Endocrinologie/Hormones
Les inhibiteurs en endocrinologie/hormonaux sont des composés qui bloquent l'action des hormones ou interfèrent avec les voies de signalisation hormonales. Ces inhibiteurs sont essentiels pour étudier la régulation des systèmes endocriniens et pour développer des traitements pour les maladies liées aux hormones, telles que le diabète, les troubles de la thyroïde et les cancers hormonodépendants. En modulant l'activité hormonale, ces inhibiteurs peuvent aider à élucider les interactions complexes au sein du système endocrinien. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité en endocrinologie/hormonaux pour soutenir vos recherches en endocrinologie, pharmacologie et sciences médicales.
Sous-catégories appartenant à la catégorie "Endocrinologie/Hormones"
- Récepteur des androgènes(209 produits)
- Annexine A(11 produits)
- Aromatase(20 produits)
- Récepteur d'œstrogène/progestatif(49 produits)
- GPR(1 produits)
- Récepteur des glucocorticoïdes(153 produits)
- LHRH(1 produits)
- Récepteur opioïde(297 produits)
- Récepteur de prostaglandine(120 produits)
- RAAS(87 produits)
- Réductase(52 produits)
- Somatostatine(49 produits)
- Récepteur des hormones thyroïdiennes (THR)(26 produits)
- Récepteur de la vasopressine(44 produits)
Affichez 6 plus de sous-catégories
3183 produits trouvés pour "Endocrinologie/Hormones"
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Trimegestone
CAS :<p>Trimegestone, a highly effective oral progestogen, is used for endometrial protection, all doses inducing secretory endometrial transformation.</p>Formule :C22H30O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.47GPR40 Agonist 2
CAS :<p>GPR40 Agonist 2 is a GPR40 agonist. It can be used in the research of diabetes.</p>Formule :C24H30O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.49MCHR1 antagonist 2
CAS :<p>MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.</p>Formule :C23H21FN2O5Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :424.42GPR52 receptor modulator 1
CAS :<p>GPR52 receptor modulator 1, a compound delineated as per Procedure 1, is a modulator of the GPR52 receptor, offering research potential in the investigation of</p>Formule :C19H14F4N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.33SPH3127
CAS :<p>SPH3127 is a potent oral direct renin inhibitor, effective at 0.4 nM for human renin, used to study hypertension.</p>Formule :C22H32N6O4Couleur et forme :SolidMasse moléculaire :444.53MK-7246
CAS :MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM).Formule :C21H21FN2O4SCouleur et forme :SolidMasse moléculaire :416.47MB-07344
CAS :<p>MB-07344 is a selective THR-β (thyroid hormone receptor β) agonist with a Ki of 2.17 nM, capable of reducing plasma total cholesterol (TPC).</p>Formule :C19H25O5PDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :364.37THR-β modulator-1
CAS :<p>THR-β Modulator-1 (Compound 1a) is a potent modulator of the thyroid hormone receptor β, utilized in the study of thyroid hormone receptor-associated disorders</p>Formule :C17H14Cl2N6O4Couleur et forme :SolidMasse moléculaire :437.24A81988
CAS :<p>A81988 is an antagonist of angiotensin AT1 receptors.</p>Formule :C23H22N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.46DS08210767
CAS :<p>DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.</p>Formule :C31H39N5O2Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :513.67Baxdrostat
CAS :<p>Baxdrostat is an aldosterone synthase inhibitor.</p>Formule :C22H25N3O2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :363.45CO23
CAS :<p>CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.</p>Formule :C19H18I2N2O4Degré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :592.17Rovatirelin
CAS :<p>Rovatirelin (S-0373) is a TRH analog that improves motor dysfunction in a rat model of cytosine arabinoside-induced spinal cerebellar degeneration.</p>Formule :C16H22N4O4SDegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :366.43Giredestrant tartrate
CAS :<p>Giredestrant tartrate: a new oral, selective non-steroidal ER antagonist, inhibits ER-mediated gene activation and degrades ER protein, treating tumors.</p>Formule :C31H37F5N4O7Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :672.64GW-803430
