Endocrinologie/Hormones
Les inhibiteurs en endocrinologie/hormonaux sont des composés qui bloquent l'action des hormones ou interfèrent avec les voies de signalisation hormonales. Ces inhibiteurs sont essentiels pour étudier la régulation des systèmes endocriniens et pour développer des traitements pour les maladies liées aux hormones, telles que le diabète, les troubles de la thyroïde et les cancers hormonodépendants. En modulant l'activité hormonale, ces inhibiteurs peuvent aider à élucider les interactions complexes au sein du système endocrinien. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité en endocrinologie/hormonaux pour soutenir vos recherches en endocrinologie, pharmacologie et sciences médicales.
Sous-catégories appartenant à la catégorie "Endocrinologie/Hormones"
- Récepteur des androgènes(209 produits)
- Annexine A(11 produits)
- Aromatase(20 produits)
- Récepteur d'œstrogène/progestatif(49 produits)
- GPR(1 produits)
- Récepteur des glucocorticoïdes(153 produits)
- LHRH(1 produits)
- Récepteur opioïde(297 produits)
- Récepteur de prostaglandine(120 produits)
- RAAS(87 produits)
- Réductase(52 produits)
- Somatostatine(49 produits)
- Récepteur des hormones thyroïdiennes (THR)(26 produits)
- Récepteur de la vasopressine(44 produits)
Affichez 6 plus de sous-catégories
3183 produits trouvés pour "Endocrinologie/Hormones"
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AR antagonist 11
CAS :<p>AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM). Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM). This compound is applicable in prostate cancer (PCa) research.</p>Formule :C20H17ClN2OCouleur et forme :SolidMasse moléculaire :336.815JDTic Dihydrochloride
CAS :JDTic Dihydrochloride is a high-affinity and selective κ-opioid receptor (KOR) antagonist that blocks dynorphin-KOR signalling,antidepressant.Formule :C28H41Cl2N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.55Elacestrant S enantiomer dihydrochloride
<p>Elacestrant (RAD1901) dihydrochloride, an oral ERR degrader, has IC50 of 48 nM (ERα) and 870 nM (ERβ). Its S enantiomer has low activity.</p>Formule :C30H40Cl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.56Estrogen receptor antagonist 7
CAS :<p>ER antagonist 7, compound 13, inhibits ERs, halts breast/ovarian cancer cell growth, has anticancer properties.</p>Formule :C23H17N3O4Couleur et forme :SolidMasse moléculaire :399.4(+)-JJ-74-138
CAS :<p>(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).</p>Formule :C22H22F8N2OSCouleur et forme :SolidMasse moléculaire :514.48LEO 134310
CAS :<p>LEO 134310: Selective, non-steroidal GR agonist with 14 nM EC50, for topical skin disease treatment.</p>Formule :C34H40N2O8Couleur et forme :SolidMasse moléculaire :604.69A 74273
CAS :<p>A 74273, a nonpeptidic and renin inhibitor, may be used to treat cardiovascular diseases due to renin inhibition.</p>Formule :C44H74N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.08EN1441
CAS :<p>EN1441 is a covalent degrader that targets the androgen receptor (AR) with an EC50 value of 4.2 μM, as well as its truncated variant AR-V7. It selectively and effectively degrades AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 holds potential for research into androgen-independent prostate cancer.</p>Formule :C13H13ClN2O2Couleur et forme :SolidMasse moléculaire :264.708Estrogen receptor antagonist 6
