IκB/IKK
Le complexe IκB/IKK est un régulateur clé de la voie de signalisation NF-κB, qui contrôle l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation et la survie cellulaire. Les protéines IκB inhibent l'activité de NF-κB en le séquestrant dans le cytoplasme, tandis que les IKK phosphorylent IκB, conduisant à sa dégradation et à l'activation de NF-κB. La dérégulation de la voie IκB/IKK est liée à l'inflammation chronique, au cancer et aux maladies auto-immunes. Chez CymitQuimica, nous offrons une sélection de modulateurs IκB/IKK de haute qualité pour soutenir vos recherches en transduction de signal, inflammation et développement thérapeutique.
58 produits trouvés pour "IκB/IKK"
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Ac2-26 ammonium
Ac2-26 ammonium is an N-terminal derivative peptide of Annexin-A1 (AnxA1) with anti-inflammatory activity.Formule :C141H210N32O44S·xNH3Degré de pureté :95.58%Couleur et forme :SolidMasse moléculaire :3089.43 (free base)BAY-985
CAS :BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Formule :C27H30F3N9ODegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :553.58Ref: TM-T10477
1mg163,00€5mg334,00€10mg502,00€25mg853,00€50mg1.161,00€100mg1.558,00€1mL*10mM (DMSO)408,00€TBK1/IKKε-IN-2
CAS :TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Formule :C26H27N5O3Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :457.52Ref: TM-T15559
1mg52,00€5mg111,00€10mg173,00€25mg278,00€50mg375,00€100mg482,00€1mL*10mM (DMSO)111,00€IMD-0560
CAS :IMD-0560 is a novel inhibitor of IκB kinase β.Formule :C15H8BrF6NO2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :428.12Vinpocetine
CAS :Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).Formule :C22H26N2O2Degré de pureté :99.85% - 99.98%Couleur et forme :White Crystalline SolidMasse moléculaire :350.45LY2409881
CAS :LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.Formule :C24H29ClN6OSCouleur et forme :SolidMasse moléculaire :485.05PS 1145 dihydrochloride
CAS :IκB kinase (IKK) inhibitorFormule :C17H13Cl3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.67Siegesbeckialide I
Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.Formule :C20H28O6Couleur et forme :SolidMasse moléculaire :364.43SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Couleur et forme :Odour SolidIKK-IN-3
CAS :IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).Formule :C17H17N5SCouleur et forme :SolidMasse moléculaire :323.42TBK1/IKKε-IN-6
CAS :TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.Formule :C31H36F2N8O4Couleur et forme :SolidMasse moléculaire :622.678PROTAC STING degrader-4
PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI).Formule :C39H42Cl2N8O9Couleur et forme :SolidMasse moléculaire :836.24518Verproside
CAS :Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.Formule :C22H26O13Couleur et forme :SolidMasse moléculaire :498.437MRT67307
CAS :Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Formule :C26H36N6O2Degré de pureté :99.25% - 99.84%Couleur et forme :SolidMasse moléculaire :464.6HOIPIN-1
CAS :HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-Formule :C17H13NaO4Degré de pureté :98.65%Couleur et forme :SoildMasse moléculaire :304.27IKK 16 hydrochloride
CAS :IKK 16 hydrochloride, a potent IKK1/2 and LRRK2 inhibitor, IC50s: 40-200 nM and 50 nM respectively.Formule :C28H30ClN5OSCouleur et forme :SolidMasse moléculaire :520.09ML 120B dihydrochloride
CAS :MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.Formule :C19H17Cl3N4O2Couleur et forme :SolidMasse moléculaire :439.72MLN120B
CAS :MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Formule :C19H15ClN4O2Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :366.8Ref: TM-TQ0306
1mg49,00€2mg70,00€5mg96,00€10mg160,00€25mg329,00€50mg567,00€100mg777,00€1mL*10mM (DMSO)116,00€AZD3264
CAS :AZD3264 is a new type IKK2 inhibitor.Formule :C21H23N5O4SDegré de pureté :98.98% - 99.17%Couleur et forme :SolidMasse moléculaire :441.5Ref: TM-T6771
1mg52,00€2mg70,00€5mg103,00€10mg160,00€25mg311,00€50mg502,00€100mg805,00€500mg1.605,00€1mL*10mM (DMSO)114,00€GSK8612
CAS :GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .Formule :C17H17BrF3N7O2SDegré de pureté :99.68% - 99.99%Couleur et forme :SolidMasse moléculaire :520.33SC-514
CAS :SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
Formule :C9H8N2OS2Degré de pureté :99.88% - >99.99%Couleur et forme :SolidMasse moléculaire :224.3BMS-345541
CAS :BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.Formule :C14H17N5Degré de pureté :99.36% - 99.74%Couleur et forme :SolidMasse moléculaire :255.32TBK1/IKKε-IN-5
CAS :TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).Formule :C28H31N7O3Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :513.59Ref: TM-T7951
1mg88,00€5mg182,00€10mg269,00€25mg429,00€50mg587,00€100mg837,00€200mg1.125,00€1mL*10mM (DMSO)224,00€JTP 0819958 - HOIPIN-1
JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.Formule :C17H13NaO4Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :304.27Ref: TM-T8951
1mg37,00€2mg50,00€5mg65,00€10mg95,00€25mg210,00€50mg339,00€100mg495,00€500mg1.099,00€1mL*10mM (DMSO)77,00€2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS :2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.
