Hydroxylase
Les hydroxylases sont une classe d'enzymes qui catalysent l'hydroxylation des substrats, ajoutant souvent des groupes hydroxyles (-OH) à des positions spécifiques au sein des molécules. Ces enzymes sont impliquées dans une grande variété de voies biochimiques, y compris la synthèse d'hormones, les processus de détoxification et le métabolisme des médicaments. Les inhibiteurs et activateurs des hydroxylases sont des outils précieux dans la recherche sur les troubles métaboliques, le métabolisme des médicaments et la régulation hormonale. Chez CymitQuimica, nous offrons une sélection de réactifs pour hydroxylases de haute qualité pour soutenir vos recherches en biochimie, pharmacologie et régulation métabolique.
37 produits trouvés pour "Hydroxylase".
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Fenclonine
CAS :Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin.Formule :C9H10ClNO2Degré de pureté :98.81% - >99.99%Couleur et forme :Crystals From Methanol White SolidMasse moléculaire :199.634p-Ethynylphenylalanine hydrochloride
CAS :p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1].Formule :C11H12ClNO2Degré de pureté :98.02% - 99.83%Couleur et forme :SolidMasse moléculaire :225.671ACT-678689
CAS :ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].Formule :C23H22ClFN6O4S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :565.04Telotristat ethyl
CAS :Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.Formule :C27H26ClF3N6O3Degré de pureté :98% - 99.89%Couleur et forme :White SolidMasse moléculaire :574.982TPH1-IN-1
TPH1-IN-1 (compound 40) is a xanthine derivative that serves as an inhibitor of tryptophan hydroxylase TPH1, with an IC50 of 110.1 nM.Formule :C21H18N6O4SCouleur et forme :SolidMasse moléculaire :450.47TPH2 agonist-1
TPH2 agonist-1 (compound 20e) is an orally active TPH2 agonist that can penetrate the blood-brain barrier and is derived from 1,3,4-oxadiazol-2(3H)-one. In models with SCN1A defects, TPH2 agonist-1 enhances TPH2 expression and increases levels of 5-HT and GABA, demonstrating anticonvulsant activity. It stabilizes neuronal network electrophysiological activity and suppresses abnormal spike and burst activities. TPH2 agonist-1 shows no significant hERG inhibition or cytotoxicity and is suitable for studies related to severe myoclonic epilepsy in infancy (Dravet syndrome).TPT-004
TPT-004, a TPH inhibitor, exhibits superior pharmacokinetic and pharmacodynamic properties, and demonstrates efficacy in preclinical models for attenuatingCouleur et forme :Odour SolidGSK180
CAS :GSK180 is a potent KMO inhibitor (IC50 ~6 nM) that modulates kynurenine metabolism for metabolic, neurological, and inflammatory research.Formule :C10H7Cl2NO4Couleur et forme :White SolidMasse moléculaire :276.0732-Mercaptobenzothiazole (Standard)
CAS :2-Mercaptobenzothiazole (Standard) exhibits cell type-dependent cytotoxicity, induces cardiovascular developmental abnormalities in zebrafish, and can inhibit dopamine β-hydroxylase.Formule :C7H5NS2Masse moléculaire :167.25Cuprizone
CAS :Cuprizone is a copper chelator.Cuprizone is used to induce schizophrenia in mice.Cuprizone induces oligodendrocyte death and induces a demyelination response.Formule :C14H22N4O2Degré de pureté :99.88% - 99.94%Couleur et forme :Yellow SolidMasse moléculaire :278.3501FG-2216
CAS :FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Formule :C12H9ClN2O4Degré de pureté :97.13% - >99.99%Couleur et forme :SolidMasse moléculaire :280.664Nepicastat
CAS :Nepicastat (SYN117) is a potent, BBB-permeable, selective DBH inhibitor with IC50s of 8.5/9 nM in bovine/human.Formule :C14H15F2N3SCouleur et forme :SolidMasse moléculaire :295.35Ro 61-8048
CAS :Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.Formule :C17H15N3O6S2Degré de pureté :98% - >99.99%Couleur et forme :Yellow SolidMasse moléculaire :421.45p-Fluoro-L-phenylalanine
CAS :p-Fluoro-L-phenylalanine: TH substrate, studies enzyme regulation, binds E. coli L-leucine receptor, KD 0.26μM.Formule :C9H10FNO2Degré de pureté :99.63%Couleur et forme :White SolidMasse moléculaire :183.1796Telotristat Etiprate
CAS :Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.Formule :C36H35ClF3N7O6Degré de pureté :99.21% - 99.83%Couleur et forme :White SolidMasse moléculaire :754.155Mildronate
CAS :Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitineFormule :C6H14N2O2Degré de pureté :99.94%Couleur et forme :White SolidMasse moléculaire :146.1876TETRAHYDROPIPERINE
CAS :Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.Formule :C17H23NO3Degré de pureté :98.04% - 99.61%Couleur et forme :SolidMasse moléculaire :289.3694Guanoclor
CAS :Guanoclor (VATENSOL) (INN), also known as guanochlor, is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes.Formule :C9H12Cl2N4ODegré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :263.124Telotristat
CAS :Telotristat, active metabolite of LX1606, is an oral tryptophan hydroxylase inhibitor with potential antiserotonergic effects.Formule :C25H22ClF3N6O3Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :546.929Fenclonine hydrochloride
CAS :Fenclonine hydrochloride is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin.Formule :C9H11Cl2NO2Couleur et forme :SolidMasse moléculaire :236.095
