NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
383 produits trouvés pour "NF-κB"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Asatone
CAS :Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).Formule :C24H32O8Degré de pureté :99.84% - 99.92%Couleur et forme :SolidMasse moléculaire :448.51Ref: TM-T10383
1mg77,00€5mg167,00€1mL*10mM (DMSO)178,00€10mg260,00€25mg440,00€50mg628,00€100mg872,00€200mg1.153,00€Indacaterol maleate
CAS :Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.Formule :C28H32N2O7Degré de pureté :99.03% - 99.67%Couleur et forme :SolidMasse moléculaire :508.56Mevastatin
CAS :Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formule :C23H34O5Degré de pureté :99.12%Couleur et forme :White-Yellowish To Yellow Powder Solid PowderMasse moléculaire :390.51DCZ0415
CAS :DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.Formule :C23H20N2O2Degré de pureté :99.34% - 99.95%Couleur et forme :SolidMasse moléculaire :356.42Ref: TM-T10981
1mg50,00€5mg110,00€1mL*10mM (DMSO)119,00€10mg178,00€25mg334,00€50mg505,00€100mg707,00€200mg973,00€Mangiferin
CAS :Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.Formule :C19H18O11Degré de pureté :99.78% - 99.86%Couleur et forme :Light Yellow PowderMasse moléculaire :422.34Sulfasalazine
CAS :Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.Formule :C18H14N4O5SDegré de pureté :98.00% - 99.28%Couleur et forme :Minute Brownish-Yellow CrystalsMasse moléculaire :398.39Articaine hydrochloride
CAS :Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Formule :C13H21ClN2O3SDegré de pureté :99.76%Couleur et forme :White Crystalline PowderMasse moléculaire :320.84Lidocaine
CAS :Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Formule :C14H22N2ODegré de pureté :99.95% - >99.99%Couleur et forme :Needles From Benzene Or Alcohol SolidMasse moléculaire :234.34Erdosteine
CAS :Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.Formule :C8H11NO4S2Degré de pureté :99.65% - 99.94%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :249.31NIK SMI1
CAS :NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).Formule :C20H19N3O4Degré de pureté :99.04% - 99.99%Couleur et forme :SolidMasse moléculaire :365.38Ref: TM-T16290
1mg82,00€5mg173,00€10mg281,00€1mL*10mM (DMSO)410,00€25mg563,00€50mg885,00€100mg1.425,00€200mg1.948,00€Sinomenine hydrochloride
CAS :Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.Formule :C19H24ClNO4Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :365.85Theophylline monohydrate
CAS :Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calciumFormule :C7H8N4O2·H2ODegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :198.18Oxaprozin
CAS :Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.Formule :C18H15NO3Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :293.32Nimbolide
CAS :Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.Formule :C27H30O7Degré de pureté :95.84% - 99.4%Couleur et forme :SolidMasse moléculaire :466.52Ref: TM-T16324
1mg67,00€5mg167,00€1mL*10mM (DMSO)180,00€10mg289,00€25mg595,00€50mg820,00€100mg1.108,00€200mg1.440,00€BAY-985
CAS :BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Formule :C27H30F3N9ODegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :553.58Ref: TM-T10477
1mg163,00€5mg334,00€1mL*10mM (DMSO)408,00€10mg502,00€25mg853,00€50mg1.161,00€100mg1.558,00€Theophylline
CAS :Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and centralFormule :C7H8N4O2Degré de pureté :99.65% - 99.98%Couleur et forme :White Solid PowderMasse moléculaire :180.16Guaiacol
CAS :Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.Formule :C7H8O2Degré de pureté :99.95%Couleur et forme :Colourless To Pale Yellow Solid CrystallineMasse moléculaire :124.14α-Lipoic Acid
CAS :α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.Formule :C8H14O2S2Degré de pureté :98.39% - 99.83%Couleur et forme :Forms Yellowish Flakes Light Yellow To Yellow PowderMasse moléculaire :206.33TBK1/IKKε-IN-2
CAS :TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Formule :C26H27N5O3Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :457.52Ref: TM-T15559
1mg52,00€5mg111,00€1mL*10mM (DMSO)111,00€10mg173,00€25mg278,00€50mg375,00€100mg482,00€Urolithin B
CAS :Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormule :C13H8O3Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :212.2Aspirin
CAS :Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Formule :C9H8O4Degré de pureté :99.78% - 99.91%Couleur et forme :White Solid CrystallineMasse moléculaire :180.16Lidocaine hydrochloride
CAS :Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.Formule :C14H23ClN2ODegré de pureté :99.81% - 99.92%Couleur et forme :White Crystal PowderMasse moléculaire :270.798Naringin dihydrochalcone
CAS :Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.Formule :C27H34O14Degré de pureté :99.07% - 99.73%Couleur et forme :Solid PowderMasse moléculaire :582.55(E/Z)-BCI
