Endocrinologie/Hormones
Les inhibiteurs en endocrinologie/hormonaux sont des composés qui bloquent l'action des hormones ou interfèrent avec les voies de signalisation hormonales. Ces inhibiteurs sont essentiels pour étudier la régulation des systèmes endocriniens et pour développer des traitements pour les maladies liées aux hormones, telles que le diabète, les troubles de la thyroïde et les cancers hormonodépendants. En modulant l'activité hormonale, ces inhibiteurs peuvent aider à élucider les interactions complexes au sein du système endocrinien. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité en endocrinologie/hormonaux pour soutenir vos recherches en endocrinologie, pharmacologie et sciences médicales.
Sous-catégories appartenant à la catégorie "Endocrinologie/Hormones"
- Récepteur des androgènes(229 produits)
- Annexine A(16 produits)
- Aromatase(22 produits)
- Récepteur d'œstrogène/progestatif(59 produits)
- GPR(1 produits)
- Récepteur des glucocorticoïdes(166 produits)
- LHRH(2 produits)
- Récepteur opioïde(326 produits)
- Récepteur de prostaglandine(122 produits)
- RAAS(90 produits)
- Réductase(50 produits)
- Somatostatine(57 produits)
- Récepteur des hormones thyroïdiennes (THR)(32 produits)
- Récepteur de la vasopressine(48 produits)
Affichez 6 plus de sous-catégories
3373 produits trouvés pour "Endocrinologie/Hormones"
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C108297
CAS :C108297: glucocorticoid modulator, combats diet obesity/inflammation, reduces appetite/lipid storage, boosts fat burn.Formule :C30H36FN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.69J-113397
CAS :J-113397 is a potent and selective NOP receptor antagonist (IC50 = 2.3 nM).Formule :C24H37N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :399.57BMS-986034
CAS :BMS-986034 is a GPR119 agonist.Formule :C24H24Cl2N6O4Couleur et forme :SolidMasse moléculaire :531.39LEO 134310
CAS :LEO 134310: Selective, non-steroidal GR agonist with 14 nM EC50, for topical skin disease treatment.Formule :C34H40N2O8Couleur et forme :SolidMasse moléculaire :604.69LNS8801
CAS :LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.Formule :C21H18BrNO3Couleur et forme :SolidMasse moléculaire :412.277Dazucorilant
CAS :Dazucorilant (CORT113176), a selective non-steroidal GR modulator, has high affinity with a K i <1 nM, useful for neurological research.Formule :C29H22F4N4O3SCouleur et forme :SolidMasse moléculaire :582.57PD 134922
CAS :PD 134922 is a HIV-1 protease inhibitors. Inactivation of the protease prevents infectious virion formation.Formule :C37H61N5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :719.97Galaxolide
CAS :Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), oxidative stress, and genotoxicity. It also stimulates the enzymatic activities of EROD and GST (Glutathione S-transferase).Formule :C18H26OCouleur et forme :SolidMasse moléculaire :258.40Erα-IN-1
Erα-IN-1 (compound 3c) is an inhibitor of the estrogen receptor α (ERα), effectively blocking ERα activity in MCF7/ERE-LUC cells.Formule :C16H11FN2Couleur et forme :SolidMasse moléculaire :250.27SC13
CAS :SC13, a novel mitragynine analog, exhibits low-efficacy agonism at Mu opioid receptors and provides antinociception while minimizing adverse effects.Formule :C26H30N2O5Couleur et forme :SolidMasse moléculaire :450.53FSH receptor antagonist 1
CAS :FSH receptor antagonist 1 (compound 10) is a potent antagonist of the G(s) protein-coupled human follicle-stimulating hormone (FSH) receptor. It exhibits an IC50 value of 28 nM in cell lines expressing the human FSH receptor. This compound significantly inhibits follicle growth and ovulation in in vitro mouse models.Formule :C33H32N2O2Couleur et forme :SolidMasse moléculaire :488.619LY2066948
CAS :LY2066948 is a selective oral estrogen receptor modulator (SERM) with high affinity for estrogen receptors ERα and ERβ (Ki of 0.51 and 1.36 nM, respectively) and displays potent anti-estrogenic activity. It effectively blocks the increase in uterine weight induced by ethinylestradiol in immature rats. LY2066948 is utilized in the research of uterine fibroids and myomas.Formule :C30H31NO5SCouleur et forme :SolidMasse moléculaire :517.64Daeatal
