NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
383 produits trouvés pour "NF-κB"
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4-Hydroxychalcone
CAS :4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.Formule :C15H12O2Degré de pureté :99.75%Couleur et forme :Yellow PowderMasse moléculaire :224.25Mevastatin
CAS :Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formule :C23H34O5Degré de pureté :99.12%Couleur et forme :White-Yellowish To Yellow Powder Solid PowderMasse moléculaire :390.51DRI-C21045
CAS :Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).Formule :C32H24N2O7SDegré de pureté :97.20%Couleur et forme :SolidMasse moléculaire :580.61Mangiferin
CAS :Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.Formule :C19H18O11Degré de pureté :99.78% - 99.86%Couleur et forme :Light Yellow PowderMasse moléculaire :422.34Lidocaine Hydrochloride hydrate
CAS :Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formule :C14H22N2O·HCl·H2ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :288.82Ergolide
CAS :Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.Formule :C17H22O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :306.35Ref: TM-T13686
1mg71,00€5mg139,00€1mL*10mM (DMSO)166,00€10mg230,00€25mg374,00€50mg520,00€100mg697,00€Methylthiouracil
CAS :Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Formule :C5H6N2OSDegré de pureté :99.89% - >99.99%Couleur et forme :Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Masse moléculaire :142.18BAY-985
CAS :BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Formule :C27H30F3N9ODegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :553.58Ref: TM-T10477
1mg163,00€5mg334,00€1mL*10mM (DMSO)408,00€10mg502,00€25mg853,00€50mg1.161,00€100mg1.558,00€Theophylline
CAS :Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and centralFormule :C7H8N4O2Degré de pureté :99.65% - 99.98%Couleur et forme :White Solid PowderMasse moléculaire :180.16DCZ0415
CAS :DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.Formule :C23H20N2O2Degré de pureté :99.34% - 99.95%Couleur et forme :SolidMasse moléculaire :356.42Ref: TM-T10981
1mg50,00€5mg110,00€1mL*10mM (DMSO)119,00€10mg178,00€25mg334,00€50mg505,00€100mg707,00€200mg973,00€TBK1/IKKε-IN-2
CAS :TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Formule :C26H27N5O3Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :457.52Ref: TM-T15559
1mg52,00€5mg111,00€1mL*10mM (DMSO)111,00€10mg173,00€25mg278,00€50mg375,00€100mg482,00€Oxaprozin
CAS :Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.Formule :C18H15NO3Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :293.32Naringin dihydrochalcone
CAS :Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.Formule :C27H34O14Degré de pureté :99.07% - 99.73%Couleur et forme :Solid PowderMasse moléculaire :582.55Erdosteine
CAS :Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.Formule :C8H11NO4S2Degré de pureté :99.65% - 99.94%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :249.31Theophylline monohydrate
CAS :Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calciumFormule :C7H8N4O2·H2ODegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :198.18Nimbolide
CAS :Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.Formule :C27H30O7Degré de pureté :95.84% - 99.4%Couleur et forme :SolidMasse moléculaire :466.52Ref: TM-T16324
1mg67,00€5mg167,00€1mL*10mM (DMSO)180,00€10mg289,00€25mg595,00€50mg820,00€100mg1.108,00€200mg1.440,00€SN50 acetate (213546-53-3 free base)
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.Formule :C131H234N36O31SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :2841.55Indacaterol maleate
CAS :Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.Formule :C28H32N2O7Degré de pureté :99.03% - 99.67%Couleur et forme :SolidMasse moléculaire :508.56Baicalin
CAS :Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFormule :C21H18O11Degré de pureté :90.08% - 99.32%Couleur et forme :Yellow PowderMasse moléculaire :446.36Ref: TM-T2775
50mg34,00€100mg49,00€200mg49,00€1mL*10mM (DMSO)50,00€500mg55,00€1g80,00€2g102,00€5g152,00€Sinomenine hydrochloride
CAS :Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.Formule :C19H24ClNO4Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :365.85(E/Z)-BCI
CAS :(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROSFormule :C22H23NODegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :317.42Ref: TM-T11139
