Réductase
Les réductases sont une large classe d'enzymes qui catalysent la réduction de molécules dans diverses voies biochimiques. En endocrinologie, des réductases spécifiques, telles que la 5α-réductase, sont cruciales pour le métabolisme des hormones stéroïdes, y compris la conversion de la testostérone en dihydrotestostérone (DHT). Les inhibiteurs des enzymes réductases sont utilisés dans le traitement de conditions telles que l'hyperplasie bénigne de la prostate et l'alopécie androgénique. Chez CymitQuimica, nous offrons une variété d'inhibiteurs de réductases de haute qualité pour soutenir vos recherches en régulation hormonale, voies métaboliques et développement thérapeutique.
52 produits trouvés pour "Réductase"
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Turosteride
CAS :<p>Turosteride is a small molecule steroidal 5α-reductase (5α-reductase) inhibitor.Turosteride has antitumor activity for the treatment of oncologic diseases and</p>Formule :C27H45N3O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :459.66Imirestat
CAS :<p>Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.</p>Formule :C15H8F2N2O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :286.23Methotrexate
CAS :<p>Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR.</p>Formule :C20H22N8O5Degré de pureté :96.84% - 99.91%Couleur et forme :Orange-Brown Crystalline Powder Chemotherapy Drug That Interferes With Dna And Rna SynthesisMasse moléculaire :454.44Antitrypanosomal agent 1
CAS :<p>Potent TR inhibitor with IC50: 3.3μM, also inhibits glutathione reductase (IC50: 64.8μM) and T. brucei (EC50: 1μM).</p>Formule :C11H14Cl3NODegré de pureté :97.76%Couleur et forme :SolidMasse moléculaire :282.59Trimethoprim
CAS :<p>Trimethoprim (NSC-106568) inhibits dihydrofolate reductase, CYP2C8, and OCT2 - an antibacterial agent.</p>Formule :C14H18N4O3Degré de pureté :99.80% - 99.81%Couleur et forme :White To Yellowish PowderMasse moléculaire :290.32Alconil
CAS :<p>Alconil is a biochemical.</p>Formule :C15H9FN2O2Degré de pureté :99% - 99.34%Couleur et forme :SolidMasse moléculaire :268.24Finasteride
CAS :<p>Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.</p>Formule :C23H36N2O2Degré de pureté :99.04% - 99.97%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :372.54Aldose reductase-IN-1
CAS :<p>Aldose reductase-IN-1 (AT-001, Caficrestat) is a highly potent inhibitor of aldose reductase.Cost-effective and quality-assured.</p>Formule :C17H10F3N5O3SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :421.35Epalrestat
CAS :<p>Epalrestat (ONO2235), an aldose reductase inhibitor, helps manage diabetic neuropathy symptoms and slows disease progression.</p>Formule :C15H13NO3S2Degré de pureté :99.2% - 99.54%Couleur et forme :Deep Red Acicular CrystalMasse moléculaire :319.4MK 0434
CAS :<p>MK 0434 is a steroid 5α-reductase inhibitor and hormone antagonist associated with a significant reduction in DHT.</p>Formule :C25H31NO2Degré de pureté :99.66% - 99.67%Couleur et forme :SolidMasse moléculaire :377.52Fluvastatin sodium
CAS :<p>Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol</p>Formule :C24H25FNNaO4Degré de pureté :98.54% - 99.56%Couleur et forme :Light Yellow Solid PowderMasse moléculaire :433.45AT-007
CAS :<p>AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM).</p>Formule :C17H10F3N3O3S2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :425.4ALR2-IN-1
CAS :<p>ALR2-IN-1: potent, selective inhibitor of ALR2 (IC50=1.42 μM), antiglycemic, antioxidant; for diabetes research.</p>Formule :C16H17N3O2SDegré de pureté :98.79%Couleur et forme :SoildMasse moléculaire :315.39ALR2-IN-6
<p>ALR2-IN-6 (compound 9) is a potent competitive inhibitor of ALR2, with a Ki value of 0.064 μM. It is applicable in research related to neuropathy, retinopathy, and nephropathy.</p>Formule :C21H19BrFN3OCouleur et forme :SolidMasse moléculaire :427.06955DDHF20
<p>DDHF20 is an inhibitor of Staphylococcus aureus, specifically targeting and inhibiting its thioredoxin reductase (TrxR) by acting as a competitive inhibitor at the NADPH binding site. DDHF20 shows potential for research in combating infections related to Staphylococcus aureus.</p>Formule :C34H28O4Couleur et forme :SolidMasse moléculaire :500.58Floramanoside C