CAS :Dynorphin A ethylamide (1-9), the opioid activities were examined in the bioassays.Formule :C56H93N19O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1192.4622-Thiocyanatosalvinorin A
CAS :22-Thiocyanatosalvinorin A (RB-64) is a potent selective agonist for the kappa-opioid receptor, exhibiting an EC50 value of 0.077 nM.Formule :C24H27NO8SCouleur et forme :SolidMasse moléculaire :489.54EN1441
CAS :EN1441 is a covalent degrader that targets the androgen receptor (AR) with an EC50 value of 4.2 μM, as well as its truncated variant AR-V7. It selectively and effectively degrades AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 holds potential for research into androgen-independent prostate cancer.Formule :C13H13ClN2O2Couleur et forme :SolidMasse moléculaire :264.708GPR81 agonist 2
CAS :GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.Formule :C26H27ClN6O5S2Couleur et forme :SolidMasse moléculaire :603.11σ1 Receptor/μ Opioid receptor modulator 2
CAS :Compound 4x, also known as σ1 Receptor/μOpioid receptormodulator 2, acts as a μOR agonist and a σ1R antagonist, exhibiting a potent μOR EC50 of 0.6 nM and strong σ1R inhibitory activity (Ki: 363.7 nM). It demonstrates significant analgesic effects in various pain models.Formule :C23H31N3OMasse moléculaire :365.51FL442
CAS :FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).Formule :C15H13F3N2OCouleur et forme :SolidMasse moléculaire :294.27ERα degrader 5
ERα degrader 5 is an orally active, selective estrogen receptor (ER) reducer that acts on ERα (EC50: 1.1 nM). ERα degrader 5 shows anti-tumour effects in vivo.Formule :C29H25F4N3O2SCouleur et forme :SolidMasse moléculaire :555.59TD-0212 TFA
CAS :TD-0212 TFA is an oral AT1 receptor antagonist & NEP inhibitor with pKi 8.9 & pIC50 9.2.Formule :C30H35F4N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :641.67AKR1C3-IN-5
AKR1C3-IN-5 inhibits AKR1C3, key in prostate/breast cancers, with MCF-7 cell IC50 of 9.6 μM.Formule :C34H44N2O7Couleur et forme :SolidMasse moléculaire :592.72TD-0212
CAS :TD-0212: Oral dual antagonist for AT1 (pKi 8.9) & NEP inhibitor (pIC50 9.2).Formule :C28H34FN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.65U 80215
CAS :U 80215 is an enzyme-competitive inhibitor.Formule :C42H60N8O6SCouleur et forme :SolidMasse moléculaire :805.045′-Guanidinonaltrindole
CAS :5′-Guanidinonaltrindole (GNTI) is a selective antagonist of the kappa opioid receptor.Formule :C27H29N5O3Couleur et forme :SolidMasse moléculaire :471.551Saprisartan potassium
CAS :Saprisartan potassium is an Angiotensin II Type 1 receptor antagonist and antihypertensive agent.Formule :C25H21BrF3KN4O4SCouleur et forme :SolidMasse moléculaire :649.52Emd 52297
CAS :Emd 52297 is an inhibitor of renin.Formule :C39H59N11O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :793.96MTI013
MTI013 is a selective inhibitor of SARS-CoV-2 nsp14 Mtase (IC50: 2.98 µM) and an antiviral agent (IC50: 10.33 µM in HCoV-229E infected Huh7 cells). Additionally, MTI013 demonstrates synergistic antiviral effects when used in conjunction with the RdRp inhibitor SHEN26.Formule :C24H26N6O4SCouleur et forme :SolidMasse moléculaire :494.57NOP agonist-1
CAS :NOP agonist-1 (compound 4) is a nociceptin opioid receptor (NOP) partial agonist that attenuates Parkinsonian disabilities in 6-OHDA hemilesioned rats [1].Formule :C22H34N2Masse moléculaire :326.52Win 45164
CAS :Win 45164 is an orally active ligand for the glucocorticoid receptor (Glucocorticoid Receptor), exhibiting activity that inhibits the pituitary-adrenal axis. It enhances liver glycogen deposition and thymolysis in adrenalectomized male rats. Additionally, Win 45164 possesses anti-inflammatory properties and is applicable in research related to inflammation and neurological disorders.Formule :C26H27FN2O2Masse moléculaire :418.503Novokinin
CAS :Angiotensin AT2 receptor agonistFormule :C39H61N11O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :795.97SB-612111
CAS :SB-612111: potent ORL-1 antagonist, Ki=0.33 nM; μ-, κ-, δ-receptor Ki=57.6, 160.5, 2109 nM; blocks nociceptin's pain effect.Formule :C24H29Cl2NOCouleur et forme :SolidMasse moléculaire :418.40SDM25N hydrochloride