1mg75,00€5mg146,00€1mL*10mM (DMSO)161,00€10mg268,00€25mg427,00€50mg605,00€100mg803,00€200mg1.063,00€NIK SMI1
CAS :NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).Formule :C20H19N3O4Degré de pureté :99.04% - 99.99%Couleur et forme :SolidMasse moléculaire :365.38Ref: TM-T16290
1mg82,00€5mg173,00€10mg281,00€1mL*10mM (DMSO)410,00€25mg563,00€50mg885,00€100mg1.425,00€200mg1.948,00€Aspirin
CAS :Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Formule :C9H8O4Degré de pureté :99.78% - 99.91%Couleur et forme :White Solid CrystallineMasse moléculaire :180.16Dihydroartemisinin
CAS :Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!Formule :C15H24O5Degré de pureté :98% - 99.41%Couleur et forme :White SolidMasse moléculaire :284.355-Aminosalicylic Acid
CAS :5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!Formule :C7H7NO3Degré de pureté :98.88% - 99.49%Couleur et forme :Purplish-Tan Solid PowderMasse moléculaire :153.14Sodium salicylate
CAS :Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.Formule :C7H5NaO3Degré de pureté :99.36% - 99.92%Couleur et forme :White Solid AmorphousMasse moléculaire :160.11Lidocaine hydrochloride
CAS :Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.Formule :C14H23ClN2ODegré de pureté :99.81% - 99.92%Couleur et forme :White Crystal PowderMasse moléculaire :270.798Asatone
CAS :Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).Formule :C24H32O8Degré de pureté :99.84% - 99.92%Couleur et forme :SolidMasse moléculaire :448.51Ref: TM-T10383
1mg77,00€5mg167,00€1mL*10mM (DMSO)178,00€10mg260,00€25mg440,00€50mg628,00€100mg872,00€200mg1.153,00€CDDO-dhTFEA
CAS :CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.Formule :C33H45F3N2O3Degré de pureté :95.61% - 99.59%Couleur et forme :SolidMasse moléculaire :574.72Ref: TM-T13604
1mg66,00€2mg96,00€5mg144,00€1mL*10mM (DMSO)177,00€10mg241,00€25mg485,00€50mg700,00€100mg982,00€500mg1.953,00€Articaine hydrochloride
CAS :Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Formule :C13H21ClN2O3SDegré de pureté :99.76%Couleur et forme :White Crystalline PowderMasse moléculaire :320.84Urolithin B
CAS :Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormule :C13H8O3Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :212.2Sulindac
CAS :Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.Formule :C20H17FO3SDegré de pureté :99.09% - 99.15%Couleur et forme :Yellow SolidMasse moléculaire :356.41Lidocaine
CAS :Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Formule :C14H22N2ODegré de pureté :99.95% - >99.99%Couleur et forme :Needles From Benzene Or Alcohol SolidMasse moléculaire :234.34Metaxalone
CAS :Metaxalone, sold as Skelaxin by King Pharmaceuticals, is a muscle relaxant for pain from strains and sprains.Formule :C12H15NO3Degré de pureté :98.84% - 99.94%Couleur et forme :White To Almost White Crystalline Powder SolidMasse moléculaire :221.25Sulfasalazine
CAS :Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.Formule :C18H14N4O5SDegré de pureté :98.00% - 99.28%Couleur et forme :Minute Brownish-Yellow CrystalsMasse moléculaire :398.39Guaiacol
CAS :Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.Formule :C7H8O2Degré de pureté :99.95%Couleur et forme :Colourless To Pale Yellow Solid CrystallineMasse moléculaire :124.14IMD-0560
CAS :IMD-0560 is a novel inhibitor of IκB kinase β.Formule :C15H8BrF6NO2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :428.12DMAPT
CAS :DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.Formule :C17H27NO3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :293.4α-Lipoic Acid
CAS :α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.Formule :C8H14O2S2Degré de pureté :98.39% - 99.83%Couleur et forme :Forms Yellowish Flakes Light Yellow To Yellow PowderMasse moléculaire :206.33OT-551 HCl
CAS :OT-551 HCl is an NF-Κb inhibitor, a disubstituted hydroxylamine with antioxidant properties can be used for the treatment of cataracts and age-related macularFormule :C13H24ClNO3Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :277.79Ref: TM-T28273L
1mg109,00€5mg233,00€1mL*10mM (DMSO)279,00€10mg344,00€25mg532,00€50mg760,00€100mg1.054,00€200mg1.414,00€Sootepin D
CAS :Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.Formule :C31H48O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.71NF-κB-IN-12
