Endocrinologie/Hormones
Les inhibiteurs en endocrinologie/hormonaux sont des composés qui bloquent l'action des hormones ou interfèrent avec les voies de signalisation hormonales. Ces inhibiteurs sont essentiels pour étudier la régulation des systèmes endocriniens et pour développer des traitements pour les maladies liées aux hormones, telles que le diabète, les troubles de la thyroïde et les cancers hormonodépendants. En modulant l'activité hormonale, ces inhibiteurs peuvent aider à élucider les interactions complexes au sein du système endocrinien. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité en endocrinologie/hormonaux pour soutenir vos recherches en endocrinologie, pharmacologie et sciences médicales.
Sous-catégories appartenant à la catégorie "Endocrinologie/Hormones"
- Récepteur des androgènes(209 produits)
- Annexine A(11 produits)
- Aromatase(20 produits)
- Récepteur d'œstrogène/progestatif(49 produits)
- GPR(1 produits)
- Récepteur des glucocorticoïdes(153 produits)
- LHRH(1 produits)
- Récepteur opioïde(297 produits)
- Récepteur de prostaglandine(120 produits)
- RAAS(87 produits)
- Réductase(52 produits)
- Somatostatine(49 produits)
- Récepteur des hormones thyroïdiennes (THR)(26 produits)
- Récepteur de la vasopressine(44 produits)
Affichez 6 plus de sous-catégories
3183 produits trouvés pour "Endocrinologie/Hormones"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
ERα degrader 11
CAS :<p>ERα degrader11 (compound B16) is a selective estrogen receptor degrader designed for use as a probe in examining the ER status within ER-positive breast cancer cells.</p>Formule :C28H27F3N2O3Couleur et forme :SolidMasse moléculaire :496.52Pentomone
CAS :<p>Pentomone (LY-113935) is an anti-androgen compound that acts as a prostate growth inhibitor.</p>Formule :C24H26O5Couleur et forme :SolidMasse moléculaire :394.46Sob-AM2
CAS :<p>Sob-AM2 is an effective substrate targeting the fatty acid amide hydrolase (FAAH) expressed in the brain, with a Km of 1.3 μM. It delivers higher concentrations of Sobetirome to the central nervous system at minimal peripheral systemic doses, thereby activating the central thyroid hormone receptor β (TRβ).</p>Formule :C21H27NO3Couleur et forme :SolidMasse moléculaire :341.44(S)-MCOPPB
CAS :<p>(S)-MCOPPB is the S-enantiomer of MCOPPB, an orally active selective agonist for the Nociceptin/Orphanin FQ-Receptor. It inhibits signal transduction in mouse brain NOP receptors and is utilized in anxiety disorder research.</p>Formule :C26H40N4Couleur et forme :SolidMasse moléculaire :408.623L162389
CAS :<p>L162389 is an angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor and stimulates the conversion of phosphatidylinositol.</p>Formule :C31H38N4O4SDegré de pureté :99.11% - 99.57%Couleur et forme :SolidMasse moléculaire :562.72PD 134922
CAS :<p>PD 134922 is a HIV-1 protease inhibitors. Inactivation of the protease prevents infectious virion formation.</p>Formule :C37H61N5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :719.97NSC 645827
CAS :<p>NSC 645827 is an inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), with an IC50 of 0.7 μM.</p>Formule :C17H17N5O2Couleur et forme :SolidMasse moléculaire :323.349J-113397
CAS :<p>J-113397 is a potent and selective NOP receptor antagonist (IC50 = 2.3 nM).</p>Formule :C24H37N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :399.57SC13
CAS :<p>SC13, a novel mitragynine analog, exhibits low-efficacy agonism at Mu opioid receptors and provides antinociception while minimizing adverse effects.</p>Formule :C26H30N2O5Couleur et forme :SolidMasse moléculaire :450.53AR antagonist 4
<p>AR antagonist 4 (Compound 67-b) is an orally active androgen receptor (AR) antagonist that acts on wild-type AR (IC50: 246.6 nM).</p>Formule :C29H36N4OCouleur et forme :SolidMasse moléculaire :456.62ERα degrader 5
<p>ERα degrader 5 is an orally active, selective estrogen receptor (ER) reducer that acts on ERα (EC50: 1.1 nM). ERα degrader 5 shows anti-tumour effects in vivo.</p>Formule :C29H25F4N3O2SCouleur et forme :SolidMasse moléculaire :555.595α-reductase-IN-1
CAS :<p>5α-reductase-IN-1 is a potent inhibitor of the enzyme 5α-reductase.</p>Formule :C31H37NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :503.63Anticancer agent 257
CAS :<p>Anticanceragent 257 (compound of formula (I)) is an anticancer agent that regulates Nur77 and Nurr1.</p>Formule :C15H9Cl2N3Couleur et forme :SolidMasse moléculaire :302.158JTP-117968
