Endocrinologie/Hormones
Les inhibiteurs en endocrinologie/hormonaux sont des composés qui bloquent l'action des hormones ou interfèrent avec les voies de signalisation hormonales. Ces inhibiteurs sont essentiels pour étudier la régulation des systèmes endocriniens et pour développer des traitements pour les maladies liées aux hormones, telles que le diabète, les troubles de la thyroïde et les cancers hormonodépendants. En modulant l'activité hormonale, ces inhibiteurs peuvent aider à élucider les interactions complexes au sein du système endocrinien. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité en endocrinologie/hormonaux pour soutenir vos recherches en endocrinologie, pharmacologie et sciences médicales.
Sous-catégories appartenant à la catégorie "Endocrinologie/Hormones"
- Récepteur des androgènes(222 produits)
- Annexine A(14 produits)
- Aromatase(21 produits)
- Récepteur d'œstrogène/progestatif(55 produits)
- GPR(1 produits)
- Récepteur des glucocorticoïdes(160 produits)
- LHRH(1 produits)
- Récepteur opioïde(310 produits)
- Récepteur de prostaglandine(120 produits)
- RAAS(89 produits)
- Réductase(51 produits)
- Somatostatine(51 produits)
- Récepteur des hormones thyroïdiennes (THR)(26 produits)
- Récepteur de la vasopressine(46 produits)
Affichez 6 plus de sous-catégories
3284 produits trouvés pour "Endocrinologie/Hormones"
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GC 14
CAS :GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 200 nM and 35 nM for hTRα and hTRβ, respectively.Formule :C26H27NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.5LIT-001 free base
CAS :LIT-001, a nonpeptide OT-R agonist, enhances mouse autism-like behavior, with EC50=55 nM and Ki=226 nM.Formule :C28H33N7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.67ADX61623
CAS :ADX61623 is an effective negative allosteric modulator (NAM) of the follicle-stimulating hormone receptor (FSHR). It also exhibits activity on the luteinizing hormone receptor (LH-R) but is inactive on the thyroid-stimulating hormone (TSH) receptor. ADX61623 can be utilized in research on estrogen-dependent diseases.Formule :C19H20N2O3Couleur et forme :SolidMasse moléculaire :324.37Sunobinop
CAS :Sunobinop (S 117957) is an opioid receptor-like orphan receptor (ORL1) modulator.Formule :C26H33N3O3Couleur et forme :SolidMasse moléculaire :435.56FSH receptor antagonist 1
CAS :<p>FSH receptor antagonist 1 (compound 10) is a potent antagonist of the G(s) protein-coupled human follicle-stimulating hormone (FSH) receptor. It exhibits an IC50 value of 28 nM in cell lines expressing the human FSH receptor. This compound significantly inhibits follicle growth and ovulation in in vitro mouse models.</p>Formule :C33H32N2O2Couleur et forme :SolidMasse moléculaire :488.619ACT 178882
CAS :ACT 178882 is a new Renin inhibitor (IC50: 1.4 nM).Formule :C33H38Cl3N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.03CCG258747
CAS :CCG258747 is a novel, selective inhibitor of the GRK2 subfamily.Formule :C28H27FN4O4Couleur et forme :SolidMasse moléculaire :502.54LNS8801
CAS :<p>LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.</p>Formule :C21H18BrNO3Couleur et forme :SolidMasse moléculaire :412.277MK-6913
CAS :MK-6913 is a potent and selective agonist of estrogen receptor β.Formule :C25H27N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.5Opioid receptor antagonist 1
CAS :<p>Opioid receptor antagonist 1 (Compound 10) is an Orvinol-based antagonist of opioid receptors. It exhibits activity as an antagonist against the analgesic properties of morphine.</p>Formule :C24H29ClF3NO4Couleur et forme :SolidMasse moléculaire :487.94L162389
CAS :L162389 is an angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor and stimulates the conversion of phosphatidylinositol.Formule :C31H38N4O4SDegré de pureté :99.11% - 99.57%Couleur et forme :SolidMasse moléculaire :562.7221-Deacetoxy deflazacort
CAS :<p>21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort, which is a glucocorticoid. As an inactive precursor, Deflazacort rapidly converts into the active metabolite, 21-Desacetyldeflazacort. This compound serves as both an anti-inflammatory and immunosuppressive agent.</p>Formule :C23H29NO4Couleur et forme :SolidMasse moléculaire :383.48Elacestrant S enantiomer dihydrochloride