CAS :<p>Estrogen receptor antagonist 6 is a potent blocker of estrogen signaling, regulating various biological effects. (Compound 166)</p>Formule :C25H31F3N2O3Couleur et forme :SolidMasse moléculaire :464.52AR antagonist 10
CAS :<p>AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.</p>Formule :C18H17ClN4O3SCouleur et forme :SolidMasse moléculaire :404.871PBPE hydrochloride
CAS :<p>PBPE hydrochloride is a derivative of tamoxifen and functions as a selective ligand for antiestrogen binding sites (AEBS). The binding affinity (Ki) of PBPE hydrochloride and MBPE to AEBS is 8.79 nM and 17.57 nM, respectively.</p>Formule :C19H24ClNOCouleur et forme :SolidMasse moléculaire :317.853Estrogen receptor modulator 11
CAS :<p>Estrogen receptor modulator11 (Compound 27) is a tetrahydroisoquinoline derivative. It exhibits affinity for the estrogen receptor (ER), with IC50 values of 285 nM for ERα and 421 nM for ERβ. Estrogen receptor modulator11 does not demonstrate antagonist activity in MCF-7 cell assays.</p>Formule :C21H18FNOCouleur et forme :SolidMasse moléculaire :319.372Mu opioid receptor antagonist 4
<p>Compound 31: Potent, selective MOR antagonist; crosses blood-brain barrier; Ki & EC50: 0.38 nM; useful for OUD research.</p>Formule :C25H28N2O4SCouleur et forme :SolidMasse moléculaire :452.57Bromadoline
CAS :<p>Bromadoline is an opioid compound that exhibits anti-nociceptive properties in rodents.</p>Formule :C15H21BrN2OCouleur et forme :SolidMasse moléculaire :325.244Androgen receptor antagonist 11
CAS :<p>Androgen receptor antagonist 11 (compound N29) is a selective, orally available antagonist.</p>Formule :C20H19F3N4O3SCouleur et forme :SolidMasse moléculaire :452.45Triisopropyl phosphate
CAS :<p>Triisopropyl phosphate inhibits TFF1 and EGR3 gene expression and exhibits anti-estrogenic activity by suppressing Estradiol-induced proliferation of MCF-7 cells, with an EC50 of 341 μM. Additionally, Triisopropyl phosphate reduces estrogen response element (ERE)-stimulated luciferase activity in MVLN cells, with an EC50 of 900 μM.</p>Formule :C9H21O4PCouleur et forme :SolidMasse moléculaire :224.234RJG-2051
CAS :<p>RJG-2051 is a selective covalent inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), with an IC50 value of 13 nM. It interferes with the metabolism of substrates such as androgens, estrogens, and prostaglandins through AKR1C3. RJG-2051 holds potential for cancer research.</p>Formule :C26H31N5O4SCouleur et forme :SolidMasse moléculaire :509.62KNT-127
CAS :<p>KNT-127 is an agonist of δ-Opioid receptor.</p>Formule :C24H24N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.46AP5
CAS :<p>AP5: GPR40 agonist, positive allosteric modulator; rat hIP1 EC50: 0.49 nM.</p>Formule :C28H28FNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.52Glucocorticoid receptor activator 1
CAS :<p>Glucocorticoid Receptor Activator 1, a phenyl nitrogen-heterocyclic precursor, acts as an activator of the glucocorticoid receptor (GR). By activating GR, it downregulates the expression of pro-inflammatory genes stimulated by TNF, making it useful for inflammation research.</p>Formule :C11H15Cl2NO2Couleur et forme :SolidMasse moléculaire :264.15Androgen receptor antagonist 12
CAS :<p>Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.</p>Formule :C12H8F3N3O2Couleur et forme :SolidMasse moléculaire :283.21Naltrindole 5′-isothiocyanate
CAS :<p>Naltrindole 5′-isothiocyanate (5'-NTII) is an irreversible delta opioid receptor antagonist that counters the analgesic effects induced by DSLET without altering the effects caused by DPDPE.</p>Formule :C27H25N3O3SCouleur et forme :SolidMasse moléculaire :471.5716:2 Cl-PFAES
