NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
365 produits trouvés pour "NF-κB".
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NF-κB Signaling Compound Library
A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;Couleur et forme :Odour SolidHalleridone
CAS :Halleridone is a natural compound isolated from the stems of Cornus walteri, recognized for its ability to activate the Nrf2 signaling pathway. It promotes Nrf2 nuclear translocation and upregulates heme oxygenase-1 (HO-1) expression in murine hippocampal HT22 cells. The compound also suppresses Aβ1-42-induced inflammatory mediators, including IL-1β, IL-6, prostaglandin E2, and nitric oxide, while reducing pNF-κB nuclear accumulation. Researchers utilize halleridone to study antioxidant response element activation and neuroinflammatory signaling in cellular models of neurodegeneration.Formule :C8H10O3Couleur et forme :SolidMasse moléculaire :154.1632TBK1/IKKε-IN-6
CAS :TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.Formule :C31H36F2N8O4Couleur et forme :SolidMasse moléculaire :622.678Transcription Factor-Targeted Compound Library
Well-chosen xnum compounds with unique structures targeting transcription factor;Couleur et forme :Odour SolidAnti-inflammatory agent 7
Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.Formule :C36H40N4O9Couleur et forme :SolidMasse moléculaire :672.727-O-Methylaloeasinol
CAS :7-O-Methylaloeasinol is a useful organic compound for research related to life sciences. The catalog number is T126468 and the CAS number is 105317-69-9.Formule :C20H26O9Couleur et forme :SolidMasse moléculaire :410.419NF-κB-IN-9
NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dualFormule :C62H50N4O4SCouleur et forme :SolidMasse moléculaire :947.15Pratensein
CAS :Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.Formule :C16H12O6Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :300.2629Apo A-I mimetic 5A peptide
Apo A-I mimetic 5A peptide is a synthetic peptide molecule designed based on the structure and function of naturally occurring apolipoprotein A-I (Apo A-I). It facilitates the efflux of cholesterol from inside cells, helping to reduce intracellular cholesterol accumulation. Additionally, Apo A-I mimetic 5A peptide exhibits anti-inflammatory properties, lowering inflammatory markers in blood and tissues. This peptide is used in cardiovascular disease research.Formule :C197H295N47O56Couleur et forme :SolidMasse moléculaire :4215.16808Mesalamine impurity P
CAS :Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.Formule :C13H11NO6SCouleur et forme :SolidMasse moléculaire :309.30MJ210
MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.Couleur et forme :Odour SolidZM600
ZM600 is an effective and orally active anti-hepatic fibrosis agent that can reduce the protein expression of collagen I, α-SM, and p-p65. This compound shows promising potential for use in hepatic fibrosis research.R-HP210
R-HP210 is a SGRM that exerts anti-inflammatory activity by acting on the NF-κB-mediated inhibitory cross-talk (IC₅₀ = 3.80 μM).Formule :C22H19N3O2S2Degré de pureté :99.35%Couleur et forme :White SolidMasse moléculaire :421.53Siegesbeckialide I
Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.Formule :C20H28O6Couleur et forme :SolidMasse moléculaire :364.43IKKγ NBD Inhibitory Peptide
CAS :A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNFFormule :C170H259N49O42S1Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3693.317-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS :DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).Formule :C22H32O3Couleur et forme :SolidMasse moléculaire :344.495R1-ICR-5
CAS :R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Formule :C54H70N8O7S2Couleur et forme :SolidMasse moléculaire :1007.31CAY10512
CAS :CAY10512 is a NF-κB inhibitor, can inhibit NF-κB-sensitive pro-inflammatory microRNAs and inflammatory signaling in human neuronal and astrocyte models.Formule :C15H13FODegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :228.27Tat-IKIP (46-60)
Tat-IKIP (46-60) is a transmembrane peptide that targets IκB kinase (IKK). It inhibits the activation of IKK and the expression of NF-κB target genes by disrupting the IKKβ/NEMO complex. In mouse models, Tat-IKIP (46-60) significantly alleviates DSS-induced acute inflammation in inflammatory bowel disease (IBD) and reduces zymosan-induced acute arthritis in acute arthritis models (AAM). This compound is applicable in research on inflammatory diseases such as IBD, pancreatitis, and rheumatoid arthritis.PS 1145 dihydrochloride
CAS :IκB kinase (IKK) inhibitorFormule :C17H13Cl3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.67