CAS :δ receptor antagonistFormule :C26H27ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :450.96Androgen receptor degrader-5
CAS :Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.Formule :C29H25F4N5O2Couleur et forme :SolidMasse moléculaire :551.53AR ligand-44
CAS :AR ligand-44 is an androgen receptor (androgen receptor) ligand that can be utilized in the synthesis of PROTACs such as [ARD-2051].Formule :C23H24ClN3O2Couleur et forme :SolidMasse moléculaire :409.91AKR1C3-IN-7
AKR1C3-IN-7 (Compound 13) is an effective and selective AKR1C3 inhibitor (IC50=0.19 μM). AKR1C3-IN-7 has antitumor activity.Formule :C24H20N2O4Couleur et forme :SolidMasse moléculaire :400.43Pentomone
CAS :Pentomone (LY-113935) is an anti-androgen compound that acts as a prostate growth inhibitor.Formule :C24H26O5Couleur et forme :SolidMasse moléculaire :394.46AR antagonist 4
AR antagonist 4 (Compound 67-b) is an orally active androgen receptor (AR) antagonist that acts on wild-type AR (IC50: 246.6 nM).Formule :C29H36N4OCouleur et forme :SolidMasse moléculaire :456.62Estrogen receptor-agonist-1
CAS :Estrogen receptor-agonist-1 (compound 4e) is an estrogen receptor (ER) agonist that binds to ERα with high affinity.Formule :C24H22N2O2Couleur et forme :SolidMasse moléculaire :370.444L162389
CAS :L162389 is an angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor and stimulates the conversion of phosphatidylinositol.Formule :C31H38N4O4SDegré de pureté :99.11% - 99.57%Couleur et forme :SolidMasse moléculaire :562.72OSU-ERb-12
CAS :OSU-ERb-12 is an ERβ agonist that suppresses ovarian cancer cell proliferation both in vitro and in vivo, and decreases the expression of Snail [1] [2].Formule :C15H30B10O2Couleur et forme :SolidMasse moléculaire :350.51ERRγ agonist-1
ERRγ agonist-1 can be used in neuropsychological disorders research.Formule :C17H21N5OCouleur et forme :SolidMasse moléculaire :311.38ZD 7155 hydrochloride
CAS :ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.Formule :C26H27ClN6ODegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :474.98Ref: TM-T13390
1mg42,00€5mg88,00€10mg135,00€25mg235,00€50mg396,00€100mg635,00€200mg887,00€1mL*10mM (DMSO)90,00€L-371,257
CAS :L-371,257 is a competitive antagonist of oxytocin receptor with pA2 of 8.4 and Ki of 19 nM. L-371,257 shows a Ki of 3.7 nM for vasopressin receptor 1a.Formule :C28H33N3O6Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :507.58GLPG0974
CAS :GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.Formule :C25H25ClN2O4SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :484.99Cort108297
CAS :Cort108297: selective GR modulator/antagonist, high GR affinity (Ki: 0.45nM), no other steroid receptor affinity.Formule :C26H25F4N3O3SDegré de pureté :98.36% - 99.94%Couleur et forme :SolidMasse moléculaire :535.55Ref: TM-T15000
1mg274,00€5mg622,00€10mg908,00€25mg1.415,00€50mg1.882,00€100mg2.745,00€1mL*10mM (DMSO)747,00€(E/Z)-GSK5182
CAS :GSK5182 is a racemic mix of (E/Z) isomers, a selective ERRγ inverse agonist (IC50: 79 nM), and induces ROS in liver cancer.Formule :C27H31NO3Degré de pureté :97.58%Couleur et forme :SolidMasse moléculaire :417.54Ref: TM-T7709
1mg81,00€5mg170,00€10mg274,00€25mg502,00€50mg747,00€100mg1.121,00€1mL*10mM (DMSO)187,00€LSZ-102
CAS :LSZ-102 is an effective and selective degrader of estrogen receptor (IC50 = 0.2 nM) and can be used in studies about ERα positive breast cancer.Formule :C25H17F3O4SDegré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :470.46PSN632408
CAS :PSN632408 is an optimized agonist of GPR119 receptors that display similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50: 5.6 and 7.9 uM, respectively).Formule :C18H24N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.41ML314
CAS :ML314 is a brain-permeable nonpeptide β-inhibin-biased neurotensin NTR1 receptor agonist (EC50: 1.9 μM), a biased neurotensin receptor ligand for methamphetamine abuse that inhibits NTR2 and GPR35.Formule :C24H28N4O3Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :420.504(S)-Mapracorat
CAS :(S)-Mapracorat is a selective and less active agonist of the glucocorticoid receptor.Formule :C25H26F4N2O2Couleur et forme :SolidMasse moléculaire :462.48
