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Endocrinologie/Hormones

Endocrinologie/Hormones

Les inhibiteurs en endocrinologie/hormonaux sont des composés qui bloquent l'action des hormones ou interfèrent avec les voies de signalisation hormonales. Ces inhibiteurs sont essentiels pour étudier la régulation des systèmes endocriniens et pour développer des traitements pour les maladies liées aux hormones, telles que le diabète, les troubles de la thyroïde et les cancers hormonodépendants. En modulant l'activité hormonale, ces inhibiteurs peuvent aider à élucider les interactions complexes au sein du système endocrinien. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité en endocrinologie/hormonaux pour soutenir vos recherches en endocrinologie, pharmacologie et sciences médicales.

Sous-catégories appartenant à la catégorie "Endocrinologie/Hormones"

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3184 produits trouvés pour "Endocrinologie/Hormones"

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  • ER degrader 10
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    ER degrader 10

    CAS :
    <p>ER degrader 10 (Compound 51) is an orally active estrogen receptor (ER) selective degrader and antagonist, with a DC50 of 0.43 nM and an IC50 of 0.56 nM. It inhibits the proliferation of ER-positive cells, with an IC50 ranging from 0 to 15 nM. ER degrader 10 exhibits weak inhibitory activity on the hERG channel, with an IC50 greater than 40 μM. It has blood-brain barrier permeability, with a brain/plasma ratio (Kp) of 3.05. In mouse models, ER degrader 10 demonstrates antitumor activity.</p>
    Formule :C28H29F2NO3S
    Couleur et forme :Solid
    Masse moléculaire :497.597

    Ref: TM-T204775

  • Allyphenyline oxalate
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    Allyphenyline oxalate

    CAS :
    <p>The pKi values of Allyphenyline oxalate (compound 9) for the α2-adrenergic receptor subtypes α2A, α2B, and α2C are 7.24, 6.47, and 7.07, respectively.</p>
    Formule :C16H20N2O5
    Couleur et forme :Solid
    Masse moléculaire :320.34

    Ref: TM-T204376

  • BU09059
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    BU09059

    CAS :
    <p>BU09059 is a potent, selective, short-acting antagonist of the κ-opioid receptor (KOR).</p>
    Formule :C28H37N3O5
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :495.61

    Ref: TM-T26919

  • Naldemedine tosylate
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    Naldemedine tosylate

    CAS :
    <p>Naldemedine (S-297995) tosylate, a PAMORA, targets μ-, δ-, κ-opioid receptors, aiding OIC research, may bind to SARS-CoV2's 3CL pro.</p>
    Formule :C39H42N4O9S
    Couleur et forme :Solid
    Masse moléculaire :742.84

    Ref: TM-T70929

  • LX1
    Targetmol
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    LX1

    CAS :
    <p>LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.</p>
    Formule :C22H15F6NO2
    Couleur et forme :Solid
    Masse moléculaire :439.35

    Ref: TM-T200147

  • Androgen receptor degrader-5
    Targetmol
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    Androgen receptor degrader-5

    CAS :
    <p>Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.</p>
    Formule :C29H25F4N5O2
    Couleur et forme :Solid
    Masse moléculaire :551.53

    Ref: TM-T200197

  • FL442
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    FL442

    CAS :
    <p>FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).</p>
    Formule :C15H13F3N2O
    Couleur et forme :Solid
    Masse moléculaire :294.27

    Ref: TM-T200138

  • LY2066948
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    LY2066948

    CAS :
    <p>LY2066948 is a selective oral estrogen receptor modulator (SERM) with high affinity for estrogen receptors ERα and ERβ (Ki of 0.51 and 1.36 nM, respectively) and displays potent anti-estrogenic activity. It effectively blocks the increase in uterine weight induced by ethinylestradiol in immature rats. LY2066948 is utilized in the research of uterine fibroids and myomas.</p>
    Formule :C30H31NO5S
    Couleur et forme :Solid
    Masse moléculaire :517.64

    Ref: TM-T200177

  • (+)-JJ-74-138
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    (+)-JJ-74-138

    CAS :
    <p>(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).</p>
    Formule :C22H22F8N2OS
    Couleur et forme :Solid
    Masse moléculaire :514.48

    Ref: TM-T200319

  • Androgen receptor ligand 1
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    Androgen receptor ligand 1