CAS :<p>Floramanoside C exhibits 2,2-diphenyl-1-picrylhydrazyl scavenging and aldose reductase inhibitory activities [1].</p>Formule :C21H18O15Couleur et forme :SolidMasse moléculaire :510.36Oxidation-Reduction Compound Library
<p>1264 small molecule compounds with pro-oxidant or anti-oxidant activity for high-throughput and high-content screening.</p>Couleur et forme :Odour SolidAntitumor agent-195
<p>Antitumor agent-195 (compound 16c) is a dual-targeting agent that simultaneously targets STAT3 and NQO1. At a concentration of 1 μM, it significantly inhibits the phosphorylation of STAT3 at the Tyr705 site and effectively induces apoptosis in MDA-MB-231 and MDA-MB-468 breast cancer cells. As a substrate of NQO1, Antitumor agent-195 markedly increases ROS production, causing severe DNA damage in a dose-dependent manner. It also demonstrates strong antitumor properties in MDA-MB-231 xenograft models.</p>Formule :C22H22N2O4Couleur et forme :SolidMasse moléculaire :378.42AKR1Cs-IN-1
<p>AKR1Cs-IN-1 (Compound 29) is an effective and broad-spectrum inhibitor of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). It achieves subtype inhibition by simultaneously binding to the SP2 and SP3 pockets, thereby blocking metabolic pathways related to drug resistance. In enzyme assays, AKR1Cs-IN-1 exhibits significant inhibitory activity with IC50 values of 0.09, 0.28, 0.05, and 0.51 µM for AKR1C1, AKR1C2, AKR1C3, and AKR1C4, respectively. The compound shows excellent resensitizing effects in doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, effectively enhancing the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on breast cancer resistance.</p>Couleur et forme :Odour SolidIsomer-Turosteride
<p>Isomer-Turosteride, a novel 5α-reductase inhibitor, reduces prostate DHT and has anticancer properties without raising T levels.</p>Formule :C27H45N3O3Degré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :459.67Ponalrestat
CAS :<p>Ponalrestat is an aldose reductase inhibitor.</p>Formule :C17H12BrFN2O3Degré de pureté :97.34% - 99.86%Couleur et forme :SolidMasse moléculaire :391.19Sorbinil
CAS :<p>Sorbinil is an Aldose reductase inhibitor.</p>Formule :C11H9FN2O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :236.2Poliumoside
CAS :<p>Poliumoside: natural, inhibits glycation (IC50=4.6-25.7 μM) & aldose reductase (IC50=0.85 μM), with antioxidant, antibacterial & hemostatic properties.</p>Formule :C35H46O19Degré de pureté :98.02% - 99.80%Couleur et forme :SolidMasse moléculaire :770.73Acid Yellow 36
CAS :<p>Acid Yellow 36 (Metanil Yellow) is an azo dye and a pH indicator. Acid Yellow 36 changes its color from red at pH 1.2 to yellow at pH 2.3.</p>Formule :C18H14N3NaO3SDegré de pureté :98.89%Couleur et forme :Orange-Yellow Solid Solid Particulate/PowderMasse moléculaire :375.38Methotrexate disodium
CAS :<p>Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor</p>Formule :C20H20N8Na2O5Degré de pureté :99.77% - 99.96%Couleur et forme :SolidMasse moléculaire :498.42-Chloro-1-(4-fluorobenzyl)benzimidazole
CAS :<p>2-Chloro-1-(4-fluorobenzyl)benzimidazole is an inhibitor of aldose reductase (ALR2).</p>Formule :C14H10ClFN2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :260.69EBPC
CAS :<p>EBPC is an inhibitor of aldose reductase.</p>Formule :C14H15NO4Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :261.27Pralatrexate
CAS :<p>Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate</p>Formule :C23H23N7O5Degré de pureté :94.32% - 99.59%Couleur et forme :SolidMasse moléculaire :477.47Aurothiomalate sodium
CAS :<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Formule :C4H3AuNa2O4SDegré de pureté :99.66%Couleur et forme :SoildMasse moléculaire :390.07AKR1C3-IN-4
CAS :<p>AKR1C3-IN-4: potent, selective AKR1C3 inhibitor, IC50 = 0.56 μM, potential for CRPC research.</p>Formule :C14H10F3NO2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :281.23Alrestatin
CAS :<p>Alrestatin (AY-22284) is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in</p>Formule :C14H9NO4Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :255.2256Fanotaprim
CAS :<p>Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.</p>Formule :C19H22N8ODegré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :378.43Sulindac sulfone
