Endocrinologie/Hormones
Les inhibiteurs en endocrinologie/hormonaux sont des composés qui bloquent l'action des hormones ou interfèrent avec les voies de signalisation hormonales. Ces inhibiteurs sont essentiels pour étudier la régulation des systèmes endocriniens et pour développer des traitements pour les maladies liées aux hormones, telles que le diabète, les troubles de la thyroïde et les cancers hormonodépendants. En modulant l'activité hormonale, ces inhibiteurs peuvent aider à élucider les interactions complexes au sein du système endocrinien. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité en endocrinologie/hormonaux pour soutenir vos recherches en endocrinologie, pharmacologie et sciences médicales.
Sous-catégories appartenant à la catégorie "Endocrinologie/Hormones"
- Récepteur des androgènes(229 produits)
- Annexine A(16 produits)
- Aromatase(23 produits)
- Récepteur d'œstrogène/progestatif(66 produits)
- GPR(1 produits)
- Récepteur des glucocorticoïdes(164 produits)
- LHRH(2 produits)
- Récepteur opioïde(327 produits)
- Récepteur de prostaglandine(122 produits)
- RAAS(89 produits)
- Réductase(51 produits)
- Somatostatine(57 produits)
- Récepteur des hormones thyroïdiennes (THR)(34 produits)
- Récepteur de la vasopressine(48 produits)
Affichez 6 plus de sous-catégories
3419 produits trouvés pour "Endocrinologie/Hormones"
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[DAla2, DArg6] Dynorphin A, (1-13) (porcine)
CAS :'[DAla2, DArg6] Dynorphin A (1-13) porcine is a potent opioid peptide resistant to enzymatic degradation.'Formule :C76H128N24O15Couleur et forme :SolidMasse moléculaire :1617.98β-Endorphin (rat)
CAS :β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities.Formule :C157H254N42O44SCouleur et forme :SolidMasse moléculaire :3466.07Dynorphin B (1-13) (TFA)
Dynorphin B (1-13) TFA acts as an agonist on opioid κ-receptor .Formule :C76H116N21F3O19Couleur et forme :SolidMasse moléculaire :1684.86Kylo-0603
CAS :KYLO-0603 is an orally active and selective THR-β agonist with an EC50 of 31.07 nM. It effectively reduces serum cholesterol and low-density lipoprotein cholesterol levels. By activating THR-β receptors, KYLO-0603 enhances the expression of THR-regulated genes like iodothyronine deiodinase 1 (Dio1), malic enzyme 1 (Me1), and thyroid hormone-responsive (Thrsp) gene, while it inhibits the expression of inflammatory and fibrosis-related genes, including low-density lipoprotein receptor (LDL-R) gene. This compound is applicable for the study of metabolic associated steatohepatitis (MASH) and liver fibrosis.Formule :C81H134N8O28Couleur et forme :SolidMasse moléculaire :1667.97(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8)
CAS :E-2078, known chemically as (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8), is a stable analog of Dynorphin A (1–8) and functions as a kappa opioidFormule :C50H81N15O9Couleur et forme :SolidMasse moléculaire :1036.27PRL 3195
CAS :PRL 3195: Somatostatin antagonist, Ki: 6 nM (sst5), 17 nM (sst2), 66 nM (sst3), 1 μM (sst1/4).Formule :C58H69ClN12O9S2Couleur et forme :SolidMasse moléculaire :1177.83ALR2-IN-6
ALR2-IN-6 (compound 9) is a potent competitive inhibitor of ALR2, with a Ki value of 0.064 μM. It is applicable in research related to neuropathy, retinopathy, and nephropathy.Formule :C21H19BrFN3OCouleur et forme :SolidMasse moléculaire :427.06955Prepro-TRH-(160-169)
CAS :Prepro-TRH-(160-169), a pro-TRH peptide, enhances TRH-stimulated TSH secretion.Formule :C54H75N11O18SCouleur et forme :SolidMasse moléculaire :1198.3THR-β agonist 2 diacetate
THR-β agonist 2 diacetate (Compound 3) is a potent THR-β agonist with potential applications in researching metabolic disorders such as obesity, hyperlipidemia, hypercholesterolemia, and diabetes, as well as other conditions like steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis, and other related diseases and conditions.Couleur et forme :Odour SolidAc-RYYRWK-NH2 TFA
CAS :Ac-RYYRWK-NH2: potent, specific NOP receptor partial agonist with 0.071 nM affinity; no affinity for μ/κ/δ-opioid receptors.Formule :C51H70F3N15O11Couleur et forme :SolidMasse moléculaire :1126.21PROTAC ERα Degrader-7
CAS :PROTAC ERα Degrader-7 (Compound i-320) is a powerful PROTAC degrader targeting the estrogen receptor alpha (ERα), exhibiting a DC50 of 0.000006 µM. This compound consists of a cereblon-binding segment, LBM, connected to ERBM, an ERα-binding ligand that includes a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring [1].Formule :C46H49F2N5O4Couleur et forme :SolidMasse moléculaire :773.91Melanin Concentrating Hormone, salmon TFA