    CAS :
    <p>Androgen receptorligand 1 is a ligand for the androgen receptor (AR). It interacts with the CRBN E3 ligase via a linker to form an AR-PROTAC degrader. This compound is useful in prostate cancer research.</p>
    Formule :C19H16F4N2O
    Couleur et forme :Solid
    Masse moléculaire :364.34

    Ref: TM-T207737

  • OT-R agonist 1 TFA
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    OT-R agonist 1 TFA

    CAS :
    <p>OT-R agonist 1 TFA (compound 5) is an oxytocin receptor (OT-R) agonist with an EC50 value of 0.39 nM. It exhibits V1A antagonist activity, with an EC50 value of 2432 nM, and can be utilized in studies related to central nervous system diseases.</p>
    Formule :C37H40F3N7O7S
    Couleur et forme :Solid
    Masse moléculaire :783.82

    Ref: TM-T207687

  • L162389
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    L162389

    CAS :
    <p>L162389 is an angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor and stimulates the conversion of phosphatidylinositol.</p>
    Formule :C31H38N4O4S
    Degré de pureté :99.11% - 99.57%
    Couleur et forme :Solid
    Masse moléculaire :562.72

    Ref: TM-T11808

  • Cort108297
    Targetmol
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    Cort108297

    CAS :
    <p>Cort108297: selective GR modulator/antagonist, high GR affinity (Ki: 0.45nM), no other steroid receptor affinity.</p>
    Formule :C26H25F4N3O3S
    Degré de pureté :98.36% - 99.94%
    Couleur et forme :Solid
    Masse moléculaire :535.55

    Ref: TM-T15000

  • GLPG0974
    Targetmol
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    GLPG0974

    CAS :
    <p>GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.</p>
    Formule :C25H25ClN2O4S
    Degré de pureté :99.8%
    Couleur et forme :Solid
    Masse moléculaire :484.99

    Ref: TM-T15388

  • ZD 7155 hydrochloride
    Targetmol
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    ZD 7155 hydrochloride

    CAS :
    <p>ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.</p>
    Formule :C26H27ClN6O
    Degré de pureté :99.8%
    Couleur et forme :Solid
    Masse moléculaire :474.98

    Ref: TM-T13390

  • Nalmefene
    Targetmol
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    Nalmefene

    CAS :
    <p>Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study of opioid overdose and alcohol dependence.</p>
    Formule :C21H25NO3
    Degré de pureté :99.86%
    Couleur et forme :Solid
    Masse moléculaire :339.43

    Ref: TM-T86954

  • L-371,257
    Targetmol
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    L-371,257

    CAS :
    <p>L-371,257 is a competitive antagonist of oxytocin receptor with pA2 of 8.4 and Ki of 19 nM. L-371,257 shows a Ki of 3.7 nM for vasopressin receptor 1a.</p>
    Formule :C28H33N3O6
    Degré de pureté :99.79%
    Couleur et forme :Solid
    Masse moléculaire :507.58

    Ref: TM-T15682

  • (E/Z)-GSK5182
    Targetmol
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    (E/Z)-GSK5182

    CAS :
    <p>GSK5182 is a racemic mix of (E/Z) isomers, a selective ERRγ inverse agonist (IC50: 79 nM), and induces ROS in liver cancer.</p>
    Formule :C27H31NO3
    Degré de pureté :97.58%
    Couleur et forme :Solid
    Masse moléculaire :417.54

    Ref: TM-T7709

  • LSZ-102
    Targetmol
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    LSZ-102

    CAS :
    <p>LSZ-102 is an effective and selective degrader of estrogen receptor (IC50 = 0.2 nM) and can be used in studies about ERα positive breast cancer.</p>
    Formule :C25H17F3O4S
    Degré de pureté :98.56%
    Couleur et forme :Solid
    Masse moléculaire :470.46

    Ref: TM-T15788

  • ZK 216348
    Targetmol
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    ZK 216348

    CAS :
    <p>ZK 216348 also binds to Progesterone and mineralocorticoid receptors (IC50s: 20.4 nM and 79.9 nM, respectively). ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist (IC50: 20.3 nM). ZK 216348 has an anti-inflammatory activity similar to</p>
    Formule :C24H23F3N2O5
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :476.45

    Ref: TM-T17291

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