CAS :<p>GW-803430: potent MCH R1 antagonist, pIC50=9.3, orally effective against obesity in animals.</p>Formule :C25H24ClN3O3SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :481.99MB-07811
CAS :<p>MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity.</p>Formule :C28H32ClO5PDegré de pureté :99.74% - 99.94%Couleur et forme :SolidMasse moléculaire :514.98AMG 837 calcium hydrate
CAS :<p>AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM.</p>Formule :C52H44CaF6O8Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :950.97Naldemedine tosylate
CAS :<p>Naldemedine (S-297995) tosylate, a PAMORA, targets μ-, δ-, κ-opioid receptors, aiding OIC research, may bind to SARS-CoV2's 3CL pro.</p>Formule :C39H42N4O9SCouleur et forme :SolidMasse moléculaire :742.84SDM25N hydrochloride
CAS :<p>δ receptor antagonist</p>Formule :C26H27ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :450.96GLPG0492 (R enantiomer)
CAS :<p>GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, a novel selective androgen receptor modulator.</p>Formule :C19H14F3N3O3Couleur et forme :SolidMasse moléculaire :389.33AVE 0991
CAS :<p>AVE 0991 is a nonpeptide analog of angiotensin-(1-7), a Mas agonist with inhibitory effects on [125I]-Ang-(1-7) and on neuroinflammation in Alzheimer's disease.</p>Formule :C29H32N4O5S2Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :580.72AP5 sodium
CAS :<p>AP5 sodium: potent oral GPR40 agonist, enhances ligands, may aid type II diabetes research.</p>Formule :C28H27FNNaO4Couleur et forme :SolidMasse moléculaire :483.515Estrogen receptor-agonist-1
CAS :<p>Estrogen receptor-agonist-1 (compound 4e) is an estrogen receptor (ER) agonist that binds to ERα with high affinity.</p>Formule :C24H22N2O2Couleur et forme :SolidMasse moléculaire :370.444Estrone acetate
CAS :<p>Estrone acetate (Hogival) is an estrogen derivative and an activator of estrogen receptors (ER). This compound can enhance breast development, stimulate the secretion of pituitary prolactin, and induce both the proliferation and activation of lactotrophs, evidenced by the reduction in prolactin storage granule size and the increase in the volume density of the rough endoplasmic reticulum and Golgi apparatus. Estrone acetate holds potential for endocrinological research and for investigating the mechanisms by which estrogen influences pituitary function, prolactin regulation, and breast tumor models.</p>Formule :C20H24O3Couleur et forme :SolidMasse moléculaire :312.403Androgen receptor degrader-5
CAS :<p>Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.</p>Formule :C29H25F4N5O2Couleur et forme :SolidMasse moléculaire :551.53ORIC-101
CAS :<p>ORIC-101 is a highly effective and selective glucocorticoid receptor antagonist (EC50: 5.6 nM). It also has anti-cancer activity.</p>Formule :C34H47NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.74ERRγ agonist-1
<p>ERRγ agonist-1 can be used in neuropsychological disorders research.</p>Formule :C17H21N5OCouleur et forme :SolidMasse moléculaire :311.38TRβ agonist 1
CAS :<p>TRβ Agonist 1, a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, demonstrates an EC50 value of 21 nM.</p>Formule :C29H25FN2O8Couleur et forme :SolidMasse moléculaire :548.52Estrogen receptor antagonist 4
CAS :<p>Estrogen receptor antagonist 4 blocks ER, impacting cell growth and cancer research potential.</p>Formule :C23H29BF4N4O2Couleur et forme :SolidMasse moléculaire :480.31rel-SB-612111 hydrochloride
CAS :<p>NOP receptor antagonist</p>Formule :C24H30Cl3NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.86Androstatrione
CAS :<p>Androstatrione is an androgenic compound.</p>Formule :C19H26O3Couleur et forme :SolidMasse moléculaire :302.41JNJ-1250132
CAS :<p>JNJ-1250132 is a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro.</p>Formule :C33H41NO4Couleur et forme :SolidMasse moléculaire :515.68Metahexestrol