Elacestrant (RAD1901) dihydrochloride, an oral ERR degrader, has IC50 of 48 nM (ERα) and 870 nM (ERβ). Its S enantiomer has low activity.Formule :C30H40Cl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.56Galaxolide
CAS :Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), oxidative stress, and genotoxicity. It also stimulates the enzymatic activities of EROD and GST (Glutathione S-transferase).Formule :C18H26OCouleur et forme :SolidMasse moléculaire :258.40A 74273
CAS :<p>A 74273, a nonpeptidic and renin inhibitor, may be used to treat cardiovascular diseases due to renin inhibition.</p>Formule :C44H74N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.08CH5447240
CAS :<p>CH5447240: potent hPTHR1 agonist, treats Hypoparathyroidism, EC50 12 nM, 55% oral bioavailability, raises rat serum calcium.</p>Formule :C26H39N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.68ERRα antagonist-2
CAS :ERRα antagonist-2 is an estrogen-related receptor α inverse agonist, inhibiting migration and invasion in ER-negative MDA-MB-231,breast cancer.Formule :C19H16N2O6SDegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :400.41ERβ agonist-1
CAS :<p>ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.</p>Formule :C25H36O2Couleur et forme :SolidMasse moléculaire :368.55Estrogen receptor antagonist 6
CAS :Estrogen receptor antagonist 6 is a potent blocker of estrogen signaling, regulating various biological effects. (Compound 166)Formule :C25H31F3N2O3Couleur et forme :SolidMasse moléculaire :464.52ID11916
CAS :<p>ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.</p>Formule :C29H27F3N8O3SCouleur et forme :SolidMasse moléculaire :624.637AR antagonist 11
CAS :AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM). Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM). This compound is applicable in prostate cancer (PCa) research.Formule :C20H17ClN2OCouleur et forme :SolidMasse moléculaire :336.815Naldemedine tosylate
CAS :<p>Naldemedine (S-297995) tosylate, a PAMORA, targets μ-, δ-, κ-opioid receptors, aiding OIC research, may bind to SARS-CoV2's 3CL pro.</p>Formule :C39H42N4O9SCouleur et forme :SolidMasse moléculaire :742.84Mu opioid receptor antagonist 4
Compound 31: Potent, selective MOR antagonist; crosses blood-brain barrier; Ki & EC50: 0.38 nM; useful for OUD research.Formule :C25H28N2O4SCouleur et forme :SolidMasse moléculaire :452.5722-Thiocyanatosalvinorin A
CAS :22-Thiocyanatosalvinorin A (RB-64) is a potent selective agonist for the kappa-opioid receptor, exhibiting an EC50 value of 0.077 nM.Formule :C24H27NO8SCouleur et forme :SolidMasse moléculaire :489.54RJG-2051
CAS :<p>RJG-2051 is a selective covalent inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), with an IC50 value of 13 nM. It interferes with the metabolism of substrates such as androgens, estrogens, and prostaglandins through AKR1C3. RJG-2051 holds potential for cancer research.</p>Formule :C26H31N5O4SCouleur et forme :SolidMasse moléculaire :509.62LEO 134310
CAS :LEO 134310: Selective, non-steroidal GR agonist with 14 nM EC50, for topical skin disease treatment.Formule :C34H40N2O8Couleur et forme :SolidMasse moléculaire :604.69EN1441
CAS :EN1441 is a covalent degrader that targets the androgen receptor (AR) with an EC50 value of 4.2 μM, as well as its truncated variant AR-V7. It selectively and effectively degrades AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 holds potential for research into androgen-independent prostate cancer.Formule :C13H13ClN2O2Couleur et forme :SolidMasse moléculaire :264.708BMS-986034
CAS :<p>BMS-986034 is a GPR119 agonist.</p>Formule :C24H24Cl2N6O4Couleur et forme :SolidMasse moléculaire :531.39Estrogen receptor antagonist 7
CAS :ER antagonist 7, compound 13, inhibits ERs, halts breast/ovarian cancer cell growth, has anticancer properties.Formule :C23H17N3O4Couleur et forme :SolidMasse moléculaire :399.4SB-612111
CAS :SB-612111: potent ORL-1 antagonist, Ki=0.33 nM; μ-, κ-, δ-receptor Ki=57.6, 160.5, 2109 nM; blocks nociceptin's pain effect.Formule :C24H29Cl2NOCouleur et forme :SolidMasse moléculaire :418.40Glucocorticoid receptor activator 1
CAS :<p>Glucocorticoid Receptor Activator 1, a phenyl nitrogen-heterocyclic precursor, acts as an activator of the glucocorticoid receptor (GR). By activating GR, it downregulates the expression of pro-inflammatory genes stimulated by TNF, making it useful for inflammation research.</p>Formule :C11H15Cl2NO2Couleur et forme :SolidMasse moléculaire :264.15AR antagonist 10
