Endocrinologie/Hormones
Les inhibiteurs en endocrinologie/hormonaux sont des composés qui bloquent l'action des hormones ou interfèrent avec les voies de signalisation hormonales. Ces inhibiteurs sont essentiels pour étudier la régulation des systèmes endocriniens et pour développer des traitements pour les maladies liées aux hormones, telles que le diabète, les troubles de la thyroïde et les cancers hormonodépendants. En modulant l'activité hormonale, ces inhibiteurs peuvent aider à élucider les interactions complexes au sein du système endocrinien. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité en endocrinologie/hormonaux pour soutenir vos recherches en endocrinologie, pharmacologie et sciences médicales.
Sous-catégories appartenant à la catégorie "Endocrinologie/Hormones"
- Récepteur des androgènes(209 produits)
- Annexine A(11 produits)
- Aromatase(20 produits)
- Récepteur d'œstrogène/progestatif(49 produits)
- GPR(1 produits)
- Récepteur des glucocorticoïdes(153 produits)
- LHRH(1 produits)
- Récepteur opioïde(297 produits)
- Récepteur de prostaglandine(120 produits)
- RAAS(87 produits)
- Réductase(52 produits)
- Somatostatine(49 produits)
- Récepteur des hormones thyroïdiennes (THR)(26 produits)
- Récepteur de la vasopressine(44 produits)
Affichez 6 plus de sous-catégories
3183 produits trouvés pour "Endocrinologie/Hormones"
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Trimegestone
CAS :<p>Trimegestone, a highly effective oral progestogen, is used for endometrial protection, all doses inducing secretory endometrial transformation.</p>Formule :C22H30O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.47GPR40 Agonist 2
CAS :<p>GPR40 Agonist 2 is a GPR40 agonist. It can be used in the research of diabetes.</p>Formule :C24H30O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.49MCHR1 antagonist 2
CAS :<p>MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.</p>Formule :C23H21FN2O5Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :424.42GPR52 receptor modulator 1
CAS :<p>GPR52 receptor modulator 1, a compound delineated as per Procedure 1, is a modulator of the GPR52 receptor, offering research potential in the investigation of</p>Formule :C19H14F4N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.33SPH3127
CAS :<p>SPH3127 is a potent oral direct renin inhibitor, effective at 0.4 nM for human renin, used to study hypertension.</p>Formule :C22H32N6O4Couleur et forme :SolidMasse moléculaire :444.53MK-7246
CAS :MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM).Formule :C21H21FN2O4SCouleur et forme :SolidMasse moléculaire :416.47MB-07344
CAS :<p>MB-07344 is a selective THR-β (thyroid hormone receptor β) agonist with a Ki of 2.17 nM, capable of reducing plasma total cholesterol (TPC).</p>Formule :C19H25O5PDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :364.37THR-β modulator-1
CAS :<p>THR-β Modulator-1 (Compound 1a) is a potent modulator of the thyroid hormone receptor β, utilized in the study of thyroid hormone receptor-associated disorders</p>Formule :C17H14Cl2N6O4Couleur et forme :SolidMasse moléculaire :437.24A81988
CAS :<p>A81988 is an antagonist of angiotensin AT1 receptors.</p>Formule :C23H22N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.46DS08210767
CAS :<p>DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.</p>Formule :C31H39N5O2Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :513.67Baxdrostat
CAS :<p>Baxdrostat is an aldosterone synthase inhibitor.</p>Formule :C22H25N3O2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :363.45CO23
CAS :<p>CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.</p>Formule :C19H18I2N2O4Degré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :592.17Rovatirelin
CAS :<p>Rovatirelin (S-0373) is a TRH analog that improves motor dysfunction in a rat model of cytosine arabinoside-induced spinal cerebellar degeneration.</p>Formule :C16H22N4O4SDegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :366.43Giredestrant tartrate
CAS :<p>Giredestrant tartrate: a new oral, selective non-steroidal ER antagonist, inhibits ER-mediated gene activation and degrades ER protein, treating tumors.</p>Formule :C31H37F5N4O7Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :672.64GW-803430
CAS :<p>GW-803430: potent MCH R1 antagonist, pIC50=9.3, orally effective against obesity in animals.</p>Formule :C25H24ClN3O3SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :481.99MB-07811
CAS :<p>MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity.</p>Formule :C28H32ClO5PDegré de pureté :99.74% - 99.94%Couleur et forme :SolidMasse moléculaire :514.98AMG 837 calcium hydrate
CAS :<p>AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM.</p>Formule :C52H44CaF6O8Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :950.97Naldemedine tosylate
CAS :<p>Naldemedine (S-297995) tosylate, a PAMORA, targets μ-, δ-, κ-opioid receptors, aiding OIC research, may bind to SARS-CoV2's 3CL pro.</p>Formule :C39H42N4O9SCouleur et forme :SolidMasse moléculaire :742.84SDM25N hydrochloride
CAS :<p>δ receptor antagonist</p>Formule :C26H27ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :450.96GLPG0492 (R enantiomer)
CAS :<p>GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, a novel selective androgen receptor modulator.</p>Formule :C19H14F3N3O3Couleur et forme :SolidMasse moléculaire :389.33AVE 0991
CAS :<p>AVE 0991 is a nonpeptide analog of angiotensin-(1-7), a Mas agonist with inhibitory effects on [125I]-Ang-(1-7) and on neuroinflammation in Alzheimer's disease.</p>Formule :C29H32N4O5S2Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :580.72AP5 sodium
