Endocrinologie/Hormones
Les inhibiteurs en endocrinologie/hormonaux sont des composés qui bloquent l'action des hormones ou interfèrent avec les voies de signalisation hormonales. Ces inhibiteurs sont essentiels pour étudier la régulation des systèmes endocriniens et pour développer des traitements pour les maladies liées aux hormones, telles que le diabète, les troubles de la thyroïde et les cancers hormonodépendants. En modulant l'activité hormonale, ces inhibiteurs peuvent aider à élucider les interactions complexes au sein du système endocrinien. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité en endocrinologie/hormonaux pour soutenir vos recherches en endocrinologie, pharmacologie et sciences médicales.
Sous-catégories appartenant à la catégorie "Endocrinologie/Hormones"
- Récepteur des androgènes(229 produits)
- Annexine A(16 produits)
- Aromatase(23 produits)
- Récepteur d'œstrogène/progestatif(66 produits)
- GPR(1 produits)
- Récepteur des glucocorticoïdes(165 produits)
- LHRH(2 produits)
- Récepteur opioïde(327 produits)
- Récepteur de prostaglandine(122 produits)
- RAAS(89 produits)
- Réductase(51 produits)
- Somatostatine(57 produits)
- Récepteur des hormones thyroïdiennes (THR)(33 produits)
- Récepteur de la vasopressine(48 produits)
Affichez 6 plus de sous-catégories
3420 produits trouvés pour "Endocrinologie/Hormones"
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EX-A5386
CAS :EX-A5386 (Glucocorticoid receptor modulator-1) is a potent glucocorticoid receptor modulator, IC50/EC50<100nM.
Formule :C29H27FN4O2Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :482.55Triphenylethylene
CAS :Compound PDK0283, with CAS No. 58-72-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0283 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C20H16Couleur et forme :White PowderMasse moléculaire :256.34Angiotensin II (1-4), human TFA
Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure.Formule :C26H38F3N7O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :665.62PROTAC ER Degrader-2
PAC, based on WO2017201449A1's LP2, enhances ERα degradation; used in making ADCs with PROTAC-linker, it's attached to antibodies.Formule :C89H104N12O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1581.85D3R/MOR antagonist 1
Compound 114 (D3R/MOR antagonist 1) exhibits dual antagonistic activity at dopamine D3 receptors (D3R) and mu-opioid receptors (MOR), with K i values of 46.5 nMFormule :C22H27Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.38BAM-22P
CAS :Bovine adrenal medulla docosapeptide (BAM-22P) is a potent opioid agonist, derived from the proenkephalin A gene, which is present in the adrenal medulla.Formule :C130H184N38O31S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2839.22TAN67
CAS :TAN67 is the first effective selective non-peptide delta1 opioid receptor.
Formule :C23H26Br2N2OCouleur et forme :SolidMasse moléculaire :506.282OT antagonist 1 demethyl derivative
OT antagonist 1 demethyl derivative is the demethyl derivative of OT antagonist 1. OT antagonist 1 is a selective Oxytocin antagonist (Ki of 50 nM. )Formule :C21H20N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.41Vasopressin Dimer (anti-parallel) (TFA)
Vasopressin Dimer (anti-parallel) TFA, an anti-parallel dimer form of vasopressin, has the capability to activate four G protein-coupled receptors: V1aR, V1bR,Formule :C94H131F3N30O26S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2282.49β-Endorphin, equine TFA
β-Endorphin, equine TFA, an endogenous opioid peptide, demonstrates high affinity binding to μ/δ opioid receptors and possesses analgesic properties [1] [2] [3Formule :C156H249F3N42O46SCouleur et forme :SolidMasse moléculaire :3537.96Frakefamide TFA
Frakefamide TFA: potent, peripherally active μ-opioid agonist; doesn't cross blood-brain barrier.Formule :C32H35F4N5O7Couleur et forme :SolidMasse moléculaire :677.6415,26-Dihydroxylanosta-7,9(11),24-trien-3-one
CAS :15,26-Dihydroxylanosta-7,9(11),24-trien-3-one is a natural product that can be used as a reference standard. The CAS number of 15,26-Dihydroxylanosta-7,9(11),24-trien-3-one is 420781-85-7.Formule :C30H46O3Couleur et forme :SolidMasse moléculaire :454.7ICI 174,864