MCH (salmon) TFA is a 19-amino-acid neuropeptide affecting appetite, energy, sleep, and heart health via GPCR SLC-1/GPR24 and MCHR2.Formule :C91H140F3N27O26S4Couleur et forme :SolidMasse moléculaire :2213.5Aclerastide
CAS :Aclerastide, an angiotensin receptor agonist, decreases fibrosis in wounds; effect increases with use duration, blocked by AT antagonist.Formule :C42H64N12O11Couleur et forme :SolidMasse moléculaire :913.03PROTAC ERα Degrader-8
CAS :PROTAC ERα Degrader-8 (compound ii-56), a highly potent degrader of Erα, achieves a DC50 of just 0.000006 μM in MCF7 cells [1].Formule :C47H51N5O4Couleur et forme :SolidMasse moléculaire :749.94[Nphe1]Nociceptin(1-13)NH2 TFA
[Nphe1]Nociceptin(1-13)NH2 is a selective nociceptin receptor antagonist with potential analgesic properties, pKi=8.4, pA2=6.0.Formule :C63H101F3N22O17Couleur et forme :SolidMasse moléculaire :1495.61Floramanoside C
CAS :Floramanoside C exhibits 2,2-diphenyl-1-picrylhydrazyl scavenging and aldose reductase inhibitory activities [1].Formule :C21H18O15Couleur et forme :SolidMasse moléculaire :510.36[Ala17]-MCH TFA
'[Ala17]-MCH TFA is an MCH analogue, a selective MCHR1 ligand (Ki=0.16 nM) with high affinity (Kd=0.37 nM), and low MCHR2 affinity (Ki=34 nM).Formule :C99H156F3N29O28S4Couleur et forme :SolidMasse moléculaire :2385.73MCH(human, mouse, rat) TFA
MCH TFA, a peptide, selectively binds MCH1R and MCH2R with IC50 of 0.3nM, 1.5nM; EC50s are 3.9nM (MCH1R) and 0.1nM (MCH2R) in CHO cells.Formule :C107H161F3N30O28S4Couleur et forme :SolidMasse moléculaire :2500.86Abaloparatide
CAS :Abaloparatide (BA 058) is a selective PTHR1 analog that promotes bone growth and may be researched for osteoporosis.Formule :C174H300N56O49Couleur et forme :SolidMasse moléculaire :3960.59hFSH-β-(33-53) (TFA)
hFSH-β-(33-53) TFA, a thiol-containing peptide representing the second follicle-stimulating hormone receptor (FSHR) binding domain, acts as an FSHR antagonist.Formule :C115H183N31O32SxC2HF3O2Couleur et forme :SolidMasse moléculaire :2657.96Yp537
CAS :Yp537 acts as an estrogen receptor (ER) inhibitor, specifically preventing the dimerization of the human estrogen receptor [1].Formule :C64H104N13O22PSCouleur et forme :SolidMasse moléculaire :1470.62(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin
CAS :'(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin blocks oxytocin receptors, stopping oxytocin effects on CA1 neuron currents.'Formule :C45H69N9O12S2Couleur et forme :SolidMasse moléculaire :992.21Eprosartan
CAS :Eprosartan is a selective AT1 receptor blocker with IC50s of 9.2 nM (rat) and 3.9 nM (human), used for hypertension.Formule :C23H24N2O4SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :424.51TrxR1 prodrug-1
TrxR1 prodrug-1 (compound 5u) is a potent inhibitor of TrxR1, demonstrating significant antitumor activity in nude mice and NSCLC organoids.Formule :C22H30N2O6S2Couleur et forme :SolidMasse moléculaire :482.6139,10-Dihydrophenanthrene
CAS :9,10-Dihydrophenanthrene has inhibitory activity against the androgen receptor and can be used in related research in the field of life sciences.Formule :C14H12Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :180.25DDHF20
DDHF20 is an inhibitor of Staphylococcus aureus, specifically targeting and inhibiting its thioredoxin reductase (TrxR) by acting as a competitive inhibitor at the NADPH binding site. DDHF20 shows potential for research in combating infections related to Staphylococcus aureus.Formule :C34H28O4Couleur et forme :SolidMasse moléculaire :500.58Rimexolone
CAS :Rimexolone is a glucocorticoid steroid used to treat inflammation in the eye.Formule :C24H34O3Couleur et forme :SolidMasse moléculaire :370.52Tetrahydro Aldosterone
CAS :Tetrahydro Aldosterone is a steroidal compound that inhibits the adrenal angiotensin II receptor, with an IC50 of 10 μM.Formule :C21H32O5Couleur et forme :SolidMasse moléculaire :364.48PRL 2915
CAS :PRL 2915 is a potent antagonist of the human somatostatin subtype 2 receptor (hsst 2), exhibiting a binding affinity (K_i) of 12 nM [1].Formule :C59H71ClN12O8S2Couleur et forme :SolidMasse moléculaire :1175.85PRO20
PRO20 is a specific and competitive antagonist of the (pro)renin receptor (PRR). It inhibits the calcium influx induced by Proproin with an IC50 value of 81 nmol/L. By blocking the binding of Prorenin to PRR, PRO20 inhibits the activation of the renin-angiotensin system (RAS), reducing the production of angiotensin II (Ang II) and exerting antihypertensive effects. PRO20 holds promise for research in antihypertensive agents.