CAS :<p>AP5 sodium: potent oral GPR40 agonist, enhances ligands, may aid type II diabetes research.</p>Formule :C28H27FNNaO4Couleur et forme :SolidMasse moléculaire :483.515Estrogen receptor-agonist-1
CAS :<p>Estrogen receptor-agonist-1 (compound 4e) is an estrogen receptor (ER) agonist that binds to ERα with high affinity.</p>Formule :C24H22N2O2Couleur et forme :SolidMasse moléculaire :370.444Estrone acetate
CAS :<p>Estrone acetate (Hogival) is an estrogen derivative and an activator of estrogen receptors (ER). This compound can enhance breast development, stimulate the secretion of pituitary prolactin, and induce both the proliferation and activation of lactotrophs, evidenced by the reduction in prolactin storage granule size and the increase in the volume density of the rough endoplasmic reticulum and Golgi apparatus. Estrone acetate holds potential for endocrinological research and for investigating the mechanisms by which estrogen influences pituitary function, prolactin regulation, and breast tumor models.</p>Formule :C20H24O3Couleur et forme :SolidMasse moléculaire :312.403Androgen receptor degrader-5
CAS :<p>Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.</p>Formule :C29H25F4N5O2Couleur et forme :SolidMasse moléculaire :551.53ORIC-101
CAS :<p>ORIC-101 is a highly effective and selective glucocorticoid receptor antagonist (EC50: 5.6 nM). It also has anti-cancer activity.</p>Formule :C34H47NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.74ERRγ agonist-1
<p>ERRγ agonist-1 can be used in neuropsychological disorders research.</p>Formule :C17H21N5OCouleur et forme :SolidMasse moléculaire :311.38TRβ agonist 1
CAS :<p>TRβ Agonist 1, a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, demonstrates an EC50 value of 21 nM.</p>Formule :C29H25FN2O8Couleur et forme :SolidMasse moléculaire :548.52Estrogen receptor antagonist 4
CAS :<p>Estrogen receptor antagonist 4 blocks ER, impacting cell growth and cancer research potential.</p>Formule :C23H29BF4N4O2Couleur et forme :SolidMasse moléculaire :480.31rel-SB-612111 hydrochloride
CAS :<p>NOP receptor antagonist</p>Formule :C24H30Cl3NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.86Androstatrione
CAS :<p>Androstatrione is an androgenic compound.</p>Formule :C19H26O3Couleur et forme :SolidMasse moléculaire :302.41JNJ-1250132
CAS :<p>JNJ-1250132 is a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro.</p>Formule :C33H41NO4Couleur et forme :SolidMasse moléculaire :515.68Metahexestrol
CAS :<p>Metahexestrol is an inhibitor of the estrogen receptor (E2R) with antitumor activity. It significantly inhibits the proliferation of estrogen receptor-positive MCF-7 human breast cancer cell line with an ED50 of 1.0 μM. Additionally, Metahexestrol shows inhibitory activity in estrogen receptor-negative MDA-MB-231 cell lines, and its antiproliferative effect is not reversed by estrogen, suggesting that its mechanism may be partially independent of the E2R pathway. Metahexestrol is applicable in research on estrogen-dependent breast cancer.</p>Formule :C18H22O2Couleur et forme :SolidMasse moléculaire :270.366GC 14
CAS :<p>GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 200 nM and 35 nM for hTRα and hTRβ, respectively.</p>Formule :C26H27NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.5LIT-001 free base
CAS :<p>LIT-001, a nonpeptide OT-R agonist, enhances mouse autism-like behavior, with EC50=55 nM and Ki=226 nM.</p>Formule :C28H33N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.67GPR84 antagonist 3
CAS :<p>Potent GPR84 antagonist 3 (compound 42), pIC50 8.28, inhibits GTPγS, with good pharmacokinetics.</p>Formule :C29H27N5OCouleur et forme :SolidMasse moléculaire :461.56Isotodesnitazene
CAS :<p>Isotodesnitazene is an opioid compound that primarily targets the μ-opioid receptor (MOR). It exhibits EC50 values of 34.8 nM and 142 nM for MOR-βarr2 and MOR-mini-Gi, respectively. Isotodesnitazene can be utilized for research in opioid drugs.</p>Formule :C23H31N3OCouleur et forme :SolidMasse moléculaire :365.51Opioid receptor antagonist 1
CAS :<p>Opioid receptor antagonist 1 (Compound 10) is an Orvinol-based antagonist of opioid receptors. It exhibits activity as an antagonist against the analgesic properties of morphine.</p>Formule :C24H29ClF3NO4Couleur et forme :SolidMasse moléculaire :487.94Sunobinop
CAS :<p>Sunobinop (S 117957) is an opioid receptor-like orphan receptor (ORL1) modulator.</p>Formule :C26H33N3O3Couleur et forme :SolidMasse moléculaire :435.56FL442
CAS :<p>FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).</p>Formule :C15H13F3N2OCouleur et forme :SolidMasse moléculaire :294.27Anilopam
CAS :<p>Anilopam is an opioid analgesic belonging to the benzazepine class and acts as an agonist at opioid receptors.</p>Formule :C20H26N2OCouleur et forme :SolidMasse moléculaire :310.4322-Thiocyanatosalvinorin A
CAS :<p>22-Thiocyanatosalvinorin A (RB-64) is a potent selective agonist for the kappa-opioid receptor, exhibiting an EC50 value of 0.077 nM.</p>Formule :C24H27NO8SCouleur et forme :SolidMasse moléculaire :489.54CH5447240
CAS :<p>CH5447240: potent hPTHR1 agonist, treats Hypoparathyroidism, EC50 12 nM, 55% oral bioavailability, raises rat serum calcium.</p>Formule :C26H39N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.68LY2066948