CAS :<p>Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac. Sulindac sulfone is an inhibitor of aldose reductase (IC50 =367 nM).</p>Formule :C20H17FO4SDegré de pureté :98.2% - 98.83%Couleur et forme :SolidMasse moléculaire :372.41COH29
CAS :<p>COH29 is an oral RNR-blocking thiazole that may reduce DNA synthesis and promote apoptosis, with potential cancer-treating properties.</p>Formule :C22H16N2O5SDegré de pureté :97.04% - 98.92%Couleur et forme :SolidMasse moléculaire :420.44Ethaselen
CAS :<p>Ethaselen (BBSKE) is an oral TrxR inhibitor with IC50 of 0.5 μM (human) and 0.35 μM (rat), targeting a selenocysteine site to fight NSCLC.</p>Formule :C16H12N2O2Se2Degré de pureté :98.06% - 99.14%Couleur et forme :SolidMasse moléculaire :422.2Kopexil
CAS :<p>Kopexil is a compound similar to minoxidil that promotes hair growthby inhibiting 5α-reductase and possibly activating potassium channel switches.</p>Formule :C4H6N4ODegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :126.12Tolrestat
CAS :<p>Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).</p>Formule :C16H14F3NO3SDegré de pureté :98.89% - >99.99%Couleur et forme :SolidMasse moléculaire :357.35Fidarestat
CAS :<p>Fidarestat (SNK 860),Aldose reductase inhibitor (IC50=26 nM). Targets AKR1B10 (33 μM) and V301L AKR1B10 (1.8 μM). Potential diabetes treatment.</p>Formule :C12H10FN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :279.22SN34037
CAS :<p>SN34037, specific Aldo-keto reductase 1C3 (AKR1C3) inhibitor, inhibiting the cytotoxic activity of PR-104A, suitable for studying PR-104A-responsive leukaemia.</p>Formule :C15H19Cl2N3O2Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :344.24Risarestat
CAS :<p>Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia.</p>Formule :C16H21NO4SDegré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :323.41Zenarestat
CAS :<p>Zenarestat is an orally active aldose reductase inhibitor capable of ameliorating diabetic peripheral neuropathy in rats with type 2 diabetes.</p>Formule :C17H11BrClFN2O4Degré de pureté :99.51% - 99.51%Couleur et forme :SolidMasse moléculaire :441.646-Hydroxyluteolin
CAS :<p>6-Hydroxyluteolin, a flavonoid compound extracted from Salvia amarissima Ortega, inhibits aldose reductase (AR) and has antimicrobial activity.</p>Formule :C15H10O7Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :302.24AY 9944
CAS :<p>AY 9944 inhibits DHCR7 enzyme (IC50=13 nM) and sterol isomerase, leading to hypocholesterolemia and 7DHC buildup.</p>Formule :C22H30Cl4N2Degré de pureté :98.92% - 99.65%Couleur et forme :SolidMasse moléculaire :464.3Izonsteride
CAS :<p>Izonsteride (LY320236) is a selective and potent 5alpha reductase inhibitor with dual action on the type I and type II isoforms of the enzyme.Izonsteride is</p>Formule :C24H26N2OS2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :422.61Lidorestat
CAS :<p>Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity.</p>Formule :C18H11F3N2O2SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :376.35Caracemide
CAS :<p>Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.</p>Formule :C6H11N3O4Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :189.17Minalrestat
CAS :<p>Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.</p>Formule :C19H11BrF2N2O4Degré de pureté :98.64% - 99.88%Couleur et forme :SolidMasse moléculaire :449.2Zopolrestat
CAS :<p>Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).</p>Formule :C19H12F3N3O3SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :419.38Ranirestat
CAS :<p>Ranirestat (AS-3201) is an AR inhibitor with neuroprotective properties that improves peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy</p>Formule :C17H11BrFN3O4Degré de pureté :98.83% - 99.44%Couleur et forme :SolidMasse moléculaire :420.19RJG-2051
CAS :<p>RJG-2051 is a selective covalent inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), with an IC50 value of 13 nM. It interferes with the metabolism of substrates such as androgens, estrogens, and prostaglandins through AKR1C3. RJG-2051 holds potential for cancer research.</p>Formule :C26H31N5O4SCouleur et forme :SolidMasse moléculaire :509.62