CAS :<p>Metahexestrol is an inhibitor of the estrogen receptor (E2R) with antitumor activity. It significantly inhibits the proliferation of estrogen receptor-positive MCF-7 human breast cancer cell line with an ED50 of 1.0 μM. Additionally, Metahexestrol shows inhibitory activity in estrogen receptor-negative MDA-MB-231 cell lines, and its antiproliferative effect is not reversed by estrogen, suggesting that its mechanism may be partially independent of the E2R pathway. Metahexestrol is applicable in research on estrogen-dependent breast cancer.</p>Formule :C18H22O2Couleur et forme :SolidMasse moléculaire :270.366GC 14
CAS :<p>GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 200 nM and 35 nM for hTRα and hTRβ, respectively.</p>Formule :C26H27NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.5LIT-001 free base
CAS :<p>LIT-001, a nonpeptide OT-R agonist, enhances mouse autism-like behavior, with EC50=55 nM and Ki=226 nM.</p>Formule :C28H33N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.67GPR84 antagonist 3
CAS :<p>Potent GPR84 antagonist 3 (compound 42), pIC50 8.28, inhibits GTPγS, with good pharmacokinetics.</p>Formule :C29H27N5OCouleur et forme :SolidMasse moléculaire :461.56Isotodesnitazene
CAS :<p>Isotodesnitazene is an opioid compound that primarily targets the μ-opioid receptor (MOR). It exhibits EC50 values of 34.8 nM and 142 nM for MOR-βarr2 and MOR-mini-Gi, respectively. Isotodesnitazene can be utilized for research in opioid drugs.</p>Formule :C23H31N3OCouleur et forme :SolidMasse moléculaire :365.51Opioid receptor antagonist 1
CAS :<p>Opioid receptor antagonist 1 (Compound 10) is an Orvinol-based antagonist of opioid receptors. It exhibits activity as an antagonist against the analgesic properties of morphine.</p>Formule :C24H29ClF3NO4Couleur et forme :SolidMasse moléculaire :487.94Sunobinop
CAS :<p>Sunobinop (S 117957) is an opioid receptor-like orphan receptor (ORL1) modulator.</p>Formule :C26H33N3O3Couleur et forme :SolidMasse moléculaire :435.56FL442
CAS :<p>FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).</p>Formule :C15H13F3N2OCouleur et forme :SolidMasse moléculaire :294.27Anilopam
CAS :<p>Anilopam is an opioid analgesic belonging to the benzazepine class and acts as an agonist at opioid receptors.</p>Formule :C20H26N2OCouleur et forme :SolidMasse moléculaire :310.4322-Thiocyanatosalvinorin A
CAS :<p>22-Thiocyanatosalvinorin A (RB-64) is a potent selective agonist for the kappa-opioid receptor, exhibiting an EC50 value of 0.077 nM.</p>Formule :C24H27NO8SCouleur et forme :SolidMasse moléculaire :489.54CH5447240
CAS :<p>CH5447240: potent hPTHR1 agonist, treats Hypoparathyroidism, EC50 12 nM, 55% oral bioavailability, raises rat serum calcium.</p>Formule :C26H39N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.68LY2066948
CAS :<p>LY2066948 is a selective oral estrogen receptor modulator (SERM) with high affinity for estrogen receptors ERα and ERβ (Ki of 0.51 and 1.36 nM, respectively) and displays potent anti-estrogenic activity. It effectively blocks the increase in uterine weight induced by ethinylestradiol in immature rats. LY2066948 is utilized in the research of uterine fibroids and myomas.</p>Formule :C30H31NO5SCouleur et forme :SolidMasse moléculaire :517.64Norbinaltorphimine dihydrochloride
CAS :<p>Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.</p>Formule :C40H45Cl2N3O6Degré de pureté :98.17% - 99.88%Couleur et forme :SolidMasse moléculaire :734.71CCG258747
CAS :CCG258747 is a novel, selective inhibitor of the GRK2 subfamily.Formule :C28H27FN4O4Couleur et forme :SolidMasse moléculaire :502.54ERRα antagonist-2
CAS :<p>ERRα antagonist-2 is an estrogen-related receptor α inverse agonist, inhibiting migration and invasion in ER-negative MDA-MB-231,breast cancer.</p>Formule :C19H16N2O6SDegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :400.41ERβ agonist-1
CAS :<p>ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.</p>Formule :C25H36O2Couleur et forme :SolidMasse moléculaire :368.55MK-6913
CAS :<p>MK-6913 is a potent and selective agonist of estrogen receptor β.</p>Formule :C25H27N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.5ID11916
CAS :<p>ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.</p>Formule :C29H27F3N8O3SCouleur et forme :SolidMasse moléculaire :624.637