CAS :<p>LY2066948 is a selective oral estrogen receptor modulator (SERM) with high affinity for estrogen receptors ERα and ERβ (Ki of 0.51 and 1.36 nM, respectively) and displays potent anti-estrogenic activity. It effectively blocks the increase in uterine weight induced by ethinylestradiol in immature rats. LY2066948 is utilized in the research of uterine fibroids and myomas.</p>Formule :C30H31NO5SCouleur et forme :SolidMasse moléculaire :517.64Norbinaltorphimine dihydrochloride
CAS :<p>Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.</p>Formule :C40H45Cl2N3O6Degré de pureté :98.17% - 99.88%Couleur et forme :SolidMasse moléculaire :734.71CCG258747
CAS :<p>CCG258747 is a novel, selective inhibitor of the GRK2 subfamily.</p>Formule :C28H27FN4O4Couleur et forme :SolidMasse moléculaire :502.54ERRα antagonist-2
CAS :<p>ERRα antagonist-2 is an estrogen-related receptor α inverse agonist, inhibiting migration and invasion in ER-negative MDA-MB-231,breast cancer.</p>Formule :C19H16N2O6SDegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :400.41ERβ agonist-1
CAS :<p>ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.</p>Formule :C25H36O2Couleur et forme :SolidMasse moléculaire :368.55MK-6913
CAS :<p>MK-6913 is a potent and selective agonist of estrogen receptor β.</p>Formule :C25H27N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.5ID11916
CAS :<p>ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.</p>Formule :C29H27F3N8O3SCouleur et forme :SolidMasse moléculaire :624.637AR antagonist 11
CAS :<p>AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM). Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM). This compound is applicable in prostate cancer (PCa) research.</p>Formule :C20H17ClN2OCouleur et forme :SolidMasse moléculaire :336.815JDTic Dihydrochloride
CAS :JDTic Dihydrochloride is a high-affinity and selective κ-opioid receptor (KOR) antagonist that blocks dynorphin-KOR signalling,antidepressant.Formule :C28H41Cl2N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.55Elacestrant S enantiomer dihydrochloride
<p>Elacestrant (RAD1901) dihydrochloride, an oral ERR degrader, has IC50 of 48 nM (ERα) and 870 nM (ERβ). Its S enantiomer has low activity.</p>Formule :C30H40Cl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.56Estrogen receptor antagonist 7
CAS :<p>ER antagonist 7, compound 13, inhibits ERs, halts breast/ovarian cancer cell growth, has anticancer properties.</p>Formule :C23H17N3O4Couleur et forme :SolidMasse moléculaire :399.4(+)-JJ-74-138
CAS :<p>(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).</p>Formule :C22H22F8N2OSCouleur et forme :SolidMasse moléculaire :514.48LEO 134310
CAS :<p>LEO 134310: Selective, non-steroidal GR agonist with 14 nM EC50, for topical skin disease treatment.</p>Formule :C34H40N2O8Couleur et forme :SolidMasse moléculaire :604.69A 74273
CAS :<p>A 74273, a nonpeptidic and renin inhibitor, may be used to treat cardiovascular diseases due to renin inhibition.</p>Formule :C44H74N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.08EN1441
CAS :<p>EN1441 is a covalent degrader that targets the androgen receptor (AR) with an EC50 value of 4.2 μM, as well as its truncated variant AR-V7. It selectively and effectively degrades AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 holds potential for research into androgen-independent prostate cancer.</p>Formule :C13H13ClN2O2Couleur et forme :SolidMasse moléculaire :264.708Estrogen receptor antagonist 6
CAS :<p>Estrogen receptor antagonist 6 is a potent blocker of estrogen signaling, regulating various biological effects. (Compound 166)</p>Formule :C25H31F3N2O3Couleur et forme :SolidMasse moléculaire :464.52AR antagonist 10
CAS :<p>AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.</p>Formule :C18H17ClN4O3SCouleur et forme :SolidMasse moléculaire :404.871PBPE hydrochloride
CAS :<p>PBPE hydrochloride is a derivative of tamoxifen and functions as a selective ligand for antiestrogen binding sites (AEBS). The binding affinity (Ki) of PBPE hydrochloride and MBPE to AEBS is 8.79 nM and 17.57 nM, respectively.</p>Formule :C19H24ClNOCouleur et forme :SolidMasse moléculaire :317.853Estrogen receptor modulator 11
CAS :<p>Estrogen receptor modulator11 (Compound 27) is a tetrahydroisoquinoline derivative. It exhibits affinity for the estrogen receptor (ER), with IC50 values of 285 nM for ERα and 421 nM for ERβ. Estrogen receptor modulator11 does not demonstrate antagonist activity in MCF-7 cell assays.</p>Formule :C21H18FNOCouleur et forme :SolidMasse moléculaire :319.372Mu opioid receptor antagonist 4
<p>Compound 31: Potent, selective MOR antagonist; crosses blood-brain barrier; Ki & EC50: 0.38 nM; useful for OUD research.</p>Formule :C25H28N2O4SCouleur et forme :SolidMasse moléculaire :452.57Bromadoline
CAS :<p>Bromadoline is an opioid compound that exhibits anti-nociceptive properties in rodents.</p>Formule :C15H21BrN2OCouleur et forme :SolidMasse moléculaire :325.244Androgen receptor antagonist 11
CAS :<p>Androgen receptor antagonist 11 (compound N29) is a selective, orally available antagonist.</p>Formule :C20H19F3N4O3SCouleur et forme :SolidMasse moléculaire :452.45Triisopropyl phosphate
CAS :<p>Triisopropyl phosphate inhibits TFF1 and EGR3 gene expression and exhibits anti-estrogenic activity by suppressing Estradiol-induced proliferation of MCF-7 cells, with an EC50 of 341 μM. Additionally, Triisopropyl phosphate reduces estrogen response element (ERE)-stimulated luciferase activity in MVLN cells, with an EC50 of 900 μM.</p>Formule :C9H21O4PCouleur et forme :SolidMasse moléculaire :224.234RJG-2051
CAS :<p>RJG-2051 is a selective covalent inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), with an IC50 value of 13 nM. It interferes with the metabolism of substrates such as androgens, estrogens, and prostaglandins through AKR1C3. RJG-2051 holds potential for cancer research.</p>Formule :C26H31N5O4SCouleur et forme :SolidMasse moléculaire :509.62KNT-127