NF-κB-IN-12 (compound 3h) serves as a potent inhibitor of NF-κB, exhibiting an IC50 value of 1.02 μM. It is applicable for research in acute lung injury [1].Formule :C30H26N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :582.63Transcription Factor-Targeted Compound Library
Well-chosen xnum compounds with unique structures targeting transcription factor;Couleur et forme :Odour SolidRef: TM-L1380
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderCTP-NBD
CAS :CTP-NBD is a cell-permeable, specific inhibitor of the NFκB peptide, which has been utilized in studies of colitis [1] [2].Formule :C121H194N46O32Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2805.12NF-κB Signaling Compound Library
A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;Couleur et forme :Odour SolidRef: TM-L3800
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderAnti-inflammatory agent 51
CAS :Anti-inflammatory agent 51 amide/sulfonamide anti-inflammatory and anti-tumor activity inhibition of NF-κB activation acute lung injury and ulcerative colitis.Formule :C22H22N6O6SDegré de pureté :99.76%Couleur et forme :SoildMasse moléculaire :498.51HS-243
CAS :HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
Formule :C17H16N4O3Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :324.33Coronalolic acid
CAS :Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.Formule :C30H46O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.68(R)-(-)-Ibuprofen
CAS :(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation.Formule :C13H18O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :206.2812-Oxo phytodienoic acid
CAS :12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.Formule :C18H28O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.41EN450
CAS :EN450 is a targeted cysteine degrader of NF-κB with antiproliferative activity and potential anticancer activity for the study of leukemia.Formule :C11H13ClN2O3SDegré de pureté :98.39%Couleur et forme :SoildMasse moléculaire :288.75Ref: TM-T77525
2mg44,00€5mg64,00€1mL*10mM (DMSO)71,00€10mg96,00€25mg187,00€50mg288,00€100mg416,00€200mg583,00€Anti-inflammatory agent 60
Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production, presenting an IC50 of 12.95 μM, and reduces iNOS, phosphorylated p65, and β-cateninDegré de pureté :98%Couleur et forme :Odour SolidIVMT-Rx-3
IVMT-Rx-3 is a chemical compound that serves as an inhibitor of SDCBP's targeting of the PDZ1 and PDZ2 domains of MDA-9/Syntenin.Formule :C69H90F3N13O24Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :1542.54Sanggenon A
CAS :Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and itFormule :C25H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :436.45Apo A-I mimetic 5A peptide
Apo A-I mimetic 5A peptide is a synthetic peptide molecule designed based on the structure and function of naturally occurring apolipoprotein A-I (Apo A-I). It facilitates the efflux of cholesterol from inside cells, helping to reduce intracellular cholesterol accumulation. Additionally, Apo A-I mimetic 5A peptide exhibits anti-inflammatory properties, lowering inflammatory markers in blood and tissues. This peptide is used in cardiovascular disease research.Formule :C197H295N47O56Masse moléculaire :4215.16808Helenalin
CAS :Helenalin: anti-inflammatory sesquiterpene, inhibits NF-κB by alkylating p65 cysteine groups, blocks DNA binding.Formule :C15H18O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :262.3Halleridone
CAS :Halleridone, a natural product, is identified in Teuanchum decipiens and Abeliophyllum distichum.Formule :C8H10O3Couleur et forme :SolidMasse moléculaire :154.165Eupenicisirenin C
CAS :Eupenicisirenin C (compound 1), a sirenin derivative, exhibits strong NF-κB inhibitory activities and suppresses the cGAS-STING pathway. Additionally, Eupenicisirenin C inhibits RANKL-induced osteoclast differentiation in bone marrow macrophage cells [1].Formule :C13H18O4Couleur et forme :SolidMasse moléculaire :238.28PROTAC STING degrader-3
PROTACSTING degrader-3 (Compound ST9) is a STINGPROTAC-type degrader with a DC50 of 0.62 μM. It induces STING degradation via the ubiquitin-proteasome pathway. This compound exerts anti-inflammatory effects by inhibiting the STING/TBK1/NF-κB signaling. Additionally, it offers renal protection and can be used in research on acute kidney injury.Couleur et forme :Odour SolidCAY10657
CAS :CAY10657 has a wide range of applications in life science related research.
