and orphanin FQ peptide receptors and is used in the study of cough.</p>

<p>ICI 199,441 hydrochloride is a potent, selective agonist of κ-opioid receptor.</p>

<p>ONC1-13B, an androgen receptor antagonist, is used potentially for the treatment of prostate cancer.</p>

PSB-CB5 (GPR18-IN-32)2 is a GRP18 antagonist with anti-inflammatory activity and can be used to study obesity and metabolic disorders.

<p>Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).</p>

<p>Endoxifen HCl, a Tamoxifen metabolite, targets estrogen receptors more effectively and blocks aromatase, showing promise for breast cancer research.</p>

<p>JNJ-20788560 is a delta opioid receptor (DOR) agonist with analgesic activity. It is more selective for DOR than for mu opioid receptors (MOR).</p>

<p>GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator.</p>

<p>Estredox, an estrogen receptor agonist, is used potentially for the treatment of vasomotor symptoms.</p>

<p>Glucocorticoid receptor agonist-1 is a potent glucocorticoid receptor agonist with an IC50 of 2.8 nM[1].</p>

<p>Finrozole (MPV 2213ad) is a novel selective aromatase inhibitor that is partially reversible for breast development.</p>

<p>Ripisartan (UP-269-6) is a potent and specific angiotensin II receptor antagonist that inhibits angiotensin II-mediated sympathetic tachycardia responses.</p>

<p>Faxeladol: adrenergic, serotonin inhibitor &amp; opioid agonist for neurological studies.</p>

<p>L-162,313 is an ANG II receptor agonist, a nonpeptide that mimics the biological actions of angiotensin II and induces an increase in MAP.</p>

<p>Palatrigine (BW-A 256C) is a compound with angiotensin-converting enzyme inhibitory and beta-adrenergic receptor blocking properties.</p>

<p>GLPG1205 is a potent, orally active GPR84 (G protein-coupled receptor) antagonist with anti-inflammatory activity.</p>

<p>AMG-009 is a prostaglandin D2 antagonist. For CRTH2 and DP receptors, the IC50s are 3 nM and 12 nM, respectively.</p>

<p>CAY10786 (GPR52 antagonist-1) is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).</p>

<p>ML-335, a μ-δ targeted agonist and MOR/DOR ligand, may lead to isomer-biased drugs with pain-relief properties.</p>

<p>NNC 63-0532 is a potentnociceptin receptor agonist, Ki=7.3 nM, EC50=305 nM.</p>

<p>ICI 204,448 is a potent κ-opioid agonist with potential analgesic activity for the study of neurological diseases.</p>

Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.

<p>Apomine inhibits HMG-CoA-reductase, induces myeloma cell apoptosis, modulates myeloma, and boosts lovastatin's antitumor effects.</p>

MK 1903 is a strong, selective HCA2/GPR109A agonist, reducing cAMP in CHO cells with EC50 of 12.9 nM.

<p>Estrogen Receptor Antagonist 8 is an ER antagonist with anti-uterine activity and may be used in the study of ovarian dysfunction.CASNETIN SODIUM (CasN)</p>

<p>LY88074, a raloxifene analog sans basic side chain, is an ERβ agonist (EC50 = 232 nM) that promotes uterine cell growth.</p>

<p>BMS-641988 is a novel nonsteroidal androgen receptor antagonist for the treatment of prostate cancer.</p>

<p>FPL-62129 is a calcium channel antagonist and a novel angiotensin-converting enzyme inhibitor with vasodilator activity for the study of cardiovascular disease.</p>

<p>Zindoxifene (D 16726) is an anti-estrogenic compound with antitumor activity that can be used in studies of breast and prostate cancer.</p>

<p>Orotirelin (CG 3509), a TRH analog, counters pentobarbital sleep; may aid in cerebral ischemia.</p>

<p>Bevenopran (CB-5945) is a peripheral antagonist of μ-opioid receptor and can be used in studies about the treatment of opioid-induced bowel dysfunction.</p>

<p>MEDICA16: GPR40 agonist, GPR120 partial agonist, ATP-citrate lyase inhibitor, lowers TG, boosts insulin sensitivity in muscle.</p>

<p>Acifran (AY 25712) is an HM74A/GPR109A and GPR109B agonist and displays antihyperlipidemic activity.</p>

<p>SSR126768A is an oxytocin receptor antagonist that inhibits uterine contractions and may be used to prevent preterm labor.</p>

<p>LP-471756 is a specific antagonist of GPR139 and inhibits LP-360924-stimulated cAMP production (IC50 = 640 nM).</p>

<p>ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective.</p>

<p>FL104 is a potent agonist of small-molecule urotensin II receptor, pEC50= 7.11.</p>

<p>GLPG0492 is a novel selective androgen receptor modulator.</p>

<p>Palazestrant, an antiestrogen and antineoplastic agent, effectively targets ER+/HER2+ cancer when used in conjunction with a HER2 inhibitor.</p>

<p>SB-657510: UT antagonist, Ki (nM) - human 61, monkey 17, cat 30, rat 65, mouse 56; reduces UII-induced inflammation, aids diabetic atherosclerosis.</p>

<p>Ralaniten triacetate (EPI-506) is a precursor of Ralaniten, an AR-NTD inhibitor, which can be used in the study of prostate and breast cancer.</p>

<p>FK 33-824, a stable synthetic analog of methionine enkephalin, reversible with naloxone.</p>

<p>A81988 is an antagonist of angiotensin AT1 receptors.</p>

<p>CL-329167, a angiotensin type 1 receptor antagonist, is used potentially for the treatment of hypertension.</p>

LY303336 is an antagonist of AT1 receptor.

<p>VPC-14228 is a specific AR-DBD inhibitor that acts by inhibiting both Y594A and Q592A mutants.</p>

<p>MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.</p>

<p>Fulvestrant S enantiomer is the less active S enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM.</p>

<p>CYT-1010, a mu-opioid receptor agonist; EC50: β-arrestin, 13.1 nM; cAMP, 0.0053 nM. Extracted from patent WO2013173730A2.</p>

<p>SQ 32970 is a potent Endothia aspartic proteinase inhibitor.</p>

<p>Nur77 modulator 2: Kd of 0.35 μM, oral anti-inflammatory, affects Nur77/mitochondria localization.</p>

<p>Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue.</p>

<p>CITFA, a GPER agonist, enhances neurite outgrowth in rat embryonic (E18) hippocampal neurons [1].</p>