CAS :<p>KNT-127 is an agonist of δ-Opioid receptor.</p>Formule :C24H24N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.46AP5
CAS :<p>AP5: GPR40 agonist, positive allosteric modulator; rat hIP1 EC50: 0.49 nM.</p>Formule :C28H28FNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.52Glucocorticoid receptor activator 1
CAS :<p>Glucocorticoid Receptor Activator 1, a phenyl nitrogen-heterocyclic precursor, acts as an activator of the glucocorticoid receptor (GR). By activating GR, it downregulates the expression of pro-inflammatory genes stimulated by TNF, making it useful for inflammation research.</p>Formule :C11H15Cl2NO2Couleur et forme :SolidMasse moléculaire :264.15Androgen receptor antagonist 12
CAS :<p>Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.</p>Formule :C12H8F3N3O2Couleur et forme :SolidMasse moléculaire :283.21Naltrindole 5′-isothiocyanate
CAS :<p>Naltrindole 5′-isothiocyanate (5'-NTII) is an irreversible delta opioid receptor antagonist that counters the analgesic effects induced by DSLET without altering the effects caused by DPDPE.</p>Formule :C27H25N3O3SCouleur et forme :SolidMasse moléculaire :471.5716:2 Cl-PFAES
CAS :<p>6:2 Cl-PFAES exhibits reproductive toxicity by elevating the levels of serum estradiol and vitellogenin in adult males, which can harm the embryonic development of offspring.</p>Formule :C8ClF16KO4SCouleur et forme :SolidMasse moléculaire :570.67Urotensin-II receptor antagonist-1
CAS :<p>Urotensin-II receptor antagonist-1 (compound 1) is a human Urotensin II receptor antagonist with low oral bioavailability (F=0-3% in rats) and a Ki of 16 nM in HEK293 cells expressing human recombinant UT receptors. It inhibits cytochrome P450 enzymes (IC50=0.75 μM for CYP2D6; 1.4 μM for CYP3A4), suppresses κ opioid receptors (EC50=3.2 μM), and targets cardiac sodium channels (Ki=2.5 μM).</p>Formule :C25H31Cl2N3OCouleur et forme :SolidMasse moléculaire :460.439SJ1008066
CAS :<p>SJ1008066 is a MAGE-A11 inhibitor with an IC50 of 0.13 μM. It binds to the MAGE homology domain (MHD) and disrupts the MAGE-A11:PCF11 interaction.</p>Formule :C21H22N4Couleur et forme :SolidMasse moléculaire :330.43Glucocorticoid receptor agonist-5
CAS :<p>Glucocorticoid Receptoragonist-5 (compound 4) is an effective glucocorticoid molecule acting as a potent agonist for glucocorticoid receptors. It exhibits anti-inflammatory and immunosuppressive activities and serves as an ADC cytotoxin.</p>Formule :C36H40O7Couleur et forme :SolidMasse moléculaire :584.722-Hydroxy mifepristone
CAS :<p>22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcohol metabolite that exhibits both anti-progestational and anti-glucocorticoid activities. This compound contains an alkyne group and is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Furthermore, 22-Hydroxy Mifepristone demonstrates a relative binding affinity of 48% to the human glucocorticoid receptor.</p>Formule :C29H35NO3Couleur et forme :SolidMasse moléculaire :445.59Galaxolide
CAS :<p>Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), oxidative stress, and genotoxicity. It also stimulates the enzymatic activities of EROD and GST (Glutathione S-transferase).</p>Formule :C18H26OCouleur et forme :SolidMasse moléculaire :258.40Erα-IN-1
<p>Erα-IN-1 (compound 3c) is an inhibitor of the estrogen receptor α (ERα), effectively blocking ERα activity in MCF7/ERE-LUC cells.</p>Formule :C16H11FN2Couleur et forme :SolidMasse moléculaire :250.27BMS-986034
CAS :<p>BMS-986034 is a GPR119 agonist.</p>Formule :C24H24Cl2N6O4Couleur et forme :SolidMasse moléculaire :531.39Novokinin
CAS :<p>Angiotensin AT2 receptor agonist</p>Formule :C39H61N11O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :795.97SB-612111
CAS :<p>SB-612111: potent ORL-1 antagonist, Ki=0.33 nM; μ-, κ-, δ-receptor Ki=57.6, 160.5, 2109 nM; blocks nociceptin's pain effect.</p>Formule :C24H29Cl2NOCouleur et forme :SolidMasse moléculaire :418.405′-Guanidinonaltrindole
CAS :<p>5′-Guanidinonaltrindole (GNTI) is a selective antagonist of the kappa opioid receptor.</p>Formule :C27H29N5O3Couleur et forme :SolidMasse moléculaire :471.551Mu opioid receptor antagonist 2
<p>Compound 25: potent, selective MOR antagonist, crosses blood-brain barrier (Ki: 0.37 nM, EC50: 0.44 nM), for OUD research.</p>Formule :C25H28N2O4SCouleur et forme :SolidMasse moléculaire :452.57BW 443C
CAS :<p>BW 443C is a selective agonist of mu-opioid receptor.</p>Formule :C33H46N10O10Couleur et forme :SolidMasse moléculaire :742.791CI 992
CAS :<p>CI 992 is a novel potent inhibitor of primate renin.</p>Formule :C33H52N6O7S2Couleur et forme :SolidMasse moléculaire :708.93TUG-2181
CAS :<p>TUG-2181 is an antagonist of GPR84, with an IC50 value of 34 nM. It inhibits reactive oxygen species (ROS) production and IL-8 secretion induced by GPR84 agonists in human neutrophils. TUG-2181 is applicable for research in inflammation and fibrosis.</p>Formule :C21H27NO4Couleur et forme :SolidMasse moléculaire :357.443BMS-248360
CAS :<p>BMS-248360: Oral dual hAT1/hETA antagonist with Kis of 10nM & 1.9nM, respectively; treats hypertension.</p>Formule :C36H45N5O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :659.84GDC-0927 Racemate
CAS :<p>GDC-0927 Racemate is a degrader of estrogen receptor, is used in the research of ER-related diseases, potently inhibits ER-α activity, with an IC50 of 0.2 nM.</p>Formule :C28H28FNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.52S-HP210