CAS :<p>6:2 Cl-PFAES exhibits reproductive toxicity by elevating the levels of serum estradiol and vitellogenin in adult males, which can harm the embryonic development of offspring.</p>Formule :C8ClF16KO4SCouleur et forme :SolidMasse moléculaire :570.67Urotensin-II receptor antagonist-1
CAS :<p>Urotensin-II receptor antagonist-1 (compound 1) is a human Urotensin II receptor antagonist with low oral bioavailability (F=0-3% in rats) and a Ki of 16 nM in HEK293 cells expressing human recombinant UT receptors. It inhibits cytochrome P450 enzymes (IC50=0.75 μM for CYP2D6; 1.4 μM for CYP3A4), suppresses κ opioid receptors (EC50=3.2 μM), and targets cardiac sodium channels (Ki=2.5 μM).</p>Formule :C25H31Cl2N3OCouleur et forme :SolidMasse moléculaire :460.439SJ1008066
CAS :<p>SJ1008066 is a MAGE-A11 inhibitor with an IC50 of 0.13 μM. It binds to the MAGE homology domain (MHD) and disrupts the MAGE-A11:PCF11 interaction.</p>Formule :C21H22N4Couleur et forme :SolidMasse moléculaire :330.43Glucocorticoid receptor agonist-5
CAS :<p>Glucocorticoid Receptoragonist-5 (compound 4) is an effective glucocorticoid molecule acting as a potent agonist for glucocorticoid receptors. It exhibits anti-inflammatory and immunosuppressive activities and serves as an ADC cytotoxin.</p>Formule :C36H40O7Couleur et forme :SolidMasse moléculaire :584.722-Hydroxy mifepristone
CAS :<p>22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcohol metabolite that exhibits both anti-progestational and anti-glucocorticoid activities. This compound contains an alkyne group and is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Furthermore, 22-Hydroxy Mifepristone demonstrates a relative binding affinity of 48% to the human glucocorticoid receptor.</p>Formule :C29H35NO3Couleur et forme :SolidMasse moléculaire :445.59Galaxolide
CAS :<p>Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), oxidative stress, and genotoxicity. It also stimulates the enzymatic activities of EROD and GST (Glutathione S-transferase).</p>Formule :C18H26OCouleur et forme :SolidMasse moléculaire :258.40Erα-IN-1
<p>Erα-IN-1 (compound 3c) is an inhibitor of the estrogen receptor α (ERα), effectively blocking ERα activity in MCF7/ERE-LUC cells.</p>Formule :C16H11FN2Couleur et forme :SolidMasse moléculaire :250.27BMS-986034
CAS :<p>BMS-986034 is a GPR119 agonist.</p>Formule :C24H24Cl2N6O4Couleur et forme :SolidMasse moléculaire :531.39Novokinin
CAS :<p>Angiotensin AT2 receptor agonist</p>Formule :C39H61N11O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :795.97SB-612111
CAS :<p>SB-612111: potent ORL-1 antagonist, Ki=0.33 nM; μ-, κ-, δ-receptor Ki=57.6, 160.5, 2109 nM; blocks nociceptin's pain effect.</p>Formule :C24H29Cl2NOCouleur et forme :SolidMasse moléculaire :418.405′-Guanidinonaltrindole
CAS :<p>5′-Guanidinonaltrindole (GNTI) is a selective antagonist of the kappa opioid receptor.</p>Formule :C27H29N5O3Couleur et forme :SolidMasse moléculaire :471.551Mu opioid receptor antagonist 2
<p>Compound 25: potent, selective MOR antagonist, crosses blood-brain barrier (Ki: 0.37 nM, EC50: 0.44 nM), for OUD research.</p>Formule :C25H28N2O4SCouleur et forme :SolidMasse moléculaire :452.57BW 443C
CAS :<p>BW 443C is a selective agonist of mu-opioid receptor.</p>Formule :C33H46N10O10Couleur et forme :SolidMasse moléculaire :742.791CI 992