CAS :(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROSFormule :C22H23NODegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :317.42Ref: TM-T11139
1mg75,00€5mg146,00€1mL*10mM (DMSO)161,00€10mg268,00€25mg427,00€50mg605,00€100mg803,00€200mg1.063,00€Dihydroartemisinin
CAS :Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!Formule :C15H24O5Degré de pureté :98% - 99.41%Couleur et forme :White SolidMasse moléculaire :284.35Sodium salicylate
CAS :Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.Formule :C7H5NaO3Degré de pureté :99.36% - 99.92%Couleur et forme :White Solid AmorphousMasse moléculaire :160.114-Hydroxychalcone
CAS :4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.Formule :C15H12O2Degré de pureté :99.75%Couleur et forme :Yellow PowderMasse moléculaire :224.255-Aminosalicylic Acid
CAS :5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!Formule :C7H7NO3Degré de pureté :98.88% - 99.49%Couleur et forme :Purplish-Tan Solid PowderMasse moléculaire :153.14Lidocaine Hydrochloride hydrate
CAS :Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formule :C14H22N2O·HCl·H2ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :288.82Sulindac
CAS :Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.Formule :C20H17FO3SDegré de pureté :99.09% - 99.15%Couleur et forme :Yellow SolidMasse moléculaire :356.41SN50 acetate (213546-53-3 free base)
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.Formule :C131H234N36O31SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :2841.55IMD-0560
CAS :IMD-0560 is a novel inhibitor of IκB kinase β.Formule :C15H8BrF6NO2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :428.12Baicalin
CAS :Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFormule :C21H18O11Degré de pureté :90.08% - 99.32%Couleur et forme :Yellow PowderMasse moléculaire :446.36Ref: TM-T2775
50mg34,00€100mg49,00€200mg49,00€1mL*10mM (DMSO)50,00€500mg55,00€1g80,00€2g102,00€5g152,00€CDDO-dhTFEA
CAS :CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.Formule :C33H45F3N2O3Degré de pureté :95.61% - 99.59%Couleur et forme :SolidMasse moléculaire :574.72Ref: TM-T13604
1mg66,00€2mg96,00€5mg144,00€1mL*10mM (DMSO)177,00€10mg241,00€25mg485,00€50mg700,00€100mg982,00€500mg1.953,00€Ergolide
CAS :Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.Formule :C17H22O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :306.35Ref: TM-T13686
1mg71,00€5mg139,00€1mL*10mM (DMSO)166,00€10mg230,00€25mg374,00€50mg520,00€100mg697,00€DRI-C21045
CAS :Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).Formule :C32H24N2O7SDegré de pureté :97.20%Couleur et forme :SolidMasse moléculaire :580.61Methylthiouracil
CAS :Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Formule :C5H6N2OSDegré de pureté :99.89% - >99.99%Couleur et forme :Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Masse moléculaire :142.18Metaxalone
CAS :Metaxalone, sold as Skelaxin by King Pharmaceuticals, is a muscle relaxant for pain from strains and sprains.Formule :C12H15NO3Degré de pureté :98.84% - 99.94%Couleur et forme :White To Almost White Crystalline Powder SolidMasse moléculaire :221.25DMAPT
CAS :DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.Formule :C17H27NO3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :293.4Ginger extract
CAS :Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).Couleur et forme :Solid3-(2-Hydroxyethyl) thio withaferin A
3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.Formule :C30H44O7SCouleur et forme :SolidMasse moléculaire :548.73Murrayafoline A
CAS :Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.Formule :C14H13NOCouleur et forme :SolidMasse moléculaire :211.264NF-κB-IN-9
NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dualFormule :C62H50N4O4SCouleur et forme :SolidMasse moléculaire :947.15Licoagrochalcone C
CAS :Licoagrochalcone C, a flavonoid, inhibits NF-κB and NO production effectively.Formule :C21H22O5Couleur et forme :SolidMasse moléculaire :354.4IKKγ NBD Inhibitory Peptide
CAS :A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF
Formule :C170H259N49O42S1Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3693.3CAY10512
CAS :CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.Formule :C15H13FOCouleur et forme :SolidMasse moléculaire :228.266MJ210
MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.Couleur et forme :Odour SolidR-HP210
R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.Formule :C22H19N3O2S2Couleur et forme :SolidMasse moléculaire :421.5412-Oxo phytodienoic acid
CAS :12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.Formule :C18H28O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.41Mesalamine impurity P
CAS :Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.Formule :C13H11NO6SCouleur et forme :SolidMasse moléculaire :309.30