<p>S-HP210: selective GR modulator, blocks NF-κB (IC50: 1.92 μM), non-toxic to mouse fibroblasts.</p>Formule :C22H19N3O2S2Couleur et forme :SolidMasse moléculaire :421.54BNTX
CAS :<p>BNTX (7-Benzylidenenaltrexone) is a selective δ1-opioid receptor antagonist. It competitively counteracts the antisecretory effects of DPDPE, Deltorphin 2, and DAMGO. BNTX is applicable in research focused on antinociceptive effects.</p>Formule :C27H27NO4Couleur et forme :SolidMasse moléculaire :429.508MLS000389544
CAS :<p>MLS000389544 is a selective and potent thyroid hormone receptor β (TRβ) antagonist with a methylsulfonyl nitrobenzoic acid structure. It effectively inhibits the interaction between TRβ and steroid receptor coactivator 2 (SRC2).</p>Formule :C20H24N2O7SCouleur et forme :SolidMasse moléculaire :436.479RX 809055AX
CAS :<p>RX 809055AX is a long lasting opioid antagonist at mu and delta receptors.</p>Formule :C29H29ClN2O4Couleur et forme :SolidMasse moléculaire :505SB-612111 hydrochloride
<p>SB-612111 is a potent ORL-1 antagonist, with high affinity (Ki: 0.33 nM) and µ-receptor activity (Ki: 57.6 nM), blocking Nociceptin-induced pain.</p>Formule :C24H30Cl3NOCouleur et forme :SolidMasse moléculaire :454.86BMS-986118
CAS :<p>BMS-986118 is a GPR40 full agonist targeting type II diabetes, prompting insulin release without hypoglycemia risk.</p>Formule :C25H28ClF3N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.96(±)-J 113397
CAS :<p>(±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist (K(i): cloned human ORL1=1.8 nM).</p>Formule :C24H37N3O2Couleur et forme :SolidMasse moléculaire :399.57DS69910557
<p>DS69910557: potent hPTHR1 antagonist, IC50 0.08 μM, oral, for hyperparathyroidism & osteoporosis research.</p>Formule :C32H33Cl2FN4O3Couleur et forme :SolidMasse moléculaire :611.53TD-0212
CAS :TD-0212: Oral dual antagonist for AT1 (pKi 8.9) & NEP inhibitor (pIC50 9.2).Formule :C28H34FN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.65ACT 178882
CAS :<p>ACT 178882 is a new Renin inhibitor (IC50: 1.4 nM).</p>Formule :C33H38Cl3N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.03ADX61623
CAS :<p>ADX61623 is an effective negative allosteric modulator (NAM) of the follicle-stimulating hormone receptor (FSHR). It also exhibits activity on the luteinizing hormone receptor (LH-R) but is inactive on the thyroid-stimulating hormone (TSH) receptor. ADX61623 can be utilized in research on estrogen-dependent diseases.</p>Formule :C19H20N2O3Couleur et forme :SolidMasse moléculaire :324.37ERα degrader 11
CAS :<p>ERα degrader11 (compound B16) is a selective estrogen receptor degrader designed for use as a probe in examining the ER status within ER-positive breast cancer cells.</p>Formule :C28H27F3N2O3Couleur et forme :SolidMasse moléculaire :496.52Pentomone
CAS :<p>Pentomone (LY-113935) is an anti-androgen compound that acts as a prostate growth inhibitor.</p>Formule :C24H26O5Couleur et forme :SolidMasse moléculaire :394.46Sob-AM2
CAS :<p>Sob-AM2 is an effective substrate targeting the fatty acid amide hydrolase (FAAH) expressed in the brain, with a Km of 1.3 μM. It delivers higher concentrations of Sobetirome to the central nervous system at minimal peripheral systemic doses, thereby activating the central thyroid hormone receptor β (TRβ).</p>Formule :C21H27NO3Couleur et forme :SolidMasse moléculaire :341.44(S)-MCOPPB
CAS :<p>(S)-MCOPPB is the S-enantiomer of MCOPPB, an orally active selective agonist for the Nociceptin/Orphanin FQ-Receptor. It inhibits signal transduction in mouse brain NOP receptors and is utilized in anxiety disorder research.</p>Formule :C26H40N4Couleur et forme :SolidMasse moléculaire :408.623L162389
CAS :<p>L162389 is an angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor and stimulates the conversion of phosphatidylinositol.</p>Formule :C31H38N4O4SDegré de pureté :99.11% - 99.57%Couleur et forme :SolidMasse moléculaire :562.72PD 134922
CAS :<p>PD 134922 is a HIV-1 protease inhibitors. Inactivation of the protease prevents infectious virion formation.</p>Formule :C37H61N5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :719.97NSC 645827
CAS :<p>NSC 645827 is an inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), with an IC50 of 0.7 μM.</p>Formule :C17H17N5O2Couleur et forme :SolidMasse moléculaire :323.349J-113397
CAS :<p>J-113397 is a potent and selective NOP receptor antagonist (IC50 = 2.3 nM).</p>Formule :C24H37N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :399.57SC13
CAS :<p>SC13, a novel mitragynine analog, exhibits low-efficacy agonism at Mu opioid receptors and provides antinociception while minimizing adverse effects.</p>Formule :C26H30N2O5Couleur et forme :SolidMasse moléculaire :450.53AR antagonist 4
<p>AR antagonist 4 (Compound 67-b) is an orally active androgen receptor (AR) antagonist that acts on wild-type AR (IC50: 246.6 nM).</p>Formule :C29H36N4OCouleur et forme :SolidMasse moléculaire :456.62ERα degrader 5
<p>ERα degrader 5 is an orally active, selective estrogen receptor (ER) reducer that acts on ERα (EC50: 1.1 nM). ERα degrader 5 shows anti-tumour effects in vivo.</p>Formule :C29H25F4N3O2SCouleur et forme :SolidMasse moléculaire :555.595α-reductase-IN-1
CAS :<p>5α-reductase-IN-1 is a potent inhibitor of the enzyme 5α-reductase.</p>Formule :C31H37NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :503.63Anticancer agent 257
CAS :<p>Anticanceragent 257 (compound of formula (I)) is an anticancer agent that regulates Nur77 and Nurr1.</p>Formule :C15H9Cl2N3Couleur et forme :SolidMasse moléculaire :302.158JTP-117968