CAS :Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.Formule :C38H53N5O7Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :691.87Hemorphin-7
CAS :Hemorphin-7, an atypical opioid peptide from hemoglobin, may enhance memory, promote cell growth, and is a potential breast cancer biomarker.Formule :C49H64N12O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :997.11BAY 1003803
CAS :BAY 1003803 is a glucocorticoid receptor agonist for the topical treatment of psoriasis or severe atopic dermatitis.Formule :C21H18ClF5N2O4Couleur et forme :SolidMasse moléculaire :492.83PROTAC ERα Degrader-2
CAS :PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader.Formule :C42H61N5O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :763.96Neuropeptide EI, rat
CAS :Displays functional MCH-antagonist and MSH-agonist activity in different behavioral paradigms.Formule :C63H98N16O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1447.55WAY267464 HCl
CAS :WAY267464: nonpeptide OT agonist, anxiolytic, modulates selectivity, improves CNS entry and oral uptake.Formule :C32H37Cl2N7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.59Dexamethasone phosphate
CAS :Dexamethasone phosphate is a synthetic adrenal corticosteroid. It also has potent anti-inflammatory properties.Formule :C22H30FO8PCouleur et forme :SolidMasse moléculaire :472.44Vasopressin Dimer (parallel) (TFA)
Vasopressin Dimer (parallel) TFA, a parallel dimer of Vasopressin, has the capability to activate four G protein-coupled receptors—namely, V1aR, V1bR, V2R, andFormule :C94H131F3N30O26S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2282.49Dynorphin A (1-10)
CAS :Dynorphin A (1-10) is an opioid peptide, binds κ-opioid receptor, blocks NMDA current, IC50: 42.0 μM.Formule :C57H91N19O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1234.45Angiotensin II 5-valine
CAS :ngiotensin II 5-valine is an angiotensin II analog which is an agonist at angiotensin receptors.Formule :C49H69N13O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :N/AERRγ agonist-2
CAS :ERRγ agonist-2 is a potent and selective ERRγ inverse agonist with a K d value of 6.5 μM.Formule :C27H21N5O2Couleur et forme :SolidMasse moléculaire :447.49OP-3633
CAS :OP-3633: potent GR antagonist (IC50: 29 nM), low PR agonism, AR antagonism, inhibits GR transcription.Formule :C30H39NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.64Zankiren
CAS :Zankiren is a renin inhibitor. Zankiren can reduce blood pressure, plasma renin activity, and angiotension II.Formule :C35H55N5O6S2Couleur et forme :SolidMasse moléculaire :705.9711-Ketodihydrotestosterone
CAS :11-Ketodihydrotestosterone is a metabolite of 11β-Hydroxyandrostenedione. It is an active androgen and is also a potent androgen receptor (AR) agonist (Ki: 20.4 nM, EC50: 1.35 nM for human AR).Formule :C19H28O3Couleur et forme :SolidMasse moléculaire :304.42Koreanoside E
CAS :Koreanoside E is a useful organic compound for research related to life sciences. The catalog number is T125538 and the CAS number is 1804014-67-2.Formule :C27H30O11Couleur et forme :SolidMasse moléculaire :530.526Prednicarbate
CAS :Prednicarbate (Hoe 777), a corticosteroid, has antipruritic, anti-inflammatory effects, reduces lymphocytes, and inhibits vasodilators.Formule :C27H36O8Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :488.57PROTAC ER Degrader-14
CAS :PROTAC ER Degrader-14 (compound 86) is a PROTAC-type estrogen receptor/ERR degrader. It comprises an E3 ubiquitin ligase ligand (blue part) (S)-Deoxy-thalidomide, a PROTAC linker (black part) N-Boc-piperazine, and a target protein ligand (red part) ER ligand-6. The combination of the E3 ligase and linker forms tert-Butyl (S)-4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carboxylate.Formule :C44H46FN5O5Couleur et forme :SolidMasse moléculaire :743.865SNIPER(ER)-87
CAS :SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (Formule :C59H73N5O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1044.32KOR agonist 5
