Récepteur des androgènes
Le récepteur aux androgènes (AR) est un récepteur hormonal nucléaire activé par la liaison aux androgènes, tels que la testostérone et la dihydrotestostérone. Ce récepteur joue un rôle crucial dans le développement et le maintien des caractéristiques masculines, ainsi que dans la régulation de plusieurs processus physiologiques, notamment la croissance musculaire, la libido et la densité osseuse. Les inhibiteurs du récepteur aux androgènes sont largement étudiés dans le contexte du cancer de la prostate, où la signalisation de l'AR est souvent régulée à la hausse. Chez CymitQuimica, nous offrons une gamme de modulateurs du récepteur aux androgènes de haute qualité pour soutenir vos recherches en endocrinologie, biologie du cancer et régulation hormonale.
207 produits trouvés pour "Récepteur des androgènes"
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Ludaterone
CAS :<p>Ludaterone is an antiandrogen agent, with potent antiandrogenic activity.</p>Formule :C20H25ClO5Couleur et forme :SolidMasse moléculaire :380.86PROTAC AR Degrader-4 TFA
<p>PROTAC AR Degrader-4: IAP ligand, linker, AR binder; it's a SNIPER that degrades AR non-genetically.</p>Formule :C45H68F3N3O11Couleur et forme :SolidMasse moléculaire :884.03ARD-69
<p>ARD-69, a potent PROTAC, degrades AR in prostate cancer, with low DC50 values in AR+ cell lines, and suppresses AR gene expression.</p>Formule :C62H74ClFN8O7SCouleur et forme :SolidMasse moléculaire :1129.83PROTAC AR Degrader-8
CAS :<p>PROTAC AR Degrader-8 (Compound NP18) functions as a PROTAC degrader targeting the androgen receptor (AR) and effectively degrades AR-FL in both 22Rv1 and LNCaP cells with DC50 values of 0.018 μM and 0.14 μM, respectively. It also degrades AR-V7 in 22Rv1 cells with a DC50 of 0.026 μM. Additionally, PROTAC AR Degrader-8 inhibits the proliferation of 22Rv1 and LNCaP cancer cells, exhibiting IC50 values of 0.038 μM and 1.11 μM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in 22Rv1 cells (apoptosis). Demonstrating anticancer efficacy, PROTAC AR Degrader-8 shows activity in both mouse and zebrafish models. [Pink: ligand for target protein AR ligand-33; Black: linker; Blue: ligand for E3 ligase Cereblon]</p>Formule :C40H41N5O7Couleur et forme :SolidMasse moléculaire :703.783ARD-2051
CAS :<p>ARD-2051 is a potent, orally active proteolysis-targeting chimera degrader of the androgen receptor (AR), exhibiting DC50 values of 0.6 nM in degrading AR</p>Formule :C43H45ClN8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :789.32MTX-23
CAS :<p>MTX-23, an AR-targeted Proteolysis Targeting Chimera (PROTAC), effectively degrades both AR-V7 and AR-FL, inhibiting the proliferation of CaP cells and inducing</p>Formule :C43H53F2N7O7S2Couleur et forme :SolidMasse moléculaire :882.05Linuron
CAS :<p>Linuron herbicide disrupts photosynthesis and acts as an androgen receptor antagonist.</p>Formule :C9H10Cl2N2O2Degré de pureté :99.08%Couleur et forme :White Crystalline Solid Linuron Is A Colorless Crystals Non Corrosive Used As An HerbicideMasse moléculaire :249.09LO-4-25
<p>LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.</p>Couleur et forme :Odour SolidRLA-5331
<p>RLA-5331: iron activator with anti-androgen properties; inhibits mCRPC cell proliferation.</p>Formule :C40H43F3N6O7SCouleur et forme :SolidMasse moléculaire :808.87Cl-4AS-1
CAS :<p>steroidal androgen receptor agonist</p>Formule :C26H33ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.012-sec-Butylphenol
CAS :<p>2-sec-Butylphenol is an inhibitor of the androgen receptor and P450 aromatase, and can be used in research and experiments in the field of life sciences.</p>Formule :C10H14OCouleur et forme :SolidMasse moléculaire :150.222-Ethylhexyl trans-4-methoxycinnamate
CAS :<p>2-Ethylhexyl trans-4-methoxycinnamate is a sunscreen agent.</p>Formule :C18H26O3Degré de pureté :98.92%Couleur et forme :Pale Yellow LiquidMasse moléculaire :290.4Faznolutamide
CAS :<p>Faznolutamide is an antiandrogen agent [1] [2] .</p>Formule :C19H17FN4O2SCouleur et forme :SolidMasse moléculaire :384.4311-Ketodihydrotestosterone
CAS :<p>11-Ketodihydrotestosterone is a metabolite of 11β-Hydroxyandrostenedione. It is an active androgen and is also a potent androgen receptor (AR) agonist (Ki: 20.4 nM, EC50: 1.35 nM for human AR).</p>Formule :C19H28O3Couleur et forme :SolidMasse moléculaire :304.42ARD-2585
CAS :<p>ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.</p>Formule :C41H43ClN8O5Couleur et forme :SolidMasse moléculaire :763.28ARD-61
CAS :<p>ARD-61: potent PROTAC, degrades AR/PR in AR+ cancers, triggers apoptosis, inhibits tumor growth in mice.</p>Formule :C61H71ClN8O7SCouleur et forme :SolidMasse moléculaire :1095.8K2-B4-5e
<p>K2-B4-5e is a PROTAC compound designed to target the degradation of BRD4 and androgen receptor (AR) through a KLHDC2-based E3 ligase mechanism. It effectively induces rapid and potent degradation of BET family proteins and AR within cells.</p>Formule :C52H49ClN8O6SMasse moléculaire :948.31843ARCC-4
CAS :<p>ARCC-4: A VHL-recruiting, low-nanomolar (DC50=5nM) AR degrader; outshines enzalutamide; degrades AR mutants resistant to therapy.</p>Formule :C53H56F3N7O7S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1024.18RLA-4842
<p>RLA-4842: iron-based anti-androgen; inhibits mCRPC cell proliferation.</p>Formule :C42H46F3N5O8SCouleur et forme :SolidMasse moléculaire :837.9PROTAC AR Degrader-9
<p>PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]</p>Formule :C43H49ClN6O5Couleur et forme :SolidMasse moléculaire :765.339