CAS :<p>JTP-117968: Non-steroidal SGRM, glucocorticoid receptor modulator, IC50 = 6.8 nM, offers better inhibitory/activatory balance.</p>Formule :C31H31F3N2O2Couleur et forme :SolidMasse moléculaire :520.59TD-0212 TFA
CAS :<p>TD-0212 TFA is an oral AT1 receptor antagonist & NEP inhibitor with pKi 8.9 & pIC50 9.2.</p>Formule :C30H35F4N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :641.67L 365209
CAS :<p>L 365209 is an oxytocin antagonist.</p>Formule :C40H50N8O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :738.88Mu opioid receptor antagonist 3
<p>Potent, selective MOR antagonist (compound 26); crosses blood-brain barrier. Ki: 0.24 nM, EC50: 0.54 nM; for studying OUD.</p>Formule :C25H28N2O4SCouleur et forme :SolidMasse moléculaire :452.57Mepixetil
<p>Mepixetil is a potent angiotensin II receptor antagonist[1].</p>Formule :C12H18N2O3Couleur et forme :SolidMasse moléculaire :238.28Mopivabil
<p>Mopivabil is the angiotensin II receptor antagonist[1].</p>Formule :C14H20O3Couleur et forme :SolidMasse moléculaire :236.31GPR84 antagonist 1
<p>GPR84 antagonist 1 is a highly selective, high-affinity competitive antagonist of human GPR84.</p>Formule :C26H22N4O2Couleur et forme :SolidMasse moléculaire :422.48AT1R antagonist 2
<p>AT1R antagonist 2 is a potent AT1R selective ligand with good AT1R affinity (Ki: 26 nM).</p>Formule :C29H37N5O4S2Couleur et forme :SolidMasse moléculaire :583.77Mu opioid receptor antagonist 5
<p>Compound NAP: MOR antagonist, crosses blood-brain barrier, EC50: 1.14 nM, Ki: 0.37 nM, useful for OUD research.</p>Formule :C26H29N3O4Couleur et forme :SolidMasse moléculaire :447.53DS34942424
<p>DS34942424 is an orally potent analgesic which did not exhibit mu opioid receptor agonist activity.</p>Formule :C15H17FN2OCouleur et forme :SolidMasse moléculaire :260.31GNTI dihydrochloride
CAS :<p>κ opioid receptor antagonist</p>Formule :C27H30ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.01A4B17
<p>A4B17 is an inhibitor of androgen receptor N-terminal with potential for androgen-responsive prostate cancer treatment.</p>Formule :C14H7F4NSCouleur et forme :SolidMasse moléculaire :297.27KR31173
CAS :<p>KR31173 is an AT1 antagonist with an IC50 of 3.27 nM. When labeled with the 11C isotope, KR31173 can be used as a tracer for positron emission tomography (PET). In mice, KR31173 exhibits favorable biodistribution and pharmacological characteristics. It selectively binds to organs in CD-1 mice known to have a high density of AT1 angiotensin receptors.</p>Formule :C31H30N8O2Couleur et forme :SolidMasse moléculaire :546.626β-Naltrexol
CAS :<p>6β-Naltrexol is a peripherally selective opioid antagonist that reduces constipation from opioids while minimizing central nervous system effects.</p>Formule :C20H25NO4Degré de pureté :99.933%Couleur et forme :SolidMasse moléculaire :343.42ER degrader 10
CAS :<p>ER degrader 10 (Compound 51) is an orally active estrogen receptor (ER) selective degrader and antagonist, with a DC50 of 0.43 nM and an IC50 of 0.56 nM. It inhibits the proliferation of ER-positive cells, with an IC50 ranging from 0 to 15 nM. ER degrader 10 exhibits weak inhibitory activity on the hERG channel, with an IC50 greater than 40 μM. It has blood-brain barrier permeability, with a brain/plasma ratio (Kp) of 3.05. In mouse models, ER degrader 10 demonstrates antitumor activity.</p>Formule :C28H29F2NO3SCouleur et forme :SolidMasse moléculaire :497.597Mu opioid receptor antagonist 8
CAS :<p>Muopioid Receptor Antagonist 8 (368) serves as an antagonist to the μ-opioid receptor, significantly inhibiting the activation of Gi induced by met-enkephalin at the µOR.</p>Formule :C36H35N3O4SCouleur et forme :SolidMasse moléculaire :605.75Riminkefon
CAS :<p>Riminkefon is a kappa opioid receptor agonist .</p>Formule :C38H57N7O6Couleur et forme :SolidMasse moléculaire :707.9(Rac)-Fidarestat
CAS :<p>(Rac)-Fidarestat ((Rac)-SNK 860) is the racemic form of Fidarestat, functioning as a potent inhibitor of the enzyme aldose reductase.</p>Formule :C12H10FN3O4Couleur et forme :SolidMasse moléculaire :279.224Amoitone B
CAS :<p>Amoitone B, a cystosporone B derivative, functions as an NR4A1 agonist and exhibits anticancer activity [1].</p>Formule :C22H34O5Couleur et forme :SolidMasse moléculaire :378.5BU72
CAS :<p>BU72 is a potent, long-lasting agonist for μ and κ opioid receptors, with partial agonistic activity at the δ opioid receptor (EC50 values of 0.054, 0.033, and 0.58 nM, respectively). It provides strong, enduring analgesic effects primarily mediated through μ opioid receptors. BU72 also exhibits a prolonged duration of activity and can partially reverse morphine-induced analgesia. It is applicable in studies of opioid dependence.</p>Formule :C28H32N2O2Couleur et forme :SolidMasse moléculaire :428.57Allyphenyline oxalate
CAS :<p>The pKi values of Allyphenyline oxalate (compound 9) for the α2-adrenergic receptor subtypes α2A, α2B, and α2C are 7.24, 6.47, and 7.07, respectively.</p>Formule :C16H20N2O5Couleur et forme :SolidMasse moléculaire :320.34OSU-ERb-12
CAS :OSU-ERb-12 is an ERβ agonist that suppresses ovarian cancer cell proliferation both in vitro and in vivo, and decreases the expression of Snail [1] [2].Formule :C15H30B10O2Couleur et forme :SolidMasse moléculaire :350.51MB-07344 sodium
<p>"MB-07344 sodium is a TR-β agonist with a 2.17 nM Ki, boosts Atorvastatin's cholesterol-lowering effects in various animals."</p>Formule :C19H25NaO5PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.36Androgen receptor ligand 1