Formule :C17H20N4O3SCouleur et forme :SolidMasse moléculaire :360.43HOIPIN-1
CAS :HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-Formule :C17H13NaO4Degré de pureté :98.65%Couleur et forme :SoildMasse moléculaire :304.27IKK-IN-3
CAS :IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).Formule :C17H17N5SCouleur et forme :SolidMasse moléculaire :323.42IKKγ NBD Inhibitory Peptide
CAS :A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF
Formule :C170H259N49O42S1Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3693.3Anti-osteoporosis agent-8
Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.Formule :C18H19F3N2O2SeMasse moléculaire :432.05638PS 1145 dihydrochloride
CAS :IκB kinase (IKK) inhibitorFormule :C17H13Cl3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.67Aloenin aglycone
CAS :Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate.Formule :C13H12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.23R-HP210
R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.Formule :C22H19N3O2S2Couleur et forme :SolidMasse moléculaire :421.54Gliotoxin
CAS :Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Formule :C13H14N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.39Anti-inflammatory agent 48
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatoryFormule :C24H21Cl2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.33Diprovocim-1
CAS :Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.Formule :C56H56N6O6Couleur et forme :SolidMasse moléculaire :909.1SjDX5-271
CAS :SjDX5-271 is a 3 kDa peptide that inhibits the TLR4/MyD88/NF-κB signaling pathway. It induces cell polarization, alleviates liver inflammation, and protects mice from liver ischemia-reperfusion injury.Formule :C137H215N47O49SCouleur et forme :SolidMasse moléculaire :3336.52TBK1/IKKε-IN-6
CAS :TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.Formule :C31H36F2N8O4Couleur et forme :SolidMasse moléculaire :622.678SN50 TFA
SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.Formule :C129H230N36O29S·XCF3COOHCouleur et forme :SolidMasse moléculaire :2781.5 (free base)NBD peptide
CAS :NBD peptide inhibits the NF-κB signaling pathway by preventing the binding of the NEMO-IKK complex. It exhibits anti-inflammatory activity by blocking the production of pro-inflammatory cytokines. Additionally, NBD peptide demonstrates immunosuppressive effects through the regulation of immune cells. It enhances transmembrane capacity by conjugating with the cell-penetrating peptide HIV-TAT.Formule :C62H88N14O20Couleur et forme :SolidMasse moléculaire :1349.447-O-Methylaloeasinol
CAS :7-O-Methylaloeasinol is a useful organic compound for research related to life sciences. The catalog number is T126468 and the CAS number is 105317-69-9.Formule :C20H26O9Couleur et forme :SolidMasse moléculaire :410.419Siegesbeckialide I
Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.Formule :C20H28O6Couleur et forme :SolidMasse moléculaire :364.43Anti-inflammatory agent 7
Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.Formule :C36H40N4O9Couleur et forme :SolidMasse moléculaire :672.72SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Couleur et forme :Odour Solid17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS :DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).
Formule :C22H32O3Couleur et forme :SolidMasse moléculaire :344.495N-Acetyldopamine dimer-2
CAS :Compound 2, an N-acetyldopamine dimer from Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties.Formule :C20H20N2O6Couleur et forme :SolidMasse moléculaire :384.383-(2-Hydroxyethyl) thio withaferin A
3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.Formule :C30H44O7SCouleur et forme :SolidMasse moléculaire :548.73Nasunin
CAS :Delphanin, also known as Nasunin, is an anthocyanin isolated as purple colored crystals from eggplant peels.Formule :C42H47ClO23Couleur et forme :SolidMasse moléculaire :955.26LY2409881
CAS :LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.Formule :C24H29ClN6OSCouleur et forme :SolidMasse moléculaire :485.05Mesalamine impurity P
CAS :Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.Formule :C13H11NO6SCouleur et forme :SolidMasse moléculaire :309.30Ginger extract
CAS :Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).Couleur et forme :SolidNF-κΒ activator 1
CAS :NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.Formule :C16H11FN2O2SDegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :314.33Ref: TM-T39965
1mg95,00€5mg202,00€1mL*10mM (DMSO)224,00€10mg329,00€25mg560,00€50mg800,00€100mg1.103,00€500mg2.213,00€Licoagrochalcone C
CAS :Licoagrochalcone C, a flavonoid, inhibits NF-κB and NO production effectively.Formule :C21H22O5Couleur et forme :SolidMasse moléculaire :354.4NLRP3-IN-51
NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.Couleur et forme :Odour SolidLemnalol
CAS :Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.Formule :C15H24ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :220.35Antidesmone
CAS :Antidesmone from Ajuga decumbens inhibits acute lung injury by modulating MAPK and NF-κB.Formule :C19H29NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.44CAY10512
CAS :CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.Formule :C15H13FOCouleur et forme :SolidMasse moléculaire :228.266Pratensein
CAS :Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.Formule :C16H12O6Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :300.26Murrayafoline A
CAS :Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.Formule :C14H13NOCouleur et forme :SolidMasse moléculaire :211.264R1-ICR-5
CAS :R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Formule :C54H70N8O7S2Couleur et forme :SolidMasse moléculaire :1007.31Cyclo(L-Pro-L-Val)
CAS :Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.
Formule :C10H16N2O2Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :196.25MJ210
MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.Couleur et forme :Odour SolidNF-κB-IN-9
NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dualFormule :C62H50N4O4SCouleur et forme :SolidMasse moléculaire :947.15SN50M
CAS :SN50M (NF-κB Control) is a synthetic peptide containing a hydrophobic region and mutant nuclear localization sequences that can enter cells.Formule :C123H215N33O30SCouleur et forme :SolidMasse moléculaire :2668.29Mitogen-activated protein kinase 1
CAS :Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Degré de pureté :98%Couleur et forme :SolidNF-κB-IN-10
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviatingFormule :C26H30N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.53
