NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
384 produits trouvés pour "NF-κB"
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3-(2-Hydroxyethyl) thio withaferin A
3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.Formule :C30H44O7SCouleur et forme :SolidMasse moléculaire :548.73Nasunin
CAS :Delphanin, also known as Nasunin, is an anthocyanin isolated as purple colored crystals from eggplant peels.Formule :C42H47ClO23Couleur et forme :SolidMasse moléculaire :955.26LY2409881
CAS :LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.Formule :C24H29ClN6OSCouleur et forme :SolidMasse moléculaire :485.05Mesalamine impurity P
CAS :Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.Formule :C13H11NO6SCouleur et forme :SolidMasse moléculaire :309.30Ginger extract
CAS :Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).Couleur et forme :SolidNF-κΒ activator 1
CAS :NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.Formule :C16H11FN2O2SDegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :314.33Ref: TM-T39965
1mg95,00€5mg202,00€1mL*10mM (DMSO)224,00€10mg329,00€25mg560,00€50mg800,00€100mg1.103,00€500mg2.213,00€Licoagrochalcone C
CAS :Licoagrochalcone C, a flavonoid, inhibits NF-κB and NO production effectively.Formule :C21H22O5Couleur et forme :SolidMasse moléculaire :354.4NLRP3-IN-51
NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.Couleur et forme :Odour SolidLemnalol
CAS :Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.Formule :C15H24ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :220.35Antidesmone
CAS :Antidesmone from Ajuga decumbens inhibits acute lung injury by modulating MAPK and NF-κB.Formule :C19H29NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.44CAY10512
CAS :CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.Formule :C15H13FOCouleur et forme :SolidMasse moléculaire :228.266Pratensein
CAS :Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.Formule :C16H12O6Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :300.26Murrayafoline A
CAS :Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.Formule :C14H13NOCouleur et forme :SolidMasse moléculaire :211.264R1-ICR-5
CAS :R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.Formule :C54H70N8O7S2Couleur et forme :SolidMasse moléculaire :1007.31Cyclo(L-Pro-L-Val)
CAS :Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.
Formule :C10H16N2O2Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :196.25MJ210
MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.Couleur et forme :Odour SolidNF-κB-IN-9
NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dualFormule :C62H50N4O4SCouleur et forme :SolidMasse moléculaire :947.15SN50M
CAS :SN50M (NF-κB Control) is a synthetic peptide containing a hydrophobic region and mutant nuclear localization sequences that can enter cells.Formule :C123H215N33O30SCouleur et forme :SolidMasse moléculaire :2668.29Anti-inflammatory agent 48
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatoryFormule :C24H21Cl2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.33NF-κB-IN-10
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviatingFormule :C26H30N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.53