CAS :<p>JTP-117968: Non-steroidal SGRM, glucocorticoid receptor modulator, IC50 = 6.8 nM, offers better inhibitory/activatory balance.</p>Formule :C31H31F3N2O2Couleur et forme :SolidMasse moléculaire :520.59TD-0212 TFA
CAS :<p>TD-0212 TFA is an oral AT1 receptor antagonist & NEP inhibitor with pKi 8.9 & pIC50 9.2.</p>Formule :C30H35F4N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :641.67L 365209
CAS :<p>L 365209 is an oxytocin antagonist.</p>Formule :C40H50N8O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :738.88Mu opioid receptor antagonist 3
<p>Potent, selective MOR antagonist (compound 26); crosses blood-brain barrier. Ki: 0.24 nM, EC50: 0.54 nM; for studying OUD.</p>Formule :C25H28N2O4SCouleur et forme :SolidMasse moléculaire :452.57Mepixetil
<p>Mepixetil is a potent angiotensin II receptor antagonist[1].</p>Formule :C12H18N2O3Couleur et forme :SolidMasse moléculaire :238.28Mopivabil
<p>Mopivabil is the angiotensin II receptor antagonist[1].</p>Formule :C14H20O3Couleur et forme :SolidMasse moléculaire :236.31GPR84 antagonist 1
<p>GPR84 antagonist 1 is a highly selective, high-affinity competitive antagonist of human GPR84.</p>Formule :C26H22N4O2Couleur et forme :SolidMasse moléculaire :422.48AT1R antagonist 2
<p>AT1R antagonist 2 is a potent AT1R selective ligand with good AT1R affinity (Ki: 26 nM).</p>Formule :C29H37N5O4S2Couleur et forme :SolidMasse moléculaire :583.77Mu opioid receptor antagonist 5
<p>Compound NAP: MOR antagonist, crosses blood-brain barrier, EC50: 1.14 nM, Ki: 0.37 nM, useful for OUD research.</p>Formule :C26H29N3O4Couleur et forme :SolidMasse moléculaire :447.53DS34942424
<p>DS34942424 is an orally potent analgesic which did not exhibit mu opioid receptor agonist activity.</p>Formule :C15H17FN2OCouleur et forme :SolidMasse moléculaire :260.31GNTI dihydrochloride
CAS :<p>κ opioid receptor antagonist</p>Formule :C27H30ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.01A4B17
<p>A4B17 is an inhibitor of androgen receptor N-terminal with potential for androgen-responsive prostate cancer treatment.</p>Formule :C14H7F4NSCouleur et forme :SolidMasse moléculaire :297.27KR31173
CAS :<p>KR31173 is an AT1 antagonist with an IC50 of 3.27 nM. When labeled with the 11C isotope, KR31173 can be used as a tracer for positron emission tomography (PET). In mice, KR31173 exhibits favorable biodistribution and pharmacological characteristics. It selectively binds to organs in CD-1 mice known to have a high density of AT1 angiotensin receptors.</p>Formule :C31H30N8O2Couleur et forme :SolidMasse moléculaire :546.626β-Naltrexol
CAS :<p>6β-Naltrexol is a peripherally selective opioid antagonist that reduces constipation from opioids while minimizing central nervous system effects.</p>Formule :C20H25NO4Degré de pureté :99.933%Couleur et forme :SolidMasse moléculaire :343.42ER degrader 10
CAS :<p>ER degrader 10 (Compound 51) is an orally active estrogen receptor (ER) selective degrader and antagonist, with a DC50 of 0.43 nM and an IC50 of 0.56 nM. It inhibits the proliferation of ER-positive cells, with an IC50 ranging from 0 to 15 nM. ER degrader 10 exhibits weak inhibitory activity on the hERG channel, with an IC50 greater than 40 μM. It has blood-brain barrier permeability, with a brain/plasma ratio (Kp) of 3.05. In mouse models, ER degrader 10 demonstrates antitumor activity.</p>Formule :C28H29F2NO3SCouleur et forme :SolidMasse moléculaire :497.597Mu opioid receptor antagonist 8
CAS :<p>Muopioid Receptor Antagonist 8 (368) serves as an antagonist to the μ-opioid receptor, significantly inhibiting the activation of Gi induced by met-enkephalin at the µOR.</p>Formule :C36H35N3O4SCouleur et forme :SolidMasse moléculaire :605.75Riminkefon
CAS :<p>Riminkefon is a kappa opioid receptor agonist .</p>Formule :C38H57N7O6Couleur et forme :SolidMasse moléculaire :707.9(Rac)-Fidarestat
CAS :<p>(Rac)-Fidarestat ((Rac)-SNK 860) is the racemic form of Fidarestat, functioning as a potent inhibitor of the enzyme aldose reductase.</p>Formule :C12H10FN3O4Couleur et forme :SolidMasse moléculaire :279.224Amoitone B
CAS :<p>Amoitone B, a cystosporone B derivative, functions as an NR4A1 agonist and exhibits anticancer activity [1].</p>Formule :C22H34O5Couleur et forme :SolidMasse moléculaire :378.5BU72
