NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
383 produits trouvés pour "NF-κB"
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TBK1/IKKε-IN-6
CAS :TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.Formule :C31H36F2N8O4Couleur et forme :SolidMasse moléculaire :622.678N-Acetyldopamine dimer-2
CAS :Compound 2, an N-acetyldopamine dimer from Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties.Formule :C20H20N2O6Couleur et forme :SolidMasse moléculaire :384.38Licoagrochalcone C
CAS :Licoagrochalcone C, a flavonoid, inhibits NF-κB and NO production effectively.Formule :C21H22O5Couleur et forme :SolidMasse moléculaire :354.47-O-Methylaloeasinol
CAS :7-O-Methylaloeasinol is a useful organic compound for research related to life sciences. The catalog number is T126468 and the CAS number is 105317-69-9.Formule :C20H26O9Couleur et forme :SolidMasse moléculaire :410.419Siegesbeckialide I
Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.Formule :C20H28O6Couleur et forme :SolidMasse moléculaire :364.433-(2-Hydroxyethyl) thio withaferin A
3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.Formule :C30H44O7SCouleur et forme :SolidMasse moléculaire :548.73Ginger extract
CAS :Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).Couleur et forme :SolidMesalamine impurity P
CAS :Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.Formule :C13H11NO6SCouleur et forme :SolidMasse moléculaire :309.30Murrayafoline A
CAS :Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.Formule :C14H13NOCouleur et forme :SolidMasse moléculaire :211.264CAY10512
CAS :CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.Formule :C15H13FOCouleur et forme :SolidMasse moléculaire :228.26612-Oxo phytodienoic acid
CAS :12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.Formule :C18H28O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.41NF-κB-IN-9
NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dualFormule :C62H50N4O4SCouleur et forme :SolidMasse moléculaire :947.15NF-κB Signaling Compound Library
A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;Couleur et forme :Odour SolidRef: TM-L3800
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderSN50 TFA
SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.Formule :C129H230N36O29S·XCF3COOHCouleur et forme :SolidMasse moléculaire :2781.5 (free base)R1-ICR-5
CAS :R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Formule :C54H70N8O7S2Couleur et forme :SolidMasse moléculaire :1007.3117-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS :DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).
Formule :C22H32O3Couleur et forme :SolidMasse moléculaire :344.495Transcription Factor-Targeted Compound Library
Well-chosen xnum compounds with unique structures targeting transcription factor;Couleur et forme :Odour SolidRef: TM-L1380
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderAnti-inflammatory agent 7
Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.Formule :C36H40N4O9Couleur et forme :SolidMasse moléculaire :672.72R-HP210
R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.Formule :C22H19N3O2S2Couleur et forme :SolidMasse moléculaire :421.54Helenalin
CAS :Helenalin: anti-inflammatory sesquiterpene, inhibits NF-κB by alkylating p65 cysteine groups, blocks DNA binding.Formule :C15H18O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :262.3