CAS :<p>AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.</p>Formule :C18H17ClN4O3SCouleur et forme :SolidMasse moléculaire :404.871PBPE hydrochloride
CAS :<p>PBPE hydrochloride is a derivative of tamoxifen and functions as a selective ligand for antiestrogen binding sites (AEBS). The binding affinity (Ki) of PBPE hydrochloride and MBPE to AEBS is 8.79 nM and 17.57 nM, respectively.</p>Formule :C19H24ClNOCouleur et forme :SolidMasse moléculaire :317.853Estrogen receptor modulator 11
CAS :<p>Estrogen receptor modulator11 (Compound 27) is a tetrahydroisoquinoline derivative. It exhibits affinity for the estrogen receptor (ER), with IC50 values of 285 nM for ERα and 421 nM for ERβ. Estrogen receptor modulator11 does not demonstrate antagonist activity in MCF-7 cell assays.</p>Formule :C21H18FNOCouleur et forme :SolidMasse moléculaire :319.372Mu opioid receptor antagonist 2
Compound 25: potent, selective MOR antagonist, crosses blood-brain barrier (Ki: 0.37 nM, EC50: 0.44 nM), for OUD research.Formule :C25H28N2O4SCouleur et forme :SolidMasse moléculaire :452.57Bromadoline
CAS :<p>Bromadoline is an opioid compound that exhibits anti-nociceptive properties in rodents.</p>Formule :C15H21BrN2OCouleur et forme :SolidMasse moléculaire :325.244Triisopropyl phosphate
CAS :Triisopropyl phosphate inhibits TFF1 and EGR3 gene expression and exhibits anti-estrogenic activity by suppressing Estradiol-induced proliferation of MCF-7 cells, with an EC50 of 341 μM. Additionally, Triisopropyl phosphate reduces estrogen response element (ERE)-stimulated luciferase activity in MVLN cells, with an EC50 of 900 μM.Formule :C9H21O4PCouleur et forme :SolidMasse moléculaire :224.234BW 443C
CAS :BW 443C is a selective agonist of mu-opioid receptor.Formule :C33H46N10O10Couleur et forme :SolidMasse moléculaire :742.791CI 992
CAS :<p>CI 992 is a novel potent inhibitor of primate renin.</p>Formule :C33H52N6O7S2Couleur et forme :SolidMasse moléculaire :708.93TUG-2181
CAS :<p>TUG-2181 is an antagonist of GPR84, with an IC50 value of 34 nM. It inhibits reactive oxygen species (ROS) production and IL-8 secretion induced by GPR84 agonists in human neutrophils. TUG-2181 is applicable for research in inflammation and fibrosis.</p>Formule :C21H27NO4Couleur et forme :SolidMasse moléculaire :357.443KNT-127
CAS :KNT-127 is an agonist of δ-Opioid receptor.Formule :C24H24N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.46AP5
CAS :<p>AP5: GPR40 agonist, positive allosteric modulator; rat hIP1 EC50: 0.49 nM.</p>Formule :C28H28FNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.52Naltrindole 5′-isothiocyanate
CAS :Naltrindole 5′-isothiocyanate (5'-NTII) is an irreversible delta opioid receptor antagonist that counters the analgesic effects induced by DSLET without altering the effects caused by DPDPE.Formule :C27H25N3O3SCouleur et forme :SolidMasse moléculaire :471.571S-HP210
S-HP210: selective GR modulator, blocks NF-κB (IC50: 1.92 μM), non-toxic to mouse fibroblasts.Formule :C22H19N3O2S2Couleur et forme :SolidMasse moléculaire :421.54TD-0212
CAS :TD-0212: Oral dual antagonist for AT1 (pKi 8.9) & NEP inhibitor (pIC50 9.2).Formule :C28H34FN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.65MLS000389544
CAS :MLS000389544 is a selective and potent thyroid hormone receptor β (TRβ) antagonist with a methylsulfonyl nitrobenzoic acid structure. It effectively inhibits the interaction between TRβ and steroid receptor coactivator 2 (SRC2).Formule :C20H24N2O7SCouleur et forme :SolidMasse moléculaire :436.479RX 809055AX
CAS :RX 809055AX is a long lasting opioid antagonist at mu and delta receptors.Formule :C29H29ClN2O4Couleur et forme :SolidMasse moléculaire :505SB-612111 hydrochloride
SB-612111 is a potent ORL-1 antagonist, with high affinity (Ki: 0.33 nM) and µ-receptor activity (Ki: 57.6 nM), blocking Nociceptin-induced pain.Formule :C24H30Cl3NOCouleur et forme :SolidMasse moléculaire :454.86GW856464
CAS :GW856464 is an antagonist of MCHR1. It is utilized in research related to cardiovascular diseases and obesity.Formule :C23H20ClN3O3SCouleur et forme :SolidMasse moléculaire :453.94GSK866
CAS :GSK866 is a selective glucocorticoid receptor agonist (SEGRA).Formule :C23H21Cl2F4N5O3Couleur et forme :SolidMasse moléculaire :562.34