CAS :<p>Androgen receptorligand 1 is a ligand for the androgen receptor (AR). It interacts with the CRBN E3 ligase via a linker to form an AR-PROTAC degrader. This compound is useful in prostate cancer research.</p>Formule :C19H16F4N2OCouleur et forme :SolidMasse moléculaire :364.34BU09059
CAS :<p>BU09059 is a potent, selective, short-acting antagonist of the κ-opioid receptor (KOR).</p>Formule :C28H37N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.61σ1 Receptor/μ Opioid receptor modulator 2
CAS :<p>Compound 4x, also known as σ1 Receptor/μOpioid receptormodulator 2, acts as a μOR agonist and a σ1R antagonist, exhibiting a potent μOR EC50 of 0.6 nM and strong σ1R inhibitory activity (Ki: 363.7 nM). It demonstrates significant analgesic effects in various pain models.</p>Formule :C23H31N3OMasse moléculaire :365.51Daeatal
CAS :<p>Dynorphin A ethylamide (1-9), the opioid activities were examined in the bioassays.</p>Formule :C56H93N19O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1192.46OT-R agonist 1 TFA
CAS :<p>OT-R agonist 1 TFA (compound 5) is an oxytocin receptor (OT-R) agonist with an EC50 value of 0.39 nM. It exhibits V1A antagonist activity, with an EC50 value of 2432 nM, and can be utilized in studies related to central nervous system diseases.</p>Formule :C37H40F3N7O7SCouleur et forme :SolidMasse moléculaire :783.8221-Deacetoxy deflazacort
CAS :<p>21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort, which is a glucocorticoid. As an inactive precursor, Deflazacort rapidly converts into the active metabolite, 21-Desacetyldeflazacort. This compound serves as both an anti-inflammatory and immunosuppressive agent.</p>Formule :C23H29NO4Couleur et forme :SolidMasse moléculaire :383.48BNTX maleate
CAS :<p>δ1 opioid receptor antagonist</p>Formule :C31H31NO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :545.58EN171
CAS :<p>EN171, a covalent ligand, selectively binds to C38 and C96 on 14-3-3, intensifying 14-3-3's interactions with ERα, YAP, and TAZ. This action impairs both estrogen receptor and Hippo pathway transcriptional activities. Beyond serving as a molecular glue to augment native protein interactions, EN171 also functions as a covalent recruiter for 14-3-3 in heterobifunctional molecules. This facilitates the sequestration of nuclear neo-substrates, such as BRD4 and BLC6, into the cytosol.</p>Formule :C17H22N2OCouleur et forme :SolidMasse moléculaire :270.37Dazucorilant
CAS :<p>Dazucorilant (CORT113176), a selective non-steroidal GR modulator, has high affinity with a K i <1 nM, useful for neurological research.</p>Formule :C29H22F4N4O3SCouleur et forme :SolidMasse moléculaire :582.57LNS8801
CAS :<p>LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.</p>Formule :C21H18BrNO3Couleur et forme :SolidMasse moléculaire :412.277GPR81 agonist 2
CAS :<p>GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.</p>Formule :C26H27ClN6O5S2Couleur et forme :SolidMasse moléculaire :603.11C108297
CAS :<p>C108297: glucocorticoid modulator, combats diet obesity/inflammation, reduces appetite/lipid storage, boosts fat burn.</p>Formule :C30H36FN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.69LX1
CAS :<p>LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.</p>Formule :C22H15F6NO2Couleur et forme :SolidMasse moléculaire :439.35Fonsartan free acid
CAS :<p>Fonsartan: Angiotensin receptor blocker, halts angiotensin II effects on rat vascular cells.</p>Formule :C26H32N4O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.69FSH receptor antagonist 1
CAS :<p>FSH receptor antagonist 1 (compound 10) is a potent antagonist of the G(s) protein-coupled human follicle-stimulating hormone (FSH) receptor. It exhibits an IC50 value of 28 nM in cell lines expressing the human FSH receptor. This compound significantly inhibits follicle growth and ovulation in in vitro mouse models.</p>Formule :C33H32N2O2Couleur et forme :SolidMasse moléculaire :488.619L-371,257
CAS :<p>L-371,257 is a competitive antagonist of oxytocin receptor with pA2 of 8.4 and Ki of 19 nM. L-371,257 shows a Ki of 3.7 nM for vasopressin receptor 1a.</p>Formule :C28H33N3O6Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :507.58GLPG0974
CAS :<p>GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.</p>Formule :C25H25ClN2O4SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :484.99ZD 7155 hydrochloride
CAS :<p>ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.</p>Formule :C26H27ClN6ODegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :474.98Cort108297
CAS :<p>Cort108297: selective GR modulator/antagonist, high GR affinity (Ki: 0.45nM), no other steroid receptor affinity.</p>Formule :C26H25F4N3O3SDegré de pureté :98.36% - 99.94%Couleur et forme :SolidMasse moléculaire :535.55Nalmefene
CAS :<p>Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study of opioid overdose and alcohol dependence.</p>Formule :C21H25NO3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :339.43(E/Z)-GSK5182
CAS :<p>GSK5182 is a racemic mix of (E/Z) isomers, a selective ERRγ inverse agonist (IC50: 79 nM), and induces ROS in liver cancer.</p>Formule :C27H31NO3Degré de pureté :97.58%Couleur et forme :SolidMasse moléculaire :417.54LSZ-102
CAS :<p>LSZ-102 is an effective and selective degrader of estrogen receptor (IC50 = 0.2 nM) and can be used in studies about ERα positive breast cancer.</p>Formule :C25H17F3O4SDegré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :470.46ML314
CAS :<p>ML314 is a brain-permeable nonpeptide β-inhibin-biased neurotensin NTR1 receptor agonist (EC50: 1.9 μM), a biased neurotensin receptor ligand for methamphetamine abuse that inhibits NTR2 and GPR35.</p>Formule :C24H28N4O3Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :420.504ZK 216348