Couleur et forme :Odour SolidDPC-AJ1951 TFA
DPC-AJ1951 TFA is a 14 amino acid peptide, potent PTH/PPR agonist, tested in bone resorption assays.Formule :C78H128F3N23O21Couleur et forme :SolidMasse moléculaire :1781.02(Glu2)-TRH
CAS :(Glu2)-TRH: Stable TRH analog; reduces TRH's cholinergic action; no thyroliberinase metabolism; neuroprotective with antidepressant, anticonvulsant effects.Formule :C15H22N4O6Couleur et forme :SolidMasse moléculaire :354.36Osteostatin
CAS :Osteostatin, derived from parathyroid hormone-related protein (PTHrP) 107-111, has demonstrated properties conducive to bone repair in animal models presentingFormule :C27H41N9O8Couleur et forme :SolidMasse moléculaire :619.677α-(Thiomethyl)spironolactone
CAS :7α-(Thiomethyl)spironolactone is a steroid receptor antagonist and major spironolactone metabolite, steroid metabolism, nuclear receptor, and coronavirus.Formule :C23H32O3SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :388.56NPFF1-R antagonist 1
NPFF1-R antagonist 1 (compound 8b) is a piperidine analog and an effective neuropeptide FF (NPFF) receptor antagonist. It exhibits 15-fold selectivity for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.Formule :C37H44N4OMasse moléculaire :560.35151VinclozolinM2-2204
VinclozolinM2-2204 is an androgen receptor AUTOTAC degrader with a DC50 of 200 nM in LNCaP prostate cancer cells. It induces the formation of AR+LC3+ autophagic membranes and is applicable for cancer research.Formule :C43H51Cl2N3O9Masse moléculaire :823.30024DP50
DP50 is a bifunctional compound containing both an opioid receptor agonist (MOP) and a neuropeptide FF receptor (NPFFR) antagonist. It can be utilized in studies related to analgesia.Formule :C58H72N8O7Masse moléculaire :992.5524PIPE-3297
PIPE-3297 (compound 25) is a selective kappa opioid receptor (KOR) agonist that activates the G protein signaling pathway with an EC50 of 1.1 nM and exhibits low β-arrestin-2 recruitment activity (10%). Additionally, PIPE-3297 promotes myelination and has anti-inflammatory properties.Formule :C23H30N2OMasse moléculaire :350.23581Nurr1 agonist 9
Nurr1 agonist 9 (Compound 36) acts as an agonist for Nurr1, with an EC50 of 0.090 µM and a Kd of 0.17 µM. It activates Nurr1 homodimers (NurRE, EC50 = 0.094 µM) and Nurr1-RXR heterodimers (DR5, EC50 = 0.165 µM). This compound induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in Parkinson's disease organoid models and can penetrate the human brain endothelial cell barrier.
Formule :C21H19ClN4O2Masse moléculaire :394.11965Awl 60
CAS :Awl 60 is a substance P (6-11) non-competitive antagonist.Formule :C57H65N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1036.25SB 205607 dihydrobromide
CAS :non-peptide δ1 opioid receptor agonistFormule :C23H24N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :344.45Ethamoxytriphetol
CAS :Ethamoxytriphetol is a non-steroidal estrogen antagonist.Formule :C27H33NO3Couleur et forme :SolidMasse moléculaire :419.56Bradykinin potentiator-5
CAS :Bradykinin potentiator-5 is a peptide inflammatory mediator, causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall.Formule :C30H41N7O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :611.69Enalapril
CAS :Enalapril is a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.Formule :C20H28N2O5Degré de pureté :99.47% - 99.51%Couleur et forme :SolidMasse moléculaire :376.455-O-β-D-Glucopyranosylmyricanol
5-O-beta-D-Glucopyranosylmyricanol is a useful organic compound for research related to life sciences and the catalog number is T123967.Formule :C27H36O10Couleur et forme :SolidMasse moléculaire :520.575RU-39411
CAS :RU-39411 is a steroidal anti-estrogen.Formule :C28H37NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.60Acetiromate
CAS :Acetiromate is a drug of antilipidemic. It is used to treat hyperlipidemia.Formule :C15H9I3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :649.94LY301875
CAS :LY301875 is an antagonist of nonpeptide angiotensin receptor.Formule :C31H36N4O10SCouleur et forme :SolidMasse moléculaire :656.70AT2R antagonist 2
Compound I-16 (AT2R antagonist 2) is an orally active AT2R antagonist.Formule :C20H23F3N8SCouleur et forme :SolidMasse moléculaire :464.51TRIP13-IN-1
TRIP13-IN-1 (compound 20) is a potent ligand and inhibitor of TRIP13, demonstrating anticancer effects both in vivo and in vitro.Formule :C24H25NO9SCouleur et forme :SolidMasse moléculaire :503.52
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