KOR agonist 5 (Compound 10a) is both a KOR/MOR modulator, exhibiting agonistic effects on KOR and antagonistic effects on MOR. It effectively blocks morphine-induced antinociception and gastrointestinal motility inhibition. KOR agonist 5 is applicable in research related to substance use disorder (SUD).Formule :C38H38N2O5Couleur et forme :SolidMasse moléculaire :602.72ERα degrader 12
ERα degrader12 (Compound RA3) is an estrogen receptor alpha (ERα) degrader with antitumor properties. It significantly suppresses tumor growth in a xenograft mouse model of breast cancer.Formule :C39H41NO9SCouleur et forme :SolidMasse moléculaire :699.81Nurr1 agonist 5
Compound 5o, a Nurr1 agonist, exhibits neuroprotective properties as a transcription factor Nurr1 agonist, possessing a dissociation constant (Kd) of 0.5 μM andCouleur et forme :Odour SolidLO-4-25
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.Couleur et forme :Odour SolidUrotensin II (114-124), human TFA
Urotensin II (114-124), human TFA, is an 11-amino acid peptide and potent vasoconstrictor, acting as GPR14 agonist.Formule :C66H86F3N13O20S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1502.59Zavacorilant
CAS :Zavacorilant is capable of modulating glucocorticoid receptor (GR).Formule :C25H26FN7O3S2Couleur et forme :SolidMasse moléculaire :555.65PROTAC AR Degrader-4 TFA
PROTAC AR Degrader-4: IAP ligand, linker, AR binder; it's a SNIPER that degrades AR non-genetically.Formule :C45H68F3N3O11Couleur et forme :SolidMasse moléculaire :884.03KOR agonist 4
KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.Formule :C21H25N3Couleur et forme :SolidMasse moléculaire :319.44HINT1-IN-1
HINT1-IN-1 (compound 8) is an inhibitor of histidine triad nucleotide-binding protein 1 (HINT1) with a Ki of 1.14 μM. It influences the cross-regulation between μ-opioid receptors (MOR) and NMDA receptors (NMDAR).Formule :C23H24N8O5Couleur et forme :SolidMasse moléculaire :492.49PROTAC AR-V7 degrader-1
CAS :Potent, oral AR-V7 degrader (Compound 6); DC50: 0.32µM; targets AR-DBD via VHL E3; EC50: 0.88µM in 22Rv1 cells.Formule :C41H52N6O6S2Couleur et forme :SolidMasse moléculaire :789.02BI 653048 phosphate
CAS :BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).Formule :C23H28F4N3O8PSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :613.52Enclomiphene-d4
Enclomiphene-d4 is the deuterium-labeled analog of Enclomiphene. Enclomiphene functions as a potent and orally active estrogen receptor antagonist, exhibiting antiestrogenic properties.Couleur et forme :Odour SolidCgp 29287
CAS :Cgp 29287 is a primate-specific renin inhibitor. It also has a prolonged duration of action.Formule :C72H110N20O15Couleur et forme :SolidMasse moléculaire :1495.77RLA-4842
RLA-4842: iron-based anti-androgen; inhibits mCRPC cell proliferation.Formule :C42H46F3N5O8SCouleur et forme :SolidMasse moléculaire :837.94A7C-301
4A7C-301, a Nurr1 agonist, exhibits potent neuroprotective effects in vitro and markedly mitigates neuropathological abnormalities while enhancing motor andCouleur et forme :Odour SolidARCC-4
CAS :ARCC-4: A VHL-recruiting, low-nanomolar (DC50=5nM) AR degrader; outshines enzalutamide; degrades AR mutants resistant to therapy.Formule :C53H56F3N7O7S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1024.18Parathyroid hormone (1-34) (rat)
CAS :Parathyroid hormone (PTH) receptor agonist. Increases serum PTH levels and bone mass in rats.Formule :C180H291N55O48S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4057.74Biphalin TFA
CAS :Biphalin TFA is an opioid peptide analog that penetrates the blood-brain barrier (BBB) and encompasses two active enkephalin pharmacophores.Formule :C46H56N10O10·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :909.00 (free base)Betamethasone acibutate
CAS :Betamethasone acibutate, a glucocorticoid, is derived from Betamethasone.Formule :C28H37FO7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.59Remikiren
CAS :Remikiren is a highly specific renin inhibitor with oral activity for the treatment of hypertensio.Formule :C33H50N4O6SCouleur et forme :SolidMasse moléculaire :630.84