CAS :<p>ZK 216348 also binds to Progesterone and mineralocorticoid receptors (IC50s: 20.4 nM and 79.9 nM, respectively). ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist (IC50: 20.3 nM). ZK 216348 has an anti-inflammatory activity similar to</p>Formule :C24H23F3N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.45PSN632408
CAS :<p>PSN632408 is an optimized agonist of GPR119 receptors that display similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50: 5.6 and 7.9 uM, respectively).</p>Formule :C18H24N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.41Mapracorat
CAS :<p>Mapracorat (ZK-245186, BOL-303242X) is a selective glucocorticoid receptor agonist,anti-inflammatory agent for atopic dermatitis and allergic conjunctivitis.</p>Formule :C25H26F4N2O2Couleur et forme :SolidMasse moléculaire :462.48(S)-Mapracorat
CAS :<p>(S)-Mapracorat is a selective and less active agonist of the glucocorticoid receptor.</p>Formule :C25H26F4N2O2Couleur et forme :SolidMasse moléculaire :462.48Relacorilant
CAS :<p>Relacorilant is an oral glucocorticoid receptor antagonist with Ki of 7.2 nM, potential for treating Cushing's syndrome.</p>Formule :C27H22F4N6O3SDegré de pureté :98.53% - 99%Couleur et forme :SolidMasse moléculaire :586.56Ref: TM-T16727
Produit arrêtéBudesonide
CAS :<p>Budesonide (Pulmicort), an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Budesonide has extensively inhibitory effects against multiple cells types and mediators referred to allergic and nonallergic-mediated inflammatory. What's more, the anti-inflammatory action of budesonide has been revealed to contribute to the effectiveness of asthma.</p>Formule :C25H34O6Degré de pureté :99.03% - 99.72%Couleur et forme :Crystals SolidMasse moléculaire :430.53Exemestane
CAS :<p>Exemestane (EXE) is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.</p>Formule :C20H24O2Degré de pureté :99.35% - 99.35%Couleur et forme :White To Light Yellow Crystal PowderMasse moléculaire :296.421-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
<p>21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is a valuable organic compound for life sciences research [Catalog No.: T67476, CAS No.: 37413-91-5].</p>Formule :C23H26O4Couleur et forme :SolidMasse moléculaire :366.457Phosphoramidon Disodium
CAS :<p>Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.</p>Formule :C23H34N3Na2O10PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :588.48GPR109 receptor agonist-2
CAS :<p>Compound 5, a selective GPR109a agonist, exhibits a pEC50 value of 5.53 [1].</p>Formule :C7H10N2O2Couleur et forme :SolidMasse moléculaire :154.17PF-998425
CAS :<p>non-steroidal androgen receptor (AR) antagonist</p>Formule :C14H14F3NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :269.26AZD9496 maleate
CAS :<p>AZD9496 maleate is a highly potent and selective antagonist of the estrogen receptor alpha (ERα), exhibiting an IC50 value of 0.28 nM. This compound, AZD9496 maleate, is an orally bioavailable selective estrogen receptor degrader (SERD).</p>Formule :C29H29F3N2O6Couleur et forme :SolidMasse moléculaire :558.554ERB-196
CAS :<p>Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.</p>Formule :C17H10FNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :279.27L-372662
CAS :<p>L-372662 is bioactive chemical.</p>Formule :C33H38N4O6Couleur et forme :SolidMasse moléculaire :586.68Pamoic acid
CAS :<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Formule :C23H16O6Degré de pureté :99.99%Couleur et forme :Fine Yellow PowderMasse moléculaire :388.37SR17018
CAS :<p>SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM.</p>Formule :C19H18Cl3N3ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :410.72Cebranopadol
CAS :<p>Cebranopadol (GRT6005) is an analgesic NOP and opioid receptor agonist with Kis of 0.9 nM, 0.7 nM, 2.6 nM, 18 nM for human NOP, μ-opioid (MOP), κ-opioid (KOP)</p>Formule :C24H27FN2ODegré de pureté :98.32% - 99.78%Couleur et forme :SolidMasse moléculaire :378.48Ref: TM-T5167
Produit arrêtéYK11
CAS :<p>YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM, with osteogenic activity.</p>Formule :C25H34O6Degré de pureté :98.91%Couleur et forme :SoildMasse moléculaire :430.53Ceronapril
CAS :<p>Ceronapril (SQ 29852) is an orally active and potent angiotensin-converting enzyme (ACE) inhibitor (IC50 : 36 nM) for the study of dementia and hypertension.</p>Formule :C21H33N2O6PDegré de pureté :97.94%Couleur et forme :SolidMasse moléculaire :440.47Bromadoline maleate
CAS :<p>Bromadoline is an opioid analgesic selective for the μ-opioid receptor.</p>Formule :C19H25BrN2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.322SR14150
CAS :<p>SR14150 is a partial agonist of high-affinity NOP receptor.</p>Formule :C21H30N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.48Estrogen receptor modulator 8
CAS :<p>Estrogen Receptor Modulator 8 (compound 4) is an orally active inhibitor targeting Estrogen Receptor/ERR α with potent efficacy (IC50 = 0.437 nM in MCF-7 cells</p>Formule :C25H24F4N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.46MOR agonist-1
CAS :<p>MOR Agonist-1 is a μ-opioid receptor (MOR) agonist noted for its potent analgesic properties and is utilized in research concerning pain and associated</p>Formule :C22H26ClFN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.91ALS-I-41
CAS :<p>ALS-I-41 is a novel, potent and selective antagonist of oxytocin receptor.</p>Formule :C30H38FN3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.7