CAS :<p>CI 992 is a novel potent inhibitor of primate renin.</p>Formule :C33H52N6O7S2Couleur et forme :SolidMasse moléculaire :708.93TUG-2181
CAS :<p>TUG-2181 is an antagonist of GPR84, with an IC50 value of 34 nM. It inhibits reactive oxygen species (ROS) production and IL-8 secretion induced by GPR84 agonists in human neutrophils. TUG-2181 is applicable for research in inflammation and fibrosis.</p>Formule :C21H27NO4Couleur et forme :SolidMasse moléculaire :357.443BMS-248360
CAS :<p>BMS-248360: Oral dual hAT1/hETA antagonist with Kis of 10nM & 1.9nM, respectively; treats hypertension.</p>Formule :C36H45N5O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :659.84GDC-0927 Racemate
CAS :<p>GDC-0927 Racemate is a degrader of estrogen receptor, is used in the research of ER-related diseases, potently inhibits ER-α activity, with an IC50 of 0.2 nM.</p>Formule :C28H28FNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.52S-HP210
<p>S-HP210: selective GR modulator, blocks NF-κB (IC50: 1.92 μM), non-toxic to mouse fibroblasts.</p>Formule :C22H19N3O2S2Couleur et forme :SolidMasse moléculaire :421.54BNTX
CAS :<p>BNTX (7-Benzylidenenaltrexone) is a selective δ1-opioid receptor antagonist. It competitively counteracts the antisecretory effects of DPDPE, Deltorphin 2, and DAMGO. BNTX is applicable in research focused on antinociceptive effects.</p>Formule :C27H27NO4Couleur et forme :SolidMasse moléculaire :429.508MLS000389544
CAS :<p>MLS000389544 is a selective and potent thyroid hormone receptor β (TRβ) antagonist with a methylsulfonyl nitrobenzoic acid structure. It effectively inhibits the interaction between TRβ and steroid receptor coactivator 2 (SRC2).</p>Formule :C20H24N2O7SCouleur et forme :SolidMasse moléculaire :436.479RX 809055AX
CAS :<p>RX 809055AX is a long lasting opioid antagonist at mu and delta receptors.</p>Formule :C29H29ClN2O4Couleur et forme :SolidMasse moléculaire :505SB-612111 hydrochloride
<p>SB-612111 is a potent ORL-1 antagonist, with high affinity (Ki: 0.33 nM) and µ-receptor activity (Ki: 57.6 nM), blocking Nociceptin-induced pain.</p>Formule :C24H30Cl3NOCouleur et forme :SolidMasse moléculaire :454.86BMS-986118
CAS :<p>BMS-986118 is a GPR40 full agonist targeting type II diabetes, prompting insulin release without hypoglycemia risk.</p>Formule :C25H28ClF3N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.96(±)-J 113397
CAS :<p>(±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist (K(i): cloned human ORL1=1.8 nM).</p>Formule :C24H37N3O2Couleur et forme :SolidMasse moléculaire :399.57DS69910557
<p>DS69910557: potent hPTHR1 antagonist, IC50 0.08 μM, oral, for hyperparathyroidism & osteoporosis research.</p>Formule :C32H33Cl2FN4O3Couleur et forme :SolidMasse moléculaire :611.53TD-0212
CAS :TD-0212: Oral dual antagonist for AT1 (pKi 8.9) & NEP inhibitor (pIC50 9.2).Formule :C28H34FN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.65ACT 178882
CAS :<p>ACT 178882 is a new Renin inhibitor (IC50: 1.4 nM).</p>Formule :C33H38Cl3N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.03ADX61623
CAS :<p>ADX61623 is an effective negative allosteric modulator (NAM) of the follicle-stimulating hormone receptor (FSHR). It also exhibits activity on the luteinizing hormone receptor (LH-R) but is inactive on the thyroid-stimulating hormone (TSH) receptor. ADX61623 can be utilized in research on estrogen-dependent diseases.</p>Formule :C19H20N2O3Couleur et forme :SolidMasse moléculaire :324.37