Formule :C11H10N2OSDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :218.27BMS-345541 hydrochloride
CAS :BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Formule :C14H18ClN5Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :291.78Ref: TM-T8542
1mg38,00€2mg50,00€5mg82,00€10mg119,00€25mg212,00€50mg356,00€100mg533,00€1mL*10mM (DMSO)52,00€BOT-64
CAS :BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathioleFormule :C15H15NO2SDegré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :273.35Ref: TM-T8705
1mg50,00€5mg110,00€10mg170,00€25mg323,00€50mg494,00€100mg665,00€200mg893,00€1mL*10mM (DMSO)102,00€IMD-0354
CAS :IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Formule :C15H8ClF6NO2Degré de pureté :99.65% - 99.98%Couleur et forme :SolidMasse moléculaire :383.67Ref: TM-T6141
2mg46,00€5mg63,00€10mg87,00€25mg155,00€50mg210,00€100mg294,00€500mg713,00€1mL*10mM (DMSO)65,00€NF-κB-IN-1
CAS :NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFormule :C31H30O8Degré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :530.57Ref: TM-T9105
1mg166,00€5mg341,00€10mg550,00€25mg898,00€50mg1.216,00€100mg1.644,00€1mL*10mM (DMSO)398,00€INH14
CAS :INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).Formule :C15H16N2ODegré de pureté :95.41%Couleur et forme :SolidMasse moléculaire :240.3GSK319347A
CAS :GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Formule :C22H19N3O5S2Degré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :469.53BAY32-5915
CAS :BAY32-5915 is a selective inhibitor of IKKalpha.Formule :C10H7NO3Degré de pureté :96.48% - 97%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :189.17Bay 65-1942 free base
CAS :Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Formule :C22H25N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.45Ertiprotafib
CAS :Ertiprotafib (PTP 112), a PTP1B and IKK-β inhibitor, is a novel insulin sensitizer for the study of type 2 diabetes and breast cancer.
Formule :C31H27BrO3SDegré de pureté :98.70%Couleur et forme :SolidMasse moléculaire :559.51TBK1/IKKε-IN-4
CAS :TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nMFormule :C28H35N7O4Couleur et forme :SolidMasse moléculaire :533.62PHA-408
CAS :PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.Formule :C29H27ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.02DMX-129
CAS :DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].Formule :C19H17FN8Couleur et forme :SolidMasse moléculaire :376.39IKK2-IN-4
CAS :IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Formule :C12H11N3O2SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :261.3Ref: TM-T36524
1mg108,00€5mg261,00€10mg401,00€25mg622,00€50mg837,00€100mg1.125,00€200mg1.504,00€500µg82,00€1-Dehydro-[10]-gingerdione
CAS :1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.Formule :C21H30O4Couleur et forme :SolidMasse moléculaire :346.46CS12192
CAS :CS12192 enhances survival, boosts weight, and shows promise in GVHD research per patent CN112773802A.Formule :C25H23ClFN7O2Couleur et forme :SolidMasse moléculaire :507.95HPN-01
CAS :HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Formule :C19H16ClN3O3SDegré de pureté :98.07% - 98.17%Couleur et forme :SolidMasse moléculaire :401.87Ref: TM-T11573
2mg137,00€5mg222,00€10mg356,00€25mg708,00€50mg1.063,00€100mg1.603,00€200mg2.187,00€1mL*10mM (DMSO)245,00€CAY10575
CAS :CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Formule :C22H21N3O6S2Couleur et forme :SolidMasse moléculaire :487.55Bay 65-1942 hydrochloride
CAS :Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Formule :C22H26ClN3O4Couleur et forme :SolidMasse moléculaire :431.91IKKβ-IN-1
CAS :IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).Formule :C31H30N4O4SCouleur et forme :SolidMasse moléculaire :554.66CGA-JK3
CAS :CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.Formule :C15H19NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :261.32PF 184
CAS :IKKβ inhibitorFormule :C32H32ClFN6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :619.09(Rac)-BAY-985
CAS :(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Formule :C27H30F3N9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.58Bay 65-1942 (R form)
CAS :Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.Formule :C22H25N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.45IKK-IN-1
CAS :IKK-IN-1 is an inhibitor of IKK.Formule :C22H26ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.91ACHP Hydrochloride
CAS :ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.Formule :C21H25ClN4O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :400.9Ref: TM-T10237
1mg66,00€5mg144,00€10mg227,00€25mg375,00€50mg540,00€100mg777,00€500mg1.549,00€1mL*10mM (DMSO)159,00€IKK-IN-4
CAS :IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].Formule :C18H19N5SCouleur et forme :SolidMasse moléculaire :337.44PF-184
PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.Formule :C32H32ClFN6O4Couleur et forme :SolidMasse moléculaire :619.09Glabrescone C
CAS :Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.
Formule :C19H22O7Couleur et forme :SolidMasse moléculaire :362.37TBK1-IN-1
CAS :TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Formule :C27H37N7O2Degré de pureté :99.81% - >99.99%Couleur et forme :SolidMasse moléculaire :491.63Anti-inflammatory agent 6
Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.Formule :C22H20O12Couleur et forme :SolidMasse moléculaire :476.39BMS-066
CAS :BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.Formule :C19H21N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.42GTCpFE
CAS :GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formule :C22H20O8Couleur et forme :SolidMasse moléculaire :412.39TBK1/IKKε-IN-1
CAS :TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).Formule :C28H26N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.53
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