CAS :<p>BU72 is a potent, long-lasting agonist for μ and κ opioid receptors, with partial agonistic activity at the δ opioid receptor (EC50 values of 0.054, 0.033, and 0.58 nM, respectively). It provides strong, enduring analgesic effects primarily mediated through μ opioid receptors. BU72 also exhibits a prolonged duration of activity and can partially reverse morphine-induced analgesia. It is applicable in studies of opioid dependence.</p>Formule :C28H32N2O2Couleur et forme :SolidMasse moléculaire :428.57Allyphenyline oxalate
CAS :<p>The pKi values of Allyphenyline oxalate (compound 9) for the α2-adrenergic receptor subtypes α2A, α2B, and α2C are 7.24, 6.47, and 7.07, respectively.</p>Formule :C16H20N2O5Couleur et forme :SolidMasse moléculaire :320.34OSU-ERb-12
CAS :OSU-ERb-12 is an ERβ agonist that suppresses ovarian cancer cell proliferation both in vitro and in vivo, and decreases the expression of Snail [1] [2].Formule :C15H30B10O2Couleur et forme :SolidMasse moléculaire :350.51MB-07344 sodium
<p>"MB-07344 sodium is a TR-β agonist with a 2.17 nM Ki, boosts Atorvastatin's cholesterol-lowering effects in various animals."</p>Formule :C19H25NaO5PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.36Androgen receptor ligand 1
CAS :<p>Androgen receptorligand 1 is a ligand for the androgen receptor (AR). It interacts with the CRBN E3 ligase via a linker to form an AR-PROTAC degrader. This compound is useful in prostate cancer research.</p>Formule :C19H16F4N2OCouleur et forme :SolidMasse moléculaire :364.34BU09059
CAS :<p>BU09059 is a potent, selective, short-acting antagonist of the κ-opioid receptor (KOR).</p>Formule :C28H37N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :495.61σ1 Receptor/μ Opioid receptor modulator 2
CAS :<p>Compound 4x, also known as σ1 Receptor/μOpioid receptormodulator 2, acts as a μOR agonist and a σ1R antagonist, exhibiting a potent μOR EC50 of 0.6 nM and strong σ1R inhibitory activity (Ki: 363.7 nM). It demonstrates significant analgesic effects in various pain models.</p>Formule :C23H31N3OMasse moléculaire :365.51Daeatal
CAS :<p>Dynorphin A ethylamide (1-9), the opioid activities were examined in the bioassays.</p>Formule :C56H93N19O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1192.46OT-R agonist 1 TFA
CAS :<p>OT-R agonist 1 TFA (compound 5) is an oxytocin receptor (OT-R) agonist with an EC50 value of 0.39 nM. It exhibits V1A antagonist activity, with an EC50 value of 2432 nM, and can be utilized in studies related to central nervous system diseases.</p>Formule :C37H40F3N7O7SCouleur et forme :SolidMasse moléculaire :783.8221-Deacetoxy deflazacort
CAS :<p>21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort, which is a glucocorticoid. As an inactive precursor, Deflazacort rapidly converts into the active metabolite, 21-Desacetyldeflazacort. This compound serves as both an anti-inflammatory and immunosuppressive agent.</p>Formule :C23H29NO4Couleur et forme :SolidMasse moléculaire :383.48BNTX maleate
CAS :<p>δ1 opioid receptor antagonist</p>Formule :C31H31NO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :545.58EN171
CAS :<p>EN171, a covalent ligand, selectively binds to C38 and C96 on 14-3-3, intensifying 14-3-3's interactions with ERα, YAP, and TAZ. This action impairs both estrogen receptor and Hippo pathway transcriptional activities. Beyond serving as a molecular glue to augment native protein interactions, EN171 also functions as a covalent recruiter for 14-3-3 in heterobifunctional molecules. This facilitates the sequestration of nuclear neo-substrates, such as BRD4 and BLC6, into the cytosol.</p>Formule :C17H22N2OCouleur et forme :SolidMasse moléculaire :270.37Dazucorilant
CAS :<p>Dazucorilant (CORT113176), a selective non-steroidal GR modulator, has high affinity with a K i <1 nM, useful for neurological research.</p>Formule :C29H22F4N4O3SCouleur et forme :SolidMasse moléculaire :582.57LNS8801
CAS :<p>LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.</p>Formule :C21H18BrNO3Couleur et forme :SolidMasse moléculaire :412.277GPR81 agonist 2
CAS :<p>GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.</p>Formule :C26H27ClN6O5S2Couleur et forme :SolidMasse moléculaire :603.11C108297
CAS :<p>C108297: glucocorticoid modulator, combats diet obesity/inflammation, reduces appetite/lipid storage, boosts fat burn.</p>Formule :C30H36FN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.69LX1
CAS :<p>LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.</p>Formule :C22H15F6NO2Couleur et forme :SolidMasse moléculaire :439.35Fonsartan free acid
CAS :<p>Fonsartan: Angiotensin receptor blocker, halts angiotensin II effects on rat vascular cells.</p>Formule :C26H32N4O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.69
